Rabbit haemorrhagic disease (RHD) and rabbit haemorrhagic disease virus (RHDV): a review

Rabbit haemorrhagic disease virus (RHDV) is a calicivirus of the genus Lagovirus that causes rabbit haemorrhagic disease (RHD) in adult European rabbits (Oryctolagus cuniculus). First described in China in 1984, the virus rapidly spread worldwide and is nowadays considered as endemic in several countries. In Australia and New Zealand where rabbits are pests, RHDV was purposely introduced for rabbit biocontrol. Factors that may have precipitated RHD emergence remain unclear, but non-pathogenic strains seem to pre-date the appearance of the pathogenic strains suggesting a key role for the comprehension of the virus origins. All pathogenic strains are classified within one single serotype, but two subtypes are recognised, RHDV and RHDVa. RHD causes high mortality in both domestic and wild adult animals, with individuals succumbing between 48-72 h post-infection. No other species has been reported to be fatally susceptible to RHD. The disease is characterised by acute necrotising hepatitis, but haemorrhages may also be found in other organs, in particular the lungs, heart, and kidneys due to disseminated intravascular coagulation. Resistance to the disease might be explained in part by genetically determined absence or weak expression of attachment factors, but humoral immunity is also important. Disease control in rabbitries relies mainly on vaccination and biosecurity measures. Such measures are difficult to be implemented in wild populations. More recent research has indicated that RHDV might be used as a molecular tool for therapeutic applications. Although the study of RHDV and RHD has been hampered by the lack of an appropriate cell culture system for the virus, several aspects of the replication, epizootology, epidemiology and evolution have been disclosed. This review provides a broad coverage and description of the current knowledge on the disease and the virus

Towards precision medicine for pain: diagnostic biomarkers and repurposed drugs

We endeavored to identify objective blood biomarkers for pain, a subjective sensation with a biological basis, using a stepwise discovery, prioritization, validation, and testing in independent cohorts design. We studied psychiatric patients, a high risk group for co-morbid pain disorders and increased perception of pain. For discovery, we used a powerful within-subject longitudinal design. We were successful in identifying blood gene expression biomarkers that were predictive of pain state, and of future emergency department (ED) visits for pain, more so when personalized by gender and diagnosis. MFAP3, which had no prior evidence in the literature for involvement in pain, had the most robust empirical evidence from our discovery and validation steps, and was a strong predictor for pain in the independent cohorts, particularly in females and males with PTSD. Other biomarkers with best overall convergent functional evidence for involvement in pain were GNG7, CNTN1, LY9, CCDC144B, and GBP1. Some of the individual biomarkers identified are targets of existing drugs. Moreover, the biomarker gene expression signatures were used for bioinformatic drug repurposing analyses, yielding leads for possible new drug candidates such as SC-560 (an NSAID), and amoxapine (an antidepressant), as well as natural compounds such as pyridoxine (vitamin B6), cyanocobalamin (vitamin B12), and apigenin (a plant flavonoid). Our work may help mitigate the diagnostic and treatment dilemmas that have contributed to the current opioid epidemic

Transient deformations in the Suez-Sinai area from GPS observations

We analyze data from four GPS campaigns carried out between 1997 and 2002 on a network of 11 sites in the Suez-Sinai, the area of collision between the African and the Arabian plates. This is the key area to understand how and in which way Sinai behaves like a sub-plate of the African plate and the role played between seismic and geodetic (long term) deformation release. Our analysis shows that, on average, the Suez-Sinai area motion (in terms of ITRF00 velocities) matches African plate motion (NNR-NUVEL-1A model). However, the baseline length variations show transient deformations in Sinai and across the Gulf of Suez, reaching up a maximum value of about 1.5 cm in five years. Since current geodynamical models do not predict significant tectonic deformation in this area, we worked under the hypothesis that a contribute may be due to post-seismic relaxation. Under this hypothesis, we compared the baselines length variations with the post-seismic relaxation field associated with five major local earthquakes occurred in the area, testing two different viscoelastic models. Our results show that the transient deformations are better modelled for viscosity values of 1018 Pa s in the lower crust and 1020 Pa s in the asthenosphere. However, since the modelled post-seismic effect results modest and a certain amount of the detected deformation is not accounted for, we think that an improved modelling should take into account the lateral heterogeneities of crust and upper mantle structures

