Structured testing during seizures: A practical guide for assessing and interpreting ictal and postictal signs during video EEG long term monitoring

Background: Ictal and postictal testing carried out in long-term epilepsy monitoring units is often sub-optimal. Recently, a European consensus protocol for testing patients during and after seizures was developed by a joint taskforce of the International League Against Epilepsy – Commission on European Affairs and the European Epilepsy Monitoring Unit Association. / Aim: Using this recently developed standardised assessment battery as a framework, the goal of this narrative review is to outline the proposed testing procedure in detail and explain the rationale for each individual component, focusing on the underlying neurobiology. This is intended to serve as an educational resource for staff working in epilepsy monitoring units. / Methods: A literature review of PubMed was performed; using the search terms “seizure”, “ictal”, “postictal”, “testing”, “examination”, and “interview”. Relevant literature was reviewed and relevant references were chosen. The work is presented as a narrative review. / Results: The proposed standardised assessment battery provides a comprehensive and user-friendly format for ictal-postictal testing, and examines consciousness, language, motor, sensory, and visual function. Conclusion The standardised approach proposed has the potential to make full use of data recorded during video EEG increasing the diagnostic yield with regards to lateralisation and localisation, aiding both presurgical and diagnostic studies

Measuring and Modelling the Redshift Evolution of Clustering: the Hubble Deep Field North

(abridged) The evolution of galaxy clustering from z=0 to z=4.5 is analyzed using the angular correlation function and the photometric redshift distribution of galaxies brighter than I_{AB}\le 28.5 in the HDF North. The reliability of the photometric redshift estimates is discussed on the basis of the available spectroscopic redshifts, comparing different codes and investigating the effects of photometric errors. The redshift bins in which the clustering properties are measured are then optimized to take into account the uncertainties of the photometric redshifts. The results show that the comoving correlation length has a small decrease in the range 0<z<1 followed by an increase at higher z. We compare these results with the theoretical predictions of a variety of cosmological models belonging to the general class of CDM. The comparison with the expected mass clustering evolution indicates that the observed high-redshift galaxies are biased tracers of the dark matter with an effective bias b strongly increasing with redshift. Assuming an Einstein-de Sitter universe, we obtain b\simeq 2 at z=2 and b\simeq 5 at z=4. A comparison of the clustering amplitudes that we measured at z=3 with those reported for LBG suggests that the clustering depends on the abundance of the objects: more abundant objects are less clustered, as expected in the paradigm of hierarchical galaxy formation. The strong clustering and high bias measured at z=3 are consistent with the expected density of massive haloes predicted for the various cosmologies here considered. At z=4, the strong clustering observed in the HDF requires a significant fraction of massive haloes to be already formed by that epoch. This feature could be a discriminant test for the cosmological parameters if confirmed by future observations.Comment: 23 pages, Latex using MN style, figures enclosed. Version accepted for publication in MNRA

Velocity-Metallicity Correlation for high-z DLA Galaxies: Evidence for a Mass-Metallicity Relation?

We used our database of VLT-UVES quasar spectra to build up a sample of 70 Damped Lyman-alpha (DLA) or strong sub-DLA systems with total neutral hydrogen column densities of log N(HI)>20 and redshifts in the range 1.7<z_abs<4.3. For each of the systems, we measured in an homogeneous manner the metallicities relative to Solar, [X/H] (with X=Zn, or S or Si), and the velocity widths of low-ionization line profiles, Delta V. We provide for the first time evidence for a correlation between DLA metallicity and line profile velocity width, which is detected at the 6.1sigma significance level. This confirms the trend previously observed in a much smaller sample by Wolfe & Prochaska (1998). The best-fit linear relation is [X/H]=1.55(\pm 0.12) log Delta V -4.33(\pm 0.23) with Delta V expressed in km/s. The slope of the DLA velocity-metallicity relation is the same within uncertainties between the higher (z_abs>2.43) and the lower (z_abs<2.43) redshift halves of our sample. However, the two populations of systems are statistically different. There is a strong redshift evolution in the sense that the mean metallicity and mean velocity width increase with decreasing redshift. We argue that the existence of a DLA velocity-metallicity correlation, over more than a factor of 100 spread in metallicity, is probably the consequence of an underlying mass-metallicity relation for the galaxies responsible for DLA absorption lines. Assuming a simple linear scaling of the galaxy luminosity with the mass of the dark-matter halo, we find that the slope of the DLA velocity-metallicity relation is consistent with that of the luminosity-metallicity relation derived for local galaxies. [...] abridged.Comment: 10 pages, 4 figures, A&A in pres

