Endotrivial modules over groups with quaternion or semi-dihedral Sylow 2-subgroup

Let G be a finite group with a Sylow 2-subgroup P which is either quaternion or semi-dihedral. Let k be an algebraically closed field of characteristic 2. We prove the existence of exotic endotrivial kG-modules, whose restrictions to P are isomorphic to the direct sum of the known exotic endotrivial kP-modules and some projective modules. This provides a description of the group T(G) of endotrivial kG-modules

High-level transgene expression by homologous recombination-mediated gene transfer

Gene transfer and expression in eukaryotes is often limited by a number of stably maintained gene copies and by epigenetic silencing effects. Silencing may be limited by the use of epigenetic regulatory sequences such as matrix attachment regions (MAR). Here, we show that successive transfections of MAR-containing vectors allow a synergistic increase of transgene expression. This finding is partly explained by an increased entry into the cell nuclei and genomic integration of the DNA, an effect that requires both the MAR element and iterative transfections. Fluorescence in situ hybridization analysis often showed single integration events, indicating that DNAs introduced in successive transfections could recombine. High expression was also linked to the cell division cycle, so that nuclear transport of the DNA occurs when homologous recombination is most active. Use of cells deficient in either non-homologous end-joining or homologous recombination suggested that efficient integration and expression may require homologous recombination-based genomic integration of MAR-containing plasmids and the lack of epigenetic silencing events associated with tandem gene copies. We conclude that MAR elements may promote homologous recombination, and that cells and vectors can be engineered to take advantage of this property to mediate highly efficient gene transfer and expressio

The Production Rate of SN Ia Events in Globular Clusters

In globular clusters, dynamical evolution produces luminous X-ray emitting binaries at a rate about 200 times greater than in the field. If globular clusters also produce SNe Ia at a high rate, it would account for much of the SN Ia events in early type galaxies and provide insight into their formation. Here we use archival HST images of nearby galaxies that have hosted SNe Ia to examine the rate at which globular clusters produce these events. The location of the SN Ia is registered on an HST image obtained before the event or after the supernova faded. Of the 36 nearby galaxies examined, 21 had sufficiently good data to search for globular cluster hosts. None of the 21 supernovae have a definite globular cluster counterpart, although there are some ambiguous cases. This places an upper limit to the enhancement rate of SN Ia production in globular clusters of about 42 at the 95% confidence level, which is an order of magnitude lower than the enhancement rate for luminous X-ray binaries. Even if all of the ambiguous cases are considered as having a globular cluster counterpart, the upper bound for the enhancement rate is 82 at the 95% confidence level, excluding an enhancement rate of 200. Barring unforeseen selection effects, we conclude that globular clusters are not responsible for producing a significant fraction of the SN Ia events in early-type galaxies.Comment: 28 pages, 5 figures; ApJ submitte

Apesar de você, amanhã há de ser outro dia: características da automutilação entre estudantes do ensino médio

Objective: to present the characteristics of self-mutilation in students from a public school in the interior of the state of Ceará, Brazil. Methodology: cross-sectional study with 995 high school students from an integral public school. Data collection was carried out in person. The Self-Mutilation Behavior Scale and Student's t test and Analysis of Variance were used to compare the variables of interest. Results: in relation to the frequency of self-mutilation behaviors, biting oneself, picking at a wound and hitting oneself on purpose stood out. There were significant associations between positive social reinforcement and marital status, with greater susceptibility among singles (p=0.018), automatic and social reinforcers and sex, with greater susceptibility in males (p=0.000) and between automatic reinforcers (negative, p=0.036 and positive, p=0.027) and negative social (p=0.017) and non-practice of religion. Conclusion: the behaviors of self-harm and the reasons identified in the study indicate the need to implement intersectoral actions in schools to prevent such behaviors among the population of high school students.Objetivo: apresentar as características da automutilação em estudantes de uma escola pública no interior do estado do Ceará, Brasil. Metodologia: estudo transversal com 995 estudantes do ensino médio de uma escola pública integral. A coleta de dados foi realizada presencialmente. Utilizou-se a Escala de Comportamento de Automutilação e o teste t de Student e a Análise de Variância para comparação das variáveis de interesse. Resultados: em relação à frequência dos comportamentos de automutilação, destacaram-se morder a si próprio, cutucar um ferimento e bater em si mesmo de forma proposital. Houve associações significativas entre reforço social positivo e estado civil, com maior susceptibilidade entre solteiros (p=0,018), reforços automático e social e sexo, com maior susceptibilidade no sexo masculino (p=0,000) e entre reforços automáticos (negativo, p=0,036 e positivo, p=0,027) e social negativo (p=0,017) e a não prática de religião. Conclusão: os comportamentos de automutilação e os motivos identificados no estudo indicam a necessidade de implementar ações intersetoriais nas escolas para prevenir tais comportamentos entre a população de estudantes do ensino médio

