1,000 research outputs found
Recognition and management of abdominal compartment syndrome among German anesthetists and surgeons: a national survey
- Publication venue
- Springer
- Publication date
- 01/01/2012
- Field of study
Get PDFRecognition and management of abdominal compartment syndrome among German pediatric intensivists: results of a national survey
- Author
- Publication venue
- Springer
- Publication date
- 01/01/2012
- Field of study
Get PDFInhibition of neogenin fosters resolution of inflammation and tissue regeneration
- Author
- Publication venue
- 'American Society for Clinical Investigation'
- Publication date
- 01/10/2018
- Field of study
Get PDFProteomic
Sema7A is crucial for resolution of severe inflammation
- Publication venue
- 'Proceedings of the National Academy of Sciences'
- Publication date
- 02/03/2021
- Field of study
Get PDFEndogenous mediators regulating acute inflammatory responses in both the induction and resolution phases of inflammatory processes are pivotal in host defense and tissue homeostasis. Recent studies have identified neuronal guidance proteins characterized in axonal development that display immunomodulatory functions. Here, we identify the neuroimmune guidance cue Semaphorin 7A (Sema7A), which appears to link macrophage (M Phi) metabolic remodeling to inflammation resolution. Sema7A orchestrated M Phi chemotaxis and chemokinesis, activated M Phi differentiation and polarization toward the proresolving M2 phenotype, and promoted leukocyte clearance. Peritoneal M Phi(sema7A-/-) displayed metabolic reprogramming, characterized by reductions in fatty acid oxidation and oxidative phosphorylation, increases in glycolysis and the pentose phosphate pathway, and truncation of the tricarboxylic acid cycle, which resulted in increased levels of the intermediates succinate and fumarate. The low accumulation of citrate in M Phi(sema7A-/-) correlated with the decreased synthesis of prostaglandins, leading to a reduced impact on lipid-mediator class switching and the generation of specialized pro resolving lipid mediators. Signaling network analysis indicated that Sema7A induced the metabolic reprogramming of M Phi by activating the mTOR-and AKT2-signaling pathways. Administration of Sema7A(SL4cd) orchestrated the resolution response to tissue homeostasis by shortening the resolution interval, promoting tissue protection in murine peritonitis, and enhancing survival in polymicrobial sepsis.Proteomic
Measurements of branching fraction ratios and CP-asymmetries in suppressed B^- -> D(-> K^+ pi^-)K^- and B^- -> D(-> K^+ pi^-)pi^- decays
- Author
- Aaltonen T.
- Abbiendi G.
- Abbrescia M.
- Abdulsalam A.
- Ahmad W. Haj
- Ahuja S.
- Albergo S.
- Almenar C. Cuenca
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- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2011
- Field of study
Get PDFWe report the first reconstruction in hadron collisions of the suppressed
decays B^- -> D(-> K^+ pi^-)K^- and B^- -> D(-> K^+ pi^-)pi^-, sensitive to the
CKM phase gamma, using data from 7 fb^-1 of integrated luminosity collected by
the CDF II detector at the Tevatron collider. We reconstruct a signal for the
B^- -> D(-> K^+ pi^-)K^- suppressed mode with a significance of 3.2 standard
deviations, and measure the ratios of the suppressed to favored branching
fractions R(K) = [22.0 \pm 8.6(stat)\pm 2.6(syst)]\times 10^-3, R^+(K) =
[42.6\pm 13.7(stat)\pm 2.8(syst)]\times 10^-3, R^-(K)= [3.8\pm 10.3(stat)\pm
2.7(syst]\times 10^-3, as well as the direct CP-violating asymmetry A(K) =
-0.82\pm 0.44(stat)\pm 0.09(syst) of this mode. Corresponding quantities for
B^- -> D(-> K^+ pi^-)pi^- decay are also reported.Comment: 8 pages, 1 figure, accepted by Phys.Rev.D Rapid Communications for
Publicatio
Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV
- Author
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- Yildirim E
- Yilmaz Y
- Yohay R
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- Yoo J
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- Yumiceva F
- Yun JC
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- Zablocki J
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- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
- Zang SL
- Zarubin A
- Zatserklyaniy A
- Zeinali M
- Zeise M
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang Z
- Zheng Y
- Zhokin A
- Zhu B
- Zhu RY
- Zhukov V
- Zhukova V
- Ziebarth EB
- Ziegler J
- Zielinski M
- Zito G
- Zoeller MH
- Zotto P
- Zou W
- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2012
- Field of study
Get PDFThe performance of muon reconstruction, identification, and triggering in CMS
has been studied using 40 inverse picobarns of data collected in pp collisions
at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection
criteria covering a wide range of physics analysis needs have been examined.
