Sistema de gestão e planejamento de conteúdos didáticos digitais para EaD / Digital didactic content management and planning system for EaD

Neste artigo, apresentamos um sistema de gestão e planejamento para as disciplinas dos cursos na modalidade a Distância (Made). Trata-se de um sistema de informações que atua como ferramenta de apoio na elaboração e no planejamento da Matriz de Design Educacional das disciplinas a distância. Ele possibilita a seus usuários (alunos, professores e gestores) sistematizar os processos educacionais, gerenciar os trabalhos acadêmicos e organizar o fluxo de mensagens entre os sujeitos envolvidos nas disciplinas. Como bases teóricas, utilizamos os modelos pedagógicos de Behar (2009); o Design instrucional de Filatro (2003); a Engenharia Pedagógica de Paquette (2002) e a Engenharia de Requisitos tradicional.

Sistema de gestão e planejamento de conteúdos didáticos digitais para EaD / Digital didactic content management and planning system for EaD

Neste artigo, apresentamos um sistema de gestão e planejamento para as disciplinas dos cursos na modalidade a Distância (Made). Trata-se de um sistema de informações que atua como ferramenta de apoio na elaboração e no planejamento da Matriz de Design Educacional das disciplinas a distância. Ele possibilita a seus usuários (alunos, professores e gestores) sistematizar os processos educacionais, gerenciar os trabalhos acadêmicos e organizar o fluxo de mensagens entre os sujeitos envolvidos nas disciplinas. Como bases teóricas, utilizamos os modelos pedagógicos de Behar (2009); o Design instrucional de Filatro (2003); a Engenharia Pedagógica de Paquette (2002) e a Engenharia de Requisitos tradicional.

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ABSTRACT Purpose: to estimate the prevalence of oral communication, memory, reading and writing, voice and oral motor skills problems in elderly people. Methods: cross-sectional study with 75 older people registered in a Family Clinic of Rio de Janeiro. It was estimated the prevalence, in all cases and by sex. The presence of differences between the sexes was verified by statistical tests t and chi-square. Results: the problems most frequently related to oral communication and memory were the avoidance to communicate (20.5%), difficulty in remembering recent and past events (34.7% and 26.4% respectively). There was a high prevalence of difficulty in reading and writing. According to hearing, 43.10% reported "watching television and listening to radio too loud." Related to voice perception, 71.2% referred "speak loudly or shouting" and 23.6% to "get hoarse frequently." As far as Myofunctional oral motor skill, 24.7% had "difficulties in chewing in general" and 54.8% "snoring while sleeping." Conclusion: in this study, there was a large proportion of elderly people who referred difficulties related to language, hearing, speech and chewing skills, which are functions related to socialization, welfare and maintenance of functional autonomy and can directly interfere with their quality of life and health. Keywords: Speech and Language Pathology; Health of Elderly; Prevalence RESUMO Objetivo: estimar a prevalência de problemas da comunicação oral, memória, leitura, escrita, voz, audição e motricidade orofacial em idosos. Métodos: estudo transversal, com 75 idosos cadastrados em uma Clínica da Família carioca. Foram estimadas as prevalências por sexos e conjuntamente. Verificou-se a presença de diferenças entre os sexos por meio dos testes t e qui-quadrado. Resultados: os principais problemas de comunicação oral e memória foram "evita se comunicar" (20,5%) e "dificuldades em lembrar fatos recentes e passados" (34,7% e 26,4%, respectivamente). Observou-se elevada prevalência de dificuldade na leitura e escrita. Em relação à audição, 43,1% relataram "ver televisão e ouvir rádio muito alto". Quanto à voz, 71,2% referiam "falar alto ou gritando" e 23,6% "ficar roucos com frequência". Na motricidade orofacial, 24,7% apresentavam "dificuldades na mastigação em geral" e 54,8% "roncavam ao dormir". Conclusão: neste estudo, observou-se uma grande parcela de idosos que referia dificuldades relacionadas às habilidades de linguagem, audição, fonação e mastigação, que são funções relacionadas à socialização, bem-estar e manutenção da autonomia funcional, podendo interferir diretamente na sua qualidade de vida e saúde

