152 research outputs found
Self-Interest versus Group-Interest in Antiviral Control
- Author
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2008
- Field of study
Antiviral agents have been hailed to hold considerable promise for the treatment and prevention of emerging viral diseases like H5N1 avian influenza and SARS. However, antiviral drugs are not completely harmless, and the conditions under which individuals are willing to participate in a large-scale antiviral drug treatment program are as yet unknown. We provide population dynamical and game theoretical analyses of large-scale prophylactic antiviral treatment programs. Throughout we compare the antiviral control strategy that is optimal from the public health perspective with the control strategy that would evolve if individuals make their own, rational decisions. To this end we investigate the conditions under which a large-scale antiviral control program can prevent an epidemic, and we analyze at what point in an unfolding epidemic the risk of infection starts to outweigh the cost of antiviral treatment. This enables investigation of how the optimal control strategy is moulded by the efficacy of antiviral drugs, the risk of mortality by antiviral prophylaxis, and the transmissibility of the pathogen. Our analyses show that there can be a strong incentive for an individual to take less antiviral drugs than is optimal from the public health perspective. In particular, when public health asks for early and aggressive control to prevent or curb an emerging pathogen, for the individual antiviral drug treatment is attractive only when the risk of infection has become non-negligible. It is even possible that from a public health perspective a situation in which everybody takes antiviral drugs is optimal, while the process of individual choice leads to a situation where nobody is willing to take antiviral drugs
Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV
- Author
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2013
- Field of study
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of √s = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pT≥20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60≤pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2≤{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration
Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector
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- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/12/2010
- Field of study
The inclusive and dijet production cross-sections have been measured for jets
containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass
energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The
measurements use data corresponding to an integrated luminosity of 34 pb^-1.
The b-jets are identified using either a lifetime-based method, where secondary
decay vertices of b-hadrons in jets are reconstructed using information from
the tracking detectors, or a muon-based method where the presence of a muon is
used to identify semileptonic decays of b-hadrons inside jets. The inclusive
b-jet cross-section is measured as a function of transverse momentum in the
range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet
cross-section is measured as a function of the dijet invariant mass in the
range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets
and the angular variable chi in two dijet mass regions. The results are
compared with next-to-leading-order QCD predictions. Good agreement is observed
between the measured cross-sections and the predictions obtained using POWHEG +
Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet
cross-section. However, it does not reproduce the measured inclusive
cross-section well, particularly for central b-jets with large transverse
momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final
version published in European Physical Journal
Body Fluid Cytokine Levels in Mild Cognitive Impairment and Alzheimer’s Disease: a Comparative Overview
- Author
- A Alvarez
- A Baranowska-Bik
- A Garlind
- A Hernanz
- A Koyama
- A Luigi De
- A Luigi De
- A Mocali
- AA Helmy
- AA Zasada
- AS Lanzrein
- B Juraskova
- B Servi De
- BA Lawlor
- BM Bettcher
- BS Diniz
- C Choi
- C Holmes
- C Laske
- C Laske
- C Laske
- C Lindberg
- C Ozturk
- C Yasutake
- CA Dinarello
- CC Chao
- CC Chao
- CE Teunissen
- CM Duijn van
- CR Jack Jr
- D Blum-Degen
- D Galimberti
- D Galimberti
- D Galimberti
- D Galimberti
- D Johnstone
- DA Llano
- E Gomez-Tortosa
- E Matsubara
- E Richartz
- E Rodriguez-Rodriguez
- E Rota
- E Tarkowski
- E Tarkowski
- E Tarkowski
- E Tarkowski
- EE Tuppo
- F Angelucci
- F Licastro
- F Licastro
- F Licastro
- F Licastro
- F Licastro
- Frederic Brosseron
- G Ait-ghezala
- G Li
- G McKhann
- G Zuliani
- G Zuliani
- H Bruunsgaard
- H Bruunsgaard
- H Fillit
- H Hampel
- H Hampel
- H Hampel
- H Inadera
- H Zetterberg
- HD Soares
- HD Soares
- I Blasko
- IM Cojocaru
- J Kalman
- J Lieberman
- J Marksteiner
- J Ojala
- J Vom Berg
- JC Jackson
- JD Correa
- JD Doecke
- JD Doecke
- JD Weaver
- JJ Locascio
- JK Kiecolt-Glaser
- JM Ringman
- JP Jia
- JS Rao
- K Blennow
- K Bonotis
- K Murase
- K Westin
- K Yaffe
- K Yamada
- KS Lee
- KS Lee
- L Malaguarnera
- L Parkitny
- M Bjorkqvist
- M Maes
- M Martinez
- M Martinez
- M Motta
- M Reale
- Marius Krauthausen
- Markus Kummer
- MF Folstein
- MG Dik
- MI Kester
- Michael T. Heneka
- MJ Engelhart
- MM Corsi
- N Rosler
- OV Forlenza
- P Angelis
- P Angelopoulos
- P Bermejo
- P Buchhave
- P Buchhave
- P Eikelenboom
- P Marz
- R Cacabelos
- R Chen
- R Craig-Schapiro
- R Schmidt
- S Bonaccorso
- S Engelborghs
- S Ray
- SB Solerte
- SD Mulder
- SE O’Bryant
- SE O’Bryant
- SM Kim
- SS Kale
- SS Kassner
- ST DeKosky
- T Honma
- T Pirttila
- TB Martins
- VH Perry
- VK Singh
- W Swardfager
- XA Alvarez
- Y Han
- Y Harigaya
- Y Hasegawa
- ZS Tan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
This article gives a comprehensive overview of cytokine and other inflammation associated protein levels in plasma, serum and cerebrospinal fluid (CSF) of patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI). We reviewed 118 research articles published between 1989 and 2013 to compare the reported levels of 66 cytokines and other proteins related to regulation and signaling in inflammation in the blood or CSF obtained from MCI and AD patients. Several cytokines are evidently regulated in (neuro-) inflammatory processes associated with neurodegenerative disorders. Others do not display changes in the blood or CSF during disease progression. However, many reports on cytokine levels in MCI or AD are controversial or inconclusive, particularly those which provide data on frequently investigated cytokines like tumor necrosis factor alpha (TNF-α) or interleukin-6 (IL-6). The levels of several cytokines are possible indicators of neuroinflammation in AD. Some of them might increase steadily during disease progression or temporarily at the time of MCI to AD conversion. Furthermore, elevated body fluid cytokine levels may correlate with an increased risk of conversion from MCI to AD. Yet, research results are conflicting. To overcome interindividual variances and to obtain a more definite description of cytokine regulation and function in neurodegeneration, a high degree of methodical standardization and patients collective characterization, together with longitudinal sampling over years is essential
Measurement of the cross-section for b-jets produced in association with a Z boson at root s=7 TeV with the ATLAS detector ATLAS Collaboration
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- Zhemchugov A
- Zheng S
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- Zhu Y
- Zhuang X
- Zhuravlov V
- Zieminska D
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- Zolnierowski Y
- Zsenei A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2011
- Field of study
A measurement is presented of the inclusive cross-section for b-jet production in association with a Z boson in pp collisions at a centre-of-mass energy of root s = 7 TeV. The analysis uses the data sample collected by the ATLAS experiment in 2010, corresponding to an integrated luminosity of approximately 36 pb(-1). The event selection requires a Z boson decaying into high P-T electrons or muons, and at least one b-jet, identified by its displaced vertex, with transverse momentum p(T) > 25 GeV and rapidity vertical bar y vertical bar < 2.1. After subtraction of background processes, the yield is extracted from the vertex mass distribution of the candidate b-jets. The ratio of this cross-section to the inclusive Z cross-section (the average number of b-jets per Z event) is also measured. Both results are found to be in good agreement with perturbative QCD predictions at next-to-leading order
Global Role and Burden of Influenza in Pediatric Respiratory Hospitalizations, 1982-2012:A Systematic Analysis
- Author
- Adebayo Adedeji
- AM Ropero-Alvarez
- Amal Barakat
- Andrew Corwin
- Andros Theo
- BD Gessner
- BD Gessner
- CM Cox
- Daddi Jima
- Daniel E. Noyola
- Daouda Coulibaly
- Eduardo Azziz-Baumgartner
- FS Dawood
- FS Dawood
- Fátima Valente
- Gideon O. Emukule
- Guiselle Guzman
- H Nair
- H Nair
- H Nair
- H Yu
- H Zhou
- Harish Nair
- Harry Campbell
- Hongjie Yu
- I Rudan
- IM Longini Jr
- James K. Tumwine
- Jean Michel Heraud
- JM Bender
- JM Radin
- JM Simmerman
- Joseph Bresee
- JR Ortiz
- Julio Armero
- K Ampofo
- KA Poehling
- Kathryn E. Lafond
- KM Neuzil
- KP Klugman
- Mahmudur Rahman
- Malinee Chittaganpitch
- Mandeep Chadha
- Marc-Alain Widdowson
- Marietjie Venter
- Marta von Horoch
- Melissa Whaley
- ML Perdue
- Mohammad Hafiz Rasooly
- MS Chadha
- NT Nzussouo
- Ondri Dwi Sampurno
- Pagbajabyn Nymadawa
- Paul Kitsutani
- R Lozano
- Radu Cojocaru
- Remigio Olveda
- Ricardo Mena
- Robert Booy
- Stephen R. C. Howie
- T Jartti
- Thierry Nyatanyi
- Tran Hien Nguyen
- Vida Mmbaga
- William Ampofo
- WW Thompson
- Zuridin Nurmatov
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND:The global burden of pediatric severe respiratory illness is substantial, and influenza viruses contribute to this burden. Systematic surveillance and testing for influenza among hospitalized children has expanded globally over the past decade. However, only a fraction of the data has been used to estimate influenza burden. In this analysis, we use surveillance data to provide an estimate of influenza-associated hospitalizations among children worldwide. METHODS AND FINDINGS:We aggregated data from a systematic review (n = 108) and surveillance platforms (n = 37) to calculate a pooled estimate of the proportion of samples collected from children hospitalized with respiratory illnesses and positive for influenza by age group (<6 mo, <1 y, <2 y, <5 y, 5-17 y, and <18 y). We applied this proportion to global estimates of acute lower respiratory infection hospitalizations among children aged <1 y and <5 y, to obtain the number and per capita rate of influenza-associated hospitalizations by geographic region and socio-economic status. Influenza was associated with 10% (95% CI 8%-11%) of respiratory hospitalizations in children <18 y worldwide, ranging from 5% (95% CI 3%-7%) among children <6 mo to 16% (95% CI 14%-20%) among children 5-17 y. On average, we estimated that influenza results in approximately 374,000 (95% CI 264,000 to 539,000) hospitalizations in children <1 y-of which 228,000 (95% CI 150,000 to 344,000) occur in children <6 mo-and 870,000 (95% CI 610,000 to 1,237,000) hospitalizations in children <5 y annually. Influenza-associated hospitalization rates were more than three times higher in developing countries than in industrialized countries (150/100,000 children/year versus 48/100,000). However, differences in hospitalization practices between settings are an important limitation in interpreting these findings. CONCLUSIONS:Influenza is an important contributor to respiratory hospitalizations among young children worldwide. Increasing influenza vaccination coverage among young children and pregnant women could reduce this burden and protect infants <6 mo
The possible link between elevated serum levels of epithelial cell-derived neutrophil- activating peptide-78 (ENA-78/CXCL5) and autoimmunity in autistic children
- Author
- A Vojdani
- A Zlotnik
- American Psychiatric Association
- B Mazur-Kolecka
- C Nathan
- D Odell
- D Wechsler
- DL Greenwood
- DL Vargas
- E Schopler
- EM Minshall
- G Anderson
- GA Mostafa
- GA Mostafa
- GA Mostafa
- GA Mostafa
- GA Mostafa
- GA Mostafa
- GA Mostafa
- GA Mostafa
- GA Mostafa
- Gehan Ahmed Mostafa
- H1 Okabe
- HH Cohly
- I Gentile
- I Zineh
- I Zineh
- IM Cojocaru
- IS Piras
- J Song
- JJ Smit
- JJ Smith
- JV Ravetch
- K Kessenbrock
- L Keglowich
- L Li
- Laila Yousef AL-Ayadhi
- LK Meleka
- LR Bisset
- LY Al-Ayadhi
- LY Al-ayadhi
- LY Al-Ayadhi
- MJ Sanz
- MM Amoli
- P Ashwood
- R Alam
- R Huizinga
- S Jancar
- S Nakayama
- SA Lira
- SJ Ono
- T Persson
- TC Theoharides
- TL Sweeten
- VK Singh
- WJ Karpus
- WJ Karpus
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Pathobiology of tobacco smoking and neurovascular disorders: untied strings and alternative products
- Author
- A Abdul-Aziz
- A Alfieri
- A Alfieri
- A Boutten
- A Cherubini
- A Johri
- A Khanna
- A Koul
- A Shoamanesh
- A Sobczak
- A Tuttolomondo
- A Voigt
- A Yamauchi
- AA Kanner
- AH Schinkel
- AK Hedstrom
- AL Al-Malki
- AM Cantin
- AM Romanic
- AR Togna
- AR Vansickel
- AR Vansickel
- B Aravamudan
- B Hagenbuch
- B Messner
- BA King
- BK Nordskog
- BT Hawkins
- C Borland
- C Bullen
- C Gallo
- C Ghosh
- CA Lerner
- CA Lerner
- CA Weber
- CC Lin
- CS Johnston
- CY Chang
- D Goldeck
- D Malhotra
- D Tang
- D Tang
- D Wong
- DH Lee
- DM DeMarini
- E Arato
- E Oby
- ER Miller III
- F Cervellati
- F Dutheil
- G Bazzoni
- G Chen
- G Girdhar
- G Howard
- G Kaplanski
- G Mushtaq
- G Peluffo
- G Poli
- G Romagna
- GA Rosenberg
- GJ Miller
- H Mast
- H Pan
- H Tsuneki
- H Wolburg
- H Yao
- HJ Chiu
- HK Bryan
- HW Chen
- I Rahman
- IL Chen
- IM Cojocaru
- J Huang
- J Palmblad
- J Ren
- J Salzer
- J Zhang
- J Zhang
- JD Hayes
- JD Hayes
- JM Gidday
- JM Wardlaw
- JR Paulson
- JR Paulson
- K Aoshiba
- K Fagerstrom
- K Gumustekin
- K Stone
- KE Farsalinos
- KE Farsalinos
- KE Farsalinos
- L Rochette
- L Zuo
- LM Roberts
- LS Cox
- M Dietrich
- M Hossain
- M Hossain
- M Hua
- M Sandberg
- M Tsuchiya
- M van der Toorn
- MA Hernan
- MC Polidori
- MD Blank
- MV Vadhanam
- N Chalouhi
- N Marchi
- N Marchi
- N Strazielle
- N Tournier
- National Center For Chronic Disease Prevention and Health Promotion (US) Office on Smoking and Health
- NJ Abbott
- NJ Abbott
- NJ Abbott
- P Hutamekalin
- P Naik
- P Naik
- P Naik
- P Naserzadeh
- P Pokhrel
- P Venditti
- PB Pun
- PR Lockman
- PS dos Santos
- R Deane
- R Talhout
- RK Sajja
- RL O’Kane
- RM Tuder
- RW Robey
- S Abboud
- S Bennett
- S Gupta
- S Mansoor
- S Petri
- S Prasad
- S Prasad
- S Scheffler
- S Shiffman
- SH Chen
- SM Gloor
- SS Hecht
- T Holmoy
- T Iizuka
- T Mannami
- T Masubuchi
- T Muller
- T Nguyen
- TJ Abbruscato
- TJ Abbruscato
- TJ Abbruscato
- TN Kelly
- U Garbin
- V Bahl
- V Bahl
- V Calabrese
- V Varlet
- VK Manda
- VK Manda
- WA Pryor
- WH Piao
- Y Okuma
- Y Shen
- Y Xu
- YJ Surh
- Z Chen
- Z Huang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
- Author
- Aarestrup J
- Abarca-Gomez L
- Abbasi-Kangevari M
- Abdeen ZA
- Abdrakhmanova S
- Abdurrahmonova Z
- Abril GL
- Abu-Rmeileh NM
- Acosta-Cazares B
- Adam I
- Adamczyk M
- Adams RJ
- Adu-Afarwuah S
- Aekplakorn W
- Afsana K
- Afzal S
- Agbor VN
- Agdeppa IA
- Aghazadeh-Attari J
- Agren A
- Aguenaou H
- Aguilar-Salinas CA
- Aguilar-Salinas CA
- Agyemang C
- Ahmad MH
- Ahmad NA
- Ahmadi A
- Ahmadi N
- Ahmadi N
- Ahmed I
- Ahmed SH
- Ahrens W
- Aitmurzaeva G
- Ajlouni K
- Al Asfoor D
- Al Hourani HM
- Al Nsour M
- Al Qaoud NM
- Al-Hazzaa HM
- Al-Hinai H
- Al-Lahou B
- Al-Lawati JA
- Al-Raddadi R
- Alarouj M
- AlBuhairan F
- AlDhukair S
- Aldwairji MA
- Alexius S
- Ali MM
- Alieva AV
- Alkandari A
- Alkerwi A
- Alkhatib BM
- Allin K
- Alomary SA
- Alomirah HF
- Alshangiti AM
- Alvarez-Pedrerol M
- Aly E
- Amarapurkar DN
- Amoah J
- Amougou N
- Amouyel P
- Andersen LB
- Anderssen SA
- Androutsos O
- Angquist L
- Anicet AK
- Anjana RM
- Ansari-Moghaddam A
- Anufrieva E
- Aounallah-Skhiri H
- Araujo J
- Ariansen I
- Aris T
- Arku RE
- Arlappa N
- Aryal KK
- Aspelund T
- Assah FK
- Assefa N
- Assembekov B
- Assuncao MCF
- Aung MS
- Auvinen J
- Avdicova M
- Avi S
- Azad K
- Azevedo A
- Azimi-Nezhad M
- Azizi F
- Babu BV
- Bacopoulou F
- Baharudin A
- Bahijri S
- Bajramovic I
- Bakacs M
- Baker JL
- Baker JL
- Balakrishna N
- Balanova Y
- Bamoshmoosh M
- Banach M
- Banegas JR
- Baran J
- Baran R
- Barbagallo CM
- Barcelo A
- Baretic M
- Barkat A
- Barkat A
- Barnoya J
- Barradas-Pires A
- Barrera L
- Barreto M
- Barros AJD
- Barros MVG
- Bartosiewicz A
- Basit A
- Bastos JL
- Bata I
- Batieha AM
- Batista AP
- Batista RL
- Battakova Z
- Baur LA
- Bayauli PM
- Beaglehole R
- Bebakar WMW
- Bel-Serrat S
- Belavendra A
- Ben Romdhane H
- Benchekor SM
- Benedek T
- Benedics J
- Benet M
