Auflistung von regional Relevantem. Das Vorhandensein von Druckausgaben der Werke von Frane Petrić in deutschen Bibliotheken

Using bibliographical data from the major electronic German libraries’ catalogues for the editions of the works by Frane Petrić, and the copies of these works, it is possible to arrive at results which probably cannot be obtained using other means and instruments. There are strong indicators that the pre-20th century German reception of Petrić differs considerably from his reception elsewhere (especially in the U.K.). In this phase of reception the impact of the Discussiones peripateticae and the Militia romana is particularly conspicuous. The results for the impact of the 1953sqq editions of Petrić’s works are under many aspects different from the results obtained for the earlier editions of his works. This is a preliminary case study for Germany, using data from the U.K. and from the AHCI database for comparisons.L’utilisation des données des plus grands catalogues électroniques des bibliothčques allemandes concernant les éditions des ouvrages de Franjo Petrić et leurs exemplaires permet d’arriver ŕ des résultats qu’il serait probablement impossible d’obtenir par d’autres moyens et instruments. Il existe de fortes indications qui montrent que la réception allemande de Petrić antérieure au XXe siecle diffčre sensiblement de sa réception dans d’autres pays (et notamment en Grande-Bretagne). A ce stade-lŕ de réception, l’impact des ses Discussiones peripateticae et Militia romana est particuličrement évident. Les résultats concernant l’impact des éditions de 1952 et postérieures different ŕ maints égards de ceux obtenus pour les éditions antérieures. Cet article est une étude de cas préliminaire utilisant, ŕ des fins de comparaison, des données puisées dans des sources britanniques et dans la banque de données AHCI.Indem man den Katalogen der größten deutschen elektronischen Bibliotheken mit Ausgaben der Werke von Frane Petrić und einzelnen Exemplaren dieser Ausgaben bibliographische Daten entnimmt, lassen sich Ergebnisse vorlegen, die auf anderen Wegen oder mit Hilfe anderer Mittel kaum erfolgreich wären. Es bestehen ernsthafte Indizien dafür, dass sich die deutsche Petrić-Rezeption vor dem XX. Jahrhundert von anderweitigen Rezeptionen (namentlich in Großbritannien) wesentlich unterscheidet. In dieser Rezeptionsphase hebt sich besonders der Einfluss von Discussiones peripateticae und Militia romana hervor. Die Ergebnisse bezüglich des Einflusses der seit 1953 erschienenen Werkausgaben von Petrić unterscheiden sich in vielerlei Hinsicht von jenen, die sich aus den älteren Ausgaben seiner Werke ergeben. Dies ist eine vorläufige Fallstudie für Deutschland, die zum Vergleich Daten aus Großbritannien und der AHCI-Datenbank heranzieht

Counting What May Count Regionally. The Presence of Prints of Works by Frane Petrić in German

Using bibliographical data from the major electronic German libraries’ catalogs for the editions of the works by Frane Petrić and the copies of these works, it is possible to arrive at results which probably cannot be obtained using other means and instruments. There are strong indicators that the pre20th-century German reception of Petrić differs considerably from his reception elsewhere (especially in the U.K.). In this phase of reception, the impact of the Discussiones peripateticae and the Militia romana is particularly conspicuous. The results for the impact of the 1953sqq editions of Petrić’s works are under many aspects different from the results obtained for the earlier editions of his works. This is a preliminary case study for Germany, using data from the U.K. and from the AHCI database for comparisons

Preparative fractionation of a random copolymer (SAN) with respect to either chain length or chemical composition

The possibilities to fractionate copolymers with respect to their chemical composition on a preparative scale by means of the establishment of liquid/liquid phase equilibria were studied for random copolymers of styrene and acrylonitrile (san). Experiments with solutions of san in toluene have shown that fractionation does in this quasi-binary system, where demixing results from marginal solvent quality, take place with respect to the chain length of the polymer only. On the other hand, if phase separation is induced by a second, chemically different polymer one can find conditions under which fractionation with respect to composition becomes dominant. This opportunity is documented for the quasi-ternary system dmac/san/polystyrene, where the solvent dimethyl acetamide is completely miscible with both polymers. The theoretical reasons for the different fractionation mechanisms are discussed

Structure-guided selection of specificity determining positions in the human kinome

Background: The human kinome contains many important drug targets. It is well-known that inhibitors of protein kinases bind with very different selectivity profiles. This is also the case for inhibitors of many other protein families. The increased availability of protein 3D structures has provided much information on the structural variation within a given protein family. However, the relationship between structural variations and binding specificity is complex and incompletely understood. We have developed a structural bioinformatics approach which provides an analysis of key determinants of binding selectivity as a tool to enhance the rational design of drugs with a specific selectivity profile. Results: We propose a greedy algorithm that computes a subset of residue positions in a multiple sequence alignment such that structural and chemical variation in those positions helps explain known binding affinities. By providing this information, the main purpose of the algorithm is to provide experimentalists with possible insights into how the selectivity profile of certain inhibitors is achieved, which is useful for lead optimization. In addition, the algorithm can also be used to predict binding affinities for structures whose affinity for a given inhibitor is unknown. The algorithm’s performance is demonstrated using an extensive dataset for the human kinome. Conclusion: We show that the binding affinity of 38 different kinase inhibitors can be explained with consistently high precision and accuracy using the variation of at most six residue positions in the kinome binding site. We show for several inhibitors that we are able to identify residues that are known to be functionally important

Old English macian, Its Origin and Dissemination

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66612/2/10.1177_007542428601900105.pd

Strong Interaction Physics at the Luminosity Frontier with 22 GeV Electrons at Jefferson Lab

This document presents the initial scientific case for upgrading the Continuous Electron Beam Accelerator Facility (CEBAF) at Jefferson Lab (JLab) to 22 GeV. It is the result of a community effort, incorporating insights from a series of workshops conducted between March 2022 and April 2023. With a track record of over 25 years in delivering the world's most intense and precise multi-GeV electron beams, CEBAF's potential for a higher energy upgrade presents a unique opportunity for an innovative nuclear physics program, which seamlessly integrates a rich historical background with a promising future. The proposed physics program encompass a diverse range of investigations centered around the nonperturbative dynamics inherent in hadron structure and the exploration of strongly interacting systems. It builds upon the exceptional capabilities of CEBAF in high-luminosity operations, the availability of existing or planned Hall equipment, and recent advancements in accelerator technology. The proposed program cover various scientific topics, including Hadron Spectroscopy, Partonic Structure and Spin, Hadronization and Transverse Momentum, Spatial Structure, Mechanical Properties, Form Factors and Emergent Hadron Mass, Hadron-Quark Transition, and Nuclear Dynamics at Extreme Conditions, as well as QCD Confinement and Fundamental Symmetries. Each topic highlights the key measurements achievable at a 22 GeV CEBAF accelerator. Furthermore, this document outlines the significant physics outcomes and unique aspects of these programs that distinguish them from other existing or planned facilities. In summary, this document provides an exciting rationale for the energy upgrade of CEBAF to 22 GeV, outlining the transformative scientific potential that lies within reach, and the remarkable opportunities it offers for advancing our understanding of hadron physics and related fundamental phenomena.Comment: Updates to the list of authors; Preprint number changed from theory to experiment; Updates to sections 4 and 6, including additional figure

Measurement of the charge asymmetry in highly boosted top-quark pair production in √s=8 TeV pp collision data collected by the ATLAS experiment

In the pp→tt process the angular distributions of top and anti-top quarks are expected to present a subtle difference, which could be enhanced by processes not included in the Standard Model. This Letter presents a measurement of the charge asymmetry in events where the top-quark pair is produced with a large invariant mass. The analysis is performed on 20.3 fb-1 of pp collision data at √s=8TeV collected by the ATLAS experiment at the LHC, using reconstruction techniques specifically designed for the decay topology of highly boosted top quarks. The charge asymmetry in a fiducial region with large invariant mass of the top-quark pair (mtt>0.75 TeV) and an absolute rapidity difference of the top and anti-top quark candidates within -2<|yt|-|yt|<2 is measured to be 4.2±3.2%, in agreement with the Standard Model prediction at next-to-leading order. A differential measurement in three tt- mass bins is also presented