Roma kolonisi augusta firma’daki kraliyet sarayı plaza de armas’ın domus I mozaikleri – astigi (écija, sevilla, İspanya) - I

The Domus I of the Plaza de Armas of the Royal Alcazar of Ecija (Seville, Spain) has been object of archaeological excavations and restoration interventions since 2001, which have revealed that this luxurious urban residence was completely reformed in the Severan period, when several rooms and the central courtyard were decorated with mosaic pavements. The first one in being unearthed was the well-known mosaic of the Satyr / Silenus, with the double representation of these two companions of Dionysus in a single head, thanks to a singular visual play. In 2015 was discovered the so-called mosaic of the Loves of Zeus, which decorate the triclinium of the domus, with several scenes from this mythological cycle, along with Bacchic themes and characters, and the representation of the seasons. More recently, in 2019-2020, the monumental central peristyle of the residence was excavated, which perimetral corridor was covered with mosaic decoration. The thematic represented in the new mosaic is varied, including several planets, meteorological phenomena or the god Dyonisus himself, together with a panel which contained a scene following a hunt –unfortunately, in this case largely lost, but still recognizable–, all framed by a singular geometric pattern. In this paper is offered the first publication of the remarkable mosaic of the peristyle, just discovered.Ecija’nın Kraliyet Sarayı (Sevilla, İspanya) Plaza de Armas’taki Domus I, 2001’den beri arkeolojik kazılar ile restorasyon müdahalelerinin nesnesi olmuştur ve bu lüks kentsel konutun Severan döneminde tamamen yenilendiği, bazı odalar ve merkezde yer alan avlunun farklı temalardaki mozaiklerle dekore edildiği tespit edilmiştir. Ortaya çıkarılan ilk mozaik, Dionysos’un bu iki yoldaşının tek bir görsel oyun sayesinde tek bir kafada çifte temsil edildiği, ünlü Satyr / Silenus mozaiğidir. 2015 yılında, domusun triclinium’unu süsleyen Zeus’un Aşkları mozaiği, bu mitolojik döngüden birkaç sahne, Bacchic temaları ve karakterleri ile mevsimlerin temsili keşfedilmiştir. Daha yakın zamanlarda, 2019-2020’de, konutun anıtsal merkezi peristilinin kazılmasıyla, perimetral koridordaki mozaik döşemeler ortaya çıkarılmıştır. Bu -yeni keşfedilen mozaikte işlenen tema, çeşitli gezegenler, meteorolojik fenomenler veya tanrı Dionisus’un kendisi ile birlikte bir avın devamının işlendiği bir sahneyi içeren bir panel –ne yazık ki bu kısım büyük oranda kayıptır, fakat yine de tespit edilebilir durumdadırdahil olmak üzere çok çeşitlidir ve hepsi tekil bir geometrik örüntü ile çerçeve içine alınmıştır. Bu makalede, henüz keşfedilen dikkate değer peristil mozaiğinin ilk yayını sunulmaktadır

Manejo de la mucositis oral en pacientes que reciben quimioterapia, radioterapia o quimioradiación

La mucositis oral es exclusivamente la inflamación y ulceración de la mucosa bucal, secundario a tratamiento anticancerígeno y ocurre en el 40-90% de pacientes. Ocasionando atrasos, suspensiones o reducciones en la intensidad del tratamiento; disminuye el control de la enfermedad y aumenta la morbimortalidad. Se trata de un artículo de actualización que revisa el manejo de la mucosistis oral secundaria a tratamiento quimio/radioterapeútico o ambos

An analysis of the difficulties associated to sustainability insertion in engineering education: Examples from HEIs in Brazil

This paper aims to understand how the difficulties associated with the inclusion of sustainability in engineering education are related. From the literature review, eleven difficulties were compiled and posteriorly, a panel of experts was conducted to divide them into two groups, namely “difficulties associated with structure and planning” and “difficulties observed in didactic practice”. These groups were used as a basis of a survey, involving Brazilian lecturers who work with sustainability in engineering courses. The collected data were analysed through Structural Equation Modelling, using Partial Least Squares method. The validation of the model was divided into nine different steps. A causal relationship between the two groups was verified through the present research, that is, the greater the difficulties associated with the structure and planning, the greater will be the difficulties observed in didactic practice. The results of this paper may be used by researchers in their future studies and by lecturers and coordinators as a guide to the inclusion of sustainability in engineering education

An assessment of the integration between corporate social responsibility practices and management systems in Brazil aiming at sustainability in enterprises

The concept of corporate social responsibility (CSR) is associated with the idea that every organization should integrate environmental, economic and social issues as part of their organizational philosophy. In companies with a higher degree of development in terms of CSR, sustainable practices are integrated into management systems. When focusing on Latin America, this integration may be at its first steps, but there is a vacuum in the literature in this field. Based on this reality, this paper aims to evaluate the integration between CSR practices and management systems in companies in Brazil based on experts’ perceptions. Employing a conceptual model covering how stakeholder demands are incorporated in organizational practices using a continuous improvement approach, we performed a survey with experts in the area. Results revealed opportunities for improvements in all CSR practices evaluated, most of which were considered by the experts to have been implemented only superficially. In a comparative analysis, two practices stood out in relation to the others: reporting of CSR results to stakeholders and evaluation of the performance of CSR activities using pre-established indicators. Practices associated with planning of CSR activities are the most superficially implemented, adversely affecting CSR performance. The authors believe that the findings of this study could be useful for business managers and academics as guidance towards improved CSR efforts

Implementation of cleaner production: A ten-year retrospective on benefits and difficulties found

leaner production is a fast-growing area with numerous important developments seen over the years,which have led to substantial improvements, both in technological, process and organization terms. Yet there is a paucity of literature organizing the body of knowledge on the benefits and difficulties seen inthis field. Thus, following a systematic literature review protocol, this paper provides a ten-year state-of-the-art analysis on the benefits and difficulties faced in the implementation of cleaner productionstrategies, and outlines some means via which they may be addressed. Main results point out thatcompanies and governments have been able to successfully reap both tangible and intangible benefits after Cleaner Production implementation as its appeal to attract customers and reap reputation gain increases, for example. However, the results also show a series of difficulties that remain and hinders the widespread advancement of this methodology

The Towuti Drilling Project:paleoenvironments, biological evolution, and geomicrobiology of a tropical Pacific lake

The Towuti Drilling Project (TDP) is an international research program, whose goal is to understand long-term environmental and climatic change in the tropical western Pacific, the impacts of geological and environmental changes on the biological evolution of aquatic taxa, and the geomicrobiology and biogeochemistry of metal-rich, ultramafic-hosted lake sediments through the scientific drilling of Lake Towuti, southern Sulawesi, Indonesia. Lake Towuti is a large tectonic lake at the downstream end of the Malili lake system, a chain of five highly biodiverse lakes that are among the oldest lakes in Southeast Asia. In 2015 we carried out a scientific drilling program on Lake Towuti using the International Continental Scientific Drilling Program (ICDP) Deep Lakes Drilling System (DLDS). We recovered a total of  ∼ 1018 m of core from 11 drilling sites with water depths ranging from 156 to 200 m. Recovery averaged 91.7 %, and the maximum drilling depth was 175 m below the lake floor, penetrating the entire sedimentary infill of the basin. Initial data from core and borehole logging indicate that these cores record the evolution of a highly dynamic tectonic and limnological system, with clear indications of orbital-scale climate variability during the mid- to late Pleistocene

How does study quality affect the results of a diagnostic meta-analysis?

Background: The use of systematic literature review to inform evidence based practice in diagnostics is rapidly expanding. Although the primary diagnostic literature is extensive, studies are often of low methodological quality or poorly reported. There has been no rigorously evaluated, evidence based tool to assess the methodological quality of diagnostic studies. The primary objective of this study was to determine the extent to which variations in the quality of primary studies impact the results of a diagnostic meta-analysis and whether this differs with diagnostic test type. A secondary objective was to contribute to the evaluation of QUADAS, an evidence-based tool for the assessment of quality in diagnostic accuracy studies. Methods: This study was conducted as part of large systematic review of tests used in the diagnosis and further investigation of urinary tract infection (UTI) in children. All studies included in this review were assessed using QUADAS, an evidence-based tool for the assessment of quality in systematic reviews of diagnostic accuracy studies. The impact of individual components of QUADAS on a summary measure of diagnostic accuracy was investigated using regression analysis. The review divided the diagnosis and further investigation of UTI into the following three clinical stages: diagnosis of UTI, localisation of infection, and further investigation of the UTI. Each stage used different types of diagnostic test, which were considered to involve different quality concerns. Results: Many of the studies included in our review were poorly reported. The proportion of QUADAS items fulfilled was similar for studies in different sections of the review. However, as might be expected, the individual items fulfilled differed between the three clinical stages. Regression analysis found that different items showed a strong association with test performance for the different tests evaluated. These differences were observed both within and between the three clinical stages assessed by the review. The results of regression analyses were also affected by whether or not a weighting (by sample size) was applied. Our analysis was severely limited by the completeness of reporting and the differences between the index tests evaluated and the reference standards used to confirm diagnoses in the primary studies. Few tests were evaluated by sufficient studies to allow meaningful use of meta-analytic pooling and investigation of heterogeneity. This meant that further analysis to investigate heterogeneity could only be undertaken using a subset of studies, and that the findings are open to various interpretations. Conclusion: Further work is needed to investigate the influence of methodological quality on the results of diagnostic meta-analyses. Large data sets of well-reported primary studies are needed to address this question. Without significant improvements in the completeness of reporting of primary studies, progress in this area will be limited

The inhibition of FGF receptor 1 activity mediates sorafenib-induced antiproliferative effects in human mesothelioma tumor-initiating cells

Tumor-initiating cells (TICs), the subset of cells within tumors endowed with stem-like features, being highly resistant to conventional cytotoxic drugs, are the major cause of tumor relapse. The identification of molecules able to target TICs remains a significant challenge in cancer therapy. Using TIC-enriched cultures (MM1, MM3 and MM4), from 3 human malignant pleural mesotheliomas (MPM), we tested the effects of sorafenib on cell survival and the intracellular mechanisms involved. Sorafenib inhibited cell-cycle progression in all the TIC cultures, but only in MM3 and MM4 cells this effect was associated with induction of apoptosis via the down-regulation of Mcl-1. Although sorafenib inhibits the activity of several tyrosine kinases, its effects are mainly ascribed to Raf inhibition. To investigate the mechanisms of sorafenib-mediated antiproliferative activity, TICs were treated with EGF or bFGF causing, in MM3 and MM4 cells, MEK, ERK1/2, Akt and STAT3 phosphorylation. These effects were significantly reduced by sorafenib in bFGF-treated cells, while a slight inhibition occurred after EGF stimulation, suggesting that sorafenib effects are mainly due to FGFR inhibition. Indeed, FGFR1 phosphorylation was inhibited by sorafenib. A different picture was observed in MM1 cells, which, releasing high levels of bFGF, showed an autocrine activation of FGFR1 and a constitutive phosphorylation/activation of MEK-ERK1/2. A powerful inhibitory response to sorafenib was observed in these cells, indirectly confirming the central role of sorafenib as FGFR inhibitor. These results suggest that bFGF signaling may impact antiproliferative response to sorafenib of MPM TICs, which is mainly mediated by a direct FGFR targeting

Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector

The inclusive and dijet production cross-sections have been measured for jets containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The measurements use data corresponding to an integrated luminosity of 34 pb^-1. The b-jets are identified using either a lifetime-based method, where secondary decay vertices of b-hadrons in jets are reconstructed using information from the tracking detectors, or a muon-based method where the presence of a muon is used to identify semileptonic decays of b-hadrons inside jets. The inclusive b-jet cross-section is measured as a function of transverse momentum in the range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet cross-section is measured as a function of the dijet invariant mass in the range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets and the angular variable chi in two dijet mass regions. The results are compared with next-to-leading-order QCD predictions. Good agreement is observed between the measured cross-sections and the predictions obtained using POWHEG + Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet cross-section. However, it does not reproduce the measured inclusive cross-section well, particularly for central b-jets with large transverse momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final version published in European Physical Journal

Measurement of the polarisation of W bosons produced with large transverse momentum in pp collisions at sqrt(s) = 7 TeV with the ATLAS experiment

This paper describes an analysis of the angular distribution of W->enu and W->munu decays, using data from pp collisions at sqrt(s) = 7 TeV recorded with the ATLAS detector at the LHC in 2010, corresponding to an integrated luminosity of about 35 pb^-1. Using the decay lepton transverse momentum and the missing transverse energy, the W decay angular distribution projected onto the transverse plane is obtained and analysed in terms of helicity fractions f0, fL and fR over two ranges of W transverse momentum (ptw): 35 < ptw < 50 GeV and ptw > 50 GeV. Good agreement is found with theoretical predictions. For ptw > 50 GeV, the values of f0 and fL-fR, averaged over charge and lepton flavour, are measured to be : f0 = 0.127 +/- 0.030 +/- 0.108 and fL-fR = 0.252 +/- 0.017 +/- 0.030, where the first uncertainties are statistical, and the second include all systematic effects.Comment: 19 pages plus author list (34 pages total), 9 figures, 11 tables, revised author list, matches European Journal of Physics C versio