- Bennett JE
- Bennett JE
- Bentham J
- Benzeval M
- Bere E
- Berger N
- Bergh IH
- Berhane Y
- Berkinbayev S
- Bernabe-Ortiz A
- Bernotiene G
- Bettiol H
- Beutel ME
- Beybey AF
- Bezerra J
- Bhagyalaxmi A
- Bharadwaj S
- Bhargava SK
- Bhutta ZA
- Bhutta ZA
- Bi H
- Bi Y
- Bia D
- Biasch K
- Bikbov MM
- Bista B
- Bixby H
- Bjelica DJ
- Bjerregaard AA
- Bjerregaard P
- Bjertness E
- Bjertness MB
- Bjorkelund C
- Bloch KV
- Blokstra A
- Bo S
- Bobak M
- Boddy LM
- Boehm BO
- Boer JMA
- Boggia JG
- Bogova E
- Boissonnet CP
- Bojesen SE
- Boker LK
- Bonaccio M
- Bongard V
- Bonilla-Vargas A
- Bopp M
- Borghs H
- Botomba S
- Bourne RRA
- Bovet P
- Boymatova K
- Braeckevelt L
- Braeckman L
- Bragt MCE
- Braithwaite T
- Brajkovich I
- Branca F
- Branca F
- Braunerova RT
- Breckenkamp J
- Breda J
- Brenner H
- Brewster LM
- Brian GR
- Briceno Y
- Brinduse L
- Bringolf-Isler B
- Brito M
- Brophy S
- Brug J
- Bruno G
- Bugge A
- Buoncristiano M
- Burazeri G
- Burns C
- Cacciottolo J
- Cadena LH
- Cai H
- Caixeta RB
- Caixeta RB
- Cama T
- Cameron C
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- Can G
- Candido APC
- Canete F
- Capanzana MV
- Capkova N
- Capuano E
- Capuano R
- Capuano V
- Cardol M
- Cardoso VC
- Carlsson AC
- Carmuega E
- Carrasola XB
- Carrillo-Larco RM
- Carrillo-Larco RM
- Carvalho J
- Casajus JA
- Casanueva FF
- Casas M
- Celikcan E
- Censi L
- Cervantes-Loaiza M
- Cesar JA
- Chamnan P
- Chamukuttan S
- Chan A
- Chan Q
- Charchar FJ
- Charles M-A
- Chaturvedi HK
- Chaturvedi N
- Chee ML
- Chen C-J
- Chen F
- Chen H
- Chen L-S
- Chen S
- Chen Z
- Cheng C-Y
- Cheng YJ
- Cheraghian B
- Chetrit A
- Chikova-Iscener E
- Chinapaw MJM
- Chinh NH
- Chinnock A
- Chiolero A
- Chiou S-T
- Chirita-Emandi A
- Chirlaque M-D
- Cho B
- Christensen K
- Christofaro DG
- Chudek J
- Cifkova R
- Cilia M
- Cinteza E
- Cirillo M
- Cisneros JZ
- Claessens F
- Clare P
- Clarke J
- Clays E
- Cohen E
- Cojocaru CR
- Colorado-Yohar S
- Compan-Gabucio L-M
- Concin H
- Confortin SC
- Cooper C
- Coppinger TC
- Corpeleijn E
- Cortes LY
- Costanzo S
- Cottel D
- Cowan MJ
- Cowell C
- Craig CL
- Crampin AC
- Cross AJ
- Crujeiras AB
- Cruz JJ
- Csanyi T
- Csilla S
- Cucu AM
- Cuesta MG
- Cui L
- Cureau FV
- Cuschieri S
- Cuschieri S
- Czenczek-Lewandowska E
- D'Arrigo G
- d'Orsi E
- da Silva AG
- da Silva BGC
- Dacica L
- Dahm CC
- Dallongeville J
- Damasceno A
- Damsgaard CT
- Danaei G
- Danaei G
- Dankner R
- Dantoft TM
- Dasgupta P
- Dastgiri S
- Dauchet L
- Davletov K
- de Assis MAA
- De Backer G
- De Bacquer D
- De Bacquer J
- de Bont J
- De Curtis A
- de Gaetano G
- De Henauw S
- de Leon AC
- De Miguel-Etayo P
- De Neve J-W
- de Oliveira PD
- de Paiva KM
- De Ridder D
- De Ridder K
- de Rooij SR
- de Sa ACMGN
- De Smedt D
- de Valois CJMA
- de Vasconcelos FDAG
- de Wit TFR
- Deepa M
- Deev AD
- DeGennaro VJ
- Delisle H
- Delpeuch F
- Demarest S
- Dennison E
- Deren K
- Deschamps V
- Devrishov RD
- Dhimal M
- Di Castelnuovo A
- Di Cesare M
- Dias-da-Costa JS
- Diaz A
- Diaz-Sanchez ME
- Dika Z
- Djalalinia S
- Djordjic V
- Do HTP
- Dobson AJ
- Dominguez L
- Donati MB
- Donfrancesco C
- Dong G
- Dong Y
- Donoso SP
- Doring A
- Dorobantu M
- Dorosty AR
- Dorr M
- Doua K
- Dragano N
- Drygas W
- Du S
- Duan JL
- Duante CA
- Duboz P
- Duleva VL
- Dulskiene V
- Dumith SC
- Dushpanova A
- Dwyer T
- Dyussupova A
- Dzerve V
- Dziankowska-Zaborszczyk E
- Ebrahimi N
- Echeverria G
- Eddie R
- Eftekhar E
- Efthymiou V
- Egbagbe EE
- Eggertsen R
- Eghtesad S
- Eiben G
- Ekelund U
- El Ammari L
- El Ati J
- El-Khateeb M
- Eldemire-Shearer D
- Elliott P
- Enang O
- Endevelt R
- Engle-Stone R
- Erasmus RT
- Erem C
- Ergor G
- Eriksen L
- Eriksson JG
- Escobedo-de la Pena J
- Eslami S
- Esmaeili A
- Etxezarreta PA
- Evans A
- Evans RG
- Ezzati M
- Faeh D
- Fagherazzi G
- Fakhradiyev I
- Fakhretdinova AA
- Fall CH
- Faramarzi E
- Farjam M
- Farzadfar F
- Farzadfar F
- Farzi Y
- Fattahi MR
- Fawwad A
- Fawzi WW
- Felix-Redondo FJ
- Ferguson TS
- Fernandes RA
- Fernandez PD
- Fernandez-Berges D
- Ferrante D
- Ferrao T
- Ferrari G
- Ferrari M
- Ferrario MM
- Ferreccio C
- Ferreira HS
- Ferrer E
- Ferrieres J
- Figueiro TH
- Fijalkowska A
- Filho VB
- Fink G
- Fisberg M
- Fischer K
- Foo LH
- Forsner M
- Fottrell EF
- Fouad HM
- Francis DK
- Franco MDC
