MUJER SIN IDENTIFICAR [Material gráfico]

LA PLACA RECOGE EL MISMO DIBUJO QUE LA REFERENCIA 00193MUJER JOVEN. PLANO TRES CUARTOS.SENTADA. SE AGARRA LAS MANOS. FLORES EN EL PELO. DECORADO DE FONDO PINTADO (PAISAJE CON PUENTE)Copia digital. Madrid : Ministerio de Educación, Cultura y Deporte. Subdirección General de Coordinación Bibliotecaria, 201

SPIDER VII - Revealing the Stellar Population Content of Massive Early-type Galaxies out to 8Re

Radial trends of stellar populations in galaxies provide a valuable tool to understand the mechanisms of galaxy growth. In this paper, we present the first comprehensive analysis of optical-optical and optical-NIR colours, as a function of galaxy mass, out to the halo region (8Re) of early-type galaxies (ETGs). We select a sample of 674 massive ETGs (M*>3x10^10MSun) from the SDSS-based SPIDER survey. By comparing with a large range of population synthesis models, we derive robust constraints on the radial trends in age and metallicity. Metallicity is unambiguously found to decrease outwards, with a measurable steepening of the slope in the outer regions (Re<R<8Re). The gradients in stellar age are found to be more sensitive to the models used, but in general, the outer regions of ETGs feature older populations compared to the cores. This trend is strongest for the most massive galaxies in our sample (M*>10^11MSun). Furthermore, when segregating with respect to large scale environment, the age gradient is more significant in ETGs residing in higher density regions. These results shed light on the processes leading from the formation of the central core to the growth of the stellar envelope of massive galaxies. The fact that the populations in the outer regions are older and more metal-poor than in the core suggests a process whereby the envelope of massive galaxies is made up of accreted small satellites (i.e. minor mergers) whose stars were born during the first stages of galaxy formation.Comment: 20 pages, 13 figures, 10 tables. Accepted for publication in MNRA

Glycan processing in gut microbiomes

Microbiomes and their enzymes process many of the nutrients accessible in the gastrointestinal tract of bilaterians and play an essential role in host health and nutrition. In this review, we describe recent insights into nutrient processing in microbiomes across three exemplary yet contrasting gastrointestinal ecosystems (humans, ruminants and insects), with focus on bacterial mechanisms for the utilization of common and atypical dietary glycans as well as host-derived mucus glycans. In parallel, we discuss findings from multi-omic studies that have provided new perspectives on understanding glycan-dependent interactions and the complex food-webs of microbial populations in their natural habitat. Using key examples, we emphasize how increasing understanding of glycan processing by gut microbiomes can provide critical insights to assist ‘microbiome reprogramming’, a growing field that seeks to leverage diet to improve animal growth and host health

Newborn spheroids at high redshift: when and how did the dominant, old stars in today's massive galaxies form?

We study ~330 massive (M* > 10^9.5 MSun), newborn spheroidal galaxies (SGs) around the epoch of peak star formation (1<z<3), to explore the high-redshift origin of SGs and gain insight into when and how the old stellar populations that dominate today's Universe formed. The sample is drawn from the HST/WFC3 Early-Release Science programme, which provides deep 10-filter (0.2 - 1.7 micron) HST imaging over a third of the GOODS-South field. We find that the star formation episodes that built the SGs likely peaked in the redshift range 2<z<5 (with a median of z~3) and have decay timescales shorter than ~1.5 Gyr. Starburst timescales and ages show no trend with stellar mass in the range 10^9.5 < M* < 10^10.5 MSun. However, the timescales show increased scatter towards lower values ( 10^10.5 MSun, and an age trend becomes evident in this mass regime: SGs with M* > 10^11.5 MSun are ~2 Gyrs older than their counterparts with M* < 10^10.5 MSun. Nevertheless, a smooth downsizing trend with galaxy mass is not observed, and the large scatter in starburst ages indicate that SGs are not a particularly coeval population. Around half of the blue SGs appear not to drive their star formation via major mergers, and those that have experienced a recent major merger, show only modest enhancements (~40%) in their specific star formation rates. Our empirical study indicates that processes other than major mergers (e.g. violent disk instability driven by cold streams and/or minor mergers) likely play a dominant role in building SGs, and creating a significant fraction of the old stellar populations that dominate today's Universe.Comment: MNRAS in pres