Inhomogeneously doped two-leg ladder systems

A chemical potential difference between the legs of a two-leg ladder is found to be harmful for Cooper pairing. The instability of superconductivity in such systems is analyzed by compairing results of various analytical and numerical methods. Within a strong coupling approach for the t-J model, supplemented by exact numerical diagonalization, hole binding is found unstable beyond a finite, critical chemical potential difference. The spinon-holon mean field theory for the t-J model shows a clear reduction of the the BCS gaps upon increasing the chemical potential difference leading to a breakdown of superconductivity. Based on a renormalization group approach and Abelian bosonization, the doping dependent phase diagram for the weakly interacting Hubbard model with different chemical potentials was determined.Comment: Revtex4, 11 pages, 7 figure

Revisiting the chemistry of apple pomace polyphenols

Hot water is an easily implementable process for polyphenols extraction. To evaluate the effect of this process on apple pomace, the overall polyphenolic composition was assessed before and after hot water extraction, followed by extractions with aqueous/organic solutions. As determined by UHPLC-DAD, flavan-3-ols were the main apple native polyphenols. Their amount decreased 50% after hot water extraction, while the other classes remained unchanged. Dihydrochalcones and hydroxycinnamic acid oxidation products, were also observed, alongside with non-extractable oxidised procyanidins that represented more than 4-fold the amount of native apple polyphenols in the pomace. Microwave superheated-water extraction of the insoluble cell wall material in water/acetone solutions and the high amounts of polyphenols that were insoluble in water/ethanol solutions suggested that oxidised procyanidins could be covalently linked to polysaccharides. These complexes represented up to 40% of the available polyphenols from apple pomace, potentially relevant for agro-food waste valuation.publishe

Superconductivity close to the Mott state: From condensed-matter systems to superfluidity in optical lattices

Since the discovery of high-temperature superconductivity in 1986 by Bednorz and Mueller, great efforts have been devoted to finding out how and why it works. From the d-wave symmetry of the order parameter, the importance of antiferromagnetic fluctuations, and the presence of a mysterious pseudogap phase close to the Mott state, one can conclude that high-Tc superconductors are clearly distinguishable from the well-understood BCS superconductors. The d-wave superconducting state can be understood through a Gutzwiller-type projected BCS wave-function. In this review article, we revisit the Hubbard model at half-filling and focus on the emergence of exotic superconductivity with d-wave symmetry in the vicinity of the Mott state, starting from ladder systems and then studying the dimensional crossovers to higher dimensions. This allows to confirm that short-range antiferromagnetic fluctuations can mediate superconductivity with d-wave symmetry. Ladders are also nice prototype systems allowing to demonstrate the truncation of the Fermi surface and the emergence of a Resonating Valence Bond (RVB) state with preformed pairs in the vicinity of the Mott state. In two dimensions, a similar scenario emerges from renormalization group arguments. We also discuss theoretical predictions for the d-wave superconducting phase as well as the pseudogap phase, and address the crossover to the overdoped regime. Finally, cold atomic systems with tunable parameters also provide a complementary insight into this outstanding problem.Comment: 98 pages and 18 figures; Final version (references added and misprints corrected

Genetical genomics: spotlight on QTL hotspots

No abstract available

Joint approach combining damage and paleoseismology observations constrains the 1714 A.D. Bhutan earthquake at magnitude 8±0.5

International audienceThe region of Bhutan is thought to be the only segment of the Himalayas not having experienced a major earthquake over the past half millennium. A proposed explanation for this apparent seismic gap is partial accommodation of the India-Asia convergence further south across the Shillong Plateau, yet the seismic behavior of the Himalayan megathrust in Bhutan is unknown. Here we present historical documents from the region reporting on an earthquake in 1714 A.D. and geological evidence of surface rupture to constrain the latest large event in this area. We compute various earthquake scenarios using empirical scaling relationships relating magnitude with intensity, source location and rupture geometry. Our results constrain the 1714 A.D. earthquake to have ruptured the megathrust in Bhutan, most likely during a M7.5–8.5 event. This finding reclassifies the apparent seismic gap to a former information gap and implies that the entire Himalayan arc has a high level of earthquake potential