- Fras Z
- Fraser B
- Frontera G
- Fuchs FD
- Fuchs SC
- Fujiati II
- Fujita Y
- Fumihiko M
- Furdela V
- Furusawa T
- Gabriela SA
- Gaciong Z
- Gafencu M
- Galbarczyk A
- Galcheva SV
- Galenkamp H
- Galeone D
- Galfo M
- Galvano F
- Ganapathy S
- Gao J
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- Garcia MY
- Garcia-de-la-Hera M
- Gareta D
- Garnett SP
- Gaspoz J-M
- Gasull M
- Gaya ACA
- Gaya AR
- Gazzinelli A
- Gehring U
- Geiger H
- Geleijnse JM
- George R
- Gerdts E
- Ghaderi E
- Ghaffar SA
- Ghamari S-H
- Ghanbari A
- Ghasemi E
- Gheorghe-Fronea O-F
- Gialluisi A
- Giampaoli S
- Gianfagna F
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- Giovannelli J
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- Glushkova N
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- Gogen S
- Goldberg M
- Goltzman D
- Gomez G
- Gomez JHG
- Gomez LF
- Gomez SF
- Gomula A
- Goncalves H
- Goncalves M
- Gonzalez AR
- Gonzalez EG
- Gonzalez-Alvarez AD
- Gonzalez-Chica DA
- Gonzalez-Gil EM
- Gonzalez-Gross M
- Gonzalez-Leon M
- Gonzalez-Rivas JP
- Gonzalez-Villalpando C
- Gonzalez-Villalpando M-E
- Gottrand F
- Graca AP
- Grafnetter D
- Grajda A
- Grammatikopoulou MG
- Gregg EW
- Gregor RD
- Gregorio MJ
- Groholt EK
- Grontved A
- Grosso G
- Gruden G
- Gu D
- Guajardo V
- Gualdi-Russo E
- Guallar-Castillon P
- Gualtieri A
- Gudmundsson EF
- Gudnason V
- Guerchet M
- Guerrero R
- Guessous I
- Guimaraes AL
- Gujral UP
- Gulliford MC
- Gunnlaugsdottir J
- Gunter MJ
- Guo X-H
- Guo Y
- Gupta PC
- Gupta R
- Gureje O
- Gurinovic MA
- Gutierrez L
- Gutzwiller F
- Gwee X
- Ha S
- Hadaegh F
- Hadjigeorgiou CA
- Haghshenas R
- Hakimi H
- Halkjaer J
- Hambleton IR
- Hamzeh B
- Hanekom WA
- Hange D
- Hanif AAM
- Hantunen S
- Hao J
- Hardman CM
- Hardy L
- Harooni J
- Hashemi-Shahri SM
- Hassapidou M
- Hata J
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- Hayes AJ
- He J
- He Y
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- Heidinger-Felso R
- Heier M
- Heinen M
- Hejgaard T
- Hendriks ME
- Henrique RDS
- Henriques A
- Herrala S
- Herrera VM
- Herrera-Cuenca M
- Herter-Aeberli I
- Herzig K-H
- Heshmat R
- Heude B
- Hill AG
- Hinnig PDF
- Ho SC
- Ho SY
- Hobbs M
- Hofelmann DA
- Holdsworth M
- Homayounfar R
- Homs C
- Hoogendijk E
- Hopman WM
- Horimoto ARVR
- Hormiga CM
- Horta BL
- Houti L
- Howitt C
- Htay TT
- Htet AS
- Htike MMT
- Hu Y
- Huerta JM
- Huhtaniemi IT
- Huiart L
- Husseini A
- Huybrechts I
- Hwalla N
- Hyska J
- Iacoviello L
- Iakupova EM
- Ibarluzea J
- Ibrahim MM
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- Ijoma C
- Ikeda N
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- Irazola VE
- Ishida T
- Isiguzo GC
- Islam M
- Islam SMS
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- Ivanova-Pandourska IY
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- Kajantie EO
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- Katzmarzyk PT
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- Kengne AP
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- Keramati M
- Kerimkulova A
- Kersting M
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- Khaledifar A
- Khalili D
- Khang Y-H
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- Khanh LNB
- Kheiri B
- Kheradmand M
- Khosravi A
- Khouw IMSL
- Khuong QL
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- Kriaucioniene V
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- Kristensen PL
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- Luksiene D
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- Yiallouros PK
- Yngve A
- Yoosefi M
- Yoshihara A
- Yotov Y
- You QS
- You S-L
- Younger-Coleman NO
- Yu Y
- Yu Y-L
- Yusof SM
- Yusoff AF
- Yusoff MFM
- Zaccagni L
- Zafiropulos V
- Zainuddin AA
- Zakavi SR
- Zamani F
- Zambon S
- Zampelas A
- Zamrazilova H
- Zapata ME
- Zargar AH
- Zaw KK
- Zayed AA
- Zdrojewski T
- Zeglen M
- Zejglicova K
- Zeng Y
- Zentai A
- Zhang B
- Zhang L
- Zhang Z-Y
- Zhao D
- Zhao M-H
- Zhao W
- Zhecheva YV
- Zhen S
- Zheng W
- Zheng Y
- Zholdin B
- Zhou B
- Zhou M
- Zhu D
- Zimmet P
- Zins M
- Zitt E
- Zocalo Y
- Zoghlami N
- Zuziak M
- Publication venue
- Elsevier
- Publication date
- 01/01/2024
- Field of study
Background
Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories.
Methods
We used data from 3663 population-based studies with 222 million participants that measured height and weight in representative samples of the general population. We used a Bayesian hierarchical model to estimate trends in the prevalence of different BMI categories, separately for adults (age ≥20 years) and school-aged children and adolescents (age 5–19 years), from 1990 to 2022 for 200 countries and territories. For adults, we report the individual and combined prevalence of underweight (BMI 2 SD above the median).
Findings
From 1990 to 2022, the combined prevalence of underweight and obesity in adults decreased in 11 countries (6%) for women and 17 (9%) for men with a posterior probability of at least 0·80 that the observed changes were true decreases. The combined prevalence increased in 162 countries (81%) for women and 140 countries (70%) for men with a posterior probability of at least 0·80. In 2022, the combined prevalence of underweight and obesity was highest in island nations in the Caribbean and Polynesia and Micronesia, and countries in the Middle East and north Africa. Obesity prevalence was higher than underweight with posterior probability of at least 0·80 in 177 countries (89%) for women and 145 (73%) for men in 2022, whereas the converse was true in 16 countries (8%) for women, and 39 (20%) for men. From 1990 to 2022, the combined prevalence of thinness and obesity decreased among girls in five countries (3%) and among boys in 15 countries (8%) with a posterior probability of at least 0·80, and increased among girls in 140 countries (70%) and boys in 137 countries (69%) with a posterior probability of at least 0·80. The countries with highest combined prevalence of thinness and obesity in school-aged children and adolescents in 2022 were in Polynesia and Micronesia and the Caribbean for both sexes, and Chile and Qatar for boys. Combined prevalence was also high in some countries in south Asia, such as India and Pakistan, where thinness remained prevalent despite having declined. In 2022, obesity in school-aged children and adolescents was more prevalent than thinness with a posterior probability of at least 0·80 among girls in 133 countries (67%) and boys in 125 countries (63%), whereas the converse was true in 35 countries (18%) and 42 countries (21%), respectively. In almost all countries for both adults and school-aged children and adolescents, the increases in double burden were driven by increases in obesity, and decreases in double burden by declining underweight or thinness.
Interpretation
The combined burden of underweight and obesity has increased in most countries, driven by an increase in obesity, while underweight and thinness remain prevalent in south Asia and parts of Africa. A healthy nutrition transition that enhances access to nutritious foods is needed to address the remaining burden of underweight while curbing and reversing the increase in obesity.
Funding
UK Medical Research Council, UK Research and Innovation (Research England), UK Research and Innovation (Innovate UK), and European Union
Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
- Author
- Aarestrup J
- Abarca-Gómez L
- Abbasi-Kangevari M
- Abdeen ZA
- Abdrakhmanova S
- Abdul Ghaffar S
- Abdul Rahim HF
- Abdurrahmonova Z
- Abu-Rmeileh NM
- Abubakar Garba J
- Acosta-Cazares B
- Adam I
- Adamczyk M
- Adams RJ
- Adu-Afarwuah S
- Aekplakorn W
- Afsana K
- Afzal S
- Agbor VN
- Agdeppa IA
- Aghazadeh-Attari J
- Aguenaou H
- Aguilar-Salinas CA
- Agyemang C
- Ahmad MH
- Ahmad NA
- Ahmadi A
- Ahmadi N
- Ahmadi N
- Ahmed I
- Ahmed SH
- Ahrens W
- Aitmurzaeva G
- Ajlouni K
- Al Asfoor D
- Al Hourani HM
- Al Qaoud NM
- Al-Hazzaa HM
- Al-Hinai H
- Al-Lahou B
- Al-Lawati JA
- Al-Raddadi R
- Alarouj M
- AlBuhairan F
- AlDhukair S
- Aldwairji MA
- Alexius S
- Ali MM
- Alieva AV
- Alkandari A
- Alkerwi A
- Alkhatib BM
- Allin K
- Alomary SA
- Alomirah HF
- Alshangiti AM
- Alvarez-Pedrerol M
- Aly E
- Amarapurkar DN
- Amiano Etxezarreta P
- Amoah J
- Amougou N
- Amouyel P
- Andersen LB
- Anderssen SA
- Androutsos O
- Anjana RM
- Ansari-Moghaddam A
- Anufrieva E
- Aounallah-Skhiri H
- Araújo J
- Ariansen I
- Aris T
- Arku RE
- Arlappa N
- Aryal KK
- Aspelund T
- Assah FK
- Assefa N
- Assembekov B
- Assunção MCF
- Aung MS
- Aurélio de Valois CJM
- Auvinen J
- Avdičová M
- Avi S
- Azad K
- Azevedo A
- Azimi-Nezhad M
- Azizi F
- Babu BV
- Bacopoulou F
- Baharudin A
- Bahijri S
- Bajramovic I
- Bakacs M
- Baker JL
- Balakrishna N
- Balanova Y
- Bamoshmoosh M
- Banach M
- Banegas JR
- Baran J
- Baran R
- Barbagallo CM
- Barbosa Filho V
- Barceló A
- Baretić M
- Barkat A
- Barnoya J
- Barradas-Pires A
- Barrera L
- Barreto M
- Barros AJD
- Barros MVG
- Bartosiewicz A
- Basit A
- Bastos JL
- Bata I
- Batieha AM
- Batista AP
- Batista RL
- Battakova Z
- Baur LA
- Bayauli PM
- Beaglehole R
- Bel-Serrat S
- Belavendra A
- Ben Romdhane H
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- Benedics J
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- Bentham J
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- Bernotiene G
- Berrios Carrasola X
- Bettiol H
- Beutel ME
- Beybey AF
- Bezerra J
- Bhagyalaxmi A
- Bharadwaj S
- Bhargava SK
- Bhutta ZA
- Bi H
- Bi Y
- Bia D
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- Bika Lele EC
- Bikbov MM
- Bista B
- Bixby H
- Bjelica DJ
- Bjerregaard AA
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- Bjertness E
- Bjertness MB
- Björkelund C
- Bloch KV
- Blokstra A
- Blychfeld Magnazu M
- Bo S
- Bobak M
- Boddy LM
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- Bojesen SE
- Bonaccio M
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- Boymatova K
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- Braithwaite T
- Brajkovich I
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- Breda J
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- Elsevier
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- Field of study
Background Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories. Methods We used data from 3663 population-based studies with 222 million participants that measured height and weight in representative samples of the general population. We used a Bayesian hierarchical model to estimate trends in the prevalence of different BMI categories, separately for adults (age ≥20 years) and school-aged children and adolescents (age 5–19 years), from 1990 to 2022 for 200 countries and territories. For adults, we report the individual and combined prevalence of underweight (BMI 2 SD above the median). Findings From 1990 to 2022, the combined prevalence of underweight and obesity in adults decreased in 11 countries (6%) for women and 17 (9%) for men with a posterior probability of at least 0·80 that the observed changes were true decreases. The combined prevalence increased in 162 countries (81%) for women and 140 countries (70%) for men with a posterior probability of at least 0·80. In 2022, the combined prevalence of underweight and obesity was highest in island nations in the Caribbean and Polynesia and Micronesia, and countries in the Middle East and north Africa. Obesity prevalence was higher than underweight with posterior probability of at least 0·80 in 177 countries (89%) for women and 145 (73%) for men in 2022, whereas the converse was true in 16 countries (8%) for women, and 39 (20%) for men. From 1990 to 2022, the combined prevalence of thinness and obesity decreased among girls in five countries (3%) and among boys in 15 countries (8%) with a posterior probability of at least 0·80, and increased among girls in 140 countries (70%) and boys in 137 countries (69%) with a posterior probability of at least 0·80. The countries with highest combined prevalence of thinness and obesity in school-aged children and adolescents in 2022 were in Polynesia and Micronesia and the Caribbean for both sexes, and Chile and Qatar for boys. Combined prevalence was also high in some countries in south Asia, such as India and Pakistan, where thinness remained prevalent despite having declined. In 2022, obesity in school-aged children and adolescents was more prevalent than thinness with a posterior probability of at least 0·80 among girls in 133 countries (67%) and boys in 125 countries (63%), whereas the converse was true in 35 countries (18%) and 42 countries (21%), respectively. In almost all countries for both adults and school-aged children and adolescents, the increases in double burden were driven by increases in obesity, and decreases in double burden by declining https://researchonline.ljmu.ac.uk/images/research_banner_face_lab_290.jpgunderweight or thinness. Interpretation The combined burden of underweight and obesity has increased in most countries, driven by an increase in obesity, while underweight and thinness remain prevalent in south Asia and parts of Africa. A healthy nutrition transition that enhances access to nutritious foods is needed to address the remaining burden of underweight while curbing and reversing the increase in obesity
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