On the evolution of clustering of 24um-selected galaxies

This paper investigates the clustering properties of a complete sample of 1041 24um-selected sources brighter than F[24um]=400 uJy in the overlapping region between the SWIRE and UKIDSS UDS surveys. We have concentrated on the two (photometric) interval ranges z=[0.6-1.2] (low-z sample) and z>1.6 (high-z sample) as it is in these regions were we expect the mid-IR population to be dominated by intense dust-enshrouded activity such as star formation and black hole accretion. Investigations of the angular correlation function produce a correlation length are r0~15.9 Mpc for the high-z sample and r0~8.5 Mpc for the low-z one. Comparisons with physical models reveal that the high-z sources are exclusively associated with very massive (M>~10^{13} M_sun)haloes, comparable to those which locally host groups-to-clusters of galaxies, and are very common within such (rare) structures. Conversely, lower-z galaxies are found to reside in smaller halos (M_min~10^{12} M_sun) and to be very rare in such systems. While recent studies have determined a strong evolution of the 24um luminosity function between z~2 and z~0, they cannot provide information on the physical nature of such an evolution. Our clustering results instead indicate that this is due to the presence of different populations of objects inhabiting different structures, as active systems at z<~1.5 are found to be exclusively associated with low-mass galaxies, while very massive sources appear to have concluded their active phase before this epoch. Finally, we note that the small-scale clustering data seem to require steep profiles for the distribution of galaxies within their halos. This is suggestive of close encounters and/or mergers which could strongly favour both AGN and star-formation activity.Comment: 13 pages, 8 figures, to appear in MNRA

Galaxy Group at z=0.3 Associated with the Damped Lyman Alpha System Towards Quasar Q1127-145

(Abridged) We performed a spectroscopic galaxy survey, complete to m<20.3 (L_B>0.15L_B* at z=0.3), within 100x100" of the quasar Q1127-145 (z=1.18). The VLT/UVES quasar spectrum contains three z<0.33 MgII absorption systems. We obtained eight new galaxy redshifts, adding to the four previously known, and galaxy star formation rates and metallicities were computed where possible. A strong MgII system [W_r(2796)=1.8A], which is a known DLA, had three previously identified galaxies; we found two additional galaxies associated with this system. These five galaxies form a group with diverse properties, such as a luminosity range of 0.04<L_B<0.63L_B*, an impact parameter range of 17<D<241kpc and velocity dispersion of 115km/s. The DLA group galaxy redshifts span beyond the 350km/s velocity spread of the metallic absorption lines of the DLA itself. The two brightest group galaxies have SFRs of a few Msun/yr and should not have strong winds. We have sufficient spectroscopic information to directly compare three of the five group galaxies' (emission-line) metallicities with the DLA (absorption) metallicity: the DLA metallicity is 1/10th solar, substantially lower than the three galaxies' which range between less than 1/2 solar to solar metallicity. HST/WFPC-2 imaging shows perturbed morphologies for the three brightest group galaxies, with tidal tails extending 25kpc. We favor a scenario where the DLA absorption originates from tidal debris in the group environment. Another absorber exhibits weak MgII absorption [W_r(2796)=0.03A] and had a previously identified galaxy at a similar redshift. We have identified a second galaxy associated with this system. Both galaxies have solar metallicities and unperturbed morphologies. The SFR of one galaxy is much lower than expected for strong outflows. Finally, we have identified five galaxies at large impact parameters with no associated MgII absorption.Comment: 15 pages, 7 figures, 5 tables. Accepted for publication in MNRAS

On the APM power spectrum and the CMB anisotropy: Evidence for a phase transition during inflation?

