17,665 research outputs found
Estimated IR and phosphorescence emission fluxes for specific Polycyclic Aromatic Hydrocarbons in the Red Rectangle
Following the tentative identification of the blue luminescence in the Red
Rectangle by Vijh et al. (2005), we compute absolute fluxes for the vibrational
IR emission and phosphorescence bands of three small polycyclic aromatic
hydrocarbons. The calculated IR spectra are compared with available ISO
observations. A subset of the emission bands are predicted to be observable
using presently available facilities, and can be used for an immediate,
independent, discriminating test on their alleged presence in this well-known
astronomical object.Comment: accepted for publication on A&
Feasibility of wearable monitors to detect heart rate variability in children with hand, foot and mouth disease
Hand foot and mouth disease (HFMD) is caused by a variety of enteroviruses, and occurs in large outbreaks in which a small proportion of children deteriorate rapidly with cardiopulmonary failure. Determining which children are likely to deteriorate is difficult and health systems may become overloaded during outbreaks as many children require hospitalization for monitoring. Heart rate variability (HRV) may help distinguish those with more severe diseases but requires simple scalable methods to collect ECG data.We carried out a prospective observational study to examine the feasibility of using wearable devices to measure HRV in 142 children admitted with HFMD at a children's hospital in Vietnam. ECG data were collected in all children. HRV indices calculated were lower in those with enterovirus A71 associated HFMD compared to those with other viral pathogens.HRV analysis collected from wearable devices is feasible in a low and middle income country (LMIC) and may help classify disease severity in HFMD
Post-starburst galaxies: more than just an interesting curiosity
From the VIMOS VLT DEEP Survey (VVDS) we select a sample of 16 galaxies with
spectra which identify them as having recently undergone a strong starburst and
subsequent fast quenching of star formation. These post-starburst galaxies lie
in the redshift range 0.510^9.75Msun. They have a number
density of 1x10^-4 per Mpc^3, almost two orders of magnitude sparser than the
full galaxy population with the same mass limit. We compare with simulations to
show that the galaxies are consistent with being the descendants of gas rich
major mergers. Starburst mass fractions must be larger than ~5-10% and decay
times shorter than ~10^8 years for post-starburst spectral signatures to be
observed in the simulations. We find that the presence of black hole feedback
does not greatly affect the evolution of the simulated merger remnants through
the post-starburst phase. The multiwavelength spectral energy distributions of
the post-starburst galaxies show that 5/16 have completely ceased the formation
of new stars. These 5 galaxies correspond to a mass flux entering the
red-sequence of rhodot(A->Q, PSB) = 0.0038Msun/Mpc^3/yr, assuming the defining
spectroscopic features are detectable for 0.35Gyr. If the galaxies subsequently
remain on the red sequence, this accounts for 38(+4/-11)% of the growth rate of
the red sequence. Finally, we compare our high redshift results with a sample
of galaxies with 0.05<z<0.1 observed in the SDSS and UKIDSS surveys. We find a
very strong redshift evolution: the mass density of strong post-starburst
galaxies is 230 times lower at z~0.07 than at z~0.7.Comment: 18 pages, 12 figures, to match version accepted to MNRAS. Minor
reordering of text in places and Sec 2.2 on SPH simulation comparisons
expande
Non-equilibrium transitions in fully frustrated Josephson junction arrays
We study the effect of thermal fluctuations in a fully frustrated Josephson
junction array driven by a current I larger than the apparent critical current
I_c(T). We calculate numerically the behavior of the chiral order parameter of
Z_2 symmetry and the transverse helicity modulus (related to the U(1) symmetry)
as a function of temperature. We find that the Z_2 transition occurs at a
temperature T_{Z_2}(I) which is lower than the temperature T_{U(1)}(I) for the
U(1) transition. Both transitions could be observed experimentally from
measurements of the longitudinal and transverse voltages.Comment: 4 pages, 4 figure
Generation and characterization of hair-bearing skin organoids from human pluripotent stem cells
Human skin uses millions of hairs and glands distributed across the body surface to function as an external barrier, thermoregulator and stimuli sensor. The large-scale generation of human skin with these appendages would be beneficial, but is challenging. Here, we describe a detailed protocol for generating hair-bearing skin tissue entirely from a homogeneous population of human pluripotent stem cells in a three-dimensional in vitro culture system. Defined culture conditions are used over a 2-week period to induce differentiation of pluripotent stem cells to surface ectoderm and cranial neural crest cells, which give rise to the epidermis and dermis, respectively, in each organoid unit. After 60 d of incubation, the skin organoids produce hair follicles. By day similar to 130, the skin organoids reach full complexity and contain stratified skin layers, pigmented hair follicles, sebaceous glands, Merkel cells and sensory neurons, recapitulating the cell composition and architecture of fetal skin tissue at week 18 of gestation. Skin organoids can be maintained in culture using this protocol for up to 150 d, enabling the organoids to be used to investigate basic skin biology, model disease and, further, reconstruct or regenerate skin tissue.Disorders of the head and nec
Multiorder coherent Raman scattering of a quantum probe field
We study the multiorder coherent Raman scattering of a quantum probe field in
a far-off-resonance medium with a prepared coherence. Under the conditions of
negligible dispersion and limited bandwidth, we derive a Bessel-function
solution for the sideband field operators. We analytically and numerically
calculate various quantum statistical characteristics of the sideband fields.