Contribution of the carbohydrate-binding ability of Vatairea guianensis lectin to induce edematogenic activity

Vatairea guianensis lectin (VGL), Dalbergiae tribe, is a N-acetyl-galactosamine (GalNAc)/Galactose (Gal) lectin previously purified and characterized. In this work, we report its structural features, obtained from bioinformatics tools, and its inflammatory effect, obtained from a rat paw edema model. The VGL model was obtained by homology with the lectin of Vatairea macrocarpa (VML) as template, and we used it to demonstrate the common characteristics of legume lectins, such as the jellyroll motif and presence of a metal-binding site in the vicinity of the carbohydrate-recognition domain (CRD). Protein-ligand docking revealed favorable interactions with N-acetyl-D-galactosamine, D-galactose and related sugars as well as several biologically relevant N- and O-glycans. In vivo testing of paw edema revealed that VGL induces edematogenic effect involving prostaglandins, interleukins and VGL CRD. Taken together, these data corroborate with previous reports showing that VGL interacts with N- and/or O-glycans of molecular targets, particularly in those presenting galactosides in their structure, contributing to the lectin inflammatory effect. © 2017 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM

Non-classical forms of pemphigus: pemphigus herpetiformis, IgA pemphigus, paraneoplastic pemphigus and IgG/IgA pemphigus

The pemphigus group comprises the autoimmune intraepidermal blistering diseases classically divided into two major types: pemphigus vulgaris and pemphigus foliaceous. Pemphigus herpetiformis, IgA pemphigus, paraneoplastic pemphigus and IgG/IgA pemphigus are rarer forms that present some clinical, histological and immunopathological characteristics that are different from the classical types. These are reviewed in this article. Future research may help definitively to locate the position of these forms in the pemphigus group, especially with regard to pemphigus herpetiformis and the IgG/ IgA pemphigus.Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM) Dermatology DepartmentUniversidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM) Dermatology and Pathology DepartmentsUNIFESP, EPM, Dermatology DepartmentUNIFESP, EPM, Dermatology and Pathology DepartmentsSciEL

Buenas prácticas lecheras : guía para la implementación en la producción de leche bovina

Las “Buenas Prácticas Agropecuarias” hacen referencia a una producción sana, segura y amigable con el ambiente, los animales y las personas. Son numerosos los temas que abarca e involucra la producción primaria de leche: las vacas y su manejo, el ambiente donde producen y las personas que cumplen distintas funciones para potenciar la producción lechera independientemente del sistema y escala, impactando directamente en toda la cadena láctea (desde la producción primaria, la industria y la comercialización) corresponsables de transformar la cosecha de la ubre y ofrecerla al consumidor de forma fluida o a través de derivados lácteos. De acuerdo a las tendencias actuales los consumidores tienen interés en adquirir productos no sólo de acuerdo a su calidad sino también a cómo fueron producidos. La calidad entonces es reconocida en el producto en sí y en todo su proceso desde la producción primaria. En respuesta a estas exigencias surge la Red de Buenas Prácticas Agropecuarias (BPA) como resultado de un proceso de intercambio entre las principales entidades públicas y privadas de Argentina, contando actualmente con más de 90 instituciones. Tiene la misión de contribuir al desarrollo sostenible promoviendo las buenas prácticas agropecuarias en diálogo con la comunidad. Dispone de diversas comisiones entre las que se encuentra la de lechería, que aborda y promueve la implementación de las BPA en los tambos. Los integrantes de la Comisión de Lechería de la Red BPA sentimos una gran satisfacción al presentar esta guía de buenas prácticas lecheras destinada a tamberos, profesionales del agro, entusiastas lecheros, operarios y aquellos inquietos, preocupados y ocupados por lograr leche sana. El presente documento contiene 13 capítulos escritos con terminología sencilla, entendible y adecuada para motivar al lector a aplicar o mejorar las BPA en todos los sectores y categorías de animales que involucra el tambo. Esta guía de buenas prácticas es una herramienta que permite el aseguramiento de la calidad de la leche en los tambos e introduce un cambio de paradigma: pasar de sistemas enfocados sólo en la calidad final de la leche a sistemas proactivos basados en el control, el orden y la mejora de procesos, trabajando en la prevención con capacidad de planificación y anticipación, y manteniendo una coherencia hacia las normas internacionales, buscando así la excelencia de su eslabón primario, el tambo.EEA PergaminoFil: Aimar, María Verónica. Universidad Nacional de Córdoba. Facultad de Ciencias Agropecuarias; ArgentinaFil: Amalfi, José María. Instituto Nacional de Asociativismo y Economía Social; ArgentinaFil: Campos Carlés, Silvina. Confederación Intercooperativa Agropecuaria - CONINAGRO; ArgentinaFil: Charlón, Verónica. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; ArgentinaFil: Cristiano, Gabriela. Universidad Nacional del Sur. Departamento de Economía; ArgentinaFil: Delbino, Fernando. Universidad Nacional del Litoral. Facultad de Ciencias Agrarias; ArgentinaFil: Diaz Cano, Muncha. Sociedad Rural Argentina; ArgentinaFil: Estevez Acuña, Rodrigo Rubén. Ministerio de Agricultura y Ganadería de la Provincia de Córdoba. Departamento de Producción Láctea; ArgentinaFil: Gigli, Isabel. Universidad Nacional de La Pampa; ArgentinaFil: Glauber, Claudio Eduardo. Servicio Nacional de Sanidad y Calidad Agroalimentaria (SENASA); ArgentinaFil: Guillermón, José. Provincia de Santiago del Estero. Ministerio de Producción, Recursos Naturales, Forestación y Tierras. Programa Ganadero Provincial (PROCARNE); ArgentinaFil: Ibargoyen, José María. Provincia de Buenos Aires. Ministerio de Desarrollo Agrario. Dirección de Lechería; ArgentinaFil: Iorio, Jesica Daniela. Universidad de Buenos Aires. Facultad de Agronomía; ArgentinaFil: Jaureguiberry, Horacio Sebastián. Provincia de Entre Ríos. Ministerio de Producción, Turismo y Desarrollo Económico. Dirección General de Producción Animal. Coordinación de Lechería; ArgentinaFil: Jarkowsky, Andrés. Fundación para la Promoción y Desarrollo de la Cadena Láctea Argentina; ArgentinaFil: Lesman, María de los Ángeles. Universidad Nacional del Litoral. Facultad de Ciencias Agrarias; ArgentinaFil: Llano, Agustina. Ministerio de Agricultura, Ganadería y Pesca de la Nación. Dirección Nacional de Lechería; ArgentinaFil: Mazzitelli, José. Cámara Empresaria de Medio Ambiente; ArgentinaFil: Moro, Santiago. Consorcios Regionales de Experimentación Agrícola; ArgentinaFil: Mozeris, Gustavo. Fundación para la Promoción y Desarrollo de la Cadena Láctea Argentina; ArgentinaFIL: Negri Rodriguez, Livia María. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Tecnología de Alimentos; ArgentinaFil: Olivieri, Daniela Ivana. Provincia de La Pampa. Ministerio de la Producción. Dirección de Ganadería; ArgentinaFil: Osan, Oscar. Universidad Nacional del Litoral. Facultad de Ciencias Agrarias; ArgentinaFil: Pérez, Gabriela Guadalupe. Provincia de Santa Fé. Ministerio de Producción, Ciencia y Tecnología. Dirección Provincial de Producción Lechera y Apícola; ArgentinaFil: Preumayr, Fernando Martín. Proyecto Factor Humano en Tambo; ArgentinaFil: Serrano, Pedro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Pergamino. Agencia de Extensión Rural Coronel Brandsen; ArgentinaFil: Tonero, María Eugenia. Provincia de Santa Fé. Ministerio de Producción, Ciencia y Tecnología. Dirección Provincial de Producción Lechera y Apícola; ArgentinaFil: Trombert, José María. Centro de la Industria Lechera Argentina; ArgentinaFil: Trombert, José María. Colegio de Ingenieros Agrónomos de Santa Fe; ArgentinaFil: Troya, Paula. Fundación de Investigación y Desarrollo Agropecuario; ArgentinaFil: Urruspuru, María Luz. Proyecto Factor Humano en Tambo; ArgentinaFil: Varaldo, Estefanía. Cluster Lechero Regional; Argentin

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV

Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio