Psoriasis and Hypertension Severity: Results from a Case-Control Study

BACKGROUND: Epidemiologic studies have provided new insights into the association between psoriasis and cardiovascular diseases. Previous population studies have examined hypertension frequency in psoriasis patients. However, the relationship between severity of hypertension and psoriasis has not been characterized. OBJECTIVE: We sought to investigate whether patients with psoriasis have more difficult-to-manage hypertension compared to non-psoriatic hypertensive patients. APPROACH: We performed a case-control study using the University of California Davis electronic medical records. The cases were defined as patients diagnosed with both psoriasis and hypertension, and controls were defined as patients with hypertension and without psoriasis. In this identified population, 835 cases were matched on age, sex, and body mass index (BMI) to 2418 control patients. KEY RESULTS: Treatment with multiple anti-hypertensives was significantly associated with the presence of psoriasis using univariate (p < 0.0001) and multivariable analysis, after adjusting for diabetes, hyperlipidemia, and race (p < 0.0001). Compared to hypertensive patients without psoriasis, psoriasis patients with hypertension were 5 times more likely to be on a monotherapy antihypertensive regimen (95% CI 3.607.05), 9.5 times more likely to be on dual antihypertensive therapy (95% CI 6.68-13.65), 16.5 times more likely to be on triple antihypertensive regimen (95% CI 11.01-24.84), and 19.9 times more likely to be on quadruple therapy or centrally-acting agent (95% CI 10.58-37.33) in multivariable analysis after adjusting for traditional cardiac risk factors. CONCLUSIONS: Psoriasis patients appear to have more difficult-to-control hypertension compared to non-psoriatic, hypertensive patients

School crime and disruption as a function of student-school fit: An empirical assessment

A theoretical model is described which conceptualizes school crime and disruption as a function of the congruence or fit between the personal characteristics of students and the social environments of the schools they attend. In a direct empirical test of the model, indices representing 10 distinct dimensions of student-school fit are related to three composite measures of school misconduct: school crime, school avoidance, and class misbehavior. A number of significant relationships are found between dimensions of student-school fit and the three indices of school misbehavior, several of which manifest one of the nonlinear forms specified by the model, providing at least modest support for a person-environment fit theory of school crime and disruption.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45305/1/10964_2005_Article_BF02087987.pd

Aggression, deviance, and personality adaptation as antecedents and consequences of alienation and involvement in high school

Alienation from, or involvement in, the social and educational systems of the high school are investigated in an effort to determine the extent that school experiences may influence aggressive and deviant behavior in school and personality styles or orientations. Drawing upon longitudinal data collected from 250 boys followed from grades 8 through 12, potential antecedent-consequence relationships between dimensions of alienation and involvement and these two basic types of student outcomes are examined by cross-lagged panel analyses. Differences between cross-lagged panel correlations provide evidence that student reactions and attachments to school manifest relationships with aggression, deviance, and personality, serving as both antecedents and consequences of these student adaptations. The major findings provide evidence that (1) boys who more frequently break school rules and engage in aggressive or deviant behavior may often come to have more negative attitudes toward school staff and less involvement in school; and (2) student involvement and participation in school life can influence certain aspects of adolescent personality. Possible evidence of reciprocal causation is presented and discussed, as are additional theoretical and methodological implications of the data.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45259/1/10964_2005_Article_BF01537471.pd

Two-particle BoseEinstein correlations in pp collisions at √s = 0.9 and 7 TeV measured with the ATLAS detector

The paper presents studies of Bose–Einstein Correlations (BEC) for pairs of like-sign charged particles measured in the kinematic range pT > 100 MeV and |η| <2.5 in proton–proton collisions at centre-of-mass energies of 0.9 and 7 TeV with the ATLAS detector at the CERN Large Hadron Collider. The integrated luminosities are approximately 7 μb−1, 190 μb−1 and 12.4 nb-1 for 0.9 TeV,7 TeV minimum-bias and 7 TeV high-multiplicity data samples, respectively. The multiplicity dependence of the BEC parameters characterizing the correlation strength and the correlation source size are investigated for charged-particle multiplicities of up to 240. A saturation effect in the multiplicity dependence of the correlation source size parameter is observed using the high-multiplicity 7 TeV data sample. The dependence of the BEC parameters on the average transverse momentum of the particle pair is also investigated

Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry

Objective: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) following Phase

Recent changes in the winter distribution and movements of northern Atlantic cod (Gadus morhua Linnaeus, 1758) on the Newfoundland-Labrador Shelf

Using catch data collected by fishery observers from the otter trawl fleet, we describe changes in the winter distribution of cod on the Newfoundland–Labrador Shelf between 1980 and 1992. We determined the relative abundance of cod in three areas of winter aggregation: south-east of Hamilton Bank, south-east of Belle Isle Bank and south-east of Funk Island Bank. The principal finding was that the cod, during their reproductive period, exhibited significant changes in distribution and behaviour, well before the stock showed signs of collapse. There were three indicators of these changes. First, there was a progressive disappearance of fish from the north with time. Most of the biomass was located in the Hamilton Bank area before 1984. By 1989, most of the fish were found at the Belle Isle Bank and south-east of Funk Island Bank locations and by 1991, only to the south (Funk Island Bank). Second, movements of the prespawning/spawning schools became more limited. Compared with the extensive along-shelf migrations, often covering distances of about 100 km, observed in earlier years, the fish schools after 1989 exhibited less movement to the north. Density of fish in the schools was highest in 1990. By 1991, the schools remained nearly stationary around 49°30′N, near the southern end of their distribution. Third, the schools spread over an increasingly greater range of depths. The greatest density of fish as reflected by high catch rates was generally observed no deeper than 600 m between 1980 and 1988. By 1989–1990, substantial catch rates were observed as deep as 1100 m, particularly to the north although catches continued to be considerable at the shallower depths. These changes in distribution and behaviour were generally coincident with the occurrence of anomalously cold ocean temperatures and heavy ice conditions, but no direct link between these changes and the environment was evident