Adams et al. (1997b) have noted that according to our current understanding of the unification of fundamental interactions, there should have been phase transitions associated with spontaneous symmetry breaking {\em during} the inflationary era. This may have resulted in the breaking of scale-invariance of the primordial density perturbation for brief periods. A possible such feature was identified in the power spectrum of galaxy clustering in the APM survey at the scale $k \sim 0.1 h$ Mpc^{-1} and it was shown that the secondary acoustic peaks in the power spectrum of the CMB anisotropy should consequently be suppressed. We demonstrate that this prediction is confirmed by the recent Boomerang and Maxima observations, which favour a step-like spectral feature in the range $k \sim (0.06-0.6)h$ Mpc^{-1}, independently of the similar previous indication from the APM data. Such a spectral break enables an excellent fit to both APM and CMB data with a baryon density consistent with the BBN value. It also allows the possibility of a matter-dominated universe with zero cosmological constant, which we show can now account for even the evolution of the abundance of rich clusters.Comment: 11 pages (LaTeX, mn.sty) incl. 9 eps figs; small changes to match version accepted for publication in MNRA

Inclusive Electron Scattering from Nuclei at x≃1x \simeq 1

The inclusive A(e,e') cross section for $x \simeq 1$ was measured on $^2$H, C, Fe, and Au for momentum transfers $Q^2$ from 1-7 (GeV/c)$^2$. The scaling behavior of the data was examined in the region of transition from y-scaling to x-scaling. Throughout this transitional region, the data exhibit $\xi$-scaling, reminiscent of the Bloom-Gilman duality seen in free nucleon scattering.Comment: 4 pages, RevTeX; 4 figures (postscript in .tar.Z file

The zCOSMOS Redshift Survey: the role of environment and stellar mass in shaping the rise of the morphology-density relation from z~1

For more than two decades we have known that galaxy morphological segregation is present in the Local Universe. It is important to see how this relation evolves with cosmic time. To investigate how galaxy assembly took place with cosmic time, we explore the evolution of the morphology-density relation up to redshift z~1 using about 10000 galaxies drawn from the zCOSMOS Galaxy Redshift Survey. Taking advantage of accurate HST/ACS morphologies from the COSMOS survey, of the well-characterised zCOSMOS 3D environment, and of a large sample of galaxies with spectroscopic redshift, we want to study here the evolution of the morphology-density relation up to z~1 and its dependence on galaxy luminosity and stellar mass. The multi-wavelength coverage of the field also allows a first study of the galaxy morphological segregation dependence on colour. We further attempt to disentangle between processes that occurred early in the history of the Universe or late in the life of galaxies. The zCOSMOS field benefits of high-resolution imaging in the F814W filter from the Advanced Camera for Survey (ACS). We use standard morphology classifiers, optimised for being robust against band-shifting and surface brightness dimming, and a new, objective, and automated method to convert morphological parameters into early, spiral, and irregular types. We use about 10000 galaxies down to I_AB=22.5 with a spectroscopic sampling rate of 33% to characterise the environment of galaxies up to z~1 from the 100 kpc scales of galaxy groups up to the 100 Mpc scales of the cosmic web. ABRIDGEDComment: 23 pages, 12 figures, accepted for publication in Astronomy and Astrophysic

Shadowing in Inelastic Scattering of Muons on Carbon, Calcium and Lead at Low XBj

Nuclear shadowing is observed in the per-nucleon cross-sections of positive muons on carbon, calcium and lead as compared to deuterium. The data were taken by Fermilab experiment E665 using inelastically scattered muons of mean incident momentum 470 GeV/c. Cross-section ratios are presented in the kinematic region 0.0001 < XBj <0.56 and 0.1 < Q**2 < 80 GeVc. The data are consistent with no significant nu or Q**2 dependence at fixed XBj. As XBj decreases, the size of the shadowing effect, as well as its A dependence, are found to approach the corresponding measurements in photoproduction.Comment: 22 pages, incl. 6 figures, to be published in Z. Phys.

A perspective on SIDS pathogenesis. The hypotheses: plausibility and evidence

Several theories of the underlying mechanisms of Sudden Infant Death Syndrome (SIDS) have been proposed. These theories have born relatively narrow beach-head research programs attracting generous research funding sustained for many years at expense to the public purse. This perspective endeavors to critically examine the evidence and bases of these theories and determine their plausibility; and questions whether or not a safe and reasoned hypothesis lies at their foundation. The Opinion sets specific criteria by asking the following questions: 1. Does the hypothesis take into account the key pathological findings in SIDS? 2. Is the hypothesis congruent with the key epidemiological risk factors? 3. Does it link 1 and 2? Falling short of any one of these answers, by inference, would imply insufficient grounds for a sustainable hypothesis. Some of the hypotheses overlap, for instance, notional respiratory failure may encompass apnea, prone sleep position, and asphyxia which may be seen to be linked to co-sleeping. For the purposes of this paper, each element will be assessed on the above criteria