Characterisation of analogue Monolithic Active Pixel Sensor test structures implemented in a 65 nm CMOS imaging process

Analogue test structures were fabricated using the Tower Partners Semiconductor Co. CMOS 65 nm ISC process. The purpose was to characterise and qualify this process and to optimise the sensor for the next generation of Monolithic Active Pixels Sensors for high-energy physics. The technology was explored in several variants which differed by: doping levels, pixel geometries and pixel pitches (10-25 $\mu$m). These variants have been tested following exposure to varying levels of irradiation up to 3 MGy and $10^{16}$ 1 MeV n$_\text{eq}$ cm$^{-2}$. Here the results from prototypes that feature direct analogue output of a 4$\times$4 pixel matrix are reported, allowing the systematic and detailed study of charge collection properties. Measurements were taken both using $^{55}$Fe X-ray sources and in beam tests using minimum ionizing particles. The results not only demonstrate the feasibility of using this technology for particle detection but also serve as a reference for future applications and optimisations

The Go-GN Open Research Handbook

This Handbook draws together work done between 2020 and 2023 by members of the Global OER Graduate Network (GO-GN). GO-GN is a network of PhD candidates around the world whose research projects include a focus on open education. GO-GN is currently funded through the OER programme of The William and Flora Hewlett Foundation and administered by the Open Education Research Hub from the Institute of Educational Technology at The Open University, UK. In our current phase of activity, we began these collaborative writing efforts with a Research Methods Handbook which was created during the depths of the Covid-19 pandemic. Working together at distance provided an important way to strengthen community links when meeting in person was not possible. The Research Methods Handbook was well received by a much larger audience than we anticipated, and went on to win an Open Research Award. We followed this up with a sister publication, our Conceptual Frameworks Guide. This explores a less well traversed (but nonetheless important) area of scholarly focus. Together, these two explore open approaches to the theory and practice of research in open education. One distinctive feature of our presentation is to foreground the authentic experiences of doctoral researchers who have used specific approaches in researching open education. While it is not possible to cover all approaches in this detail, we hope that important insights are presented in this form of open practice. Throughout 2020-2022 we also regularly engaged our membership through collective reviews of recently published papers and articles. The Research Reviews serve as an overview of recent research but also as a snapshot of the critical responses recorded by doctoral and post-doctoral researchers working in relevant areas. No one volume can claim to comprehensively contain the diversity and variety of open approaches, and this is no exception. But one virtue of openness is that we can draw on the openly licensed works of others to increase our coverage of relevant areas. The Additional Resources at the end of this volume bring together a range of openly licensed texts on open education research and suggests places for further reading and research. Consequently, the information contained here represents a wide range of contributors and collaborators. The original and intended audience for this volume is the doctoral student working on an open education research project - in short, the typical student member of GO-GN and the profile the network exists to support. However, we’ve learned through feedback and analytics that the potential audience for works like this is much larger. Many people who wouldn’t describe themselves as researchers still do research and evaluation. Presenting accessible insights into research foundations and practices helps with this and can be understood as a form of open practice

Immobility-associated thromboprotection is conserved across mammalian species from bear to human

Venous thromboembolism (VTE) comprising deep venous thrombosis and pulmonary embolism is a major cause of morbidity and mortality. Short-term immobility-related conditions are a major risk factor for the development of VTE. Paradoxically, long-term immobilized free-ranging hibernating brown bears and paralyzed spinal cord injury (SCI) patients are protected from VTE. Here we aimed to identify mechanisms of immobility-associated VTE protection in a cross-species approach. Mass spectrometry-based proteomics revealed an antithrombotic signature in platelets of hibernating brown bears with heat shock protein 47 (HSP47) as most substantially reduced protein. HSP47 downregulation or ablation attenuated immune cell activation and NET formation, contributing to thromboprotection in bears, SCI patients and mice. This cross-species conserved platelet signature may give rise to antithrombotic therapeutics and prognostic markers beyond immobility-associated VTE

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements