Landslide hazard assessment for National Rail Network

There have been a number of high profile reports of landslides on the national rail network of Great Britain (comprising England, Scotland and Wales) over recent years. Events range in size from small wash out failures (St. Bees, Cumbria) to well publicised large failures causing major longer term disruption (Hatfield Colliery, South Yorkshire). In conjunction with negative media attention, derailment and damage to railway infrastructure, failures along the rail network have the potential to cause injury and loss of life. The national rail network comprises ten strategic routes that cover a variety of terrains and geologies. The British Geological Survey (BGS) have produced, for Network Rail, a high level susceptibility model of landslide hazard from Outside Party Slopes adjacent to the strategic rail network. This assessment was compiled based on Geographic Information System (GIS) techniques and historical landslide records (landslide inventory). The model was designed to give a high level overview of potential landslide hazard to Network Rail senior management and individual Route Asset Managers. The national study adopted a fixed buffer style analysis of each 5 chain section (∼100 m length) of the entire railway network. It included event data from the BGS National Landslide Database superimposed on mapped data from the BGS GeoSure land instability susceptibility model and geologically mapped landslide polygons. The National Landslide Database is the most comprehensive inventory of landslide events in Great Britain. The BGS GeoSure slope instability layer provides a scientifically based 1:50 000 scale assessment of national susceptibility to natural slope failure. The results of this study have been provided as a spatially attributed dataset with total hazard susceptibility scores A (low)–E (high). Maximum hazard scores are attributed for both up and down- track and 5 chain length for the full network. A high score indicates where conditions imply a significant potential for future landslide hazard. Further refinement of the hazard layers are being developed by BGS to include specific landslide processes such as Rockfall, Earthflow and Debris Flow hazards

Looking for magnetic monopoles at LHC with diphoton events

Magnetic monopoles have been a subject of interest since Dirac established the relation between the existence of monopoles and charge quantization. The intense experimental search carried thus far has not met with success. The Large Hadron Collider is reaching energies never achieved before allowing the search for exotic particles in the TeV mass range. In a continuing effort to discover these rare particles we propose here other ways to detect them. We study the observability of monopoles and monopolium, a monopole-antimonopole bound state, at the Large Hadron Collider in the $\gamma \gamma$ channel for monopole masses in the range 500-1000 GeV. We conclude that LHC is an ideal machine to discover monopoles with masses below 1 TeV at present running energies and with 5 fb$^{-1}$ of integrated luminosity.Comment: This manuscript contains information appeared in Looking for magnetic monopoles at LHC, arXiv:1104.0218 [hep-ph] and Monopolium detection at the LHC.,arXiv:1107.3684 [hep-ph] by the same authors, rewritten for joint publication in The European Physica Journal Plus. 26 pages, 22 figure

Slope dynamics project report : Holderness Coast - Aldbrough, survey & monitoring, 2001-2013

This report is a published product of an ongoing study by the British Geological Survey (BGS) of the coastal change at Aldbrough on the Holderness coast, East Riding of Yorkshire, UK. The test site at Aldbrough has been selected as one of the BGS Landslide Observatories because it is representative of the high rates of coastal recession along this stretch of the east coast. The Aldbrough Landslide Observatory is operated under the BGS ‘Slope Dynamics’ task within the BGS’s ‘Landslide’ project of the ‘Shallow Geohazards and Risk’ team. As well as providing new insights with respect to the volumetric rates of recession and the near surface processes, it is a focus for the trialling of new surface and subsurface monitoring technologies. The establishment of the Aldbrough observatory and the initial research findings are reported in a series of reports in addition to this report. These are: Hobbs, P.R.N., Jones, L.D., & Kirkham, M.P. (2015) Slope Dynamics project report: Holderness Coast – Aldbrough: Drilling & Instrumentation, 2012-2015. British Geological Survey, Internal Report No IR/15/001. Hobbs, P.R.N., Kirkham, M.P. & Morgan, D.J.R. (2016) Geotechnical laboratory testing of glacial deposits from Aldbrough, Phase 2 boreholes. British Geological Survey, Open Report No. OR/15/056. Whilst this report is focused on the survey and monitoring programme, it should be read in conjunction with the reports listed above, which provide further details on drilling and instrumentation and the geotechnical properties of the underlying geology. A series of reports will follow presenting the updated survey and monitoring reports, and their publication will be announced through the BGS project web page. Readers of these reports will probably also be interested in the context for this research, which can be found in: Hobbs, P.R.N., Pennington, C.V.L., Pearson, S.G., Jones, L.D., Foster, C., Lee, J.R., Gibson, A. (2008) Slope Dynamics Project Report: the Norfolk Coast (2000-2006). British Geological Survey, Open Report No. OR/08/018

Monopolium production from photon fusion at the Large Hadron Collider

Magnetic monopoles have attracted the attention of physicists since the founding of the electromagnetic theory. Their search has been a constant endeavor which was intensified when Dirac established the relation between the existence of monopoles and charge quantization. However, these searches have been unsuccessful. We have recently proposed that monopolium, a monopole-antimonopole bound state, so strongly bound that it has a relatively small mass, could be easier to find and become an indirect but clear signature for the existence of magnetic monopoles. In here we extend our previous analysis for its production to two photon fusion at LHC energies

