823 research outputs found
How to Build Transcriptional Network Models of Mammalian Pattern Formation
- Author
- A Graham
- A John
- A Pierani
- A Sandelin
- A Simeone
- AL Barabasi
- AW Helms
- C Kioussi
- Chrissa Kioussi
- E Hedlund
- E Mizuhara
- E Smith
- EH Davidson
- EH Davidson
- G Oliver
- H Bolouri
- H Bolouri
- H Bolouri
- JR Erselius
- JS Dasen
- JS Dasen
- JT Kadonaga
- K Gowan
- K Sharma
- L Moran-Rivard
- L Tiret
- M Ensini
- M Goulding
- M Hargrave
- M Levine
- Michael K. Gross
- MK Gross
- MK Gross
- MZ Li
- Nick Monk
- O Britanova
- PJ Bailey
- R Shirasaki
- SK Lee
- SL Pfaff
- T Caspary
- T Marquardt
- T Muller
- T Tsuchida
- TM Jessell
- W Wang
- WJ Longabaugh
- YQ Ding
- Publication venue
- Public Library of Science
- Publication date
- 14/05/2008
- Field of study
Genetic regulatory networks of sequence specific transcription factors underlie pattern formation in multicellular organisms. Deciphering and representing the mammalian networks is a central problem in development, neurobiology, and regenerative medicine. Transcriptional networks specify intermingled embryonic cell populations during pattern formation in the vertebrate neural tube. Each embryonic population gives rise to a distinct type of adult neuron. The homeodomain transcription factor Lbx1 is expressed in five such populations and loss of Lbx1 leads to distinct respecifications in each of the five populations. allele, respectively. Microarrays were used to show that expression levels of 8% of all transcription factor genes were altered in the respecified pool. These transcription factor genes constitute 20–30% of the active nodes of the transcriptional network that governs neural tube patterning. Half of the 141 regulated nodes were located in the top 150 clusters of ultraconserved non-coding regions. Generally, Lbx1 repressed genes that have expression patterns outside of the Lbx1-expressing domain and activated genes that have expression patterns inside the Lbx1-expressing domain.nalysis, and think that it will be generally useful in discovering and assigning network interactions to specific populations. We discuss how ANCEA, coupled with population partitioning analysis, can greatly facilitate the systematic dissection of transcriptional networks that underlie mammalian patterning
Activation of H+-ATPase of the Plasma Membrane of Saccharomyces cerevisiae by Glucose: The Role of Sphingolipid and Lateral Enzyme Mobility
- Author
- A Partikian
- A Pralle
- A Toulmay
- A Volkmer
- Airat Valiakhmetov
- AN Bader
- AN Bader
- AN Bader
- AN Campetelli
- B Gaigg
- B Gaigg
- B Zanolari
- BC Monk
- BF Lillemeier
- CB Brachmann
- CC Chadwick
- D Herbert
- D Seto-Young
- DJ Stewart
- EA Permyakov
- EK Yeow
- G Grossmann
- Hendrik W. van Veen
- JR Lacowicz
- JR Lakowicz
- JS Robinson
- K Malinska
- K Malinska
- KH Rhee
- LW Runnels
- M Auer
- M Bagnat
- M Bagnat
- M Cyrklaff
- MA Hink
- MA Souza
- MC Lee
- MG Palmgren
- Nataliya Suzina
- P Eraso
- P Morsomme
- Q Wang
- R Rao
- R Serrano
- R Serrano
- R Serrano
- R Varma
- S Lecchi
- S Lecchi
- S Lutsenko
- Sergey Permyakov
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
Activation of the plasma membrane H+-ATPase of the yeast Saccharomyces cerevisiae by glucose is a complex process that has not yet been completely elucidated. This study aimed to shed light on the role of lipids and the lateral mobility of the enzyme complex during its activation by glucose. The significance of H+-ATPase oligomerization for the activation of H+-ATPase by glucose was shown using the strains lcb1-100 and erg6, with the disturbed synthesis of sphyngolipid and ergosterol, respectively. Experiments with GFP-fused H+-ATPase showed a decrease in fluorescence anisotropy during the course of glucose activation, suggesting structural reorganization of the molecular domains. An immunogold assay showed that the incubation with glucose results in the spatial redistribution of ATPase complexes in the plasma membrane. The data suggest that (1) to be activated by glucose, H+-ATPase is supposed to be in an oligomeric state, and (2) glucose activation is accompanied by the spatial movements of H+-ATPase clusters in the PM
Continuous Theta Burst Transcranial Magnetic Stimulation of the Right Dorsolateral Prefrontal Cortex Impairs Inhibitory Control and Increases Alcohol Consumption
- Author
- A Jones
- Adam McNeill
- Adam W. Qureshi
- AE Goudriaan
- AJ Caswell
- AJ Lawrence
- AK Montoya
- AK Rose
- AK Rose
- AK Rose
- B Borsari
- C Nederkoorn
- CJ Lowe
- CJ Lowe
- CJ Lowe
- Derek Heim
- E Karam
- EM Wassermann
- F Verbruggen
- GD Logan
- GD Logan
- GPH Band
- H Wit De
- H Wit de
- J Weafer
- J Weafer
- J Weafer
- JB Davies
- JH Patton
- JM Bjork
- JM Jansen
- JR Knight
- JS Fadardi
- K Houben
- K Houben
- KS Button
- LC Sobell
- M Field
- M Field
- M Luijten
- MC Olmstead
- MT Fillmore
- ND Volkow
- P Christiansen
- P Christiansen
- P Murphy
- Rebecca L. Monk
- S Pridmore
- SD Lane
- SS Cho
- Stergios Makris
- World Health Organization
- YZ Huang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 15/12/2018
- Field of study
Integration of Global Signaling Pathways, cAMP-PKA, MAPK and TOR in the Regulation of FLO11
- Author
- A Santhanam
- A Stanhill
- A Van Nuland
- AGD Adams
- C Berset
- C Gallego
- CG Hounsa
- CJ DiComo
- CJ Gimeno
- D Rua
- DD Markwardt
- DE Koshland Jr
- HP Liu
- HU Mosch
- J Francois
- J Rohde
- JDJ Loeb
- JE Ferrell
- JE Ferrell
- JL Crespo
- JL Parrou
- JM Gancedo
- JR Rohde
- JS Hardwick
- K Biswas
- K. V. Venkatesh
- KEH Hojeong
- L Hubler
- L Oehlen
- M Batlle
- M Gagiano
- MC Lorenz
- MC Lorenz
- MC Lorenz
- ME Cardenas
- N Sengupta
- NC Barbet
- Neelanjan Sengupta
- Nick Monk
- NS Cutler
- P. J. Bhat
- P. K. Vinod
- PJ Cullen
- RD Gietz
- RL Roberts
- S Rupp
- SA Zurita-Martinez
- SH Ahn
- SJ Kron
- SM O'Rourke
- T Harashima
- T Harashima
- T Harashima
- T Peeters
- T Schmelzle
- TG Cooper
- VA Cherkasova
- W Gorner
- WS Lo
- WS Lo
- XJ Liu Chuanbin
- XW Pan
- XW Pan
- Y Jiang
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2008
- Field of study
The budding yeast, Saccharomyces cerevisiae, responds to various environmental cues by invoking specific adaptive mechanisms for their survival. Under nitrogen limitation, S. cerevisiae undergoes a dimorphic filamentous transition called pseudohyphae, which helps the cell to forage for nutrients and reach an environment conducive for growth. This transition is governed by a complex network of signaling pathways, namely cAMP-PKA, MAPK and TOR, which controls the transcriptional activation of FLO11, a flocculin gene that encodes a cell wall protein. However, little is known about how these pathways co-ordinate to govern the conversion of nutritional availability into gene expression. Here, we have analyzed an integrative network comprised of cAMP-PKA, MAPK and TOR pathways with respect to the availability of nitrogen source using experimental and steady state modeling approach. Our experiments demonstrate that the steady state expression of FLO11 was bistable over a range of inducing ammonium sulphate concentration based on the preculturing condition. We also show that yeast switched from FLO11 expression to accumulation of trehalose, a STRE response controlled by a transcriptional activator Msn2/4, with decrease in the inducing concentration to complete starvation. Steady state analysis of the integrative network revealed the relationship between the environment, signaling cascades and the expression of FLO11. We demonstrate that the double negative feedback loop in TOR pathway can elicit a bistable response, to differentiate between vegetative growth, filamentous growth and STRE response. Negative feedback on TOR pathway function to restrict the expression of FLO11 under nitrogen starved condition and also with re-addition of nitrogen to starved cells. In general, we show that these global signaling pathways respond with specific sensitivity to regulate the expression of FLO11 under nitrogen limitation. The holistic steady state modeling approach of the integrative network revealed how the global signaling pathways could differentiate between multiple phenotypes
The Relationship between Regular Sports Participation and Vigilance in Male and Female Adolescents
- Author
- A Bonnefond
- A Luque-Casado
- A Wilson
- AF Kramer
- AL Smiley-Oyen
- BA Sibley
- C Pesce
- C Pesce
- CC Venker
- Daniel Sanabria
- DR Davies
- DT Mann
- Eugene V Aidman
- F Beijamini
- Florentino Huertas
- Francesc Llorens
- Francisco Javier Yuste
- G Gunzelmann
- G Matthews
- GR Tomkinson
- IH Robertson
- JL Etnier
- JR Jennings
- JS Warm
- K Blatter
- L Chaddock
- L Leger
- L Verburgh
- M Basner
- M Trautmann
- MA Hammami
- MB Pontifex
- MW Voss
- MW Voss
- P Krustrup
- P Ward
- R Hainsworth
- R Steinmayr
- Rafael Ballester
- RM Eime
- RT Wilkinson
- S Colcombe
- S Hüttermann
- S Loh
- SPA Drummond
- T Haugen
- T Reilly
- T Vestberg
- T Vänttinen
- T Vänttinen
- TC North
- TH Monk
- TP Singh
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2015
- Field of study
The present study investigated the relationship between regular sport participation (soccer) and vigilance performance. Two groups of male and female adolescents differentiated in terms of their sport participation (athletes, n = 39, and non-athletes, n = 36) took part in the study. In one session, participants performed the Leger Multi-stage fitness test to estimate their aerobic fitness level. In the other session, participants completed the Psychomotor Vigilance Task (PVT) to evaluate their vigilance performance. Perceived arousal prior to the task and motivation toward the task were also measured in the PVT session. The results revealed that athletes had better cardiovascular fitness and showed better performance in the PVT. However, correlation analyses did not show any significant relationship between cardiovascular fitness and performance in the PVT. Athletes showed larger scores in motivation and perceived arousal measures with respect to non-athletes, although, once again, these variables were not correlated with PVT performance. Gender differences were observed only in the Leger test, with males showing greater fitness level than females. The major outcome of this research points to a positive relationship between regular sport participation and vigilance during adolescence. This relationship did not seem to be influenced by gender, perceived arousal, motivation toward the task or cardiovascular fitness. We discuss our results in terms of the different hypotheses put forward in the literature to explain the relationship between physical activity and cognitive functioning.This research was supported by a Spanish
Ministerio de Educación y Cultura (https://sede. educacion.gob.es) predoctoral grant (FPU13-05605) to the first author, and project research grants: Junta de Andalucia Proyecto de Excelencia SEJ-6414
(http://www.juntadeandalucia.es) and Ministerio de Economía y Competitividad PSI2013-46385 (http://www.mineco.gob.es) to DS and FH
Observation of associated near-side and away-side long-range correlations in √sNN=5.02 TeV proton-lead collisions with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdel Khalek S
- Abdelalim AA
- Abdinov O
- Aben R
- Abi B
- Abolins M
- Abouzeid OS
- Abramowicz H
- Abreu H
- Acharya BS
- Adamczyk L
- Adams DL
- Addy TN
- Adelman J
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akesson TP
- Akimoto G
- Akimov AV
- Alam MA
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Allbrooke BM
- Allison LJ
- Allport PP
- Allwood-Spiers SE
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alonso F
- Altheimer A
- Alvarez Gonzalez B
- Alviggi MG
- Amako K
- Amelung C
- Ammosov VV
- Amor Dos Santos SP
- Amorim A
- Amoroso S
- Amram N
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Anduaga XS
- Angelidakis S
- Anger P
- Angerami A
- Anghinolfi F
- Anisenkov A
- Anjos N
- Annovi A
- Antonaki A
- Antonelli M
- Antonov A
- Antos J
- Anulli F
- Aoki M
- Aperio Bella L
- Apolle R
- Arabidze G
- Aracena I
- Arai Y
- Arce AT
- Arfaoui S
- Arguin JF
- Argyropoulos S
- Arik E
- Arik M
- Armbruster AJ
- Arnaez O
- Arnal V
- Artamonov A
- Artoni G
- Arutinov D
- Asai S
- Ask S
- Asman B
- Asquith L
- Assamagan K
- Astalos R
- Astbury A
- Atkinson M
- ATLAS Collaboration The
- Auerbach B
- Auge E
- Augsten K
- Aurousseau M
- Avolio G
- Axen D
- Azuelos G
- Azuma Y
- Baak MA
- Baccaglioni G
- Bacci C
- Bach AM
- Bachacou H
- Bachas K
- Backes M
- Backhaus M
- Backus Mayes J
- Badescu E
- Bagnaia P
- Bai Y
- Bailey DC
- Bain T
- Baines JT
- Baker OK
- Baker S
- Balek P
- Balli F
- Banas E
- Banerjee P
- Banerjee S
- Banfi D
- Bangert A
- Bansal V
- Bansil HS
- Barak L
- Baranov SP
- Barber T
- Barberio EL
- Barberis D
- Barbero M
- Bardin DY
- Barillari T
- Barisonzi M
- Barklow T
- Barlow N
- Barnett BM
- Barnett RM
- Baroncelli A
- Barone G
- Barr AJ
- Barreiro Guimarães da Costa J
- Barreiro F
- Bartoldus R
- Barton AE
- Bartsch V
- Basye A
- Bates RL
- Batkova L
- Batley JR
- Battaglia A
- Battistin M
- Bauer F
- Bawa HS
- Beale S
- Beau T
- Beauchemin PH
- Beccherle R
- Bechtle P
- Beck HP
- Becker K
- Becker S
- Beckingham M
- Becks KH
- Beddall A
- Beddall AJ
- Bedikian S
- Bednyakov VA
- Bee CP
- Beemster LJ
- Beermann TA
- Begel M
- Behar Harpaz S
- Belanger-Champagne C
- Bell PJ
- Bell WH
- Bella G
- Bellagamba L
- Bellomo M
- Belloni A
- Beloborodova O
- Belotskiy K
- Beltramello O
- Benary O
- Benchekroun D
- Bendtz K
- Benekos N
- Benhammou Y
- Benhar Noccioli E
- Benitez Garcia JA
- Benjamin DP
- Benoit M
- Bensinger JR
- Benslama K
- Bentvelsen S
- Berge D
- Bergeaas Kuutmann E
- Berger N
- Berghaus F
- Berglund E
- Beringer J
- Bernat P
- Bernhard R
- Bernius C
- Bernlochner FU
- Berry T
- Bertella C
- Bertin A
- Bertolucci F
- Besana MI
- Besjes GJ
- Besson N
- Bethke S
- Bhimji W
- Bianchi RM
- Bianchini L
- Bianco M
- Biebel O
- Bieniek SP
- Bierwagen K
- Biesiada J
- Biglietti M
- Bilokon H
- Bindi M
- Binet S
- Bingul A
- Bini C
- Biscarat C
- Bittner B
- Black CW
- Black JE
- Black KM
- Blair RE
- Blanchard JB
- Blazek T
- Bloch I
- Blocker C
- Blocki J
- Blum W
- Blumenschein U
- Bobbink GJ
- Bobrovnikov VS
- Bocchetta SS
- Bocci A
- Boddy CR
- Boehler M
- Boek J
- Boek TT
- Boelaert N
- Bogaerts JA
- Bogdanchikov A
- Bogouch A
- Bohm C
- Bohm J
- Boisvert V
- Bold T
- Boldea V
- Bolnet NM
- Bomben M
- Bona M
- Boonekamp M
- Bordoni S
- Borer C
- Borisov A
- Borissov G
- Borjanovic I
- Borri M
- Borroni S
- Bortfeldt J
- Bortolotto V
- Bos K
- Boscherini D
- Bosman M
- Boterenbrood H
- Bouchami J
- Boudreau J
- Bouhova-Thacker EV
- Boumediene D
- Bourdarios C
- Bousson N
- Boutouil S
- Boveia A
- Boyd J
- Boyko IR
- Bozovic-Jelisavcic I
- Bracinik J
- Branchini P
- Brandt A
- Brandt G
- Brandt O
- Bratzler U
- Brau B
- Brau JE
- Braun HM
- Brazzale SF
- Brelier B
- Bremer J
- Brendlinger K
- Brenner R
- Bressler S
- Bristow TM
- Britton D
- Brochu FM
- Brock I
- Brock R
- Broggi F
- Bromberg C
- Bronner J
- Brooijmans G
- Brooks T
- Brooks WK
- Brown G
- Bruckman de Renstrom PA
- Bruncko D
- Bruneliere R
- Brunet S
- Bruni A
- Bruni G
- Bruschi M
- Bryngemark L
- Buanes T
- Buat Q
- Bucci F
- Buchanan J
- Buchholz P
- Buckingham RM
- Buckley AG
- Buda SI
- Budagov IA
- Budick B
- Bugge L
- Bulekov O
- Bundock AC
- Bunse M
- Buran T
- Burckhart H
- Burdin S
- Burgess T
- Burke S
- Busato E
- Bussey P
- Buszello CP
- Butler B
- Butler JM
- Buttar CM
- Butterworth JM
- Buttinger W
- Byszewski M
- Büscher V
- Cabrera Urbán S
- Caforio D
- Cakir O
- Calafiura P
- Calderini G
- Calfayan P
- Calkins R
- Caloba LP
- Caloi R
- Calvet D
- Calvet S
- Camacho Toro R
- Camarri P
- Cameron D
- Caminada LM
- Caminal Armadans R
- Campana S
- Campanelli M
- Canale V
- Canelli F
- Canepa A
- Cantero J
- Cantrill R
- Cao T
- Capeans Garrido MD
- Caprini I
- Caprini M
- Capriotti D
- Capua M
- Caputo R
- Cardarelli R
- Carli T
- Carlino G
- Carminati L
- Caron S
- Carquin E
- Carrillo-Montoya GD
- Carter AA
- Carter JR
- Carvalho J
- Casadei D
- Casado MP
