Effect of Temperature on Curing Time of Single-Lap Adhesive Joints in Marine Applications

In the industrial field, manufacturing time is one of the most important factors affecting production costs. Structural adhesives require long curing times (i.e., 3–4 weeks) before the joined components can be safely employed. The aim of the present work is to test the effect of several thermal treatments on a commercial epoxy structural adhesive on the final resistance of single lap joints, trying to attain the possibility of a curing time reduction. Aluminum alloy 5083, typically employed in marine applications, is used as the substrate. Both the adhesive and the joints are treated at different temperatures/times, and then tensile tests are carried out to obtain the mechanical resistance and study the failure modes. A statistical analysis allows the evaluation of the effects of the thermal cycles on the mechanical performances of the joints and the comparison with those cured with the standard procedure

"Modern" suburbs in lockdown: the INA CASA neighbourhood by Filippo Rovigo in Messina

[EN] The recent CoViD-19 emergency, a dramatic issue for our health, and the vexata quaestio of the existing buildings recovery, especially of the neighborhood, are the ends of an Ariadne's thread that must help us find an exit from the two huge problems. These issues, coupled by the isolation constrain, can be converted in a great opportunity by using targeted choices, supported by sustainability criteria that are now unavoidable.In the present paper, a specific suburban area- former Fondo Basile by architect Filippo Rovigo, on the northern edge of Messina was selected. For this area - following the original indications formulated by the emerging "neorealist" culture for garden cities – we intend: to redefine barrier-free paths; to add green and blue infrastructures; to evaluate incidences on energy performance; to redesign interior spaces to accept the need for sterilization and “flexible” furnishings; to experiment with functionalized surfaces (self-cleaning, antibacterial, heat-insulating); to introduce ad hoc home automation.Therefore, it is necessary to start from a very serious accident on which we stumbled exploiting this experience in order to look at the virus as an opportunity for a general rebirth of the neighbourhood. This latter can be based on new or experimental concepts in order to allow a sustainable restoration of the Modern Architecture, addressed to the second post-war period heritage, not guaranteed by the constrained regime provided for by the Cultural Heritage Code. This possibility is back in the fore thanks to a more recent strategic direction for the protection of "new landscapes" promoted by the Regional Department for Sicilian culture and identity.Arena, M.; Calabrese, L.; Di Bella, G.; Fiandaca, O.; Minutoli, F.; Lione, R.; Todesco, F. (2020). "Modern" suburbs in lockdown: the INA CASA neighbourhood by Filippo Rovigo in Messina. VITRUVIO - International Journal of Architectural Technology and Sustainability. 5(2):17-36. https://doi.org/10.4995/vitruvio-ijats.2020.14465OJS17365

Composite Materials: A Review of Polymer and Metal Matrix Composites, Their Mechanical Characterization, and Mechanical Properties

Unlike conventional materials, composites have become an optimal option for a range of modern, industrial, clinical, and sports applications. This is combined with their noteworthy physical, thermal, electrical, and mechanical properties, as well as low weight and cost investment funds in certain cases. This review article attempts to give an overall outline of composite materials, regularly polymer-matrix composites (PMCs) and metal-matrix composites (MMCs). Polypropylene (PP) polymer and aluminum alloy were selected as matrices for this concentrate in light of their appealing properties and their use in different applications. Various studies address the different build-up materials, material handling, and the various properties. Mechanical characterization is an important cycle process for the development and design of composite materials and their components. It includes the determination of mechanical properties, for example, stiffness and strength according to standard test techniques (i.e., tensile, compression, and shear test strategies) distributed by the ASTM and EN ISO associations. Comparable to the determination of fatigue strength and fatigue life for composite materials. With respect to mechanical properties of composite materials, this paper reports several variables and limitations that affect mechanical property estimates, including material constituents, manufacturing process, test parameters, and environmental conditions

Evaluation of the galactogogue effect of silymarin on mothers of preterm newborns (<32 weeks)

Hypogalactia has a relative high frequency in women having delivered preterm infants, who often have difficulties in maintaining a sufficient production of milk for their infants’ needs over prolonged periods of time. Recent studies have shown a potential galactogogue effect of silymarin on milk production in animal models (cows and rats) and in humans (mothers of term newborns); nonetheless, none of the studies conducted on humans consisted of double-blind randomized clinical trials and no data are available concerning mothers who delivered preterm infants. The aim of our study was to assess the efficacy of silymarin (BIO-C®) as galactogogue and its tolerability in mothers who delivered preterm infants. We enrolled 50 mothers at 10±1 days post-partum who had delivered infants at ® and placebo arms. No adverse events were observed in the 2 arms among mothers and infants, and silymarin and its metabolites were not detectable in the analyzed human milk samples. Further investigation on specific patient groups affected by hypogalactia, defined according to stricter criteria, should be planned to assess the efficacy of the product in increasing milk production

Intravenous Fosfomycin for Systemic Multidrug-Resistant Pseudomonas aeruginosa Infections

Human Pseudomonas infections have high morbidity and mortality rates. Pseudomonas bacteria can cause sepsis or septic shock; they produce biofilm and commonly exhibit a multidrug resistant phenotype. The choice of antimicrobial therapy in many cases is challenging, and deep knowledge of clinical, microbiological, and pharmacological issues is required. Intravenous fosfomycin is being repurposed in a combination given its favorable pharmacokinetic/pharmacodynamic properties (a small molecule with favorable kinetic both in bloodstream infection and in deep-seated infections), antibiofilm activity, and its interesting synergistic effects with other antimicrobials. Recent literature on epidemiological, microbiological, pharmacological, and clinical data on intravenous fosfomycin therapy against Pseudomonas is herein reviewed and discussed

Has VZV epidemiology changed in Italy? Results of a seroprevalence study

The aim of the study was to evaluate if and how varicella prevalence has changed in Italy. In particular a seroprevalence study was performed, comparing it to similar surveys conducted in pre-immunization era. During 2013–2014, sera obtained from blood samples taken for diagnostic purposes or routine investigations were collected in collaboration with at least one laboratory/center for each region, following the approval of the Ethics Committee. Data were stratified by sex and age. All samples were processed in a national reference laboratory by an immunoassay with high sensitivity and specificity. Statutory notifications, national hospital discharge database and mortality data related to VZV infection were analyzed as well. A total of 3707 sera were collected and tested. In the studied period both incidence and hospitalization rates decreased and about 5 deaths per year have been registered. The seroprevalence decreased in the first year of life in subjects passively protected by their mother, followed by an increase in the following age classes. The overall antibody prevalence was 84%. The comparison with surveys conducted with the same methodology in 1996–1997 and 2003–2004 showed significant differences in age groups 1–19 y. The study confirms that in Italy VZV infection typically occurs in children. The impact of varicella on Italian population is changing. The comparison between studies performed in different periods shows a significant increase of seropositivity in age class 1–4 years, expression of vaccine interventions already adopted in some regions

An Italian Multicenter Study on the Epidemiology of Respiratory Syncytial Virus During SARS-CoV-2 Pandemic in Hospitalized Children

Since the beginning of 2020, a remarkably low incidence of respiratory virus hospitalizations has been reported worldwide. We prospectively evaluated 587 children, aged <12 years, admitted for respiratory tract infections from 1 September 2021 to 15 March 2022 in four Italian pediatric hospitals to assess the burden of respiratory viruses during the COVID-19 pandemic in Italy. At admission, a Clinical Respiratory Score was assigned and nasopharyngeal or nasal washing samples were collected and tested for respiratory viruses. Total admissions increased from the second half of October 2021 to the first half of December 2021 with a peak in early November 2021. The respiratory syncytial virus (RSV) incidence curve coincided with the total hospitalizations curve, occurred earlier than in the pre-pandemic years, and showed an opposite trend with respect to the incidence rate of SARS-CoV-2. Our results demonstrated an early peak in pediatric hospitalizations for RSV. SARS-CoV-2 may exhibit a competitive pressure on other respiratory viruses, most notably RSV

Methodological approach for evaluating the geo-exchange potential: VIGOR Project

In the framework of VIGOR Project, a national project coordinated by the Institute of Geosciences and Earth Resources (CNR-IGG) and sponsored by the Ministry of Economic Development (MiSE), dedicated to the evaluation of geothermal potential in the regions of the Convergence Objective in Italy (Puglia, Calabria, Campania and Sicily), is expected to evaluate the ability of the territory to heat exchange with the ground for air conditioning of buildings. To identify the conditions for the development of low enthalpy geothermal systems collected and organized on a regional scale geological and stratigraphic data useful for the preparation of a specific thematic mapping, able to represent in a synergistic and simplified way the physical parameters (geological, lithostratigraphic, hydrogeological, thermodynamic) that most influence the subsoil behavior for thermal exchange. The litho-stratigraphic and hydrogeological database created for every region led to the production of different cartographic thematic maps, such as the thermal conductivity (lithological and stratigraphical), the surface geothermal flux, the average annual temperature of air, the climate zoning, the areas of hydrogeological restrictions. To obtain a single representation of the geo-exchange potential of the region, the different thematic maps described must be combined together by means of an algorithm, defined on the basis of the SINTACS methodology. The purpose is to weigh the contributions of the involved parameters and to produce a preliminary synthesis map able to identify the territorial use of geothermal heat pump systems, based on the geological characteristics and in agreement with the existing regulatory constraints

Diagnosis of Imported Dengue and Zika Virus Infections in Italy from November 2015 to November 2022: Laboratory Surveillance Data from a National Reference Laboratory

Dengue (DENV) and Zika (ZIKV) viruses are mosquito-borne human pathogens. In Italy, the presence of the competent vector Aedes albopictus increases the risk of autochthonous transmission, and a national plan for arboviruses prevention, surveillance, and response (PNA 2020–2025) is in place. The results of laboratory diagnosis of both viruses by the National Reference Laboratory for arboviruses (NRLA) from November 2015 to November 2022 are presented. Samples from 655 suspected cases were tested by both molecular and serological assays. Virus and antibody kinetics, cross-reactivity, and diagnostic performance of IgM ELISA systems were analysed. Of 524 cases tested for DENV, 146 were classified as confirmed, 7 as probable, while 371 were excluded. Of 619 cases tested for ZIKV, 44 were classified as confirmed, while 492 were excluded. All cases were imported. Overall, 75.3% (110/146) of DENV and 50% (22/44) of ZIKV cases were confirmed through direct virus detection methods. High percentages of cross reactivity were observed between the two viruses. The median lag time from symptoms onset to sample collection was 7 days for both DENV molecular (range 0–20) and NS1 ELISA (range 0–48) tests, with high percentages of positivity also after 7 days (39% and 67%, respectively). For ZIKV, the median lag time was 5 days (range 0–22), with 16% positivity after 7 days. Diagnostic performance was assessed with negative predictive values ranging from 92% to 95% for the anti-DENV systems, and of 97% for the ZIKV one. Lower positive predictive values were seen in the tested population (DENV: 55% to 91%, ZIKV: 50%). DENV and ZIKV diagnosis by molecular test is the gold standard, but sample collection time is a limitation. Serological tests, including Plaque Reduction Neutralization Test, are thus necessary. Co-circulation and cross-reactivity between the two viruses increase diagnostic difficulty. Continuous evaluation of diagnostic strategies is essential to improve laboratory testing

Observation of associated near-side and away-side long-range correlations in √sNN=5.02 TeV proton-lead collisions with the ATLAS detector

Two-particle correlations in relative azimuthal angle (Δϕ) and pseudorapidity (Δη) are measured in √sNN=5.02  TeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1  μb-1 of data as a function of transverse momentum (pT) and the transverse energy (ΣETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Δη|<5) “near-side” (Δϕ∼0) correlation that grows rapidly with increasing ΣETPb. A long-range “away-side” (Δϕ∼π) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ΣETPb, is found to match the near-side correlation in magnitude, shape (in Δη and Δϕ) and ΣETPb dependence. The resultant Δϕ correlation is approximately symmetric about π/2, and is consistent with a dominant cos⁡2Δϕ modulation for all ΣETPb ranges and particle pT