Ротаційно–ударна обробка спіралей шнеків

Forskningsinriktningen vid den historiska avdelningen vid Linköpings universitet har sedan länge en stark socialhistorisk profil. kollektivens vardag studeras på en rad områden, på olika nivåer och över sinsemellan skilda tidsperioder. Det gäller inom såväl agrara som industriella miljöer, på samhällelig liksom på grupp-, familje- och individnivå samt över tid som omspänner senantiken till det sena 1900-talets historia. Hur identiteter skapas, tillägnas och förändras är en alltmer växande inriktning, liksom anknytningen till socialpolitiska ideer, normsystem, attityder, värderingar och mentaliteter. Även den  rättshistoriska och ekonomiskhistoriska forskningen ryms inom detta fält. Den historiska demografin utgör också traditionellt en stark del av det socialhistoriska fältet. Studier av arbeta och ohälsa, sjuklighet, dödlighet och hälsopolitik ligger långt framme. Bredden i den socialhistoriska profilen morsvaras av en mångfald melodologiska inslag. Skriftserien Socialhistoria i Linköping uppmärksammar denna profil och vilka uttryck den tar sig i grundutbildningen. I serien publiceras i första hand uppsatser skrivna på C- och D- nivå, men även bidrag från lärare och doktorander vid avdelningen förekommer. Detta nummer av Socialhistoria i Linköping är en specialutgåva till Svenska historikermötet i Linköping 23-25 april 199

Nordic homicide in deep time : lethal violence in the early modern era and present times

Nordic Homicide in Deep Time draws a unique, detailed picture of developments in human violence and presents new findings on homicide in Northern Europe in two eras – the 17th century and early 21st century. The book provides answers to questions, such as where and when did homicide typically occur, who were the victims and the offenders, and what were the circumstances of their conflicts? Additionally, it offers an empirically grounded view on how state consolidation and changing routines of everyday life transformed the patterns of criminal homicide in the Nordics. This publication is also a methodological experiment. When developing a new approach for extending homicide research into the deep past, the authors created a new instrument, the Historical Homicide Monitor. This tool combines wide explanatory scope, measurement standardization, and articulated theory expression. By retroactively expanding research data to the pre-statistical era, the method enables long-duration comparison of different periods and areas. Written by an interdisciplinary team of criminologists and historians for professionals, students and anyone interested in the history of human behaviour, Nordic Homicide in Deep Time helps the reader to understand modern homicide by revealing the historical continuities and changes in lethal violence.VertaisarvioitupeerReviewe

Felodipine-Metoprolol Combination Tablet: Maintained Health-Related Quality of Life in the Presence of Substantial Blood Pressure Reduction

Background: Most treated hypertensive patients do not achieve adequate blood pressure (BP) control. Initiating therapy with two drugs has been suggested when BP is >20/10 mm Hg above goal. To ensure patients' compliance, such treatment needs to be well tolerated and must not compromise health-related quality of life (HRQL). The primary objective of this study was to compare the effects on HRQL of initiating treatment with felodipine + metoprolol (F+M) fixed combination tablets, or enalapril (E), or placebo (P). Methods: A total of 947 patients of both sexes with primary hypertension (diastolic BP 95 to 110 mm Hg), aged 20 to 70 years, participated in this randomized, double-blind, parallel group, 12-week, multicenter trial. Treatment was initiated with F+M 5 + 50 mg, or E 10 mg, or P. Doses were doubled after 4 or 8 weeks if diastolic BP was >90 mm Hg. The HRQL was measured at baseline and at the last visit using two validated questionnaires: the Psychological General Well-being Index (PGWB) and the Subjective Symptom Assessment Profile (SSA-P). Office BP was measured at trough, that is, 24 h after the previous dose. Results: The HRQL was high at baseline and generally well maintained during the study. For example, the mean (SD) PGWB total score was 104 (16) at baseline and 105 (16) at 12 weeks in all three treatment groups. The BP reductions after F+M (18/14 mm Hg) and E (12/9 mm Hg) were significantly greater than after P (7/7 mm Hg), and the reduction after F+M was significantly greater than after E. Conclusions: The HRQL is maintained in the presence of substantial BP reduction during antihypertensive treatment with F+M fixed combination tablets. Am J Hypertens 2005;18:1313-1319 © 2005 American Journal of Hypertension, Lt

Nordic Homicide in Deep Time

Nordic Homicide in Deep Time draws a unique and detailed picture of developments in human interpersonal violence and presents new findings on rates, patterns, and long-term changes in lethal violence in the Nordics. Conducted by an interdisciplinary team of criminologists and historians, the book analyses homicide and lethal violence in northern Europe in two eras – the 17th century and early 21st century. Similar and continuous societal structures, cultural patterns, and legal cultures allow for long-term and comparative homicide research in the Nordic context. Reflecting human universals and stable motives, such as revenge, jealousy, honour, and material conflicts, homicide as a form of human behaviour enables long-duration comparison. By describing the rates and patterns of homicide during these two eras, the authors unveil continuity and change in human violence. Where and when did homicide typically take place? Who were the victims and the offenders, what where the circumstances of their conflicts? Was intimate partner homicide more prevalent in the early modern period than in present times? How long a time elapsed from violence to death? Were homicides often committed in the context of other crime? The book offers answers to these questions among others, comparing regions and eras. We gain a unique and empirically grounded view on how state consolidation and changing routines of everyday life transformed the patterns of criminal homicide in Nordic society. The path to pacification was anything but easy, punctuated by shorter crises of social turmoil, and high violence. The book is also a methodological experiment that seeks to assess the feasibility of long-duration standardized homicide analysis and to better understand the logic of homicide variation across space and over time. In developing a new approach for extending homicide research into the deep past, the authors have created the Historical Homicide Monitor. The new instrument combines wide explanatory scope, measurement standardization, and articulated theory expression. By retroactively expanding research data to the pre-statistical era, the method enables long-duration comparison of different periods and areas. Based on in-depth source critique, the approach captures patterns of criminal behaviour, beyond the control activity of the courts. The authors foresee the application of their approach in even remoter periods. Nordic Homicide in Deep Time helps the reader to understand modern homicide by revealing the historical continuities and changes in lethal violence. The book is written for professionals, university students and anyone interested in the history of human behaviour

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues