128 research outputs found
Robotic assisted Laparoscopic partial Nephrectomy for suspected Renal Cell Carcinoma: Retrospective review of surgical outcomes of 35 Cases
- Author
- Publication venue
- BioMed Central
- Publication date
- 01/01/2008
- Field of study
This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens
Process evaluation protocol for the I-WOTCH study: an opioid tapering support programme for people with chronic non-malignant pain
- Author
- Publication venue
- 'BMJ'
- Publication date
- 10/10/2019
- Field of study
58.<Nichols VP, Abraham C, Eldabe S, Sandhu HK, Underwood M, Seers K onbehalf of the I-WOTCH Team (Iglesias CP is member of the I-WOTCH team).. BMJ Open 2019; 9(10):e028998. Published online 2019 Oct 10. DOI: 10.1136/bmjopen-2019-028998PMID: 3160158
Recent advances and perspectives on starch nanocomposites for packaging applications
- Author
- A Buléon
- A Conte
- A Kaushik
- A Störmer
- AA Sapalidis
- AJ Svagan
- AT Issa
- B Adhikari
- B Chen
- B Khan
- B Schmidt
- B Schmidt
- C Huang
- C Silvestre
- CA Romero-Bastida
- D Liu
- D Parra
- D Schlemmer
- DL Corre
- E Fortunati
- E Nyankson
- ED Teixeira
- ES Medeiros
- ES Medeiros
- European Union
- F Sadegh-Hassani
- F Xie
- G Madhumitha
- GO Noonan
- H Aloui
- H Liu
- H Park
- H Schmitt
- H Schmitt
- H Schmitt
- H Zou
- HM Kim
- IS Arvanitoyannis
- IS Arvanitoyannis
- J Cheng
- J Guimarães
- J Huang
- J Rhim
- J Zhu
- JF Robyt
- JH Llanos
- K Dean
- K González
- K Majdzadeh-Ardakani
- KK Kuorwel
- L Avérous
- L Avérous
- L Famá
- L Liu
- L Wei
- LD Maio
- LM Famá
- M Avella
- M Babaee
- M Hietala
- M Huang
- M Mauricio-Iglesias
- M Mutsuga
- M Petersson
- M Raheel
- MA Busolo
- MC Galdeano
- MJ Fabra
- MR Sofla
- N Lilichenko
- N Reddy
- NL García
- NL García
- O Olatunji
- P Dong
- P Koinkar
- P Scarfato
- P Zheng
- PM Visakh
- R Li
- R Shi
- RA Talja
- RF Tester
- S Girdthep
- S Maisanaba
- S Mattioli
- S Park
- S Yoon
- SH Othman
- SK Swain
- SM Meira
- SS Paes
- ST Sam
- T Ma
- VG Souza
- VP Cyras
- X Cao
- X Ma
- X Ma
- Y Echegoyen
- Y He
- Y Xie
- Yu Dong
- Zainab Waheed Abdullah
- ZW Abdullah
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Starch nanocomposites are popular and abundant materials in packaging sectors. The aim of this work is to review some of the most popular starch nanocomposite systems that have been used nowadays. Due to a wide range of applicable reinforcements, nanocomposite systems are investigated based on nanofiller type such as nanoclays, polysaccharides and carbonaceous nanofillers. Furthermore, the structures of starch and material preparation methods for their nanocomposites are also mentioned in this review. It is clearly presented that mechanical, thermal and barrier properties of plasticised starch can be improved with well-dispersed nanofillers in starch nanocomposites
Models of chronic obstructive pulmonary disease
- Author
- A Adler
- A Churg
- A Churg
- A Churg
- A Farone
- A Kauffmann-Zeh
- A Sydbom
- AG Agusti
- AJ Sandford
- AM Schols
- AM Vignola
- B Jany
- B Meshi
- BG Cosio
- BR Celli
- C Albrecht
- C Fletcher
- C Kuhn
- C Kuhn
- C Martin
- CJL Murray
- D Stanescu
- DA Groneberg
- DA Groneberg
- DA Groneberg
- DA Groneberg
- DA Groneberg
- DA Groneberg
- DA Groneberg
- DA Groneberg
- DA Groneberg
- DA Lomas
- DE Niewoehner
- DG Morris
- DP Wendel
- DR Parkinson
- E Azoulay-Dupuis
- E Cano
- E Ogawa
- E Pizzichini
- EB Haddad
- EB Haddad
- EB Haddad
- EC Lucey
- EH Wittels
- EK Silverman
- ER Sutherland
- F Chung
- F Vai
- FM Moodie
- GA Finlay
- GD Massaro
- GD Massaro
- GL Snider
- GL Snider
- GL Snider
- GL Snider
- GW Hunninghake
- GW Hunninghake
- H Bostrom
- H Ernst
- H Parfrey
- H Tsukagoshi
- HJ Colebatch
- HP Gerber
- I Ito
- I Retamales
- I Rubio-Aliaga
- IS Mudway
- J D'Armiento
- J Kleinerman
- J Majo
- J Springer
- J Springer
- J Springer
- J Springer
- J Springer
- J Sun
- JA Marwick
- JC Hogg
- JC Kips
- JL Wright
- JL Wright
- JM Drazen
- JN Clark
- JR Foster
- JR Harkema
- JT Mao
- JY Ma
- K Donaldson
- K Donaldson
- K Fujimoto
- K Ito
- K Kostikas
- KF Chung
- KF Chung
- KF Chung
- KJ Holroyd
- KJ Leco
- L Wu
- LM Fabbri
- LM Reid
- M Corradi
- M Cosio
- M Fujita
- M Hind
- M Nishikawa
- M Saetta
- M Saetta
- M Saetta
- M Saetta
- M Saetta
- M Saetta
- M Wegmann
- M Weinstein
- M Wills-Karp
- M Yoshida
- ML Miller
- N Keicho
- N Minematsu
- NC Long
- NC Long
- NH Al-Humadi
- NM Lightowler
- P Chanez
- P Lindahl
- P Montuschi
- P Paredi
- PA Martorana
- PA Martorana
- PJ Barnes
- PJ Barnes
- PJ Barth
- PJ Rombout
- PM O'Byrne
- PR Eynott
- PR Eynott
- PR Eynott
- R Corteling
- R Dhami
- R Mahadeva
- RA Pauwels
- RA Pauwels
- RA Stockley
- RD Hautamaki
- RM Senior
- RW Penman
- S Baraldo
- S Kerzel
- S Lim
- S Nicosia
- S Shore
- SA Kharitonov
- SAM Lim
- SC McCloskey
- SD Shapiro
- SD Shapiro
- SD Shapiro
- SD Shapiro
- SD Shapiro
- SF Man
- STEVEND Shapiro
- SV Culpitt
- T Matsuse
- T Nakamura
- T Zheng
- TC O'Shaughnessy
- TH March
- TZ Vitalis
- UP Kodavanti
- V Lagente
- V Ranga
- W Klein
- WA Biernacki
- WM Elliott
- X Xu
- Y Kasahara
- Y Zhang
- YASUNORI Kasahara
- Z Xia
- Z Zhu
- Publication venue
- BioMed Central
- Publication date
- 01/01/2004
- Field of study
Chronic obstructive pulmonary disease (COPD) is a major global health problem and is predicted to become the third most common cause of death by 2020. Apart from the important preventive steps of smoking cessation, there are no other specific treatments for COPD that are as effective in reversing the condition, and therefore there is a need to understand the pathophysiological mechanisms that could lead to new therapeutic strategies. The development of experimental models will help to dissect these mechanisms at the cellular and molecular level. COPD is a disease characterized by progressive airflow obstruction of the peripheral airways, associated with lung inflammation, emphysema and mucus hypersecretion. Different approaches to mimic COPD have been developed but are limited in comparison to models of allergic asthma. COPD models usually do not mimic the major features of human COPD and are commonly based on the induction of COPD-like lesions in the lungs and airways using noxious inhalants such as tobacco smoke, nitrogen dioxide, or sulfur dioxide. Depending on the duration and intensity of exposure, these noxious stimuli induce signs of chronic inflammation and airway remodelling. Emphysema can be achieved by combining such exposure with instillation of tissue-degrading enzymes. Other approaches are based on genetically-targeted mice which develop COPD-like lesions with emphysema, and such mice provide deep insights into pathophysiological mechanisms. Future approaches should aim to mimic irreversible airflow obstruction, associated with cough and sputum production, with the possibility of inducing exacerbations
Mild cognitive impairment and deficits in instrumental activities of daily living: a systematic review
- Author
- A Bowers
- AF Jorm
- AK Desai
- AL Jefferson
- B Boeve
- B Winblad
- Bengt Winblad
- BH DeBettignies
- Bruno Dubois
- C Malinowsky
- C Malinowsky
- C Muñoz-Neira
- C Owsley
- C Wattmo
- C Wattmo
- Carina Wattmo
- CL Burton
- CM Cullum
- CW Tam
- D Galasko
- D Galasko
- DA Loewenstein
- DC Marson
- DC Marson
- DL Binegar
- E Aretouli
- E Mariani
- E Teng
- E Teng
- Elmar Graessel
- EM Ebly
- Emma Law
- Eric Salmon
- Florence Pasquier
- FS Pereira
- G Glosser
- GM McKhann
- H Agüero-Torres
- H Amieva
- H Ku
- H Pedrosa
- HR Griffith
- I Gelinas
- I Hindmarch
- IS Ahn
- J Rotrou de
- JE Graham
- Jean-Marc Orgogozo
- JN Morris
- José L Molinuevo
- K Peres
- K Pérès
- K Ritchie
- Karine Peres
- Katrin Jekel
- KL Triebel
- KR Kim
- L Nygård
- L Nygård
- L Rosenberg
- Louise Nygård
- Lucrezia Hausner
- Lutz Frölich
- M Schmitter-Edgecombe
- Magda Tsolaki
- Marcel GM Olde-Rikkert
- Maria Eriksdotter
- Marinella Damian
- MF Folstein
- MG Sherod
- MH Tabert
- Michael Ewers
- Milica G Kramberger
- ML O’Connor
- MP Lawton
- MS Albert
- O Zanetti
- OC Okonkwo
- P Werner
- Patrizia Mecocci
- Peter J Connelly
- PJ Brown
- R Bruininks
- R Levy
- R Perneczky
- R Perneczky
- RC Petersen
- RC Petersen
- RC Petersen
- René Spiegel
- RI Pfeffer
- Roger Bullock
- S Larrieu
- S Reppermund
- S Reppermund
- S Weintraub
- S Willis
- SAM Sikkes
- Sietske AM Sikkes
- SM Albert
- ST Farias
- ST Farias
- T Crook
- T Giovannetti
- T Luck
- TE Goldberg
- TL Patterson
- Tomasz Sobow
- V Njegovan
- VG Wadley
- VG Wadley
- VG Wadley
- YC Yeh
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen
- Author
- Abante J
- Abecassis BS
- Aben N
- Aghamirzaie D
- Ahsen ME
- Aittokallio T
- Akhtari FS
- Al-lazikani B
- Alam T
- Allam A
- Allen C
- Altarawy D
- Alves V
- Amadoz A
- Anchang B
- Angel Pujana M
- Antolin AA
- Ash JR
- Ba-alawi W
- Bagheri M
- Bajic V
- Ball G
- Ballester PJ
- Baptista D
- Bare C
- Bateson M
- Bender A
- Bertrand D
- Boroevich KA
- Bosdriesz E
- Bougouffa S
- Bounova G
- Brouwer T
- Bryant B
- Bulusu KC
- Calaza M
- Calderone A
- Calza S
- Capuzzi S
- Carbonell-Caballero J
- Carlin D
- Carter H
- Castagnoli L
- Celebi R
- Cesareni G
- Chang H
- Chen G
- Chen H
- Chen H
- Cheng L
- Chernomoretz A
- Chicco D
- Cho K-H
- Cho S
- Choi D
- Choi J
- Choi K
- Choi M
- Coker E
- Combinatio A-SD
- Cortes-Ciriano I
- Cserzo M
- Cubuk C
- Curtis C
- Dang CC
- de Almeida MP
- De Cock M
- de Esch I
- de Graaf C
- De Maeyer D
- De Niz C
- de Ruiter JR
- De Troyer E
- Di Veroli GY
- Dijkstra T
- Dopazo J
- Draghici S
- Drosou A
- Dry JR
- Dumontier M
- Ehrhart F
- Eid F-E
- ElHefnawi M
- Elmarakeby H
- Engin HB
- Evelo C
- Falcao AO
- Farag S
- Fawell S
- Fernandez-Lozano C
- Fisch K
- Flobak A
- Fornari C
- Foroushani ABK
- Fotso DC
- Fourches D
- Friend S
- Frigessi A
- Gao F
- Gao X
- Garnett MJ
- Gerold JM
- Gestraud P
- Ghazoui Z
- Ghosh S
- Gillberg J
- Godoy-Lorite A
- Godynyuk L
- Godzik A
- Goldenberg A
- Gomez-Cabrero D
- Gonen M
- Gray H
- Grechkin M
- Guan Y
- Guimera R
- Guinney J
- Guney E
- Haibe-Kains B
- Han Y
- Hase T
- He D
- He L
- Heath LS
- Hellton KH
- Helmer-Citterich M
- Hidalgo MR
- Hidru D
- Hill SM
- Hochreiter S
- Hong S
- Hovig E
- Hsueh Y-C
- Hu Z
- Huang JK
- Huang RS
- Hunyady L
- Hwang J
- Hwang TH
- Hwang W
- Hwang Y
- Isayev O
- Jack J
- Jahandideh S
- Jang IS
- Jeon M
- Ji J
- Jo Y
- Kamola PJ
- Kanev GK
- Kang J
- Karacosta L
- Karimi M
- Kaski S
- Kazanov M
- Khamis AM
- Khan SA
- Kiani NA
- Kim A
- Kim J
- Kim J
- Kim K
- Kim K
- Kim S
- Kim Y
- Kim Y
- Kirk PDW
- Kitano H
- Klambauer G
- Knowles D
- Ko M
- Kohn-Luque A
- Kooistra AJ
- Kuenemann MA
- Kuiper M
- Kurz C
- Kwon M
- Laegreid A
- Lederer S
- Lee H
- Lee J
- Lee YW
- Leppaho E
- Lewis R
- Li J
- Li L
- Liley J
- Lim WK
- Lin C
- Liu Y
- Lopez Y
- Low J
- Lysenko A
- Machado D
- Madhukar N
- Malpartida AB
- Mamitsuka H
- Marabita F
- Marchal K
- Marttinen P
- Mason D
- Mason MJ
- Mazaheri A
- Mehmood A
- Mehreen A
- Menden MP
- Michaut M
- Miller RA
- Mitsopoulos C
- Modos D
- Moo K
- Motsinger-Reif A
- Movva R
- Muraru S
- Muratov E
- Mushthofa M
- Nagarajan N
- Nakken S
- Nath A
- Neto EC
- Neuvial P
- Newton R
- Nguyen T
- Ning Z
- Norman T
- Oliva B
- Olsen C
- Palmeri A
- Panesar B
- Papadopoulos S
- Park J
- Park S
- Park S
- Pawitan Y
- Peluso D
- Pendyala S
- Peng J
- Perfetto L
- Pirro S
- Plevritis S
- Politi R
- Poon H
- Porta E
- Prellner I
- Preuer K
- Ramnarine R
- Reid JE
- Reyal F
- Richardson S
- Ricketts C
- Rieswijk L
- Rocha M
- Rodriguez-Gonzalvez C
- Roell K
- Romeo Aznar V
- Rotroff D
- Rukawa P
- Sadacca B
- Saez-Rodriguez J
- Safikhani Z
- Safitri F
- Sales-Pardo M
- Sauer S
- Schlichting M
- Seoane JA
- Serra J
- Shang M-M
- Sharma A
- Sharma H
- Shen Y
- Shiga M
- Shin M
- Shkedy Z
- Shopsowitz K
- Sinai S
- Skola D
- Smirnov P
- Soerensen IF
- Soerensen P
- Song J-H
- Song SO
- Soufan O
- Spitzmueller A
- Steipe B
- Stolovitzky G
- Suphavilai C
- Szalai B
- Tamayo SP
- Tamborero D
- Tang EKY
- Tang J
- Tanoli Z-U-R
- Tarres-Deulofeu M
- Tegner J
- Thommesen L
- Tonekaboni SAM
- Tran H
- Truong A
- Tsunoda T
- Turu G
- Tzeng G-Y
- Van Daele D
- van Engelen B
- van Laarhoven T
- Van Moerbeke M
- van Westen GJP
- Verbeke L
- Videla S
- Vis D
- Vogel R
- Voronkov A
- Votis K
- Walk OBD
- Wang A
- Wang D
- Wang H-QH
- Wang P-W
- Wang S
- Wang W
- Wang X
- Wang X
- Wennerberg K
- Wernisch L
- Wessels L
- Westerman BA
- White SR
- Wijayawardena B
- Willighagen E
- Wolfinger R
- Wurdinger T
- Xie L
- Xie S
- Xu H
- Yadav B
- Yau C
- Yeerna H
- Yin JW
- Yu M
- Yu M
- Yu T
- Yun SJ
- Zakharov A
- Zamichos A
- Zanin M
- Zaslavskiy M
- Zeng L
- Zenil H
- Zhang F
- Zhang P
- Zhang W
- Zhao H
- Zhao L
- Zheng W
- Zoufir A
- Zucknick M
- Publication venue
- Publication date
- 01/01/2019
- Field of study
The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZeneca’s large drug combination dataset, consisting of 11,576 experiments from 910 combinations across 85 molecularly characterized cancer cell lines, and results of a DREAM Challenge to evaluate computational strategies for predicting synergistic drug pairs and biomarkers. 160 teams participated to provide a comprehensive methodological development and benchmarking. Winning methods incorporate prior knowledge of drug-target interactions. Synergy is predicted with an accuracy matching biological replicates for >60% of combinations. However, 20% of drug combinations are poorly predicted by all methods. Genomic rationale for synergy predictions are identified, including ADAM17 inhibitor antagonism when combined with PIK3CB/D inhibition contrasting to synergy when combined with other PI3K-pathway inhibitors in PIK3CA mutant cells.Peer reviewe
Laparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study.
- Author
- Abantanga F
- Abbas M
- Abbo O
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elrasoul Y
- Abdallah E
- Abdel-Wahab NYE
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelkader M
- Abdelkareem A
- Abdelraheim M
- Abdelshafy M
- Abdulgawad M
- Abdullah AAN
- Abdullah NAN
- Abebe NS
- Abebe NS
- Aber A
- Abington E
- Aboarab A
- Aboraya M
- Aboraya M
- Abouelnasr A
- Abouzahra A
- Abozaid M
- Abozeid K
- Abozyed MAF
- Abudeeb H
- Abuseif M
- Acharya P
- Adams R
- Adebanjo A
- Adekoya A
- Adel A
- Adel A
- Ademuyiwa A
- Ademuyiwa AO
- Adeniran J
- Adeniyi A
- Adesanya O
- Adesina A
- Adesuyi A
- Adeyeye A
- Adham W
- Afandy A
- Afifi AM
- Afzal M
- Agalianos C
- Agarwal A
- Agius M
- Aguilar-Jimenez J
- Aguilera M
- Aguilera O
- Ahlqvist S
- Ahmed A
- Ahmed EA
- Ahmed H
- Ahmed SM
- Aigrain Y
- Ajao AE
- Akeel N
- Akhtar M
- Al Awwad S
- Al-Aarag AA-R
- Al-Azraqi IAA
- Al-Faifi JJ
- Al-Hameedi HII
- Al-Hasani RKMJ
- Al-Mallah A
- Al-Mousa M
- Al-Nahrawi S
- Al-Obaedi O
- Al-shammari A
- Alahmady O
- Alakaloko F
- Alamoudi U
- Albeladi B
- Aldalaq A
- Aldhafeeri S
- Aledrisy M
- Alfarsi MA
- Alghamdi B
- Alghamdi M
- Algohary O
- Alhabli I
- Alhendy M
- Ali A
- Ali A
- Ali H
- Ali SS
- Alimi Q
- Aljiffry M
- Aljohani E
- Aljohani S
- Alkammash A
- Alkhabbaz D
- Alkhouri M
- Allam M
- Allegri A
- Allen JLY
- Allott R
- Almallah A
- Almoflihi A
- Almuallem S
- Almy J
- Alnawam E
- Alnuqaydan SA
- Alomar IN
- Alqahtani E
- Alrahawy M
- Alrajraji M
- Alrifaie A
- AlRowais M
- Alsaggaf M
- Alsaggaf MU
- Altaf A
- Altamimi A
- Althwainy A
- Altoe F
- Altwigry AM
- Alvarado Jaramillo R
- Alvarez Barreda LM
- Alwafai MG
- Aly AK
- Alyami R
- AlYoussef I
- Alzahrani M
- Alzayat T
- Amandito R
- Ambrozeviciute V
- Ameen M
- Amer MA
- Amin J
- Ammar M
- Ammar MS
- Amreia M
- Anandkumar D
- Anderson D
- Anderson R
- Anderson-Knight H
- Andersson L
- Andres Garcia-Marin J
- Ansaloni L
- Antar S
- Anthoulakis C
- Anwar AW
- Anwer W
- Anyanwu L-J
- Aql S
- Arachchi PP
- Arachchige LAJJ
- Aranzabal Durand SY
- Araujo R
- Ardley R
- Arenas A
- Arevalo Azmitia JR
- Arias Pacheco RD
- Arman S
- Arnaud AP
- Arnaud AP
- Arroyo Basto CA
- Arulampalam T
- Asal M
- Asele FA
- Ashraf SF
- Ashton A
- Assouto PA
- Ata AAA
- Atkinson K
- Atobatele K
- Attallah NA
- Attard M
- Attia AM
- Aung KP
- Austraite A
- Awuku-Asabre J
- Ayad S
- Ayandipo OO
- Ayyar S
- Azmitia Mendizabal CA
- Azodo IA
- Azzie G
- Badr A
- Badwi NM
- Badwy A
- Baheeg M
- Bailey K
- Baillie K
- Baird A
- Bakhaidar M
- Baldacchino M
- Balila RMH
- Balkan AZA
- Balmaceda R
- Bamicha A
- Barakat SAE
- Barker T
- Barnacle J
- Barneo L
- Barrionuevo Ojeda RR
- Barrios E
- Barrios E
- Barros De Castro Segundo LC
- Barroso de Lima CV
- Barry J
- Basson S
- Batista Lemaire S
- Batt J
- Beasley W
- Beaton C
- Behar N
- Beisa V
- Benevento A
- Benger M
- Benons N
- Beuran M
- Beyene R
- Bezerra Morais PA
- Bezzina M
- Bhangu A
- Bhargava A
- Bharj IS
- Bhat S
- Bhattacharya S
- Bhopal KF
- Bin Mahamood A
- Birring A
- Bjorklund I
- Blencowe N
- Blower E
- Blundell R
- Boakye-Yiadom K
- Boal M
- Boddy A
- Bode C
- Boereboom C
- Boijsen M
- Bokhari S
- Bonavina L
- Bondurri A
- Bonnard A
- Borda Luque G
- Borg E
- Borin E
- Bortolasi L
- Boshnaq M
- Botes S
- Botto N
- Bouali O
- Bowe R
- Bowley D
- Bowman C
- Boyce T
- Bradulskis S
- Bratu R-M
- Braungart S
- Bray LD
- Breitenstein S
- Brogden T
- Brown D
- Brown E
- Brown J
- Brown J
- Browning DRL
- Bugaev N
- Bugeja R
- Bukari M
- Burns H
- Cabala Chiong JA
- Cacurri A
- Cadogan DD
- Cahill R
- Camacho R
- Cameron B
- Camilleri-Brennan J
- Camilleri-Brennan JF
- Capleton P
- Careta MC
- Carlucci M
- Carreira J-A
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- Iqbal FM
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- Lakhani SM
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- Macfarlane A
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- Mclean AL
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- Mendoza I
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- Menshawy A
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- Messa Aguilar WL
- Metwally MM
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- Mijuskovic B
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- Mustafa M-A
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- Naranjo Aristizabal FA
- Narvestad JK
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- Neophytou C
- Nepogodiev D
- Nesaratnam A
- Newton T
- Ng S
- Ngayu N
- Ngwa TE
- Nighat B
- Nigo S
- Nikoloudis N
- Niragire A
- Niyirera E
- Nnajiuba H
- Nocito A
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- Normile C
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- Odeyemi B
- Oefner D
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- Palliyil MM
- Palma AF
- Palomino Castillo VD
- Paludi MA
- Panait N
- Panieri E
- Parakh J
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- Parent V
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- Pereira B
- Perez Velasquez CI
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- Peycelon M
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- Pimenta ML
- Pino W
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- Regalado F
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- Skardziukaite A
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- Soeselo DA
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- Ubhi HK
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- Urbanavicius L
- Urbina Rojas NM
- Urbonas T
- Urniezius Z
- Usaityte A
- Utter M
- Valente Laufer LA
- Van Duren B
- Varcada M
- Varkalys K
- Vartic M
- Vella-Baldacchino M
- Venskutonis D
- Venugopal C
- Vergara Celis JM
- Veronese E
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- Vimalachandran D
- Vincent J
- Vivekanantham S
- Vlachogiorgos A
- Wagener M
- Waleed H
- Walsh U
- Ward AE
- Ward S
- Warda M
- Warren O
- Warwick AM
- Watson NFS
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- Weber B
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- Weinstein MS
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- Whewell H
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- Wild JRL
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- Williams G
- Williams O
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- Wilson A
- Wilson MSJ
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- Witherspoon P
- Wogensen F
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- Wold TB
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- Yallop L
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- Yaseen TM
- Yavuz MA
- Yee J
- Yeo LS
- Yeung ENW
- Yong CO
- Youssef D
- Youssef H
- Youssif JH
- Zachariades D-C
- Zakir M
- Zalabia MF
- Zamarin K
- Zani A
- Zanini N
- Zapata Ponze De Leon M
- Zapata Ponze De Leon M
- Zardab A
- Zegarra S
- Zeidan S
- Zelada Alvarez II
- Zerihun AB
- Zhang Z
- Zheng F
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- Zilinskas J
- Zilinskiene R
- Zimmermann EF
- Zuber M
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
BACKGROUND: Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described. The aim was to identify variation in surgical management and outcomes of appendicitis within low-, middle-, and high-Human Development Index (HDI) countries worldwide. METHODS: This is a multicenter, international prospective cohort study. Consecutive sampling of patients undergoing emergency appendectomy over 6 months was conducted. Follow-up lasted 30 days. RESULTS: 4546 patients from 52 countries underwent appendectomy (2499 high-, 1540 middle-, and 507 low-HDI groups). Surgical site infection (SSI) rates were higher in low-HDI (OR 2.57, 95% CI 1.33-4.99, p = 0.005) but not middle-HDI countries (OR 1.38, 95% CI 0.76-2.52, p = 0.291), compared with high-HDI countries after adjustment. A laparoscopic approach was common in high-HDI countries (1693/2499, 67.7%), but infrequent in low-HDI (41/507, 8.1%) and middle-HDI (132/1540, 8.6%) groups. After accounting for case-mix, laparoscopy was still associated with fewer overall complications (OR 0.55, 95% CI 0.42-0.71, p < 0.001) and SSIs (OR 0.22, 95% CI 0.14-0.33, p < 0.001). In propensity-score matched groups within low-/middle-HDI countries, laparoscopy was still associated with fewer overall complications (OR 0.23 95% CI 0.11-0.44) and SSI (OR 0.21 95% CI 0.09-0.45). CONCLUSION: A laparoscopic approach is associated with better outcomes and availability appears to differ by country HDI. Despite the profound clinical, operational, and financial barriers to its widespread introduction, laparoscopy could significantly improve outcomes for patients in low-resource environments. TRIAL REGISTRATION: NCT02179112
Measurements of Higgs bosons decaying to bottom quarks from vector boson fusion production with the ATLAS experiment at √=13TeV
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- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 23/06/2021
- Field of study
The paper presents a measurement of the Standard Model Higgs Boson decaying to b-quark pairs in the vector boson fusion (VBF) production mode. A sample corresponding to 126 fb−1 of s√=13TeV proton–proton collision data, collected with the ATLAS experiment at the Large Hadron Collider, is analyzed utilizing an adversarial neural network for event classification. The signal strength, defined as the ratio of the measured signal yield to that predicted by the Standard Model for VBF Higgs production, is measured to be 0.95+0.38−0.36 , corresponding to an observed (expected) significance of 2.6 (2.8) standard deviations from the background only hypothesis. The results are additionally combined with an analysis of Higgs bosons decaying to b-quarks, produced via VBF in association with a photon
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
- Aahlin EK
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
- Abantanga F
- Abantanga F
- Abbas A
- Abbas M
- Abbasy J
- Abbo O
- Abbo O
- Abbott T
- Abbouch M
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elmawla M
- Abd-Elrasoul Y
- Abdallah E
- Abdallah E
- Abdel-Aty A
- Abdel-Hameed N
- Abdel-Kader SM
- Abdel-Wahab NYE
- Abdelaal A
- Abdelaty M
- Abdelazeam AR
- Abdelazim G
- Abdelaziz MA
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- Abdelfatah A
- AbdelFattah I
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- Abdelhady S
- Abdelhamed R
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- Abdulhakeem EM
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- Lawal TA
- Lawani I
- Lawther R
- Lazzari G
- Lazzari V
- Lazzarini Cury AD
- Le VTH
- Leal A
- Leal M
- Leanne Almanon C
- Lecompte J-F
- Lee C
- Lee EX
- Lee F
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- Leppaniemi A
- Leppaniemi A
- Leroux J
- Leung KW
- Leung MF
- Leusink A
- Lewis J
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- Liew I
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- Lilford R
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- Lim G
- Lim H
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- Lim PJ
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- Lim SY
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- Limaye N
- Limoges B
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- lo Conte A
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- Macchitella Y
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- Macfarlane A
- Machaca M
- Machain Vega GM
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- Maciejec L
- Madiba T
- Madkor MH
- Madrid Barrientos LA
- Maffioli A
- Maffioli A
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- Magdy B
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- Magdy H
- Magdy M
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- Magee C
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- Mahmoud MI
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- Manchego Bautista AC
- Manchego Bautista AC
- Manfreda S
- Mangan C
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- Mangiapane M
- Manipal CE
- Maniscalco A
- Mann T
- Mannu GS
- Mano MJB
- Manrique Sila G
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- Mansor EY
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- Marroquin Rodriguez DE
- Marshall DC
- Martian B-V
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- Matos-Puig R
- Mattar O
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- Menegussi J
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- Merlo MS
- Mesbah N
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- Metwally MM
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- Mihaljevic AL
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- Mircea H
- Mirghani D
- Mironescu A
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- Mirza A
- Mirza S
- Mistry A
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- Mitroudi M
- Mitroudis N
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- Mizzi C
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- Moaty M
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- Modolo MM
- Moe TT
- Mogan YP
- Moghazy ME
- Mohamed A
- Mohamed A
- Mohamed AM
- Mohamed AR
- Mohamed B
- Mohamed F
- Mohamed I
- Mohamed M
- Mohamed MA
- Mohamed MAEH
- Mohamed MM
- Mohamed O
- Mohamed SR
- Mohameden A
- Mohammad A
- Mohammad A
- Mohammed A
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- Mohammed AR
- Mohammed H
- Mohammed MM
- Mohammed MMH
- Mohammed S
- Mohan H
- Mohan M
- Mohan M
- Mok YT
- Mokhtar A
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- Monrad-Hansen PW
- Monteleone M
- Monteleone M
- Montes I
- Montes I
- Montoya Botero JA
- Montrimaite M
- Montrimaite M
- Moodley Y
- Moore R
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- Mora JJV
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- Morandi E
- Moreira G
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- Morsi A
- Morsi M
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- Morton R
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- Mosalum O
- Mostafa HA
- Mostafa M
- Mostafa M
- Mousa M
- Moussa O
- Moustafa A
- Mouttalib S
- Mowafy B
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- Mshelbwala P
- Msiska N
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- Nanthakumaran S
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- Nwabuoku E
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- Perez Velasquez CI
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- Samaraweera DI
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- Semeda N
- Semiz A
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- Senanayake KJ
- Senanayake WSMKJ
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- Sgroi G
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- Shahbaz AR
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- Shalabi A
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- Shillito S
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- Silvani P
- Silvestre BP
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- Sleem AS
- Sleem M
- Smart N
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- Smedley A
- Smith C
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- Snyder E
- Soares Miguel GP
- Sobnach S
- Sodde P
- Soeselo DA
- Sokratous A
- Solaini L
- Solar Garcia L
- Solar Garcia L
- Soldevila-Verdeguer C
- Soley R
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- Soliman A
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- Soliman AR
- Soliman N
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- Soliman S
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- Sollazzo V
- Soltani N
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- Spurr M
- Sreedharan A
- Srinivasan R
- Sriram A
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- Sruogiene EZ
- Staerkle RF
- Starr N
- Stasinou T
- Steccanella F
- Stefanopoulos A
- Stephen A
- Stewart D
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- Suleiman SI
- Summerour V
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- Sundstrom SM
- Suresh S
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- Sutanto EPR
- Sutton P
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- Suyadi A
- Swann J
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- Syibrah KZ
- Sykes M
- Szczap A
- Szeto CCL
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- Tackie E
- Taddei A
- Tade A
- Tafazal H
- Taha EMS
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- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
Observation of Electroweak Production of a Same-Sign W Boson Pair in Association with Two Jets in pp Collisions root s=13 TeV with the ATLAS Detector
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- Zhemchugov A
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- Zivkovic L
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- Zou R
- Zu Theenhausen HM
- Zur Nedden M
- Zwalinski L
- Publication venue
- AMER PHYSICAL SOC
- Publication date
- 18/10/2019
- Field of study
This Letter presents the observation and measurement of electroweak production of a same-sign
W
boson pair in association with two jets using
36.1
fb
−
1
of proton-proton collision data recorded at a center-of-mass energy of
√
s
=
13
TeV
by the ATLAS detector at the Large Hadron Collider. The analysis is performed in the detector fiducial phase-space region, defined by the presence of two same-sign leptons, electron or muon, and at least two jets with a large invariant mass and rapidity difference. A total of 122 candidate events are observed for a background expectation of
69
±
7
events, corresponding to an observed signal significance of 6.5 standard deviations. The measured fiducial signal cross section is
σ
fid
=
2.89
+
0.51
−
0.48
(
stat
)
+
0.29
−
0.28
(
syst
)
fb
- …