High-level transgene expression by homologous recombination-mediated gene transfer

Gene transfer and expression in eukaryotes is often limited by a number of stably maintained gene copies and by epigenetic silencing effects. Silencing may be limited by the use of epigenetic regulatory sequences such as matrix attachment regions (MAR). Here, we show that successive transfections of MAR-containing vectors allow a synergistic increase of transgene expression. This finding is partly explained by an increased entry into the cell nuclei and genomic integration of the DNA, an effect that requires both the MAR element and iterative transfections. Fluorescence in situ hybridization analysis often showed single integration events, indicating that DNAs introduced in successive transfections could recombine. High expression was also linked to the cell division cycle, so that nuclear transport of the DNA occurs when homologous recombination is most active. Use of cells deficient in either non-homologous end-joining or homologous recombination suggested that efficient integration and expression may require homologous recombination-based genomic integration of MAR-containing plasmids and the lack of epigenetic silencing events associated with tandem gene copies. We conclude that MAR elements may promote homologous recombination, and that cells and vectors can be engineered to take advantage of this property to mediate highly efficient gene transfer and expression

Protocolo de manejo de suspeita de infecção viral de vias respiratórias em pacientes com neoplasia hematológica do serviço de hematologia e transplante de medula óssea do Hospital Universitário Walter Cantídio (HUWC)

Infecção respiratória viral é causa significativa de morbi-mortalidade em paciente com doenças hematológicas. Deve ser suspeitado sempre que houver sintomas como coriza, obstrução nasal, odinofagia, tosse e dispnéia e deve-se seguir à identificação viral, quando possível. Os casos podem ser classificados como possível, provável ou confirmado. E observando-se o risco de progressão da infecção para vias aéreas inferiores, o diagnóstico deve ser precoce e as medidas terapêuticas específicas aos vírus bem como medidas de controle da infecção no ambiente hospitalar devem ser prontamente tomadas. O presente trabalho visa descrever um protocolo de manejo da infecção viral de vias respiratórias em pacientes com neoplasia hematológica dentro do Serviço de Hematologia e Transplante de medula do Hospital Universitário Walter Cantídio

Rapid response to the earthquake emergency of May 2012 in the Po Plain, northern Italy

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Cause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation : Data From ROCKET AF

M. Kaste on työryhmän ROCKET AF Steering Comm jäsen.Background-Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all-cause mortality may guide interventions. Methods and Results-In the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) study, patients with nonvalvular atrial fibrillation were randomized to rivaroxaban or dose-adjusted warfarin. Cox proportional hazards regression with backward elimination identified factors at randomization that were independently associated with all-cause mortality in the 14 171 participants in the intention-to-treat population. The median age was 73 years, and the mean CHADS(2) score was 3.5. Over 1.9 years of median follow-up, 1214 (8.6%) patients died. Kaplan-Meier mortality rates were 4.2% at 1 year and 8.9% at 2 years. The majority of classified deaths (1081) were cardiovascular (72%), whereas only 6% were nonhemorrhagic stroke or systemic embolism. No significant difference in all-cause mortality was observed between the rivaroxaban and warfarin arms (P=0.15). Heart failure (hazard ratio 1.51, 95% CI 1.33-1.70, P= 75 years (hazard ratio 1.69, 95% CI 1.51-1.90, P Conclusions-In a large population of patients anticoagulated for nonvalvular atrial fibrillation, approximate to 7 in 10 deaths were cardiovascular, whereasPeer reviewe

CMS physics technical design report : Addendum on high density QCD with heavy ions

Peer reviewe

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac