Heritability Estimate of Yield Related Traits in Mungbean at Two Locations

Performance of 17 mungbean genotypes was tested at two diverse environments (Swat and Peshawar) of Khyber Pakhtunkhwa, Pakistan during 2012 to study heritability estimate of yield related triats in mungbean. Data were taken on pods plant-1, pod length, seeds pod-1, 100-seed weight, seed yield. Pooled analysis of variance across locations revealed significant differences among the two locations and genotypes for all traits. Genotype × location interaction was also highly significant (P=0.01) for all traits demonstrating differential performance of mungbean genotypes over the two test locations. Means for pods plant-1, pod length, seeds pod-1, 100-seed weight, seed yield were 21.7 vs. 39.0, 9.2 vs. 8.5 cm, 11.3 vs. 10.2, 4.2 vs. 5.4 g, 1429 vs. 1828 kg ha-1 at Peshawar and Swat, respectively. All mungbean genotypes produced more pods plant-1 and heavier seeds resulting in more seed yield per unit area at Swat than Peshawar .Genotypes AUP1210-9, AUP1210-10 and AUP1410-5 were high yielding at Swat location as well as across the two locations. AUP1210-9 and AUP6310-4 were the high yielding genotypes at Peshawar location. Genetic variances at each location as well as across locations were greater in magnitude than environmental variances for most of the traits. Magnitude of heritability and selection response for most traits varied over two locations. Heritability and selection response across two locations were 0.67 and 4.33 for pods plant-1, 0.65 and 0.70 cm for pod length, 0.55 and 0.67 for seeds pod-1, 0.66 and 0.72 g for 100-seed weight, 0.68 and 328.4 kg ha-1 for seed yield, respectively. Keywords:Mungbean, genetic association, heritability

Functional differential equations with unbounded delay in extrapolation spaces

International audienceWe study the existence, regularity and stability of solutions for nonlinear partial neutral functional differential equations with unbounded de-lay and a Hille-Yosida operator on a Banach space X. We consider two non-linear perturbations: the first one is a function taking its values in X and the second one is a function belonging to a space larger than X, an extrapolated space. We use the extrapolation techniques to prove the existence and regu-larity of solutions and we establish a linearization principle for the stability of the equilibria of our equation

Green Procurement in Construction: Analysis of the Readiness Level and Key Catalyst among Construction Enablers

In the concern of sustainability and increasing awareness of environmental degradation, the Malaysian government has promoted numerous initiatives on green growth and green procurement (GP) to maintain and minimize the ecological effects in construction. However, this initiative is still in the infancy stage as to date, there is no specific guideline delineated to the construction industry, and it has yet to be enforced by the government to the construction practitioners. In construction, green procurement is a new area, and immediate actions are needed upon the principles, guidelines, and policy and implementation framework. Hence, this research aims to analyse the readiness level, barriers, and key catalysts among construction enablers towards adopting green procurement in the construction industry. Questionnaires were distributed to 102 construction enablers, focusing on quantity surveying firms in the Klang Valley area (Kuala Lumpur and Selangor), and 87 returned the responses. The analysis uses descriptive statistics via mean score, and the standard deviation was used to measure the variables and the mean's dispersion. It is revealed that the consultants are ready to adopt green procurement. However, GP's implementation's top challenges are lack of internal expertise, low awareness about green procurement, and lack of established best practices, standardized procedures and guidelines. It can be summarized that promoting GP and its implementation requires government support in policies, initiatives, and incentives. As the current practice is fragmented, ideally, GP's adoption in construction projects needs to conform to the acceptable standards that enable specific provisions to acquire eco-friendly sustainable construction

Assessing Practice and Criteria for Green Roof Maintenance on High-rise Residential Building in Malaysia

Urbanisation inevitably shows a positive sign in increasing the economic reputation of a country. Nevertheless, it has led to several problems including the deficit in green spaces and destruction of the natural environment, therefore green building is introduced as an alternative to overcome crucial environmental issues. Numerous approaches were also adopted to reduce other environmental issues such as urban heat island, air pollution and lack of green spaces. One of the sustainable approaches that help to minimise the environmental problems is by using the means of vegetation or plant material on rooftops or also known as the green roof. The implementation of the green roof on top of buildings is becoming a trend in the urban cities as it provides numerous benefits to the green development. The green roof is also part of criteria in green building and among the benefits, implementing green roofs will reduce heat flux, optimise energy efficiency and improve stormwater management. However, despite the benefits, enhancement on the green roof installation and maintenance consideration are two factors which are still largely unexplored as the main significant factor in the viability of the green roof installation. Hence, this paper is aimed to determine the vital criteria of maintenance and its ranking towards the establishment of best practice maintenance for the green roof, by focusing on high-rise residential. Questionnaires were distributed by email and through an online survey to 30 maintenance managers of green roof of high-rise residential in Kuala Lumpur and the samples are drawn by using purposive sampling technique. The results showed that the most significant maintenance criteria of the green roof are drainage, followed by waterproofing, irrigation, water retention, and roof slab. The outcome of this study has provided a significant contribution to the current maintenance practice of green roof by prioritising the criteria of maintenance and key address of green roof, where it may help to standardise the maintenance practice of the green roof in the tropical climate of Malaysia

Review of Significant Maintenance Criteria for Tropical Green Roofs in Malaysia

The implementation of green roofs on the top of buildings is becoming a trend in urban cities as they provide numerous benefits for green development growth. In Malaysia, numerous approaches towards sustainable development have been adopted in order to overcome crucial environmental issues such as urban heat islands, air pollution and lack of green spaces. One of the sustainable approaches that helps to minimize such problems is the use of vegetation or plant material on rooftops, also known as green roofs. Among the benefits of implementing green roofs or buildings are reducing heat flux, optimizing energy efficiency, and improving storm water management. Despite the benefits of green roof installation, the maintenance consideration is still largely unexplored and is a significant factor in the viability of green roof installation. Therefore, this paper aims to identify the significant criteria for green roof maintenance practice in Malaysia, as an added value to the existing practice that has previously been more concerned with design and benefit considerations. The literature findings reveal that there are generally 20 criteria related to such maintenance. Out of these, six are identified as the most significant factors in the best practice of green roof maintenance, being appropriate and important for the Malaysian tropical climate. The findings can serve as added value to existing practice, which has previously been more concerned with design and benefit. Therefore, they will also help to improve current green roof maintenance undertaken by building operators and maintenance managers

E-procurement adoption in the Malaysian construction sector : integrating diffusionof innovations and theory of planned behaviour framework

In recent years, environmental problems have become more prominent in the construction industry. The production and use of building materials are still one of the main reasons for various ecological and environmental challenges in the industry. Compared with traditional building materials, green building materials are environmentally friendly. Therefore, the adoption of green building materials in the construction industry can generally solve the industry’s ecological and environmental problems and promote green and low-carbon development. Research on contractors’ green procurement behaviour can promote the construction industry’s sustainable development. Many scholars discuss and agree that the implementation of e-procurement is a green approach towards sustainable construction. However, current evidence indicates that procurement stakeholders, especially contractors, are struggling to implement e-procurement effectively. Therefore, there is a need to study contractors’ behaviour in relation to green e-procurement. In response, this study investigates the adoption of e-procurement by Malaysian contractors by adopting planned behaviour theories and diffusion of innovations in their decision-making process. Here, a conceptual framework has been developed which focuses on factors influencing contractors’ adoptions. The framework can be used for understanding the contractors’ adoption decision of e-procurement. The result will help to find the critical key factors affecting green procurement behaviour from contractors’ perspectives and extend the theories further. This framework is also in tandem with the Construction Industry Development Board (CIDB), Construction 4.0 Strategic Plan (2021-2025) in identifying critical factors that affect the adoption of green procurement on construction projects

