長者學習研究計劃2011-2012 : 計劃介紹及教材冊

有見長者的學歷及學習能力日高，長者的需求亦有所不同，對長者需求的研究實是需要的。加上部份長者表示希望參與較高層次的學習活動及貢獻社會，故嶺南大學服務研習處舉辦長者學習研究計劃2011-2012，培訓長者成為研究人員，期望由長者的角度出發，為長者學習 的長遠發展作出研究及提出建議。 計劃目標： • 培養長者對學術研究的興趣； • 提供研究技巧培訓課程； • 分析學苑現有課程的成效； • 探討長者學習的政策及制定長遠發展方向； • 透過長幼參與研究計劃，增加兩代溝通，促進跨代共融。 本手冊收錄了有關計劃詳情以及課程教材。https://commons.ln.edu.hk/osl_book/1002/thumbnail.jp

A handbook for using elder academy as a platform of other learning experiences

This handbook will discuss how school syllabus, Other Learning Experiences (OLE) and Elder Academy (EA) can be integrated. It will provide some structures for schools as a reference and help develop a comprehensive learning plan. Besides, the handbook will mention different roles and responsibilities of stakeholders, as well as the suggestions and guidelines for assessment. The programs and activities in the “Elder Academy at Lingnan” will be taken as examples to demonstrate the guidelines. This can provide a better understanding of the operation mode of the integration between school curricula, OLE and EA. Hence, interested stakeholders can perform their own plans more systematically and effectively.https://commons.ln.edu.hk/osl_book/1000/thumbnail.jp

Elder academy : curriculum design and operation model = 長者學苑 : 課程設計與運作模式

Ever since the launching of the Elder Academy in 2007, numerous schools have joined the fray bringing with them valuable innovations, presenting the elderly and students with a wide variety of educational activities. The experiences of the Elder Academy at Lingnan and other academies are summarized in this handbook, in order to provide a frame of reference and an operation guide for other schools and organizations, so that they may design their own comprehensive teaching and learning plans. In this handbook, the roles and responsibilities of participating organizations are explained, and there are guidelines and suggestions regarding assessment methods. Apart from the instructions on teaching and learning activities, examples of course syllabi and activities are also included to offer some insights into the operation of the schools and their courses, allowing institutions to better carry out similar projects in a more systematic manner.https://commons.ln.edu.hk/osl_book/1001/thumbnail.jp

長者學習研究計劃2011-2012 : 學員作品集

有見長者的學歷及學習能力日高，長者的需求亦有所不同，對長者需求的研究實是需要的。加上部份長者表示希望參與較高層次的學習活動及貢獻社會，故嶺南大學服務研習處舉辦長者學習研究計劃2011-2012，培訓長者成為研究人員，期望由長者的角度出發，為長者學習 的長遠發展作出研究及提出建議。計劃目標：• 培養長者對學術研究的興趣；• 提供研究技巧培訓課程；• 分析學苑現有課程的成效；• 探討長者學習的政策及制定長遠發展方向；• 透過長幼參與研究計劃，增加兩代溝通，促進跨代共融。 本作品集收錄了有關計劃中，長者學員們所撰寫的研究報告。https://commons.ln.edu.hk/osl_book/1003/thumbnail.jp

Meta-analysis Followed by Replication Identifies Loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as Associated with Systemic Lupus Erythematosus in Asians

Systemic lupus erythematosus (SLE) is a prototype autoimmune disease with a strong genetic involvement and ethnic differences. Susceptibility genes identified so far only explain a small portion of the genetic heritability of SLE, suggesting that many more loci are yet to be uncovered for this disease. In this study, we performed a meta-analysis of genome-wide association studies on SLE in Chinese Han populations and followed up the findings by replication in four additional Asian cohorts with a total of 5,365 cases and 10,054 corresponding controls. We identified genetic variants in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with the disease. These findings point to potential roles of cell-cycle regulation, autophagy, and DNA demethylation in SLE pathogenesis. For the region involving TET3 and that involving CDKN1B, multiple independent SNPs were identified, highlighting a phenomenon that might partially explain the missing heritability of complex diseases

Human germline heterozygous gain-of-function STAT6 variants cause severe allergic disease

STAT6 (signal transducer and activator of transcription 6) is a transcription factor that plays a central role in the pathophysiology of allergic inflammation. We have identified 16 patients from 10 families spanning three continents with a profound phenotype of early-life onset allergic immune dysregulation, widespread treatment-resistant atopic dermatitis, hypereosinophilia with esosinophilic gastrointestinal disease, asthma, elevated serum IgE, IgE-mediated food allergies, and anaphylaxis. The cases were either sporadic (seven kindreds) or followed an autosomal dominant inheritance pattern (three kindreds). All patients carried monoallelic rare variants in STAT6 and functional studies established their gain-of-function (GOF) phenotype with sustained STAT6 phosphorylation, increased STAT6 target gene expression, and TH2 skewing. Precision treatment with the anti-IL-4Rα antibody, dupilumab, was highly effective improving both clinical manifestations and immunological biomarkers. This study identifies heterozygous GOF variants in STAT6 as a novel autosomal dominant allergic disorder. We anticipate that our discovery of multiple kindreds with germline STAT6 GOF variants will facilitate the recognition of more affected individuals and the full definition of this new primary atopic disorder

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements