Small farmers' perception of factors influencing regional chemical control of Diaphorina citri

Regional Control Areas (RCAs) have been implemented in Mexico as a strategy to delay the spread of Candidatus Liberibacter asiaticus, the causal bacterium of the disease known as Huanglongbing (HLB). The implementation of an effective management of the vector insect, Diaphorina citri in the RCAs requires the knowledge, acceptance and coordinated engagement of small agricultural producers. This research assessed the perception and knowledge of 62 citrus growers regarding the operational, sociocultural and environmental factors influencing chemical control of D. citri in four RCAs within Veracruz State. According to their responses, the following factors have been identified as the operational factors with the highest influence on the effectiveness of insecticides against D. citri within RCAs: the lack of knowledge about the use of surfactants, application speed, poor calibration of sprayers and incorrect water quality. The most significant sociocultural factors are the general unawareness of the pest and the safe and proper application of pesticides. The most relevant environmental factors during application: temperature, relative humidity, and wind speed. Sociocultural index correlated with the perception of effectiveness. Therefore, it becomes necessary to consider differences among citrus growers in each region and setting out the most appropriatestrategies for vector and disease management. Highlights Some operational practices that citrus growers are not aware of may influence their perception of chemical control. The sociocultural context of growers determines their decision-taking on insecticide applications. During the application of insecticides in regional control areas (RCAs), growers do not take into account weather conditions. The effective management of D. citri requires a coordinated engagement of small growers' in RCAs.Regional Control Areas (RCAs) have been implemented in Mexico as a strategy to delay the spread of Candidatus Liberibacter asiaticus, the causal bacterium of the disease known as Huanglongbing (HLB). The implementation of an effective management of the vector insect, Diaphorina citri in the RCAs requires the knowledge, acceptance and coordinated engagement of small agricultural producers. This research assessed the perception and knowledge of 62 citrus growers regarding the operational, sociocultural and environmental factors influencing chemical control of D. citri in four RCAs within Veracruz State. According to their responses, the following factors have been identified as the operational factors with the highest influence on the effectiveness of insecticides against D. citri within RCAs: the lack of knowledge about the use of surfactants, application speed, poor calibration of sprayers and incorrect water quality. The most significant sociocultural factors are the general unawareness of the pest and the safe and proper application of pesticides. The most relevant environmental factors during application: temperature, relative humidity, and wind speed. Sociocultural index correlated with the perception of effectiveness. Therefore, it becomes necessary to consider differences among citrus growers in each region and setting out the most appropriatestrategies for vector and disease management. Highlights Some operational practices that citrus growers are not aware of may influence their perception of chemical control. The sociocultural context of growers determines their decision-taking on insecticide applications. During the application of insecticides in regional control areas (RCAs), growers do not take into account weather conditions. The effective management of D. citri requires a coordinated engagement of small growers' in RCAs

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

Children’s and adolescents’ rising animal-source food intakes in 1990–2018 were impacted by age, region, parental education and urbanicity

Animal-source foods (ASF) provide nutrition for children and adolescents’ physical and cognitive development. Here, we use data from the Global Dietary Database and Bayesian hierarchical models to quantify global, regional and national ASF intakes between 1990 and 2018 by age group across 185 countries, representing 93% of the world’s child population. Mean ASF intake was 1.9 servings per day, representing 16% of children consuming at least three daily servings. Intake was similar between boys and girls, but higher among urban children with educated parents. Consumption varied by age from 0.6 at <1 year to 2.5 servings per day at 15–19 years. Between 1990 and 2018, mean ASF intake increased by 0.5 servings per week, with increases in all regions except sub-Saharan Africa. In 2018, total ASF consumption was highest in Russia, Brazil, Mexico and Turkey, and lowest in Uganda, India, Kenya and Bangladesh. These findings can inform policy to address malnutrition through targeted ASF consumption programmes.publishedVersio

Incident type 2 diabetes attributable to suboptimal diet in 184 countries

The global burden of diet-attributable type 2 diabetes (T2D) is not well established. This risk assessment model estimated T2D incidence among adults attributable to direct and body weight-mediated effects of 11 dietary factors in 184 countries in 1990 and 2018. In 2018, suboptimal intake of these dietary factors was estimated to be attributable to 14.1 million (95% uncertainty interval (UI), 13.8–14.4 million) incident T2D cases, representing 70.3% (68.8–71.8%) of new cases globally. Largest T2D burdens were attributable to insufficient whole-grain intake (26.1% (25.0–27.1%)), excess refined rice and wheat intake (24.6% (22.3–27.2%)) and excess processed meat intake (20.3% (18.3–23.5%)). Across regions, highest proportional burdens were in central and eastern Europe and central Asia (85.6% (83.4–87.7%)) and Latin America and the Caribbean (81.8% (80.1–83.4%)); and lowest proportional burdens were in South Asia (55.4% (52.1–60.7%)). Proportions of diet-attributable T2D were generally larger in men than in women and were inversely correlated with age. Diet-attributable T2D was generally larger among urban versus rural residents and higher versus lower educated individuals, except in high-income countries, central and eastern Europe and central Asia, where burdens were larger in rural residents and in lower educated individuals. Compared with 1990, global diet-attributable T2D increased by 2.6 absolute percentage points (8.6 million more cases) in 2018, with variation in these trends by world region and dietary factor. These findings inform nutritional priorities and clinical and public health planning to improve dietary quality and reduce T2D globally.publishedVersio

Comparison of spinal anesthesia with combined sciatic-femoral nerve block for outpatient knee arthroscopy

Study Objective: To compare spinal anesthesia and combined sciatic-femoral nerve block for outpatient knee arthroscopy. Design: Prospective, randomized, controlled study. Setting: Postoperative recovery area at a university-affiliated medical center. Patients: 50 ASA physical status I and II adult outpatients undergoing arthroscopic knee surgery. Interventions: Study subjects were equally divided (n = 25 each) into spinal and sciatic-femoral groups. Spinal group patients received spinal anesthesia with 7.5 mg of 0.5% hyperbaric bupivacaine. Sciatic-femoral group patients received combined sciatic-femoral nerve blocks using a mixture of 20 mL of lidocaine 2% plus 20 mL of bupivacaine 0.5%. Measurements: Times including that from arrival in the operating room to readiness for surgery, duration of surgery, recovery time, and patient satisfaction were recorded. Analgesia and occurrence of adverse events also were recorded. Main Results: No significant differences between the two groups were found for any of the study measurements of recovery. After discharge, postoperative pain differed significantly between groups only at 6 hours (P less than 0.002). Patient satisfaction was high with both techniques. Conclusions: Combined sciatic-femoral nerve block for outpatient arthroscopic knee surgery offers satisfactory anesthesia, with a clinical profile similar to that of low-dose spinal anesthesia. Sciatic-femoral nerve blocks are associated with significantly lower pain scores during the first 6 postoperative hours. © 2008 Elsevier Inc. All rights reserved

Comparison of spinal anesthesia with combined sciatic-femoral nerve block for outpatient knee arthroscopy

Study Objective: To compare spinal anesthesia and combined sciatic-femoral nerve block for outpatient knee arthroscopy. Design: Prospective, randomized, controlled study. Setting: Postoperative recovery area at a university-affiliated medical center. Patients: 50 ASA physical status I and II adult outpatients undergoing arthroscopic knee surgery. Interventions: Study subjects were equally divided (n = 25 each) into spinal and sciatic-femoral groups. Spinal group patients received spinal anesthesia with 7.5 mg of 0.5% hyperbaric bupivacaine. Sciatic-femoral group patients received combined sciatic-femoral nerve blocks using a mixture of 20 mL of lidocaine 2% plus 20 mL of bupivacaine 0.5%. Measurements: Times including that from arrival in the operating room to readiness for surgery, duration of surgery, recovery time, and patient satisfaction were recorded. Analgesia and occurrence of adverse events also were recorded. Main Results: No significant differences between the two groups were found for any of the study measurements of recovery. After discharge, postoperative pain differed significantly between groups only at 6 hours (P less than 0.002). Patient satisfaction was high with both techniques. Conclusions: Combined sciatic-femoral nerve block for outpatient arthroscopic knee surgery offers satisfactory anesthesia, with a clinical profile similar to that of low-dose spinal anesthesia. Sciatic-femoral nerve blocks are associated with significantly lower pain scores during the first 6 postoperative hours. © 2008 Elsevier Inc. All rights reserved

Neurofeedback effects on cognitive performance in children with attention deficit

The objective of this research was to analyze the effects ofan intervention program through neurofeedback, on the cognitiveperformance in children with inattention indicators. Aquasi-experimental pretest-posttest study was used under apositivist epistemology, with a comparative analysis for eachevaluated cognitive process. A sample of 29 cases was intentionallyselected from a group of children and young adolescentswith low performance indicators from a TherapeuticCenter from Cucuta-Colombia. The neurofeedback programwas developed in 20 sessions with the purpose of increaselow-beta waves (12-16 Hz) and inhibition theta waves (4-7Hz). A comparative statistically analysis with five months ofdifference was carried out using Wilcoxon test, finding significantdifferences between the pretest and the posttest inneuropsychological tests of auditory-visual attention, encodingmemory and planning. The results are discussed with empiricalbackgrounds that have shown positive effects in thistype of interventions