For all considered selections, the efficiency to reconstruct and identify a
muon with a transverse momentum pT larger than a few GeV is above 95% over the
whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4,
while the probability to misidentify a hadron as a muon is well below 1%. The
efficiency to trigger on single muons with pT above a few GeV is higher than
90% over the full eta range, and typically substantially better. The overall
momentum scale is measured to a precision of 0.2% with muons from Z decays. The
transverse momentum resolution varies from 1% to 6% depending on pseudorapidity
for muons with pT below 100 GeV and, using cosmic rays, it is shown to be
better than 10% in the central region up to pT = 1 TeV. Observed distributions
of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO
Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Acosta D
- Acosta JG
- Acosta MV
- Adair A
- Adam N
- Adam W
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- Adiguzel A
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- Agostino L
- Agram JL
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- Albayrak EA
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- Aliev T
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- Anastassov A
- Anderson J
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- Andrews W
- Anghel IM
- Anjos TS
- Antonelli L
- Antunes JR
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- Azhgirey I
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- Baarmand MM
- Babb J
- Bacchetta N
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- Baden A
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- Baesso P
- Baffioni S
- Bagliesi G
- Bai Y
- Baillon P
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- Bakken JA
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- Xiao H
- Xie S
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- Yang M
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- Yazgan E
- Yelton J
- Yetkin T
- Yi K
- Yildirim E
- Yilmaz Y
- Yohay R
- Yoo HD
- Yoo J
- Yoon AS
- York A
- Yu I
- Yu SS
- Yumiceva F
- Yun JC
- Zabel J
- Zabi A
- Zablocki J
- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
- Zang SL
- Zarubin A
- Zatserklyaniy A
- Zeinali M
- Zeise M
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang Z
- Zheng Y
- Zhokin A
- Zhu B
- Zhu RY
- Zhukov V
- Zhukova V
- Ziebarth EB
- Ziegler J
- Zielinski M
- Zito G
- Zoeller MH
- Zotto P
- Zou W
- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2012
- Field of study
Get PDFThe performance of muon reconstruction, identification, and triggering in CMS
has been studied using 40 inverse picobarns of data collected in pp collisions
at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection
criteria covering a wide range of physics analysis needs have been examined.
For all considered selections, the efficiency to reconstruct and identify a
muon with a transverse momentum pT larger than a few GeV is above 95% over the
whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4,
while the probability to misidentify a hadron as a muon is well below 1%. The
efficiency to trigger on single muons with pT above a few GeV is higher than
90% over the full eta range, and typically substantially better. The overall
momentum scale is measured to a precision of 0.2% with muons from Z decays. The
transverse momentum resolution varies from 1% to 6% depending on pseudorapidity
for muons with pT below 100 GeV and, using cosmic rays, it is shown to be
better than 10% in the central region up to pT = 1 TeV. Observed distributions
of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO
X-ray emission from the Sombrero galaxy: discrete sources
- Author
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- Abbiendi G
- Abbrescia M
- Abdullin S
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2010
- Field of study
Get PDFWe present a study of discrete X-ray sources in and around the
bulge-dominated, massive Sa galaxy, Sombrero (M104), based on new and archival
Chandra observations with a total exposure of ~200 ks. With a detection limit
of L_X = 1E37 erg/s and a field of view covering a galactocentric radius of ~30
kpc (11.5 arcminute), 383 sources are detected. Cross-correlation with Spitler
et al.'s catalogue of Sombrero globular clusters (GCs) identified from HST/ACS
observations reveals 41 X-rays sources in GCs, presumably low-mass X-ray
binaries (LMXBs). We quantify the differential luminosity functions (LFs) for
both the detected GC and field LMXBs, whose power-low indices (~1.1 for the
GC-LF and ~1.6 for field-LF) are consistent with previous studies for
elliptical galaxies. With precise sky positions of the GCs without a detected
X-ray source, we further quantify, through a fluctuation analysis, the GC LF at
fainter luminosities down to 1E35 erg/s. The derived index rules out a
faint-end slope flatter than 1.1 at a 2 sigma significance, contrary to recent
findings in several elliptical galaxies and the bulge of M31. On the other
hand, the 2-6 keV unresolved emission places a tight constraint on the field
LF, implying a flattened index of ~1.0 below 1E37 erg/s. We also detect 101
sources in the halo of Sombrero. The presence of these sources cannot be
interpreted as galactic LMXBs whose spatial distribution empirically follows
the starlight. Their number is also higher than the expected number of cosmic
AGNs (52+/-11 [1 sigma]) whose surface density is constrained by deep X-ray
surveys. We suggest that either the cosmic X-ray background is unusually high
in the direction of Sombrero, or a distinct population of X-ray sources is
present in the halo of Sombrero.Comment: 11 figures, 5 tables, ApJ in pres
Azimuthal anisotropy of charged particles at high transverse momenta in PbPb collisions at sqrt(s[NN]) = 2.76 TeV
- Author
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- Abbiendi G
- Abbrescia M
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- Won S
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- Wyslouch B
- Xiao H
- Xie S
- Xu M
- Yagil A
- Yalvac M
- Yang F
- Yang M
- Yang Y
- Yang ZC
- Yazgan E
- Yelton J
- Yetkin T
- Yi K
- Yildirim E
- Yilmaz Y
- Yohay R
- Yoo HD
- Yoo J
- Yoon AS
- York A
- Yu I
- Yu SS
- Yumiceva F
- Yun JC
- Zabel J
- Zabi A
- Zablocki J
- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
- Zarubin A
- Zatserklyaniy A
- Zeinali M
- Zeise M
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang Z
- Zheng Y
- Zhokin A
- Zhu B
- Zhu RY
- Zhukov V
- Zhukova V
- Ziebarth EB
- Ziegler J
- Zielinski M
- Zito G
- Zotto P
- Zou W
- Zumerle G
- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
Get PDFThe azimuthal anisotropy of charged particles in PbPb collisions at
nucleon-nucleon center-of-mass energy of 2.76 TeV is measured with the CMS
detector at the LHC over an extended transverse momentum (pt) range up to
approximately 60 GeV. The data cover both the low-pt region associated with
hydrodynamic flow phenomena and the high-pt region where the anisotropies may
reflect the path-length dependence of parton energy loss in the created medium.