Interactive handwriting recognition with limited user effort

The final publication is available at Springer via http://dx.doi.org/10.1007/s10032-013-0204-5[EN] Transcription of handwritten text in (old) documents is an important, time-consuming task for digital libraries. Although post-editing automatic recognition of handwritten text is feasible, it is not clearly better than simply ignoring it and transcribing the document from scratch. A more effective approach is to follow an interactive approach in which both the system is guided by the user, and the user is assisted by the system to complete the transcription task as efficiently as possible. Nevertheless, in some applications, the user effort available to transcribe documents is limited and fully supervision of the system output is not realistic. To circumvent these problems, we propose a novel interactive approach which efficiently employs user effort to transcribe a document by improving three different aspects. Firstly, the system employs a limited amount of effort to solely supervise recognised words that are likely to be incorrect. Thus, user effort is efficiently focused on the supervision of words for which the system is not confident enough. Secondly, it refines the initial transcription provided to the user by recomputing it constrained to user supervisions. In this way, incorrect words in unsupervised parts can be automatically amended without user supervision. Finally, it improves the underlying system models by retraining the system from partially supervised transcriptions. In order to prove these statements, empirical results are presented on two real databases showing that the proposed approach can notably reduce user effort in the transcription of handwritten text in (old) documents.The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under Grant Agreement No 287755 (transLectures). Also supported by the Spanish Government (MICINN, MITyC, "Plan E", under Grants MIPRCV "Consolider Ingenio 2010", MITTRAL (TIN2009-14633-C03-01), erudito.com (TSI-020110-2009-439), iTrans2 (TIN2009-14511), and FPU (AP2007-02867), and the Generalitat Valenciana (Grants Prometeo/2009/014 and GV/2010/067).Serrano Martinez Santos, N.; Giménez Pastor, A.; Civera Saiz, J.; Sanchis Navarro, JA.; Juan Císcar, A. (2014). Interactive handwriting recognition with limited user effort. International Journal on Document Analysis and Recognition. 17(1):47-59. https://doi.org/10.1007/s10032-013-0204-5S4759171Agua, M., Serrano, N., Civera, J., Juan, A.: Character-based handwritten text recognition of multilingual documents. In: Proceedings of Advances in Speech and Language Technologies for Iberian Languages (IBERSPEECH 2012), Madrid (Spain), pp. 187–196 (2012)Ahn, L.V., Maurer, B., Mcmillen, C., Abraham, D., Blum, M.: reCAPTCHA: human-based character recognition via web security measures. 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Constraints from GPS measurements on the dynamics of deformation in Anatolia and the Aegean

We estimate the strength of the lithosphere in Anatolia and the Aegean, and the boundary forces acting upon it, using a dynamical model that treats the lithosphere as a thin fluid sheet deforming in response to variations in gravitational potential energy. This model has one free material parameter, the power law exponent, n, of the vertically averaged rheology of the lithosphere, and two parameters that specify the forces per unit length applied to its edges. Solutions to this model that best fit the velocities of 346 reliable GPS sites require an effective viscosity of the lithosphere of 1022 to 1021 Pa s at strain rates of 10 to 100 nanostrain per year. The best-fitting force at the Arabia-Anatolia boundary is consistent with the lithostatic pressure due to the high topography there, and the force at the Nubia-Aegean boundary is consistent with the contrast in lithostatic pressure across that boundary. No additional force, from “slab rollback” or basal tractions due to convection in the mantle, is required to explain the observations. These results are supported by scaling relations derived from approximate analytical solutions. The inverse relationship between the viscosity of the lithosphere and deviatoric stress produces strong slowly deforming regions in the Southern Aegean and Central Anatolia whose motions resemble those of microplates. The distribution of geodetic strain rates within the region, and the partitioning between normal and strike-slip faulting, are explained by the interplay between boundary conditions, internal variations in gravitational potential energy, and the power law rheology of the lithosphere