We show that the multiorder coherent Raman process can replicate the
statistical properties of a single-mode quantum probe field into a broad comb
of generated Raman sidebands. We also study the mixing and modulation of photon
statistical properties in the case of two-mode input. We show that the prepared
Raman coherence and the medium length can be used as control parameters to
switch a sideband field from one type of photon statistics to another type, or
from a non-squeezed state to a squeezed state and vice versa.Comment: 12 pages, 7 figures, to be published in Phys. Rev.
Quantifying the burden of rhodesiense sleeping sickness in Urambo district, Tanzania
Sleeping sickness (human African trypanosomiasis - HAT) is a disease transmitted by tsetse flies and is always fatal if left untreated. The disease occurs in foci affecting poor communities with limited access to health service provision and as such the disease is often left undiagnosed, mistaken for more common afflictions. Even if diagnosed, sleeping sickness is costly to treat, both for health services and patients and their families in terms of costs of diagnosis, transport, hospital care, and the prolonged period of convalescence. Here we estimate the health burden of the acute form T. b. rhodesiense sleeping sickness in Urambo District, Tanzania in terms of Disability Adjusted Life Years (DALYs), the yardstick commonly used by policy makers to prioritize disease management practices, representing a year of healthy life lost to disease. In this single district, the burden of the disease over one year was estimated at 979 DALYs and the estimated monetary costs to health services for the 143 treated patients at US 3,673 for direct medical costs and US$ 9,781 for indirect non-medical costs. Sleeping sickness thus places a considerable burden on the affected rural communities and health services
Melting and transverse depinning of driven vortex lattices in the periodic pinning of Josephson junction arrays
We study the non-equilibrium dynamical regimes of a moving vortex lattice in
the periodic pinning of a Josephson junction array (JJA) for {\it finite
temperatures} in the case of a fractional or submatching field. We obtain a
phase diagram for the current driven JJA as a function of the driving current I
and temperature T. We find that when the vortex lattice is driven by a current,
the depinning transition at and the melting transition at
become separated even for a field for which they coincide in equilibrium. We
also distinguish between the depinning of the vortex lattice in the direction
of the current drive, and the {\it transverse depinning} in the direction
perpendicular to the drive. The transverse depinning corresponds to the onset
of transverse resistance in a moving vortex lattice at a given temperature
. For driving currents above the critical current we find that the
moving vortex lattice has first a transverse depinning transition at low T, and
later a melting transition at a higher temperature, .Comment: 17 pages, 19 figure
A Measurement of the Interference Structure Function, R_LT, for the 12C(e,e'p) reaction in the Quasielastic Region
The coincidence cross-section and the interference structure function, R_LT,
were measured for the 12C(e,e'p) 11B reaction at quasielastic kinematics and
central momentum transfer of q=400 MeV/c. The measurement was at an opening
angle of theta_pq=11 degrees, covering a range in missing energy of E_m = 0 to
65 MeV. The R_LT structure function is found to be consistent with zero for E_m
> 50 MeV, confirming an earlier study which indicated that R_L vanishes in this
region. The integrated strengths of the p- and s-shell are compared with a
Distorted Wave Impulse Approximation calculation. The s-shell strength and
shape are compared with a Hartree Fock-Random Phase Approximation calculation.
The DWIA calculation overestimates the cross sections for p- and s-shell proton
knockout as expected, but surprisingly agrees with the extracted R_LT value for
both shells. The HF-RPA calculation describes the data more consistently, which
may be due to the inclusion of 2-body currents in this calculation.Comment: 8 Pages LaTex, 5 postscript figures. Submitted to Phys. Rev.
Thermally Triggered Hydrogel Injection Into Bovine Intervertebral Disc Tissue Explants Induces Differentiation Of Mesenchymal Stem Cells And Restores Mechanical Function.
We previously reported a synthetic LaponiteÂź crosslinked pNIPAM-co-DMAc (L-pNIPAM-co-DMAc) hydrogel which promotes differentiation of mesenchymal stem cells (MSCs) to nucleus pulposus (NP) cells without additional growth factors. The clinical success of this hydrogel is dependent on: integration with surrounding tissue; the capacity to restore mechanical function; as well as supporting the viability and differentiation of delivered MSCs. Bovine NP tissue explants were injected with media (control), human MSCs (hMSCs) alone, acellular L-pNIPAM-co-DMAc hydrogel or hMSCs incorporated within the L-pNIPAM-co-DMAc hydrogel and maintained at 5% O2 for 6 weeks. Viability of native NP cells and delivered MSCs was maintained. Furthermore hMSCs delivered via the L-pNIPAM-co-DMAc hydrogel differentiated and produced NP matrix components: aggrecan, collagen type II and chondroitin sulphate, with integration of the hydrogel with native NP tissue. In addition L-pNIPAM-co-DMAc hydrogel injected into collagenase digested bovine discs filled micro and macro fissures, were maintained within the disc during loading and restored IVD stiffness. The mechanical support of the L-pNIPAM-co-DMAc hydrogel, to restore disc height, could provide immediate symptomatic pain relief, whilst the delivery of MSCs over time regenerates the NP extracellular matrix; thus the L-pNIPAM-co-DMAc hydrogel could provide a combined cellular and mechanical repair approach
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