The anisotropy parameter (v2) of the particles is extracted by correlating
charged tracks with respect to the event-plane reconstructed by using the
energy deposited in forward-angle calorimeters. For the six bins of collision
centrality studied, spanning the range of 0-60% most-central events, the
observed v2 values are found to first increase with pt, reaching a maximum
around pt = 3 GeV, and then to gradually decrease to almost zero, with the
decline persisting up to at least pt = 40 GeV over the full centrality range
measured.Comment: Replaced with published version. Added journal reference and DO
Search for the standard model Higgs boson in the H to ZZ to 2l 2nu channel in pp collisions at sqrt(s) = 7 TeV
- Author
- A Bredenstein
- A Bredenstein
- A Djouadi
- A Djouadi
- A Martin
- A. A. Ocampo Rios
- A. Adair
- A. Adiguzel
- A. Anastassov
- A. Apresyan
- A. Aranyi
- A. Askew
- A. Attikis
- A. Avetisyan
- A. B. Meyer
- A. Baden
- A. Barker
- A. Bean
- A. Belyaev
- A. Belyaev
- A. Benaglia
- A. Beretvas
- A. Bethani
- A. Bhatti
- A. Biselli
- A. Bocci
- A. Bodek
- A. Bonato
- A. Bornheim
- A. Branca
- A. Brinkerhoff
- A. Burgmeier
- A. C. Benvenuti
- A. C. Mignerey
- A. Cabrera
- A. Cakir
- A. Calderon
- A. Campbell
- A. Castro
- A. Chatterjee
- A. Cimmino
- A. Colaleo
- A. CustĂłdio
- A. David
- A. De Benedetti
- A. De Cosa
- A. De Roeck
- A. Deisher
- A. Delgado Peris
- A. Dermenev
- A. Dierlamm
- A. Dimitrov
- A. Dominguez
- A. Drozdetskiy
- A. Elliott-Peisert
- A. Ellithi Kamel
- A. Ershov
- A. Everett
- A. F. Barfuss
- A. F. Osorio Oliveros
- A. Fahim
- A. Falkiewicz
- A. Fanfani
- A. Ferapontov
- A. Ferrando
- A. Flossdorf
- A. Gaddi
- A. Garcia-Bellido
- A. Gaz
- A. Geiser
- A. Ghezzi
- A. Giammanco
- A. Giassi
- A. Gilbert
- A. Givernaud
- A. Godshalk
- A. Gozzelino
- A. Graziano
- A. Gribushin
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- Y. Eshaq
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- Y. Fu
- Y. Gao
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- Y. Gotra
- Y. Guo
- Y. H. Chang
- Y. H. Chang
- Y. Hsiung
- Y. Iiyama
- Y. Ivanov
- Y. J. Lei
- Y. J. Lu
- Y. K. Choi
- Y. Kim
- Y. Kubota
- Y. Kuessel
- Y. Lu
- Y. M. Tzeng
- Y. Ma
- Y. Mao
- Y. Maravin
- Y. Musienko
- Y. Onel
- Y. Pakhotin
- Y. Roh
- Y. S. Chung
- Y. Sirois
- Y. Tschudi
- Y. Tu
- Y. W. Chang
- Y. Weng
- Y. Yang
- Y. Yilmaz
- Y. Zheng
- Y.-J. Lee
- Yu. Andreev
- Z. Antunovic
- Z. C. Yang
- Z. Chen
- Z. Hatherell
- Z. Hu
- Z. J. Guo
- Z. K. Liu
- Z. L. Trocsanyi
- Z. Szillasi
- Z. Wan
- Z. Wang
- Z. Zhang
- Zero J. Kim
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2012
- Field of study
Get PDFA search for the standard model Higgs boson in the H to ZZ to 2l 2nu decay
channel, where l = e or mu, in pp collisions at a center-of-mass energy of 7
TeV is presented. The data were collected at the LHC, with the CMS detector,
and correspond to an integrated luminosity of 4.6 inverse femtobarns. No
significant excess is observed above the background expectation, and upper
limits are set on the Higgs boson production cross section. The presence of the
standard model Higgs boson with a mass in the 270-440 GeV range is excluded at
95% confidence level.Comment: Submitted to JHE
- âŚ