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture

Epilepsy is a highly heritable disorder affecting over 50 million people worldwide, of which about one-third are resistant to current treatments. Here we report a multi-ancestry genome-wide association study including 29,944 cases, stratified into three broad categories and seven subtypes of epilepsy, and 52,538 controls. We identify 26 genome-wide significant loci, 19 of which are specific to genetic generalized epilepsy (GGE). We implicate 29 likely causal genes underlying these 26 loci. SNP-based heritability analyses show that common variants explain between 39.6% and 90% of genetic risk for GGE and its subtypes. Subtype analysis revealed markedly different genetic architectures between focal and generalized epilepsies. Gene-set analyses of GGE signals implicate synaptic processes in both excitatory and inhibitory neurons in the brain. Prioritized candidate genes overlap with monogenic epilepsy genes and with targets of current antiseizure medications. Finally, we leverage our results to identify alternate drugs with predicted efficacy if repurposed for epilepsy treatment

Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial

Background Post-partum haemorrhage is the leading cause of maternal death worldwide. Early administration of tranexamic acid reduces deaths due to bleeding in trauma patients. We aimed to assess the effects of early administration of tranexamic acid on death, hysterectomy, and other relevant outcomes in women with post-partum haemorrhage. Methods In this randomised, double-blind, placebo-controlled trial, we recruited women aged 16 years and older with a clinical diagnosis of post-partum haemorrhage after a vaginal birth or caesarean section from 193 hospitals in 21 countries. We randomly assigned women to receive either 1 g intravenous tranexamic acid or matching placebo in addition to usual care. If bleeding continued after 30 min, or stopped and restarted within 24 h of the first dose, a second dose of 1 g of tranexamic acid or placebo could be given. Patients were assigned by selection of a numbered treatment pack from a box containing eight numbered packs that were identical apart from the pack number. Participants, care givers, and those assessing outcomes were masked to allocation. We originally planned to enrol 15 000 women with a composite primary endpoint of death from all-causes or hysterectomy within 42 days of giving birth. However, during the trial it became apparent that the decision to conduct a hysterectomy was often made at the same time as randomisation. Although tranexamic acid could influence the risk of death in these cases, it could not affect the risk of hysterectomy. We therefore increased the sample size from 15 000 to 20 000 women in order to estimate the effect of tranexamic acid on the risk of death from post-partum haemorrhage. All analyses were done on an intention-to-treat basis. This trial is registered with ISRCTN76912190 (Dec 8, 2008); ClinicalTrials.gov, number NCT00872469; and PACTR201007000192283. Findings Between March, 2010, and April, 2016, 20 060 women were enrolled and randomly assigned to receive tranexamic acid (n=10 051) or placebo (n=10 009), of whom 10 036 and 9985, respectively, were included in the analysis. Death due to bleeding was significantly reduced in women given tranexamic acid (155 [1·5%] of 10 036 patients vs 191 [1·9%] of 9985 in the placebo group, risk ratio [RR] 0·81, 95% CI 0·65–1·00; p=0·045), especially in women given treatment within 3 h of giving birth (89 [1·2%] in the tranexamic acid group vs 127 [1·7%] in the placebo group, RR 0·69, 95% CI 0·52–0·91; p=0·008). All other causes of death did not differ significantly by group. Hysterectomy was not reduced with tranexamic acid (358 [3·6%] patients in the tranexamic acid group vs 351 [3·5%] in the placebo group, RR 1·02, 95% CI 0·88–1·07; p=0·84). The composite primary endpoint of death from all causes or hysterectomy was not reduced with tranexamic acid (534 [5·3%] deaths or hysterectomies in the tranexamic acid group vs 546 [5·5%] in the placebo group, RR 0·97, 95% CI 0·87-1·09; p=0·65). Adverse events (including thromboembolic events) did not differ significantly in the tranexamic acid versus placebo group. Interpretation Tranexamic acid reduces death due to bleeding in women with post-partum haemorrhage with no adverse effects. When used as a treatment for postpartum haemorrhage, tranexamic acid should be given as soon as possible after bleeding onset. Funding London School of Hygiene & Tropical Medicine, Pfizer, UK Department of Health, Wellcome Trust, and Bill & Melinda Gates Foundation

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication