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Moving from non-interventionism to industrial strategy: The roles of tentative and definitive governance in support of the UK biotech sector
This paper develops a framework for characterising tentative and definitive governance modes. Using investor financing of UK-based therapeutic biotech firms as a context, the paper traces how policy-makers have blended tentative and definitive elements in the design and implementation of six different kinds of policies to spur investor support for these firms. We find that tentative and definitive governance are used together to balance the need for certainty with necessary responsiveness to the dynamic circumstances that surround technological emergence. Moreover we show that the relative use of tentative and definitive modes is shaped as much by higher-level landscape-level influences as by technology or sector-level factors. Challenges are also identified, for instance, how to maintain synergistic rather than either/or relationships between state and non-state actors when both hesitate to engage with markets at different times
Policy instruments (ânon-price)â for medical innovation
Innovation policy instruments are policy interventions with a specific mechanism of action that influences the innovation
process. This Oslo Medicines Initiative technical report presents a broad range of such instruments available to national
policy-makers in support of innovation for new medicines (excluding those focused on price, which are covered elsewhere in
the report series). This report explores various types of policy instruments, based on reviews of the literature on policies for
innovation in the medical and other sectors. For each type identified, the report explores the mechanisms of action, the effects
these have and where they occur, and the extent to which these instruments have been implemented globally. It also sets
out considerations for their effective implementation. The report demonstrates that the long-established push/pull (supply/
demand) framing that dominates discourse around medical innovation can be broadened, providing policy-makers with
instruments to supplement push/pull approaches, by emphasizing the role of communication, collaboration and coordination
in supporting the emergence of medicines to address societal needs
Simulating Turbulence Using the Astrophysical Discontinuous Galerkin Code TENET
In astrophysics, the two main methods traditionally in use for solving the
Euler equations of ideal fluid dynamics are smoothed particle hydrodynamics and
finite volume discretization on a stationary mesh. However, the goal to
efficiently make use of future exascale machines with their ever higher degree
of parallel concurrency motivates the search for more efficient and more
accurate techniques for computing hydrodynamics. Discontinuous Galerkin (DG)
methods represent a promising class of methods in this regard, as they can be
straightforwardly extended to arbitrarily high order while requiring only small
stencils. Especially for applications involving comparatively smooth problems,
higher-order approaches promise significant gains in computational speed for
reaching a desired target accuracy. Here, we introduce our new astrophysical DG
code TENET designed for applications in cosmology, and discuss our first
results for 3D simulations of subsonic turbulence. We show that our new DG
implementation provides accurate results for subsonic turbulence, at
considerably reduced computational cost compared with traditional finite volume
methods. In particular, we find that DG needs about 1.8 times fewer degrees of
freedom to achieve the same accuracy and at the same time is more than 1.5
times faster, confirming its substantial promise for astrophysical
applications.Comment: 21 pages, 7 figures, to appear in Proceedings of the SPPEXA
symposium, Lecture Notes in Computational Science and Engineering (LNCSE),
Springe
Dependence of GAMA galaxy halo masses on the cosmic web environment from 100 deg2 of KiDS weak lensing data
Galaxies and their dark matter haloes are part of a complex network of mass structures, collectively called the cosmic web. Using the tidal tensor prescription these structures can be classified into four cosmic environments: voids, sheets, filaments and knots. As the cosmic web may influence the formation and evolution of dark matter haloes and the galaxies they host, we aim to study the effect of these cosmic environments on the average mass of galactic haloes. To this end we measure the galaxyâgalaxy lensing profile of 91â195 galaxies, within 0.039 < z < 0.263, from the spectroscopic Galaxy And Mass Assembly survey, using âź100deg2âź100deg2 of overlapping data from the Kilo-Degree Survey. In each of the four cosmic environments we model the contributions from group centrals, satellites and neighbouring groups to the stacked galaxyâgalaxy lensing profiles. After correcting the lens samples for differences in the stellar mass distribution, we find no dependence of the average halo mass of central galaxies on their cosmic environment. We do find a significant increase in the average contribution of neighbouring groups to the lensing profile in increasingly dense cosmic environments. We show, however, that the observed effect can be entirely attributed to the galaxy density at much smaller scales (within 4âhâ1âMpc), which is correlated with the density of the cosmic environments. Within our current uncertainties we find no direct dependence of galaxy halo mass on their cosmic environment
Search for the standard model Higgs boson decaying into two photons in pp collisions at sqrt(s)=7 TeV
A search for a Higgs boson decaying into two photons is described. The
analysis is performed using a dataset recorded by the CMS experiment at the LHC
from pp collisions at a centre-of-mass energy of 7 TeV, which corresponds to an
integrated luminosity of 4.8 inverse femtobarns. Limits are set on the cross
section of the standard model Higgs boson decaying to two photons. The expected
exclusion limit at 95% confidence level is between 1.4 and 2.4 times the
standard model cross section in the mass range between 110 and 150 GeV. The
analysis of the data excludes, at 95% confidence level, the standard model
Higgs boson decaying into two photons in the mass range 128 to 132 GeV. The
largest excess of events above the expected standard model background is
observed for a Higgs boson mass hypothesis of 124 GeV with a local significance
of 3.1 sigma. The global significance of observing an excess with a local
significance greater than 3.1 sigma anywhere in the search range 110-150 GeV is
estimated to be 1.8 sigma. More data are required to ascertain the origin of
this excess.Comment: Submitted to Physics Letters
Measurement of the Lambda(b) cross section and the anti-Lambda(b) to Lambda(b) ratio with Lambda(b) to J/Psi Lambda decays in pp collisions at sqrt(s) = 7 TeV
The Lambda(b) differential production cross section and the cross section
ratio anti-Lambda(b)/Lambda(b) are measured as functions of transverse momentum
pt(Lambda(b)) and rapidity abs(y(Lambda(b))) in pp collisions at sqrt(s) = 7
TeV using data collected by the CMS experiment at the LHC. The measurements are
based on Lambda(b) decays reconstructed in the exclusive final state J/Psi
Lambda, with the subsequent decays J/Psi to an opposite-sign muon pair and
Lambda to proton pion, using a data sample corresponding to an integrated
luminosity of 1.9 inverse femtobarns. The product of the cross section times
the branching ratio for Lambda(b) to J/Psi Lambda versus pt(Lambda(b)) falls
faster than that of b mesons. The measured value of the cross section times the
branching ratio for pt(Lambda(b)) > 10 GeV and abs(y(Lambda(b))) < 2.0 is 1.06
+/- 0.06 +/- 0.12 nb, and the integrated cross section ratio for
anti-Lambda(b)/Lambda(b) is 1.02 +/- 0.07 +/- 0.09, where the uncertainties are
statistical and systematic, respectively.Comment: Submitted to Physics Letters
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