Intellect Does Not Have an Accent: The Lived Experiences of Women Native Speakers of Spanish with Professional Leadership Positions in United States and Have an Accented English Speech

This qualitative study examined the experiences of eleven multilingual professional women between the ages of 35 and 65 who share the following characteristics: Spanish is their first language; they speak English with an accent and migrated to the United States as adults and are required to engage in public speaking in their professional leadership careers in the United States. The study’s interview process provided participants with a platform to share their voices and stories. The findings discussed how their accents have shaped their leadership careers as well as the social-emotional aspect of their lives through a phenomenological approach. The emergent themes offered insights about how accent is intrinsically connected to identity and is confronted by bias and microaggressions and how these have affected their professional careers. In addition, the data collected allowed for an analysis of how they feel native speakers of English perceive their capabilities and intelligence based on their accents and depending on the type of receptors, or listeners, the native speakers are. Lastly, a theme about the social-emotional impact presents how their experiences affect their confidence in public speaking. Since the United States continues to open doors to millions of immigrants who make this country their permanent residence for living and working, it is beneficial to understand that they must become English language learners and will speak English with a noticeable foreign accent. In conclusion, the participants’ stories inform how to better create safe, welcoming, and non-racist environments within the educational field, workplaces, and communities in the United States in which all can coexist harmoniously. The knowledge gained potentially eliminates unnecessary harm and biases in these spaces, co-constructing inclusively diverse and culturally competent

Características clínico-demográficas de mujeres remitidas al Instituto de Investigaciones en Ciencias de la Salud (IICS) para detección de HPV de alto riesgo oncogénico por Captura Híbrida II®.Mayo 2006-2007

El cáncer de cuello uterino (CCU) es la primera causa de morbilidad y la segunda causa de muerte por cáncer en mujeres en Paraguay. La infección genital por el virus del papiloma humano (HPV), es un factor necesario para el desarrollo del CCU, junto a otros cofactores. Este estudio descriptivo transversal en muestras biológicas de cuello uterino,tiene por objetivo determinar las características clínico-demográficas de mujeres remitidas al IICS para detección de HPV de alto riesgo oncogénico por Captura Híbrida II® entre mayo de 2006-2007. De un total de 248 mujeres estudiadas el 85% procedía del área metropolitana, con un promedio de edad de 34±11 años. El 41% de las muestrasresultó positiva para HPV de alto riego (HR-HPV). Según resultados citológicos, el 27% de las citologías inflamatorias o normales fue positivo. EL 78% de las muestras analizadas para control post tratamiento de lesiones intraepiteliales de alto grado fue negativa evidenciando la alta efectividad del tratamiento médico por medio del Test de HPV

Instruments of functional assessment of elderly submitted to orthopedic surgery: an integrative review of literature

Doenças musculoesqueléticas constituem causa de dano funcional no idoso, mas não são conseqüências inevitáveis da idade, portanto, todas as dimensões de saúde têm que ser contempladas na sua avaliação. Objetivo: Analisar artigos científicos que avaliaram o estado funcional do idoso submetido à cirurgia ortopédica. Metodologia: Revisão bibliográfica de artigos on-line indexados nas bases: www. bireme.br, www.scopus.com, www.ncbi.nlm.nih.gov/pubmed e www.embase.com, durante o período de 1996 a 2006. Utilizou-se a terminologia DeCS/Bireme e MeSH/PubMed, com os descritores: idoso, atividades cotidianas, cirurgia ortopédica ou procedimentos ortopédicos, pós-operatório e reabilitação. A busca foi realizada em abril/2006. Critério de inclusão: sujeitos com 60 anos ou mais, submetidos a qualquer procedimento cirúrgico ortopédico, e texto completo disponível on-line. Referências armazenadas e analisadas pelo Software Epilnfo versão 3.3.2. Variáveis: título, ano e país de publicação do periódico; categoria profissional dos autores; país de origem do estudo; objetivos da pesquisa; número e tipos de instrumentos de avaliação e sítio da cirurgia. Resultados: Foram selecionados 44 resumos e acessados 29 textos na íntegra. O “Journal of the American Geriatric Society” foi o periódico com mais publicações e os Estados Unidos com mais estudos. A categoria médica publicou 75,0%; 79,3% dos estudos são descritivos; 69% das cirurgias foram no quadril e 27,6% das pesquisas utilizaram apenas um instrumento de avaliação. Das dimensões avaliadas destacam-se: funcional com 43,6% e mental com 30,8%. Considerações finais: A dimensão funcional foi a mais investigada e a social não foi contemplada. Apesar das publicações estarem aumentando nos últimos anos, faz-se necessário que os serviços de saúde especializados incorporem o paradigma da avaliação funcional da saúde do idoso.Illnesses from muscles and skeleton, constitute the cause of functional damage of elderly. Nevertheless they are not inevitable consequences of age and they should be approached as specific illnesses rather then being regarded as result of aging. All aspects of health must be accounted for the measurement of the elderly health (Full Geriatric Assessment). Objective: To review the scientific publication dealing with the functional condition of elderly after subjected to orthopedic surgery. Material and Method: Bibliographic research on articles as per listing in the following databases www.bireme.br, www.ncbi.nlm.nih.gov/pubmed, www.scopus.com and www.embase.com covering a period from 1996 to 2006. It has been adopted the terminology as per Science of Health (DeCs/Birene) and at Medical Subject Headings (MeSH/PubMed) that identified the key-words: elderly, daily activity, orthopedic surgery or orthopedic procedures, post-surgery and rehabilitation. The search was carried out on April 2006 and the inclusion criterion was that the test subjects should be older than 60 and subjected to any orthopedic surgery procedure. The references meeting this criterion were listed and analyzed in EpiInfo version 3.3.2. The variables were: title, year and country of publication, professional categories of the authors, country of origin of the study, objective of the research, number of assessment tools, types of assessment tools, site of the surgery, full report available on line. Results: 44 abstracts have been selected among of which 29 were available as full reports. The Journal of the American Geriatric Society was the one that has published the largest number of articles dealing with this issue and the US was the country that has issued the greatest number of publication. 75% of the articles fitted within medical category, 79.3% of the studies are descriptive, 69% of the surgeries were on the hips and 27.6% of the searches employed only one assessment tool. Among the dimensions that have been evaluated 43.6% dealt with functional status while 30.8% were about mental status. Final Notes: The functional dimension was the most investigated while the social dimension was not contemplated. Although the number of publication is increasing in the last years, it’s necessary that health service starts to incorporate the new paradigm of functional evaluation of the elderly health

Pathologic confirmation of retinal ganglion cell loss in multiple system atrophy

Multiple system atrophy (MSA) is a rare adult-onset rapidly progressive fatal neurodegenerative disorder characterized by the abnormal aggregation of misfolded α-synuclein primarily in oligodendrocytes.NIH (U54-NS065736-01), Multiple System Atrophy Coalition, Michael J. Fox Foundation, Dysautonomia Foundation, Regional Government of Valencia (Prometeo 2016/158), Spanish Health Research Institute Carlos III (ISCIII RETICS-FEDER RD12/0034/0010), Ministry of Economy of Spain (MINECO-FEDER-BFU2015-67139-R), and Ministry of Education of Spain (FPU14/03166)

Nutrient removal and yield of different maize hybrids

Objective: to determine the macro and micronutrient removal values and potential yield of different hybrids, and, also to determine the relationship between grain nutrient removal and grain yield. Design/methodology/approach: to assess correlations and determine the association degree between the nutrient removal values and grain yield. Results: the total nutrient removal values were in N> K> Ca> Mg> P, and Mn> Fe> Zn> B> Cu order, which are higher values when compared to another research. Also, these provide the mineral content in grains, which is a nutritional quality-related parameter. Limitations on study/implications: increasing the number of hybrids, different fertilization rates, different soil conditions, and crop management practices should be evaluated to assess whether these influence/inhibit the final nutrient concentration and total removal in grain. Findings/conclusions: The total grain nutrient removal values varied as a function of hybrids, yield goal, and nutrient concentration in tissues. These values allow the adjustment of current fertilization rates. The same hybrids under different management practices (fertilization dose), or soil types, substantially influence the grain nutrient concentration and therefore total nutrient removal

TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity

Topoisomerase IIβ-binding protein 1 (TOPBP1) participates in DNA replication and DNA damage response; however, its role in DNA repair and relevance for human cancer remain unclear. Here, through an unbiased small interfering RNA screen, we identified and validated TOPBP1 as a novel determinant whose loss sensitized human cells to olaparib, an inhibitor of poly(ADP-ribose) polymerase. We show that TOPBP1 acts in homologous recombination (HR) repair, impacts olaparib response, and exhibits aberrant patterns in subsets of human ovarian carcinomas. TOPBP1 depletion abrogated RAD51 loading to chromatin and formation of RAD51 foci, but without affecting the upstream HR steps of DNA end resection and RPA loading. Furthermore, TOPBP1 BRCT domains 7/8 are essential for RAD51 foci formation. Mechanistically, TOPBP1 physically binds PLK1 and promotes PLK1 kinase–mediated phosphorylation of RAD51 at serine 14, a modification required for RAD51 recruitment to chromatin. Overall, our results provide mechanistic insights into TOPBP1’s role in HR, with potential clinical implications for cancer treatment

INT reduction is a valid proxy for eukaryotic plankton respiration despite the inherent toxicity of INT and differences in cell wall structure

The reduction of 2-para (iodophenyl)-3(nitrophenyl)-5(phenyl) tetrazolium chloride (INT) is increasingly being used as an indirect method to measure plankton respiration. Its greater sensitivity and shorter incubation time compared to the standard method of measuring the decrease in dissolved oxygen concentration, allows the determination of total and size-fractionated plankton respiration with higher precision and temporal resolution. However, there are still concerns as to the method’s applicability due to the toxicity of INT and the potential differential effect of plankton cell wall composition on the diffusion of INT into the cell, and therefore on the rate of INT reduction. Working with cultures of 5 marine plankton (Thalassiosira pseudonana CCMP1080/5, Emiliania huxleyi RCC1217, Pleurochrysis carterae PLY-406, Scrippsiella sp. RCC1720 and Oxyrrhis marina CCMP1133/5) which have different cell wall compositions (silica frustule, presence/absence of calcite and cellulose plates), we demonstrate that INT does not have a toxic effect on oxygen consumption at short incubation times. There was no difference in the oxygen consumption of a culture to which INT had been added and that of a replicate culture without INT, for periods of time ranging from 1 to 7 hours. For four of the cultures (T. pseudonana CCMP1080/5, P. carterae PLY-406, E. huxleyi RCC1217, and O. marina CCMP1133/5) the log of the rates of dissolved oxygen consumption were linearly related to the log of the rates of INT reduction, and there was no significant difference between the regression lines for each culture (ANCOVA test, F = 1.696, df = 3, p = 0.18). Thus, INT reduction is not affected by the structure of the plankton cell wall and a single INT reduction to oxygen consumption conversion equation is appropriate for this range of eukaryotic plankton. These results further support the use of the INT technique as a valid proxy for marine plankton respiration

Establishment and Characterization of Immortalized Neuronal Cell Lines Derived From the Spinal Cord of Normal and Trisomy 16 Fetal Mice, an Animal Model of Down Syndrome

We report the establishment of continuously growing cell lines from spinal cords of normal and trisomy 16 fetal mice. We show that both cell lines, named M4b (derived from a normal animal) and MTh (trisomic) possess neurological markers by immunohistochemistry (neuron specific enolase, synaptophysin, microtubule associated protein-2 [MAP-2], and choline acetyltransferase) and lack glial traits (glial fibrillary acidic protein and S10

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London