A Facile Synthetic Route to a Family of Mn(III) Monomers and their Structural, Magnetic and Spectroscopic Studies

This is an accepted manuscript of an article published by Wiley in European Journal of Inorganic Chemistry on 07/10/2016, available online: https://doi.org/10.1002/ejic.201601124 The accepted version of the publication may differ from the final published version.© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim We report a rapid and facile route to the synthesis of a family of MnIIImonomers of general formula [MnIIIF3(H2O)(L1–6)]·xH2O·yMeOH [L1= 2,2′-bipyridyl, x = 2, y = 0 (1′); L2= 1,10′-phenanthroline, x = y = 0 (2′); L3= 6-methyl-2,2′-dipyridyl, x = y = 0 (3), L4= 4,4-dimethyl-2,2′-dipyridyl, x = 2, y = 0 (4), L5= 5,5′-dimethyl-2,2′-dipyridyl, x = 0, y = 0.5 (5); L6= 5-chloro-1,10-phenanthroline, x = y = 0 (6)]. Magnetic susceptibility and magnetisation experiments have been employed to elucidate the D tensor for each family member (ranging from –3.01 cm–1in 2′ to –4.02 cm–1in 5), while multi-frequency/high-field EPR spectroscopic measurements and subsequent simulations gave similar values for complexes 1′ (–4.25 cm–1), 2′ (–4.03 cm–1), 4 (–3.90 cm–1) and 5 (–4.04 cm–1). The terminal Mn–F vibrational stretches in 1′–6 have been probed using Raman spectroscopy.The authors would like to thank the Irish Research Council for Science, Engineering and Technology (IRSCET) Embark Fellowship (E. H.) and the Engineering and Physical Sciences Research Council (EPRSC) (S. S. and E. K. B.) for funding.Published versio

Methods for managing Marine Protected Areas: options for establishing and managing a marine protected area system in the UK. Report to Natural England

This document presents a review of the available literature concerning management arrangements for Marine Protected Areas (MPAs) in the UK, Europe, and around the world with the object of providing guidance for future management of MPAs, especially European Marine Sites (EMSs), in the UK. This is partly to support the development of effective legislation for UK MPAs through the Marine Bill process, but more broadly to assist UK marine nature conservation and resource management agencies to manage their sites more effectively and to meet the agreed OSPAR goals for a network of well managed marine protected areas to be in place over the next several years. The report follows on from the directions provided in the UK government’s “Maritime State of Nature Report” (Covey and Laffoley 2002) particularly: areas free of exploitation, new or revised legislation and ecologically meaningful management (ibid page 8)

Brilliance of a fire: innocence, experience and the theory of childhood

This essay offers an extensive rehabilitation and reappraisal of the concept of childhood innocence as a means of testing the boundaries of some prevailing constructions of childhood. It excavates in detail some of the lost histories of innocence in order to show that these are more diverse and more complex than established and pejorative assessments of them conventionally suggest. Recovering, in particular, the forgotten pedigree of the Romantic account of the innocence of childhood underlines its depth and furnishes an enriched understanding of its critical role in the coming of mass education - both as a catalyst of social change and as an alternative measure of the child-centeredness of the institutions of public education. Now largely and residually confined to the inheritance of nursery education, the concept of childhood innocence, and the wider Romantic project of which it is an element, can help question the assumptions underpinning modern, competence-centred philosophies of childhood

Radical “Citizens of the World,” 1790–95: The Early Career of Henry Redhead Yorke

This article takes a new look at British radicalism in the 1790s and explores it within broad geographical and cultural frameworks and through the early career of Henry Redhead Yorke, a West Indian Creole who became a radical in England but frequently recanted his politics. It views radicalism within the Atlantic World and provides a broader interpretation of the excluded majority than as an English working class. It examines the radical “citizens of the world” and sheds new light on the apparent conflict within English radicalism between universalist and constitutionalist ideologies. Politicization and identity are the key themes here examined within micro- and macro-histories

Calf health from birth to weaning. I. General aspects of disease prevention

Calfhood diseases have a major impact on the economic viability of cattle operations. This is the first in a three part review series on calf health from birth to weaning, focusing on preventive measures. The review considers both pre- and periparturient management factors influencing calf health, colostrum management in beef and dairy calves and further nutrition and weaning in dairy calves

Giant Cell Malignant Fibrous Histiocytoma of the Breast: A Case Report

A case of primary malignant fibrous histiocytoma of the breast is reported. The patient was a 48-yr-old woman with a huge tumor involving almost the entire left breast. The central portion of her left breast was already rotted by extensive necrosis and inflammation. She was treated by radical mastectomy and axillary lymphadenectomy to level I. Pathologic examination supported by an immunohistochemical staining confirmed the tumor as malignant fibrous histiocytoma of giant cell type. Axillary lymph nodes were free from tumor metastasis. She had not taken any postoperative adjuvant therapy. The metastasis to lungs was found 2 months after the operation, and she died within 6 months

Population gene introgression and high genome plasticity for the zoonotic pathogen Streptococcus agalactiae

The influence that bacterial adaptation (or niche partitioning) within species has on gene spillover and transmission among bacteria populations occupying different niches is not well understood. Streptococcus agalactiae is an important bacterial pathogen that has a taxonomically diverse host range making it an excellent model system to study these processes. Here we analyze a global set of 901 genome sequences from nine diverse host species to advance our understanding of these processes. Bayesian clustering analysis delineated twelve major populations that closely aligned with niches. Comparative genomics revealed extensive gene gain/loss among populations and a large pan-genome of 9,527 genes, which remained open and was strongly partitioned among niches. As a result, the biochemical characteristics of eleven populations were highly distinctive (significantly enriched). Positive selection was detected and biochemical characteristics of the dispensable genes under selection were enriched in ten populations. Despite the strong gene partitioning, phylogenomics detected gene spillover. In particular, tetracycline resistance (which likely evolved in the human-associated population) from humans to bovine, canines, seals, and fish, demonstrating how a gene selected in one host can ultimately be transmitted into another, and biased transmission from humans to bovines was confirmed with a Bayesian migration analysis. Our findings show high bacterial genome plasticity acting in balance with selection pressure from distinct functional requirements of niches that is associated with an extensive and highly partitioned dispensable genome, likely facilitating continued and expansive adaptation

Extrapulmonary Small Cell Carcinoma of the Liver: Clinicopathological and Immunohistochemical Findings

Patients with primary small cell carcinoma of the liver have rarely been described in medical literature. Knowledge of clinical, pathological and immunohistochemical properties remains limited. We described an 82-year-old female patient with primary small cell carcinoma of the liver. Histologically, the tumor showed typical morphology of a pulmonary small cell carcinoma. Immunohistochemically, the tumor revealed neuroendocrine differentiation; positive reaction for chromogranin, synaptophysin, CD56, and neuron specific enolase. The tumor was also positive for TTF-1 and c-kit but completely negative for hepatocyte, carcinoembryonic antigen, cytokeratin 7; 19; and 20. Herein, we discussed the clinical, pathological and immunohistochemical findings of extrapulmonary small cell carcinoma of the liver and reviewed the relevant literature

Diversity of Prophage DNA Regions of Streptococcus agalactiae Clonal Lineages from Adults and Neonates with Invasive Infectious Disease

The phylogenetic position and prophage DNA content of the genomes of 142 S. agalactiae (group-B streptococcus, GBS) isolates responsible for bacteremia and meningitis in adults and neonates were studied and compared. The distribution of the invasive isolates between the various serotypes, sequence types (STs) and clonal complexes (CCs) differed significantly between adult and neonatal isolates. Use of the neighbor-net algorithm with the PHI test revealed evidence for recombination in the population studied (PHI, P = 2.01×10−6), and the recombination-mutation ratio (R/M) was 6∶7. Nevertheless, the estimated R/M ratio differed between CCs. Analysis of the prophage DNA regions of the genomes of the isolates assigned 90% of the isolates to five major prophage DNA groups: A to E. The mean number of prophage DNA fragments amplified per isolate varied from 2.6 for the isolates of prophage DNA group E to 4.0 for the isolates of prophage DNA group C. The isolates from adults and neonates with invasive diseases were distributed differently between the various prophage DNA groups (P<0.00001). Group C prophage DNA fragments were found in 52% of adult invasive isolates, whereas 74% of neonatal invasive isolates had prophage DNA fragments of groups A and B. Differences in prophage DNA content were also found between serotypes, STs and CCs (P<0.00001). All the ST-1 and CC1 isolates, mostly of serotype V, belonged to the prophage DNA group C, whereas 84% of the ST-17 and CC17 isolates, all of serotype III, belonged to prophage DNA groups A and B. These data indicate that the transduction mechanisms, i.e., gene transfer from one bacterium to another by a bacteriophage, underlying genetic recombination in S. agalactiae species, are specific to each intraspecies lineage and population of strains responsible for invasive diseases in adults and neonates

Supporting People With Type 2 Diabetes in the Effective Use of Their Medicine Through Mobile Health Technology Integrated With Clinical Care to Reduce Cardiovascular Risk : Protocol for an Effectiveness and Cost-effectiveness Randomized Controlled Trial

Funding Information: The Support Through Mobile Messaging and Digital Health Technology for Diabetes research team acknowledges the support of the National Institute for Health Research (NIHR) through the Clinical Research Networks. AF, LT, and RR have received support from the NIHR Oxford Biomedical Research Centre. RH received support from the NIHR Collaboration for Leadership in Applied Health Research and Care and North Thames at Bart's Health National Health Service (NHS) Trust. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR, or the Department of Health. This paper presents independent research funded by the NIHR under its Program Grants for Applied Research as part of a wider program of work (RP-PG-1214-20003). The authors thank the personnel of the University of Oxford Primary Care and Vaccines Clinical Trials Collaborative for providing support in the conduct of the trial.Peer reviewedPublisher PD