- Cascella M
- Caso C
- Castaneda-Miranda E
- Castillo Gimenez V
- Castro NF
- Cataldi G
- Catastini P
- Catinaccio A
- Catmore JR
- Cattai A
- Cattani G
- Caughron S
- Cavaliere V
- Cavalleri P
- Cavalli D
- Cavalli-Sforza M
- Cavasinni V
- Ceradini F
- Cerqueira AS
- Cerri A
- Cerrito L
- Cerutti F
- Cetin SA
- Chafaq A
- Chakraborty D
- Chalupkova I
- Chan K
- Chang P
- Chapleau B
- Chapman JD
- Chapman JW
- Charlton DG
- Chavda V
- Chavez Barajas CA
- Cheatham S
- Chekanov S
- Chekulaev SV
- Chelkov GA
- Chelstowska MA
- Chen C
- Chen H
- Chen S
- Chen X
- Chen Y
- Cheng Y
- Cheplakov A
- Cherkaoui El Moursli R
- Chernyatin V
- Cheu E
- Cheung SL
- Chevalier L
- Chiefari G
- Chikovani L
- Childers JT
- Chilingarov A
- Chiodini G
- Chisholm AS
- Chislett RT
- Chitan A
- Chizhov MV
- Choudalakis G
- Chouridou S
- Chow BK
- Christidi IA
- Christov A
- Chromek-Burckhart D
- Chu ML
- Chudoba J
- Ciapetti G
- Ciftci AK
- Ciftci R
- Cinca D
- Cindro V
- Ciocio A
- Cirilli M
- Cirkovic P
- Citron ZH
- Citterio M
- Ciubancan M
- Clark A
- Clark PJ
- Clarke RN
- Cleland W
- Clemens JC
- Clement B
- Clement C
- Coadou Y
- Cobal M
- Coccaro A
- Cochran J
- Coffey L
- Cogan JG
- Coggeshall J
- Colas J
- Cole B
- Cole S
- Colijn AP
- Collins NJ
- Collins-Tooth C
- Collot J
- Colombo T
- Colon G
- Compostella G
- Conde Muiño P
- Coniavitis E
- Conidi MC
- Consonni SM
- Consorti V
- Constantinescu S
- Conta C
- Conti G
- Conventi F
- Cooke M
- Cooper BD
- Cooper-Sarkar AM
- Copic K
- Cornelissen T
- Corradi M
- Corriveau F
- Cortes-Gonzalez A
- Cortiana G
- Costa G
- Costa MJ
- Costanzo D
- Cottin G
- Courneyea L
- Cowan G
- Cox BE
- Cranmer K
- Crescioli F
- Cristinziani M
- Crosetti G
- Crépé-Renaudin S
- Cuciuc CM
- Cuenca Almenar C
- Cuhadar Donszelmann T
- Cummings J
- Curatolo M
- Curtis CJ
- Cuthbert C
- Cwetanski P
- Czirr H
- Czodrowski P
- Czyczula Z
- Côté D
- D'Auria S
- D'Onofrio M
- D'Orazio A
- Da Cunha Sargedas De Sousa MJ
- Da Via C
- Dabrowski W
- Dafinca A
- Dai T
- Dallaire F
- Dallapiccola C
- Dam M
- Damiani DS
- Danielsson HO
- Dao V
- Darbo G
- Darlea GL
- Dassoulas JA
- Davey W
- Davidek T
- Davidson N
- Davidson R
- Davies E
- Davies M
- Davignon O
- Davison AR
- Davygora Y
- Dawe E
- Dawson I
- Daya-Ishmukhametova RK
- de Asmundis R
- De Castro S
- De Cecco S
- de Graat J
- De Groot N
- de Jong P
- De La Taille C
- De la Torre H
- De Lorenzi F
- De Nooij L
- De Pedis D
- De Salvo A
- De Sanctis U
- De Santo A
- De Vivie De Regie JB
- De Zorzi G
- De K
- Dearnaley WJ
- Debbe R
- Debenedetti C
- Dechenaux B
- Dedovich DV
- Degenhardt J
- Del Peso J
- Del Prete T
- Delemontex T
- Deliyergiyev M
- Dell'acqua A
- Dell'asta L
- Della Pietra M
- Della Volpe D
- Delmastro M
- Delsart PA
- Deluca C
- Demers S
- Demichev M
- Demirkoz B
- Denisov SP
- Derendarz D
- Derkaoui JE
- Derue F
- Dervan P
- Desch K
- Deviveiros PO
- Dewhurst A
- Dewilde B
- Dhaliwal S
- Dhullipudi R
- Di Ciaccio A
- Di Ciaccio L
- Di Donato C
- Di Girolamo A
- Di Girolamo B
- Di Luise S
- Di Mattia A
- Di Micco B
- Di Nardo R
- Di Simone A
- Di Sipio R
- Diaz MA
- Diehl EB
- Dietrich J
- Dietzsch TA
- Diglio S
- Dindar Yagci K
- Dingfelder J
- Dinut F
- Dionisi C
- Dita P
- Dita S
- Dittus F
- Djama F
- Djobava T
- do Vale MA
- Do Valle Wemans A
- Doan TK
- Dobbs M
- Dobos D
- Dobson E
- Dodd J
- Doglioni C
- Doherty T
- Dohmae T
- Doi Y
- Dolejsi J
- Dolezal Z
- Dolgoshein BA
- Donadelli M
- Donini J
- Dopke J
- Doria A
- Dos Anjos A
- Dotti A
- Dova MT
- Doyle AT
- Dressnandt N
- Dris M
- Dubbert J
- Dube S
- Dubreuil E
- Duchovni E
- Duckeck G
- Duda D
- Dudarev A
- Dudziak F
- Duerdoth IP
- Duflot L
- Dufour MA
- Duguid L
- Dunford M
- Duran Yildiz H
- Duxfield R
- Dwuznik M
- Dührssen M
- Düren M
- Ebenstein WL
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- Winkelmann S
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- Xiao M
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- Xu D
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- Yabsley B
- Yacoob S
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- Yamaguchi H
- Yamamoto A
- Yamamoto K
- Yamamoto S
- Yamamura T
- Yamanaka T
- Yamauchi K
- Yamazaki T
- Yamazaki Y
- Yan Z
- Yang H
- Yang H
- Yang UK
- Yang Y
- Yang Z
- Yanush S
- Yao L
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- Yen AL
- Yilmaz M
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- Yoshihara K
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- Youssef S
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- Zaidan R
- Zaitsev AM
- Zambito S
- Zanello L
- Zanzi D
- Zaytsev A
- Zeitnitz C
- Zeman M
- Zemla A
- Zenin O
- Zeniš T
- Zerwas D
- Zevi Della Porta G
- Zhang D
- Zhang H
- Zhang J
- Zhang L
- Zhang X
- Zhang Z
- Zhao L
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhuravlov V
- Zibell A
- Zieminska D
- Zimin NI
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zitoun R
- Zivković L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- Zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- American Physical Society
- Publication date
- 01/01/2012
- Field of study
Two-particle correlations in relative azimuthal angle (Δϕ) and pseudorapidity (Δη) are measured in √sNN=5.02 TeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1 μb-1 of data as a function of transverse momentum (pT) and the transverse energy (ΣETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Δη|<5) “near-side” (Δϕ∼0) correlation that grows rapidly with increasing ΣETPb. A long-range “away-side” (Δϕ∼π) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ΣETPb, is found to match the near-side correlation in magnitude, shape (in Δη and Δϕ) and ΣETPb dependence. The resultant Δϕ correlation is approximately symmetric about π/2, and is consistent with a dominant cos2Δϕ modulation for all ΣETPb ranges and particle pT
C5a Enhances Dysregulated Inflammatory and Angiogenic Responses to Malaria In Vitro: Potential Implications for Placental Malaria
- Author
- A Muehlenbachs
- A Muehlenbachs
- A Muehlenbachs
- AD Niederbichler
- AL Suguitan Jr
- AM Moormann
- Andrea Conroy
- BJ Brabin
- BJ Czermak
- C Lam
- C Menendez
- C Wenisch
- Constance Finney
- D Rittirsch
- D. Channe Gowda
- DE Chenoweth
- DS Charnock-Jones
- EA Albrecht
- EK Dorman
- ER Kabyemela
- ET Abrams
- G Girardi
- G Krishnegowda
- G Smedegard
- H Hawlisch
- HM Gilles
- ID McGilvray
- J Ordi
- J Zhu
- JM Bowen
- JM Moore
- JS Hunt
- JS Pober
- JS Solomkin
- Julie M. Moore
- Kevin C. Kain
- L Serghides
- Lena Serghides
- M Fried
- M Fried
- M Huber-Lang
- M Huber-Lang
- M Huber-Lang
- M Marzi
- M Roestenberg
- M Yamada
- MF Duffy
- N Diagne
- NC Riedemann
- NC Riedemann
- NW Lucchi
- NW Lucchi
- NW Lucchi
- O Leopardi
- P Hillmen
- PA Buffet
- PA Ward
- Patricia Bozza
- PN Monk
- RF Guo
- RJ Levine
- RS Naik
- S Chaisavaneeyakorn
- S Chaisavaneeyakorn
- Sanjeev Kumar
- Simon O. Owino
- SJ Rogerson
- SJ Rogerson
- SM Caucheteux
- SN Patel
- SN Patel
- SN Patel
- T Jansson
- T Nebl
- W. Conrad Liles
- WC Aird
- Y Zhou
- Publication venue
- Public Library of Science
- Publication date
- Field of study
Placental malaria (PM) is a leading cause of maternal and infant mortality. Although the accumulation of parasitized erythrocytes (PEs) and monocytes within the placenta is thought to contribute to the pathophysiology of PM, the molecular mechanisms underlying PM remain unclear. Based on the hypothesis that excessive complement activation may contribute to PM, in particular generation of the potent inflammatory peptide C5a, we investigated the role of C5a in the pathogenesis of PM in vitro and in vivo.Using primary human monocytes, the interaction between C5a and malaria in vitro was assessed. CSA- and CD36-binding PEs induced activation of C5 in the presence of human serum. Plasmodium falciparum GPI (pfGPI) enhanced C5a receptor expression (CD88) on monocytes, and the co-incubation of monocytes with C5a and pfGPI resulted in the synergistic induction of cytokines (IL-6, TNF, IL-1beta, and IL-10), chemokines (IL-8, MCP-1, MIP1alpha, MIP1beta) and the anti-angiogenic factor sFlt-1 in a time and dose-dependent manner. This dysregulated response was abrogated by C5a receptor blockade. To assess the potential role of C5a in PM, C5a plasma levels were measured in malaria-exposed primigravid women in western Kenya. Compared to pregnant women without malaria, C5a levels were significantly elevated in women with PM.These results suggest that C5a may contribute to the pathogenesis of PM by inducing dysregulated inflammatory and angiogenic responses that impair placental function
Search for the neutral Higgs bosons of the minimal supersymmetric standard model in pp collisions at root s=7 TeV with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdinov O
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Acharya BS
- Adam ER
- Adamczyk L
- Adams DL
- Addy TN
- Adelman J
- Adomeit S
- Adragna P
- Adye T
- Aesky S
- Agar-Savedra JA
- Agustoni M
- Ahlen SP
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- Publication venue
- Publication date
- 01/02/2013
- Field of study
A search for neutral Higgs bosons of the Minimal Supersymmetric Standard Model (MSSM) is reported. The analysis is based on a sample of proton-proton collisions at a centre-of-mass energy of 7TeV recorded with the ATLAS detector at the Large Hadron Collider. The data were recorded in 2011 and correspond to an integrated luminosity of 4.7 fb-1 to 4.8 fb-1. Higgs boson decays into oppositely-charged muon or τ lepton pairs are considered for final states requiring either the presence or absence of b-jets. No statistically significant excess over the expected background is observed and exclusion limits at the 95% confidence level are derived. The exclusion limits are for the production cross-section of a generic neutral Higgs boson, φ, as a function of the Higgs boson mass and for h/A/H production in the MSSM as a function of the parameters mA and tan β in the mhmax scenario for mA in the range of 90GeV to 500 GeV. Copyright CERN
Search for R-parity-violating supersymmetry in events with four or more leptons in sqrt(s) =7 TeV pp collisions with the ATLAS detector
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- Yamanaka T
- Yamazaki T
- Yamazaki Y
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- Yang Z
- Yanush S
- Yao L
- Yao Y
- Yasu Y
- Smit GVY
- Ye J
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- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Yoshihara K
- Young C
- Young CJ
- Youssef S
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- Yurkewicz A
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zajacova Z
- Zanello L
- Zanzi D
- Zaytsev A
- Zeitnitz C
- Zeman M
- Zemla A
- Zendler C
- Zenin O
- Zenis T
- Zinonos Z
- Zerwas D
- della Porta GZ
- Zhang D
- Zhang H
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- Zhang X
- Zhang Z
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- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
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- Zhou Y
- Zhu CG
- Zhu H
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- Zhu Y
- Zhuang X
- Zhuravlov V
- Zibell A
- Zieminska D
- Zimin NI
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Collaboration ATLAS
- Publication venue
- Springer Verlag
- Publication date
- 01/01/2008
- Field of study
A search for new phenomena in final states with four or more leptons (electrons or muons) is presented. The analysis is based on 4.7 fb−1 of s=7TeV proton-proton collisions delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in two signal regions: one that requires moderate values of missing transverse momentum and another that requires large effective mass. The results are interpreted in a simplified model of R-parity-violating supersymmetry in which a 95% CL exclusion region is set for charged wino masses up to 540 GeV. In an R-parity-violating MSUGRA/CMSSM model, values of m 1/2 up to 820 GeV are excluded for 10 < tan β < 40
Search for high-mass resonances decaying to dilepton final states in pp collisions at s√=7 TeV with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Acharya BS
- Adamczyk L
- Adams DL
- Addy TN
- Adelman J
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Agustoni M
- Aharrouche M
- Ahlen SP
- Ahles R
- Ahmad A
- Ahsan M
- Aielli G
- Akesson TPA
- Akimoto G
- Akimov AV
- Alam MA
- Alam MS
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Allbrooke BMM
- Allport PP
- Allwood-Spiers SE
- Almenar CC
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alonso F
- Altheimer A
- Alviggi MG
- Amako K
- Amelung C
- Ammosov VV
- Amor Dos Santos SP
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- Amram N
- Anastopoulos C
- Ancu LS
- Andari N
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- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Andrieux M-L
- Anduaga XS
- Angelidakis S
- Anger P
- Angerami A
- Anghinolfi F
- Anh TV
- Anisenkov A
- Anjos N
- Annovi A
- Antonaki A
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- Antos J
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- Apolle R
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- Arguin J-F
- Argyropoulos S
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- Arutinov D
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- Villaplana Perez M
- Vilucchi E
- Vincter MG
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- Vinogradov VB
- Virchaux M
- Virzi J
- Vitells O
- Viti M
- Vivarelli I
- Vlachos S
- Vladoiu D
- Vlasak M
- Vogel A
- Vokac P
- Volpi G
- Volpi M
- Volpini G
- von der Schmitt H
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- Vorobel V
- Vorwerk V
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- Vossebeld JH
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- Vukotic I
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- Weingarten J
- Weiser C
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- Wenaus T
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- Yamaguchi H
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- Yamanaka T
- Yamazaki T
- Yamazaki Y
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- Yanush S
- Yao L
- Yao Y
- Yasu Y
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- Yildiz HD
- Yilmaz M
- Yoosoofmiya R
- Yorita K
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- Yoshihara K
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- Young CJ
- Youssef S
- Yu D
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- Yu J
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- Yurkewicz A
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zajacova Z
- Zanello L
- Zanzi D
- Zaytsev A
- Zeitnitz C
- Zeman M
- Zemla A
- Zendler C
- Zenin O
- Zenis T
- Zerwas D
- Zhang D
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- Zhang X
- Zhang Z
- Zhao L
- Zhao Z
- Zhemchugov A
- Zhong J
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- Zhou Y
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhuravlov V
- Zibell A
- Zieminska D
- Zimin NI
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- Springer
- Publication date
- 23/11/2012
- Field of study
The ATLAS detector at the Large Hadron Collider is used to search for high-mass resonances decaying to an electron-positron pair or a muon-antimuon pair. The search is sensitive to heavy neutral Z′ gauge bosons, Randall-Sundrum gravitons, Z * bosons, techni-mesons, Kaluza-Klein Z/γ bosons, and bosons predicted by Torsion models. Results are presented based on an analysis of pp collisions at a center-of-mass energy of 7 TeV corresponding to an integrated luminosity of 4.9 fb−1 in the e + e − channel and 5.0 fb−1 in the μ + μ −channel. A Z ′ boson with Standard Model-like couplings is excluded at 95 % confidence level for masses below 2.22 TeV. A Randall-Sundrum graviton with coupling k/MPl=0.1 is excluded at 95 % confidence level for masses below 2.16 TeV. Limits on the other models are also presented, including Technicolor and Minimal Z′ Models
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