971 research outputs found
Thermal radiation processes
We discuss the different physical processes that are important to understand
the thermal X-ray emission and absorption spectra of the diffuse gas in
clusters of galaxies and the warm-hot intergalactic medium. The ionisation
balance, line and continuum emission and absorption properties are reviewed and
several practical examples are given that illustrate the most important
diagnostic features in the X-ray spectra.Comment: 37 pages, 16 figures, accepted for publication in Space Science
Reviews, special issue "Clusters of galaxies: beyond the thermal view",
Editor J.S. Kaastra, Chapter 9; work done by an international team at the
International Space Science Institute (ISSI), Bern, organised by J.S.
Kaastra, A.M. Bykov, S. Schindler & J.A.M. Bleeke
Redefining trauma in an African context : a challenge to pastoral care
This article has been
adapted from Ray Motsi’s
PhD dissertation, which
was completed under the
supervision of Prof. Maake
Masango, University of
Pretoria, South Africa.The article attempted to analyse critically the definition of trauma as it is used in the Western
medical and psychiatry contexts in order to come up with an appropriate African definition.
This was undertaken with the view to demonstrate that the Western worldview is different
from the African worldview. Superimposing solutions or providing pre-packed answers to
unique African problems will lead only to re-traumatisation, whereas cultural sensitivity and
the right diagnosis will lead to the correct treatment. The driving force behind this article was
therefore to aim to be relevant, effective and contextual in all African-based pastoral care.http://www.hts.org.zahttp://upetd.up.ac.za/thesis/available/etd-10132010-165758/nf201
An exploration of concepts of community through a case study of UK university web production
The paper explores the inter-relation and differences between the concepts of occupational community, community of practice, online community and social network. It uses as a case study illustration the domain of UK university web site production and specifically a listserv for those involved in it. Different latent occupational communities are explored, and the potential for the listserv to help realize these as an active sense of community is considered. The listserv is not (for most participants) a tight knit community of practice, indeed it fails many criteria for an online community. It is perhaps best conceived as a loose knit network of practice, valued for information, implicit support and for the maintenance of weak ties. Through the analysis the case for using strict definitions of the theoretical concepts is made
Generation of entangled states and error protection from adiabatic avoided level crossings
We consider the environment-affected dynamics of self-interacting
particles living in one-dimensional double wells. Two topics are dealt with.
First, we consider the production of entangled states of two-level systems. We
show that by adiabatically varying the well biases we may dynamically generate
maximally entangled states, starting from initially unentangled product states.
Entanglement degradation due to a common type of environmental influence is
then computed by solving a master equation. However, we also demonstrate that
entanglement production is unaffected if the system-environment coupling is of
the type that induces ``motional narrowing''. As our second but related topic,
we construct a different master equation that seamlessly merges error
protection/detection dynamics for quantum information with the environmental
couplings responsible for producing the errors in the first place. Adiabatic
avoided crossing schemes are used in both topics.Comment: 14 pages, 6 figures. Minor changes. To appear in Phys. Rev.
Equilibration processes in the Warm-Hot Intergalactic Medium
The Warm-Hot Intergalactic Medium (WHIM) is thought to contribute about 40-50
% to the baryonic budget at the present evolution stage of the universe. The
observed large scale structure is likely to be due to gravitational growth of
density fluctuations in the post-inflation era. The evolving cosmic web is
governed by non-linear gravitational growth of the initially weak density
fluctuations in the dark energy dominated cosmology. Non-linear structure
formation, accretion and merging processes, star forming and AGN activity
produce gas shocks in the WHIM. Shock waves are converting a fraction of the
gravitation power to thermal and non-thermal emission of baryonic/leptonic
matter. They provide the most likely way to power the luminous matter in the
WHIM. The plasma shocks in the WHIM are expected to be collisionless.
Collisionless shocks produce a highly non-equilibrium state with anisotropic
temperatures and a large differences in ion and electron temperatures. We
discuss the ion and electron heating by the collisionless shocks and then
review the plasma processes responsible for the Coulomb equilibration and
collisional ionisation equilibrium of oxygen ions in the WHIM. MHD-turbulence
produced by the strong collisionless shocks could provide a sizeable
non-thermal contribution to the observed Doppler parameter of the UV line
spectra of the WHIM.Comment: 13 pages, 4 figures, accepted for publication in Space Science
Reviews, special issue "Clusters of galaxies: beyond the thermal view",
Editor J.S. Kaastra, Chapter 8; work done by an international team at the
International Space Science Institute (ISSI), Bern, organised by J.S.
Kaastra, A.M. Bykov, S. Schindler & J.A.M. Bleeke
Effects of trauma-related cues on pain processing in posttraumatic stress disorder: an fMRI investigation
Background: Imaging studies of pain processing in primary psychiatric disorders are just emerging. This study explored the neural correlates of stress-induced analgesia in individuals with posttraumatic stress disorder (PTSD). It combined functional magnetic resonance imaging (fMRI) and the traumatic script-driven imagery symptom provocation paradigm to examine the effects of trauma-related cues on pain perception in individuals with PTSD. Methods: The study included 17 patients with PTSD and 26 healthy, trauma-exposed controls. Participants received warm (nonpainful) or hot (painful) thermal stimuli after listening to a neutral or a traumatic script while they were undergoing an fMRI scan at a 4.0 T field strength. Results: Between-group analyses revealed that after exposure to the traumatic scripts, the blood oxygen level–dependent (BOLD) signal during pain perception was greater in the PTSD group than the control group in the head of the caudate. In the PTSD group, strong positive correlations resulted between BOLD signal and symptom severity in a number of brain regions previously implicated in stress-induced analgesia, such as the thalamus and the head of the caudate nucleus. Trait dissociation as measured by the Dissociative Experiences Scale correlated negatively with the right amygdala and the left putamen. Limitations: This study included heterogeneous traumatic experiences, a different proportion of military trauma in the PTSD versus the control group and medicated patients with PTSD. Conclusion: These data indicate that in patients with PTSD trauma recall will lead in a state-dependent manner to greater activation in brain regions implicated in stress-induced analgesia. Correlational analyses lend support to cortical hyperinhibition of the amygdala as a function of dissociation
Similarities and differences in lipidomics profiles among healthy monozygotic twin pairs.
Differences in genetic background and/or environmental exposure among individuals are expected to give rise to differences in measurable characteristics, or phenotypes. Consequently, genetic resemblance and similarities in environment should manifest as similarities in phenotypes. The metabolome reflects many of the system properties, and is therefore an important part of the phenotype. Nevertheless, it has not yet been examined to what extent individuals sharing part of their genome and/or environment indeed have similar metabolomes. Here we present the results of hierarchical clustering of blood plasma lipid profile data obtained by liquid chromatographymass spectrometry from 23 healthy, 18-year-old twin pairs, of which 21 pairs were monozygotic, and 8 of their siblings. For 13 monozygotic twin pairs, within-pair similarities in relative concentrations of the detected lipids were indeed larger than the similarities with any other study participant. We demonstrate such high coclustering to be unexpected on basis of chance. The similarities between dizygotic twins and between nontwin siblings, as well as between nonfamilial participants, were less pronounced. In a number of twin pairs, within-pair dissimilarity of lipid profiles positively correlated with increased blood plasma concentrations of C-reactive protein in one twin. In conclusion, this study demonstrates that in healthy individuals, the individual genetic background contributes to the blood plasma lipid profile. Furthermore, lipid profiling may prove useful in monitoring health status, for example, in the context of personalized medicine. © 2008 Mary Ann Liebert, Inc. Chemicals / CAS: C-Reactive Protein, 9007-41-4; Lipid
An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types
Search for a W' boson decaying to a bottom quark and a top quark in pp collisions at sqrt(s) = 7 TeV
Results are presented from a search for a W' boson using a dataset
corresponding to 5.0 inverse femtobarns of integrated luminosity collected
during 2011 by the CMS experiment at the LHC in pp collisions at sqrt(s)=7 TeV.
The W' boson is modeled as a heavy W boson, but different scenarios for the
couplings to fermions are considered, involving both left-handed and
right-handed chiral projections of the fermions, as well as an arbitrary
mixture of the two. The search is performed in the decay channel W' to t b,
leading to a final state signature with a single lepton (e, mu), missing
transverse energy, and jets, at least one of which is tagged as a b-jet. A W'
boson that couples to fermions with the same coupling constant as the W, but to
the right-handed rather than left-handed chiral projections, is excluded for
masses below 1.85 TeV at the 95% confidence level. For the first time using LHC
data, constraints on the W' gauge coupling for a set of left- and right-handed
coupling combinations have been placed. These results represent a significant
improvement over previously published limits.Comment: Submitted to Physics Letters B. Replaced with version publishe
Search for the standard model Higgs boson decaying into two photons in pp collisions at sqrt(s)=7 TeV
A search for a Higgs boson decaying into two photons is described. The
analysis is performed using a dataset recorded by the CMS experiment at the LHC
from pp collisions at a centre-of-mass energy of 7 TeV, which corresponds to an
integrated luminosity of 4.8 inverse femtobarns. Limits are set on the cross
section of the standard model Higgs boson decaying to two photons. The expected
exclusion limit at 95% confidence level is between 1.4 and 2.4 times the
standard model cross section in the mass range between 110 and 150 GeV. The
analysis of the data excludes, at 95% confidence level, the standard model
Higgs boson decaying into two photons in the mass range 128 to 132 GeV. The
largest excess of events above the expected standard model background is
observed for a Higgs boson mass hypothesis of 124 GeV with a local significance
of 3.1 sigma. The global significance of observing an excess with a local
significance greater than 3.1 sigma anywhere in the search range 110-150 GeV is
estimated to be 1.8 sigma. More data are required to ascertain the origin of
this excess.Comment: Submitted to Physics Letters
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