Human Regulatory T Cell Suppressive Function Is Independent of Apoptosis Induction in Activated Effector T Cells

CD4(+)CD25(+)FOXP3(+) Regulatory T cells (Treg) play a central role in the immune balance to prevent autoimmune disease. One outstanding question is how Tregs suppress effector immune responses in human. Experiments in mice demonstrated that Treg restrict effector T cell (Teff) responses by deprivation of the growth factor IL-2 through Treg consumption, resulting in apoptosis of Teff.In this study we investigated the relevance of Teff apoptosis induction to human Treg function. To this end, we studied naturally occurring Treg (nTreg) from peripheral blood of healthy donors, and, to investigate Treg function in inflammation in vivo, Treg from synovial fluid of Juvenile Idiopathic Arthritis (JIA) patients (SF-Treg). Both nTreg and SF-Treg suppress Teff proliferation and cytokine production efficiently as predicted. However, in contrast with murine Treg, neither nTreg nor SF-Treg induce apoptosis in Teff. Furthermore, exogenously supplied IL-2 and IL-7 reverse suppression, but do not influence apoptosis of Teff.Our functional data here support that Treg are excellent clinical targets to counteract autoimmune diseases. For optimal functional outcome in human clinical trials, future work should focus on the ability of Treg to suppress proliferation and cytokine production of Teff, rather than induction of Teff apoptosis

CLUH couples mitochondrial distribution to the energetic and metabolic status

Mitochondrial dynamics and distribution are critical for supplying ATP in response to energy demand. CLUH is a protein involved in mitochondrial distribution whose dysfunction leads to mitochondrial clustering, the metabolic consequences of which remain unknown. To gain insight into the role of CLUH on mitochondrial energy production and cellular metabolism, we have generated CLUH-knockout cells using CRISPR/Cas9. Mitochondrial clustering was associated with a smaller cell size and with decreased abundance of respiratory complexes, resulting in oxidative phosphorylation (OXPHOS) defects. This energetic impairment was found to be due to the alteration of mitochondrial translation and to a metabolic shift towards glucose dependency. Metabolomic profiling by mass spectroscopy revealed an increase in the concentration of some amino acids, indicating a dysfunctional Krebs cycle, and increased palmitoylcarnitine concentration, indicating an alteration of fatty acid oxidation, and a dramatic decrease in the concentrations of phosphatidylcholine and sphingomyeline, consistent with the decreased cell size. Taken together, our study establishes a clear function for CLUH in coupling mitochondrial distribution to the control of cell energetic and metabolic status

First events from the CNGS neutrino beam detected in the OPERA experiment

The OPERA neutrino detector at the underground Gran Sasso Laboratory (LNGS) was designed to perform the first detection of neutrino oscillations in appearance mode, through the study of nu_mu to nu_tau oscillations. The apparatus consists of a lead/emulsion-film target complemented by electronic detectors. It is placed in the high-energy, long-baseline CERN to LNGS beam (CNGS) 730 km away from the neutrino source. In August 2006 a first run with CNGS neutrinos was successfully conducted. A first sample of neutrino events was collected, statistically consistent with the integrated beam intensity. After a brief description of the beam and of the various sub-detectors, we report on the achievement of this milestone, presenting the first data and some analysis results.Comment: Submitted to the New Journal of Physic

Highlights from the Pierre Auger Observatory

The Pierre Auger Observatory is the world's largest cosmic ray observatory. Our current exposure reaches nearly 40,000 km$^2$ str and provides us with an unprecedented quality data set. The performance and stability of the detectors and their enhancements are described. Data analyses have led to a number of major breakthroughs. Among these we discuss the energy spectrum and the searches for large-scale anisotropies. We present analyses of our X$_{max}$ data and show how it can be interpreted in terms of mass composition. We also describe some new analyses that extract mass sensitive parameters from the 100% duty cycle SD data. A coherent interpretation of all these recent results opens new directions. The consequences regarding the cosmic ray composition and the properties of UHECR sources are briefly discussed.Comment: 9 pages, 12 figures, talk given at the 33rd International Cosmic Ray Conference, Rio de Janeiro 201