The Grizzly, November 14, 2002

Did you Miss the Election 2002? • Young Voters Ignore their Political Power • Ursinus Students Writing Kids Program Grant • History, Reminder Found in Veteran\u27s Day • Tartuffe Simply Delicious • Opinions: Are Dateds Worth It?; Homecoming: A Different Opinion; More Problems with Registration; Everclear Rocks Ursinus • Get Ready to Jazz: Ursinus Concert Band Style • Dateds: Worth the Dollar? • Everclear: Clearer than Ever • Exhibit Cases Return to Myrin Library • Men\u27s, Women\u27s Basketball Get Ready to Open Seasons • Roller Hockey Records First • Swim Team Opens Winter Season with a Win • Hot Dates for Collegeville Love Birds • Louie and his Band Rock U.C. • Meet the Ladies of Suites 106 and 204https://digitalcommons.ursinus.edu/grizzlynews/1525/thumbnail.jp

Chemical Burn Injury in Kumasi

Side view of the entrance to the church from Via del Quirinale; In 1634 Cardinal Francesco Barberini helped Borromini to gain his first commission as an independent architect, the monastery and church of S Carlo alle Quattro Fontane (or S Carlino) for the Discalced Trinitarians, who had established themselves there in 1611. The monastic building, complete with cells, refectory and library, was finished by 1636, but work on the church could not begin until 1638. It was dedicated to S Carlo Borromeo in 1646, but the façade was not completed until 1677, ten years after Borromini's death. In this early masterpiece Borromini was faced with the conflicting demands of a strictly ascetic order with a severe shortage of funds that yet wished to create an impression on papal Rome. Source: Grove Art Online; http://www.groveart.com/ (accessed 12/2/2007

Assessment of glenoid chondral healing: comparison of microfracture to autologous matrix-induced chondrogenesis in a novel rabbit shoulder model.

BACKGROUND: Management of glenohumeral arthrosis in young patients is a considerable challenge, with a growing need for non-arthroplasty alternatives. The objectives of this study were to develop an animal model to study glenoid cartilage repair and to compare surgical repair strategies to promote glenoid chondral healing. METHODS: Forty-five rabbits underwent unilateral removal of the entire glenoid articular surface and were divided into 3 groups--untreated defect (UD), microfracture (MFx), and MFx plus type I/III collagen scaffold (autologous matrix-induced chondrogenesis [AMIC])--for the evaluation of healing at 8 weeks (12 rabbits) and 32 weeks (33 rabbits) after injury. Contralateral shoulders served as unoperated controls. Tissue assessments included 11.7-T magnetic resonance imaging (long-term healing group only), equilibrium partitioning of an ionic contrast agent via micro-computed tomography (EPIC-μCT), and histologic investigation (grades on International Cartilage Repair Society II scoring system). RESULTS: At 8 weeks, x-ray attenuation, thickness, and volume did not differ by treatment group. At 32 weeks, the T2 index (ratio of T2 values of healing to intact glenoids) was significantly lower for the MFx group relative to the AMIC group (P = .01) whereas the T1ρ index was significantly lower for AMIC relative to MFx (P = .01). The micro-computed tomography-derived repair tissue volume was significantly higher for MFx than for UD. Histologic investigation generally suggested inferior healing in the AMIC and UD groups relative to the MFx group, which exhibited improvements in both integration of repair tissue with subchondral bone and tidemark formation over time. DISCUSSION: Improvements conferred by AMIC were limited to magnetic resonance imaging outcomes, whereas MFx appeared to promote increased fibrous tissue deposition via micro-computed tomography and more hyaline-like repair histologically. The findings from this novel model suggest that MFx promotes biologic resurfacing of full-thickness glenoid articular injury

Assessment of glenoid chondral healing: comparison of microfracture to autologous matrix-induced chondrogenesis in a novel rabbit shoulder model

BACKGROUND: Management of glenohumeral arthrosis in young patients is a considerable challenge, with a growing need for non-arthroplasty alternatives. The objectives of this study were to develop an animal model to study glenoid cartilage repair and to compare surgical repair strategies to promote glenoid chondral healing. METHODS: Forty-five rabbits underwent unilateral removal of the entire glenoid articular surface and were divided into 3 groups—duntreated defect (UD), microfracture (MFx), and MFx plus type I/III collagen scaffold (autologous matrix-induced chondrogenesis [AMIC])—for the evaluation of healing at 8 weeks (12 rabbits) and 32 weeks (33 rabbits) after injury. Contralateral shoulders served as unoperated controls. Tissue assessments included 11.7-T magnetic resonance imaging (long-term healing group only), Equilibrium Partitioning of an Ionic Contrast agent via microcomputed tomography (EPIC-μCT), and histologic investigation (grades on International Cartilage Repair Society II scoring system). RESULTS: At 8 weeks, x-ray attenuation, thickness, and volume did not differ by treatment group. At 32 weeks, the T2 index (ratio of T2 values of healing to intact glenoids) was significantly lower for the MFx group relative to the AMIC group (P = .01) whereas the T1ρ index was significantly lower for AMIC relative to MFx (P = .01). The micro–computed tomography–derived repair tissue volume was significantly higher for MFx than for UD. Histologic investigation generally suggested inferior healing in the AMIC and UD groups relative to the MFx group, which exhibited improvements in both integration of repair tissue with subchondral bone and tidemark formation over time. DISCUSSION: Improvements conferred by AMIC were limited to magnetic resonance imaging outcomes, whereas MFx appeared to promote increased fibrous tissue deposition via micro–computed tomography and more hyaline-like repair histologically. The findings from this novel model suggest that MFx promotes biologic resurfacing of full-thickness glenoid articular injury. LEVEL OF EVIDENCE: Basic Science Study, In Vivo Animal Model