Comparison of RANS, DES and DDES Results for ONERA M-6 Wing at Transonic Flow Speed Using an In-House Parallel Code

The very first thought that comes to the mind with the application area of the DES and DDES schemes is a massively separated flow with highly unsteady flowfield. However, for various complex three dimensional cases, there is no prior knowledge of the flowfield in the domain and it may have mild separation or no separation at all with a steady domain. This study is carried out to see that what will be the behaviour of the DES and DDES schemes in comparison with the URANS scheme if they are applied to a steady state case. An in-house mpi code DG-DES is used for the present study. Three different flux computational schemes named Roe, AUSM and HLLC schemes within DES formulation are compared to check the response for the flows without massive separation and unsteadiness. The cases are run in both single and double precision mode for DES formulation using Roe flux computational scheme to appreciate the accuracy of the solver. A good comparison of pressure distribution with the experimental data is obtained for all URANS, DES and DDES simulations. The pressure distribution results for DES scheme using single and double precision agree well with the experimental data. The pressure distribution predicted by DES using Roe, AUSM and HLLC schemes agree well with the experimental data. The computed values of Cl and Cd are also in close approximity to the other studies. The drag predicted by all DES and DDES simulations is lower than the URANS scheme. It indicates that the DES and DDES schemes generate lower dissipation due to switching to the LES mode and hence result in lower drag prediction as compared with the URANS solution. There is no anomaly observed in the flow due to the use of DES or DDES for steady flow case

Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics

Essential metals, such as iron and copper, play a critical role in a plethora of cellular processes including cell growth and proliferation. However, concomitantly, excess of these metal ions in the body can have deleterious effects due to their ability to generate cytotoxic reactive oxygen species (ROS). Thus, the human body has evolved a very well-orchestrated metabolic system that keeps tight control on the levels of these metal ions. Considering their very high proliferation rate, cancer cells require a high abundance of these metals compared to their normal counterparts. Interestingly, new anti-cancer agents that take advantage of the sensitivity of cancer cells to metal sequestration and their susceptibility to ROS have been developed. These ligands can avidly bind metal ions to form redox active metal complexes, which lead to generation of cytotoxic ROS. Furthermore, these agents also act as potent metastasis suppressors due to their ability to up-regulate the metastasis suppressor gene, N-myc downstream regulated gene 1. This review discusses the importance of iron and copper in the metabolism and progression of cancer, how they can be exploited to target tumors and the clinical translation of novel anti-cancer chemotherapeutics

On the mechanisms governing gas penetration into a tokamak plasma during a massive gas injection

A new 1D radial fluid code, IMAGINE, is used to simulate the penetration of gas into a tokamak plasma during a massive gas injection (MGI). The main result is that the gas is in general strongly braked as it reaches the plasma, due to mechanisms related to charge exchange and (to a smaller extent) recombination. As a result, only a fraction of the gas penetrates into the plasma. Also, a shock wave is created in the gas which propagates away from the plasma, braking and compressing the incoming gas. Simulation results are quantitatively consistent, at least in terms of orders of magnitude, with experimental data for a D 2 MGI into a JET Ohmic plasma. Simulations of MGI into the background plasma surrounding a runaway electron beam show that if the background electron density is too high, the gas may not penetrate, suggesting a possible explanation for the recent results of Reux et al in JET (2015 Nucl. Fusion 55 093013)

Scholarly publishing depends on peer reviewers

The peer-review crisis is posing a risk to the scholarly peer-reviewed journal system. Journals have to ask many potential peer reviewers to obtain a minimum acceptable number of peers accepting reviewing a manuscript. Several solutions have been suggested to overcome this shortage. From reimbursing for the job, to eliminating pre-publication reviews, one cannot predict which is more dangerous for the future of scholarly publishing. And, why not acknowledging their contribution to the final version of the article published? PubMed created two categories of contributors: authors [AU] and collaborators [IR]. Why not a third category for the peer-reviewer?Scopu