An update on the Hirsch conjecture

The Hirsch conjecture was posed in 1957 in a letter from Warren M. Hirsch to George Dantzig. It states that the graph of a d-dimensional polytope with n facets cannot have diameter greater than n - d. Despite being one of the most fundamental, basic and old problems in polytope theory, what we know is quite scarce. Most notably, no polynomial upper bound is known for the diameters that are conjectured to be linear. In contrast, very few polytopes are known where the bound $n-d$ is attained. This paper collects known results and remarks both on the positive and on the negative side of the conjecture. Some proofs are included, but only those that we hope are accessible to a general mathematical audience without introducing too many technicalities.Comment: 28 pages, 6 figures. Many proofs have been taken out from version 2 and put into the appendix arXiv:0912.423

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types

Emoções, “stress”, ansiedade e “coping": estudo qualitativo com treinadores de nível internacional

A influência dos fatores e processos psicológicos no desempenho desportivo dos atletas está, de uma forma geral, amplamente demonstrada; todavia, poucas investigações procuraram estudar esta relação nos treinadores. Neste sentido, empregando uma entrevista semi-estruturada, a presente investigação procurou, junto de seis treinadores de elite com idades compreendidas entre os 55 e os 63 anos (M = 59 ± 3,03) de diversas modalidades, identificar as características/competências psicológicas mais importantes para o sucesso desportivo, as principais fontes de “stress” e ansiedade experienciadas e as estratégias de “coping” a que recorriam em situações estressantes e/ou problemáticas, adicionalmente, pretendeu explorar o papel de outras emoções no seu desempenho. Os resultados revelaram que: 1) a motivação era uma das competências/características psicológicas percepcionadas pelos treinadores como mais importantes para o sucesso; 2) as principais fontes de “stress” estavam relacionadas com preocupações com o desempenho dos atletas, sendo comuns a diferentes modalidades; 3) os treinadores recorriam a diversas estratégias de “coping” em simultâneo, geralmente adaptativas; e 4) para além da ansiedade, outras emoções, positivas e negativas, pareciam influenciar o desempenho dos treinadores.Fundação para a Ciência e Tecnologia (FCT

A First Search for coincident Gravitational Waves and High Energy Neutrinos using LIGO, Virgo and ANTARES data from 2007

We present the results of the first search for gravitational wave bursts associated with high energy neutrinos. Together, these messengers could reveal new, hidden sources that are not observed by conventional photon astronomy, particularly at high energy. Our search uses neutrinos detected by the underwater neutrino telescope ANTARES in its 5 line configuration during the period January - September 2007, which coincided with the fifth and first science runs of LIGO and Virgo, respectively. The LIGO-Virgo data were analysed for candidate gravitational-wave signals coincident in time and direction with the neutrino events. No significant coincident events were observed. We place limits on the density of joint high energy neutrino - gravitational wave emission events in the local universe, and compare them with densities of merger and core-collapse events.Comment: 19 pages, 8 figures, science summary page at http://www.ligo.org/science/Publication-S5LV_ANTARES/index.php. Public access area to figures, tables at https://dcc.ligo.org/cgi-bin/DocDB/ShowDocument?docid=p120000

Customer emotions in service failure and recovery encounters

Emotions play a significant role in the workplace, and considerable attention has been given to the study of employee emotions. Customers also play a central function in organizations, but much less is known about customer emotions. This chapter reviews the growing literature on customer emotions in employee–customer interfaces with a focus on service failure and recovery encounters, where emotions are heightened. It highlights emerging themes and key findings, addresses the measurement, modeling, and management of customer emotions, and identifies future research streams. Attention is given to emotional contagion, relationships between affective and cognitive processes, customer anger, customer rage, and individual differences

Time‐lapse photogrammetry reveals hydrological controls of fine‐scale High‐Arctic glacier surface roughness evolution

In a warming Arctic, as glacier snowlines rise, short- to medium-term increases in seasonal bare-ice extent are forecast for the next few decades. These changes will enhance the importance of turbulent energy fluxes for surface ablation and glacier mass balance. Turbulent energy exchanges at the ice surface are conditioned by its topography, or roughness, which has been hypothesized to be controlled by supraglacial hydrology at the glacier scale. However, current understanding of the dynamics in surface topography, and the role of drainage development, remains incomplete, particularly for the transition between seasonal snow cover and well-developed, weathered bare-ice. Using time-lapse photogrammetry, we report a daily timeseries of fine (millimetre)-scale supraglacial topography at a 2 m2 plot on the Lower Foxfonna glacier, Svalbard, over two 9-day periods in 2011. We show traditional kernel-based morphometric descriptions of roughness were ineffective in describing temporal change, but indicated fine-scale albedo feedbacks at depths of ~60 mm contributed to conditioning surface topography. We found profile-based and two-dimensional estimates of roughness revealed temporal change, and the aerodynamic roughness parameter, z0, showed a 22–32% decrease from ~1 mm following the exposure of bare-ice, and a subsequent 72–77% increase. Using geostatistical techniques, we identified ‘hole effect’ properties in the surface elevation semivariograms, and demonstrated that hydrological drivers control the plot-scale topography: degradation of superimposed ice reduces roughness while the inception of braided rills initiates a subsequent development and amplification of topography. Our study presents an analytical framework for future studies that interrogate the coupling between ice surface roughness and hydro-meteorological variables and seek to improve parameterizations of topographically evolving bare-ice areas

Pharmacotherapy review: a proposal to improve medication adherence among hypertensive patients

Abstract Pharmacotherapy review is a structured assessment of medicines, which aims to obtain a partnership with patients to achieve drug treatment goals and agreement about drug dosage, as well as when and how the drugs should be administered. The objective was to analyze the influence of pharmacotherapy review, by scheduling drug administration to improve medication adherence among antihypertensive patients. This study was an uncontrolled intervention developed in three distinct stages. The first stage included data collection on the profile of patients and their medications, and a preliminary assessment of medication adherence. In the second stage, the review report was delivered to patients. In the third stage, the results of blood pressure and medication adherence were assessed. The influence of the revision was measured through statistical tests (p<0.05). The study included 40 patients with a mean age of 58.0 (SD:11.3) years; 72.5% were women. Thirty-three (82.5 %) patients required some intervention, after when there was a significant increase in the number of daily doses (p=0.039) and drug intakes (p=0.025). There was a significant increase in the adherence rate, according to both the Morisky-Green test (p<0.001) and self-reported assessment (p=0.004). There was also an improvement in the levels of systolic (p<0.001) and diastolic (p=0.002) blood pressure and in the number of patients with controlled hypertension (p=0.006). The pharmaceutical service enhanced medication adherence and control of systemic blood pressure; however, it increased the complexity of treatment