28 research outputs found
Lattice dynamics and correlated atomic motion from the atomic pair distribution function
The mean-square relative displacements (MSRD) of atomic pair motions in
crystals are studied as a function of pair distance and temperature using the
atomic pair distribution function (PDF). The effects of the lattice vibrations
on the PDF peak widths are modelled using both a multi-parameter Born
von-Karman (BvK) force model and a single-parameter Debye model. These results
are compared to experimentally determined PDFs. We find that the near-neighbor
atomic motions are strongly correlated, and that the extent of this correlation
depends both on the interatomic interactions and crystal structure. These
results suggest that proper account of the lattice vibrational effects on the
PDF peak width is important in extracting information on static disorder in a
disordered system such as an alloy. Good agreement is obtained between the BvK
model calculations of PDF peak widths and the experimentally determined peak
widths. The Debye model successfully explains the average, though not detailed,
natures of the MSRD of atomic pair motion with just one parameter. Also the
temperature dependence of the Debye model largely agrees with the BvK model
predictions. Therefore, the Debye model provides a simple description of the
effects of lattice vibrations on the PDF peak widths.Comment: 9 pages, 11 figure
The Biochemical and Cellular Basis for Nutraceutical Strategies to Attenuate Neurodegeneration in Parkinson’s Disease
Future therapeutic intervention that could effectively decelerate the rate of degeneration within the substantia nigra pars compacta (SNc) could add years of mobility and reduce morbidity associated with Parkinson’s disease (PD). Neurodegenerative decline associated with PD is distinguished by extensive damage to SNc dopaminergic (DAergic) neurons and decay of the striatal tract. While genetic mutations or environmental toxins can precipitate pathology, progressive degenerative succession involves a gradual decline in DA neurotransmission/synaptic uptake, impaired oxidative glucose consumption, a rise in striatal lactate and chronic inflammation. Nutraceuticals play a fundamental role in energy metabolism and signaling transduction pathways that control neurotransmission and inflammation. However, the use of nutritional supplements to slow the progression of PD has met with considerable challenge and has thus far proven unsuccessful. This review re-examines precipitating factors and insults involved in PD and how nutraceuticals can affect each of these biological targets. Discussed are disease dynamics (Sections 1 and 2) and natural substances, vitamins and minerals that could impact disease processes (Section 3). Topics include nutritional influences on α-synuclein aggregation, ubiquitin proteasome function, mTOR signaling/lysosomal-autophagy, energy failure, faulty catecholamine trafficking, DA oxidation, synthesis of toxic DA-quinones, o-semiquinones, benzothiazolines, hyperhomocyseinemia, methylation, inflammation and irreversible oxidation of neuromelanin. In summary, it is clear that future research will be required to consider the multi-faceted nature of this disease and re-examine how and why the use of nutritional multi-vitamin-mineral and plant-based combinations could be used to slow the progression of PD, if possible
The remarks, which the author of the Compendious extract, &c. in the preface to his book, has friendly desired of the Rev. of Thurenstein, for the time pastor of the Luthren Congregation of J.C. in Philadelphia [electronic resource] : [Four lines from Luther].
Count Zinzendorf's rejoinder to the anonymous 'Compendious extract' said to be written by a group of new side Presbyterian clergymen including Gilbert Tennent and Samuel Blair.Signatures: A-Cp4sEvans,Hildeburn, C.R. Pennsylvania,Miller, C.W. Franklin,Electronic reproduction.English Short Title Catalog,Reproduction of original from Library of Congress