A chemical potential difference between the legs of a two-leg ladder is found
to be harmful for Cooper pairing. The instability of superconductivity in such
systems is analyzed by compairing results of various analytical and numerical
methods. Within a strong coupling approach for the t-J model, supplemented by
exact numerical diagonalization, hole binding is found unstable beyond a
finite, critical chemical potential difference. The spinon-holon mean field
theory for the t-J model shows a clear reduction of the the BCS gaps upon
increasing the chemical potential difference leading to a breakdown of
superconductivity. Based on a renormalization group approach and Abelian
bosonization, the doping dependent phase diagram for the weakly interacting
Hubbard model with different chemical potentials was determined.Comment: Revtex4, 11 pages, 7 figure