Psychosocial Treatment of Children in Foster Care: A Review

A substantial number of children in foster care exhibit psychiatric difficulties. Recent epidemiologi-cal and historical trends in foster care, clinical findings about the adjustment of children in foster care, and adult outcomes are reviewed, followed by a description of current approaches to treatment and extant empirical support. Available interventions for these children can be categorized as either symptom-focused or systemic, with empirical support for specific methods ranging from scant to substantial. Even with treatment, behavioral and emotional problems often persist into adulthood, resulting in poor functional outcomes. We suggest that self-regulation may be an important mediat-ing factor in the appearance of emotional and behavioral disturbance in these children

A novel formulation of inhaled sodium cromoglicate (PA101) in idiopathic pulmonary fibrosis and chronic cough: a randomised, double-blind, proof-of-concept, phase 2 trial

Background Cough can be a debilitating symptom of idiopathic pulmonary fibrosis (IPF) and is difficult to treat. PA101 is a novel formulation of sodium cromoglicate delivered via a high-efficiency eFlow nebuliser that achieves significantly higher drug deposition in the lung compared with the existing formulations. We aimed to test the efficacy and safety of inhaled PA101 in patients with IPF and chronic cough and, to explore the antitussive mechanism of PA101, patients with chronic idiopathic cough (CIC) were also studied. Methods This pilot, proof-of-concept study consisted of a randomised, double-blind, placebo-controlled trial in patients with IPF and chronic cough and a parallel study of similar design in patients with CIC. Participants with IPF and chronic cough recruited from seven centres in the UK and the Netherlands were randomly assigned (1:1, using a computer-generated randomisation schedule) by site staff to receive PA101 (40 mg) or matching placebo three times a day via oral inhalation for 2 weeks, followed by a 2 week washout, and then crossed over to the other arm. Study participants, investigators, study staff, and the sponsor were masked to group assignment until all participants had completed the study. The primary efficacy endpoint was change from baseline in objective daytime cough frequency (from 24 h acoustic recording, Leicester Cough Monitor). The primary efficacy analysis included all participants who received at least one dose of study drug and had at least one post-baseline efficacy measurement. Safety analysis included all those who took at least one dose of study drug. In the second cohort, participants with CIC were randomly assigned in a study across four centres with similar design and endpoints. The study was registered with ClinicalTrials.gov (NCT02412020) and the EU Clinical Trials Register (EudraCT Number 2014-004025-40) and both cohorts are closed to new participants. Findings Between Feb 13, 2015, and Feb 2, 2016, 24 participants with IPF were randomly assigned to treatment groups. 28 participants with CIC were enrolled during the same period and 27 received study treatment. In patients with IPF, PA101 reduced daytime cough frequency by 31·1% at day 14 compared with placebo; daytime cough frequency decreased from a mean 55 (SD 55) coughs per h at baseline to 39 (29) coughs per h at day 14 following treatment with PA101, versus 51 (37) coughs per h at baseline to 52 (40) cough per h following placebo treatment (ratio of least-squares [LS] means 0·67, 95% CI 0·48–0·94, p=0·0241). By contrast, no treatment benefit for PA101 was observed in the CIC cohort; mean reduction of daytime cough frequency at day 14 for PA101 adjusted for placebo was 6·2% (ratio of LS means 1·27, 0·78–2·06, p=0·31). PA101 was well tolerated in both cohorts. The incidence of adverse events was similar between PA101 and placebo treatments, most adverse events were mild in severity, and no severe adverse events or serious adverse events were reported. Interpretation This study suggests that the mechanism of cough in IPF might be disease specific. Inhaled PA101 could be a treatment option for chronic cough in patients with IPF and warrants further investigation

Teaching open and reproducible scholarship: a critical review of the evidence base for current pedagogical methods and their outcomes.

YesIn recent years, the scientific community has called for improvements in the credibility, robustness and reproducibility of research, characterized by increased interest and promotion of open and transparent research practices. While progress has been positive, there is a lack of consideration about how this approach can be embedded into undergraduate and postgraduate research training. Specifically, a critical overview of the literature which investigates how integrating open and reproducible science may influence student outcomes is needed. In this paper, we provide the first critical review of literature surrounding the integration of open and reproducible scholarship into teaching and learning and its associated outcomes in students. Our review highlighted how embedding open and reproducible scholarship appears to be associated with (i) students' scientific literacies (i.e. students' understanding of open research, consumption of science and the development of transferable skills); (ii) student engagement (i.e. motivation and engagement with learning, collaboration and engagement in open research) and (iii) students' attitudes towards science (i.e. trust in science and confidence in research findings). However, our review also identified a need for more robust and rigorous methods within pedagogical research, including more interventional and experimental evaluations of teaching practice. We discuss implications for teaching and learning scholarship.UKRI/ESRC rapid call grant, ealth Research Board Applying Researchinto Policy and Practice Fellowship, John Templeton Foundation (grant ID: 62631), Northern Ireland Department for the Economy Research Studentshi