Saint-Ouen-le-Pin – Abbaye du Val-Richer

Située à une dizaine de kilomètres à l’ouest de Lisieux, l’abbaye du Val-Richer jouit d’une certaine réputation grâce aux grandes personnalités qui l’ont habitée durant les périodes moderne et contemporaine telles que Dominique Georges – abbé du monastère durant la fin du xviie s. – un des personnages clés de la réforme cistercienne (la Stricte observance), François Guizot – historien et ministre durant le deuxième quart du xixe s., acquéreur du monastère en 1836, ou encore les frères Schlumb..

Savigny-le-Vieux – Abbaye de Savigny

La fondation de l’abbaye Savigny en 1112 est un acte majeur du monachisme réformé du nord-ouest de la France au xiie s. Cette abbaye originellement bénédictine recrute massivement dans les familles seigneuriales locales, lesquelles favorisent l’essaimage d’environ 32 maisons dans l’ouest de la France et en Angleterre. Toutefois, l’ampleur du réseau savignien et les problèmes de gestion des abbayes filles font que l’abbé de Savigny décide d’intégrer l’ordre cistercien en 1147. Forte de son rés..

Mézidon Vallée d’Auge – Prieuré de Sainte-Barbe-en-Auge

Depuis 2017, historiens et archéologues se sont regroupés à la demande de la commune nouvelle de Mézidon Vallée d’Auge pour tenter de restituer le prieuré de Sainte-Barbe-en-Auge. Sa fondation intervient durant la première moitié du xiie s. et accueille des chanoines réguliers suivant la règle de saint Augustin. Ils s’installent le long de la Dives, sur la partie basse du versant nord-est, à proximité de Mézidon. L’objectif de ce programme de recherche vise à comprendre l’organisation spatial..

Phenology of marine turtle nesting revealed by statistical model of the nesting season

BACKGROUND: Marine turtles deposit their eggs on tropical or subtropical beaches during discrete nesting seasons that span several months. The number and distribution of nests laid during a nesting season provide vital information on various aspects of marine turtle ecology and conservation. RESULTS: In the case of leatherback sea turtles nesting in French Guiana, we developed a mathematical model to explore the phenology of their nesting season, derived from an incomplete nest count dataset. We detected 3 primary components in the nest distribution of leatherbacks: an overall shape that corresponds to the arrival and departure of leatherback females in the Guianas region, a sinusoidal pattern with a period of approximately 10 days that is related to physiological constraints of nesting female leatherbacks, and a sinusoidal pattern with a period of approximately 15 days that likely reflects the influence of spring high tides on nesting female turtles. CONCLUSION: The model proposed here offers a variety of uses for both marine turtles and also other taxa when individuals are observed in a particular location for only part of the year

JAK inhibition in Aicardi-Goutières syndrome: a monocentric multidisciplinary real-world approach study

International audienceThe paradigm type I interferonopathy Aicardi-Goutières syndrome (AGS) is most typically characterized by severe neurological involvement. AGS is considered an immune-mediated disease, poorly responsive to conventional immunosuppression. Premised on a chronic enhancement of type I interferon signaling, JAK1/2 inhibition has been trialed in AGS, with clear improvements in cutaneous and systemic disease manifestations. Contrastingly, treatment efficacy at the level of the neurological system has been less conclusive. Here, we report our real-word approach study of JAK1/2 inhibition in 11 patients with AGS, providing extensive assessments of clinical and radiological status; interferon signaling, including in cerebrospinal fluid (CSF); and drug concentrations in blood and CSF. Over a median follow-up of 17 months, we observed a clear benefit of JAK1/2 inhibition on certain systemic features of AGS, and reproduced results reported using the AGS neurologic severity scale. In contrast, there was no change in other scales assessing neurological status; using the caregiver scale, only patient comfort, but no other domain of everyday-life care, was improved. Serious bacterial infections occurred in 4 out of the 11 patients. Overall, our data lead us to conclude that other approaches to treatment are urgently required for the neurologic features of AGS. We suggest that earlier diagnosis and adequate central nervous system penetration likely remain the major factors determining the efficacy of therapy in preventing irreversible brain damage, implying the importance of early and rapid genetic testing and the consideration of intrathecal drug delivery

High rates of breast conservation for large ductal and lobular invasive carcinomas combining multimodality strategies

The literature reports low rates of breast conservation after neoadjuvant chemotherapy for operable breast cancers not amenable to initial breast-conserving surgery. This study aims to compare the outcome of lobular vs ductal carcinomas after neoadjuvant chemotherapy. Between 1989 and 1999, 750 patients with clinical stage II/IIIA ductal (672) or lobular (78) invasive breast carcinomas were treated at the Institut Curie with primary anthracycline-based polychemotherapy followed by either breast conservation (surgery and/or radiotherapy) or mastectomy. Median follow-up was 10 years. Clinical response to primary chemotherapy was significantly worse for lobular than for ductal carcinomas (47 vs 60%; P=0.04), but only histological grade remained predictive in multivariate analysis. Breast conservation was high for both ductal and lobular carcinomas (65 and 54%; P=0.07), due, in part, to the use of radiotherapy, either exclusive or preoperative, for respectively 26 and 40% of patients. The lobular type had no adverse effect, neither on locoregional control nor on overall survival, even in the group of patients treated with breast conservation

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements