161 research outputs found
Quantum statistics of overlapping modes in open resonators
We study the quantum dynamics of optical fields in weakly confining
resonators with overlapping modes. Employing a recently developed quantization
scheme involving a discrete set of resonator modes and continua of external
modes we derive Langevin equations and a master equation for the resonator
modes. Langevin dynamics and the master equation are proved to be equivalent in
the Markovian limit. Our open-resonator dynamics may be used as a starting
point for a quantum theory of random lasers.Comment: 6 pages, corrected typo
Field quantization for open optical cavities
We study the quantum properties of the electromagnetic field in optical
cavities coupled to an arbitrary number of escape channels. We consider both
inhomogeneous dielectric resonators with a scalar dielectric constant
and cavities defined by mirrors of arbitrary shape. Using
the Feshbach projector technique we quantize the field in terms of a set of
resonator and bath modes. We rigorously show that the field Hamiltonian reduces
to the system--and--bath Hamiltonian of quantum optics. The field dynamics is
investigated using the input--output theory of Gardiner and Collet. In the case
of strong coupling to the external radiation field we find spectrally
overlapping resonator modes. The mode dynamics is coupled due to the damping
and noise inflicted by the external field. For wave chaotic resonators the mode
dynamics is determined by a non--Hermitean random matrix. Upon including an
amplifying medium, our dynamics of open-resonator modes may serve as a starting
point for a quantum theory of random lasing.Comment: 16 pages, added references, corrected typo
Density matrix operatorial solution of the non--Markovian Master Equation for Quantum Brownian Motion
An original method to exactly solve the non-Markovian Master Equation
describing the interaction of a single harmonic oscillator with a quantum
environment in the weak coupling limit is reported. By using a superoperatorial
approach we succeed in deriving the operatorial solution for the density matrix
of the system. Our method is independent of the physical properties of the
environment. We show the usefulness of our solution deriving explicit
expressions for the dissipative time evolution of some observables of physical
interest for the system, such as, for example, its mean energy.Comment: 16 pages, 1 figur
Dynamical aspects of quantum entanglement for weakly coupled kicked tops
We investigate how the dynamical production of quantum entanglement for
weakly coupled, composite quantum systems is influenced by the chaotic dynamics
of the corresponding classical system, using coupled kicked tops. The linear
entropy for the subsystem (a kicked top) is employed as a measure of
entanglement. A perturbative formula for the entanglement production rate is
derived. The formula contains a correlation function that can be evaluated only
from the information of uncoupled tops. Using this expression and the
assumption that the correlation function decays exponentially which is
plausible for chaotic tops, it is shown that {\it the increment of the strength
of chaos does not enhance the production rate of entanglement} when the
coupling is weak enough and the subsystems (kicked tops) are strongly chaotic.
The result is confirmed by numerical experiments. The perturbative approach is
also applied to a weakly chaotic region, where tori and chaotic sea coexist in
the corresponding classical phase space, to reexamine a recent numerical study
that suggests an intimate relationship between the linear stability of the
corresponding classical trajectory and the entanglement production rate.Comment: 16 pages, 11 figures, submitted to Phys. Rev.
Neoadjuvant pazopanib and molecular analysis of tissue response in renal cell carcinoma
BACKGROUND. Surgery remains the frontline therapy for patients with localized clear cell renal cell carcinoma (ccRCC); however, 20%â40% recur. Angiogenesis inhibitors have improved survival in metastatic patients and may result in responses in the neoadjuvant setting. The impact of these agents on the tumor genetic heterogeneity or the immune milieu is largely unknown. This phase II study was designed to evaluate safety, response, and effect on tumor tissue of neoadjuvant pazopanib. METHODS. ccRCC patients with localized disease received pazopanib (800 mg daily; median 8 weeks), followed by nephrectomy. Five tumors were examined for mutations by whole exome sequencing from samples collected before therapy and at nephrectomy. These samples underwent RNA sequencing; 17 samples were available for posttreatment assessment. RESULTS. Twenty-one patients were enrolled. The overall response rate was 8 of 21 (38%). No patients with progressive disease. At 1-year, response-free survival and overall survival was 83% and 89%, respectively. The most frequent grade 3 toxicity was hypertension (33%, 7 of 21). Sequencing revealed strong concordance between pre- and posttreatment samples within individual tumors, suggesting tumors harbor stable core profiles. However, a reduction in private mutations followed treatment, suggesting a selective process favoring enrichment of driver mutations. CONCLUSION. Neoadjuvant pazopanib is safe and active in ccRCC. Future genomic analyses may enable the segregation of driver and passenger mutations. Furthermore, tumor infiltrating immune cells persist during therapy, suggesting that pazopanib can be combined with immune checkpoint inhibitors without dampening the immune response. FUNDING. Support was provided by Novartis and GlaxoSmithKline as part of an investigator-initiated study
Ï production in pâPb collisions at âsNN=8.16 TeV
Ï production in pâPb interactions is studied at the centre-of-mass energy per nucleonânucleon collision âsNN = 8.16 TeV with the ALICE detector at the CERN LHC. The measurement is performed reconstructing bottomonium resonances via their dimuon decay channel, in the centre-of-mass rapidity intervals 2.03 < ycms < 3.53 and â4.46 < ycms < â2.96, down to zero transverse momentum. In this work, results on the Ï(1S) production cross section as a function of rapidity and transverse momentum are presented. The corresponding nuclear modification factor shows a suppression of the Ï(1S) yields with respect to pp collisions, both at forward and backward rapidity. This suppression is stronger in the low transverse momentum region and shows no significant dependence on the centrality of the interactions. Furthermore, the Ï(2S) nuclear modification factor is evaluated, suggesting a suppression similar to that of the Ï(1S). A first measurement of the Ï(3S) has also been performed. Finally, results are compared with previous ALICE measurements in pâPb collisions at âsNN = 5.02 TeV and with theoretical calculations.publishedVersio
(Anti-)deuteron production in pp collisions at 1as=13TeV
The study of (anti-)deuteron production in pp collisions has proven to be a powerful tool to investigate the formation mechanism of loosely bound states in high-energy hadronic collisions. In this paper the production of (anti-)deuterons is studied as a function of the charged particle multiplicity in inelastic pp collisions at s=13 TeV using the ALICE experiment. Thanks to the large number of accumulated minimum bias events, it has been possible to measure (anti-)deuteron production in pp collisions up to the same charged particle multiplicity (d Nch/ d \u3b7 3c 26) as measured in p\u2013Pb collisions at similar centre-of-mass energies. Within the uncertainties, the deuteron yield in pp collisions resembles the one in p\u2013Pb interactions, suggesting a common formation mechanism behind the production of light nuclei in hadronic interactions. In this context the measurements are compared with the expectations of coalescence and statistical hadronisation models (SHM)
Measurement of jet suppression in central Pb-Pb collisions at root s(NN)=2.76 TeV
The transverse momentum(p(T)) spectrum and nuclear modification factor (R-AA) of reconstructed jets in 0-10% and 10-30% central Pb-Pb collisions at root s(NN) = 2.76 TeV were measured. Jets were reconstructed using the anti-k(T) jet algorithm with a resolution parameter of R = 0.2 from charged and neutral particles, utilizing the ALICE tracking detectors and Electromagnetic Calorimeter (EMCal). The jet p(T) spectra are reported in the pseudorapidity interval of \eta(jet)\ 5 GeV/c to suppress jets constructed from the combinatorial background in Pb-Pb collisions. The leading charged particle requirement applied to jet spectra both in pp and Pb-Pb collisions had a negligible effect on the R-AA. The nuclear modification factor R-AA was found to be 0.28 +/- 0.04 in 0-10% and 0.35 +/- 0.04 in 10-30% collisions, independent of p(T), jet within the uncertainties of the measurement. The observed suppression is in fair agreement with expectations from two model calculations with different approaches to jet quenching. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V.Peer reviewe
Multiplicity dependence of inclusive J/psi production at midrapidity in pp collisions at root s=13 TeV
Measurements of the inclusive J/psi yield as a function of charged-particle pseudorapidity density dN(ch)/d eta in pp collisions at root s = 13 TeV with ALICE at the LHC are reported. The J/psi meson yield is measured at midrapidity (vertical bar y vertical bar <0.9) in the dielectron channel, for events selected based on the charged-particle multiplicity at midrapidity (vertical bar eta vertical bar <1) and at forward rapidity (-3.7 <eta <-1.7 and 2.8 <eta <5.1); both observables are normalized to their corresponding averages in minimum bias events. The increase of the normalized J/psi yield with normalized dN(ch)/d eta is significantly stronger than linear and dependent on the transverse momentum. The data are compared to theoretical predictions, which describe the observed trends well, albeit not always quantitatively. (C) 2020 European Organization for Nuclear Research. Published by Elsevier B.V.Peer reviewe
The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma
Renal cell carcinoma(RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic subtypes, including 488 clear cell RCC, 274 papillary RCC, and 81 chromophobe RCC. Comprehensive genomic and phenotypic analysis of the RCC subtypes reveals distinctive features of each subtype that provide the foundation for the development of subtype-specific therapeutic and management strategies for patients affected with these cancers. Somatic alteration of BAP1, PBRM1, and PTEN and altered metabolic pathways correlated with subtype-specific decreased survival, while CDKN2A alteration, increased DNA hypermethylation, and increases in the immune-related Th2 gene expression signature correlated with decreased survival within all major histologic subtypes. CIMP-RCC demonstrated an increased immune signature, and a uniform and distinct metabolic expression pattern identified a subset of metabolically divergent (MD) ChRCC that associated with extremely poor survival
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