51 research outputs found
Search for diffuse neutrino flux from astrophysical sources with MACRO
Many galactic and extragalactic astrophysical sources are currently
considered promising candidates as high energy neutrino emitters. Astrophysical
neutrinos can be detected as upward-going muons produced in charged-current
interactions with the medium surrounding the detector. The expected neutrino
fluxes from various models start to dominate on the atmospheric neutrino
background at neutrino energies above some tens of TeV. We present the results
of a search for an excess of high energy upward-going muons among the sample of
data collected by MACRO during ~5.8 years of effective running time. No
significant evidence for this signal was found. As a consequence, an upper
limit on the flux of upward-going muons from high-energy neutrinos was set at
the level of 1.7 10^(-14) cm^(-2) s^(-1) sr^(-1).
The corresponding upper limit for the diffuse neutrino flux was evaluated
assuming a neutrino power law spectrum. Our result was compared with
theoretical predictions and upper limits from other experiments.Comment: 19 pages, 8 figures, 2 table
Broad targeting of resistance to apoptosis in cancer
Apoptosis or programmed cell death is natural way of removing aged cells from the body. Most of the anti-cancer therapies trigger apoptosis induction and related cell death networks to eliminate malignant cells. However, in cancer, de-regulated apoptotic signaling, particularly the activation of an anti-apoptotic systems, allows cancer cells to escape this program leading to uncontrolled proliferation resulting in tumor survival, therapeutic resistance and recurrence of cancer. This resistance is a complicated phenomenon that emanates from the interactions of various molecules and signaling pathways. In this comprehensive review we discuss the various factors contributing to apoptosis resistance in cancers. The key resistance targets that are discussed include (1) Bcl-2 and Mcl-1 proteins; (2) autophagy processes; (3) necrosis and necroptosis; (4) heat shock protein signaling; (5) the proteasome pathway; (6) epigenetic mechanisms; and (7) aberrant nuclear export signaling. The shortcomings of current therapeutic modalities are highlighted and a broad spectrum strategy using approaches including (a) gossypol; (b) epigallocatechin-3-gallate; (c) UMI-77 (d) triptolide and (e) selinexor that can be used to overcome cell death resistance is presented. This review provides a roadmap for the design of successful anti-cancer strategies that overcome resistance to apoptosis for better therapeutic outcome in patients with cancer
Astrophysical Origins of Ultrahigh Energy Cosmic Rays
In the first part of this review we discuss the basic observational features
at the end of the cosmic ray energy spectrum. We also present there the main
characteristics of each of the experiments involved in the detection of these
particles. We then briefly discuss the status of the chemical composition and
the distribution of arrival directions of cosmic rays. After that, we examine
the energy losses during propagation, introducing the Greisen-Zaptsepin-Kuzmin
(GZK) cutoff, and discuss the level of confidence with which each experiment
have detected particles beyond the GZK energy limit. In the second part of the
review, we discuss astrophysical environments able to accelerate particles up
to such high energies, including active galactic nuclei, large scale galactic
wind termination shocks, relativistic jets and hot-spots of Fanaroff-Riley
radiogalaxies, pulsars, magnetars, quasar remnants, starbursts, colliding
galaxies, and gamma ray burst fireballs. In the third part of the review we
provide a brief summary of scenarios which try to explain the super-GZK events
with the help of new physics beyond the standard model. In the last section, we
give an overview on neutrino telescopes and existing limits on the energy
spectrum and discuss some of the prospects for a new (multi-particle)
astronomy. Finally, we outline how extraterrestrial neutrino fluxes can be used
to probe new physics beyond the electroweak scale.Comment: Higher resolution version of Fig. 7 is available at
http://www.angelfire.com/id/dtorres/down3.html. Solicited review article
prepared for Reports on Progress in Physics, final versio
High-energy Neutrino Astronomy: The Cosmic Ray Connection
This is a review of neutrino astronomy anchored to the observational fact
that Nature accelerates protons and photons to energies in excess of
and eV, respectively.
Although the discovery of cosmic rays dates back close to a century, we do
not know how and where they are accelerated. Basic elementary-particle physics
dictates a universal upper limit on their energy of eV, the
so-called Greisen-Kuzmin-Zatsepin cutoff; however, particles in excess of this
energy have been observed by all experiments, adding one more puzzle to the
cosmic ray mystery. Mystery is fertile ground for progress: we will review the
facts as well as the speculations about the sources including gamma ray bursts,
blazars and top-down scenarios.
The important conclusion is that, independently of the specific blueprint of
the source, it takes a kilometer-scale neutrino observatory to detect the
neutrino beam associated with the highest energy cosmic rays and gamma rays. We
also briefly review the ongoing efforts to commission such instrumentation.Comment: 83 pages, 18 figures, submitted to Reports on Progress in Physic
Far IR spectra of Ag 2CdI 4 at temperature range 10–420 K: complementary experimental and first-principle theoretical study
71.15.Mb Density functional theory, local density approximation, gradient and other corrections, 78.30.Hv Other nonmetallic inorganics,
Optical Properties of LiNbO₃-Ag Nanocomposites
The article presents the experimental results of the investigation of the absorption spectra and nonlinear refraction of the metal-dielectric nanocomposite that contains the lithium niobate pyroelectric crystal coated with the silver nanofilms on its surface. The atomic force microscopy surface research of these crystals with and without films are also provided. The nanowidth silver films impact on optical spectra and nonlinear refraction of LiNbO₃-Ag nanocomposite was analyzed depending on the sign of the side charge of the crystal, that contain nanofilms
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