872 research outputs found
In-vivo time-dependent articular cartilage contact behavior of the tibiofemoral joint
SummaryObjectiveThe purpose of this study was to investigate the in-vivo time-dependent contact behavior of tibiofemoral cartilage of human subjects during the first 300s after applying a constant full body weight loading and determine whether there are differences in cartilage contact responses between the medial and lateral compartments.DesignSix healthy knees were investigated in this study. Each knee joint was subjected to full body weight loading and the in-vivo positions of the knee were captured by two orthogonal fluoroscopes during the first 300s after applying the load. Three-dimensional models of the knee were created from MR images and used to reproduce the in-vivo knee positions recorded by the fluoroscopes. The time-dependent contact behavior of the cartilage was represented using the peak cartilage contact deformation and the cartilage contact area as functions of time under the constant full body weight.ResultsBoth medial and lateral compartments showed a rapid increase in contact deformation and contact area during the first 20s of loading. After 50s of loading, the peak contact deformation values were 10.5Âą0.8% (medial) and 12.6Âą3.4% (lateral), and the contact areas were 223.9Âą14.8mm2 (medial) and 123.0Âą22.8mm2 (lateral). Thereafter, the peak cartilage contact deformation and contact area remained relatively constant. The respective changing rates of cartilage contact deformation were 1.4Âą0.9%/s (medial) and 3.1Âą2.5%/s (lateral); and of contact areas were 40.6Âą20.8mm2/s (medial) and 24.0Âą11.4mm2/s (lateral), at the first second of loading. Beyond 50s, both changing rates approached zero.ConclusionsThe peak cartilage contact deformation increased rapidly within the first 20s of loading and remained relatively constant after âź50s of loading. The time-dependent response of cartilage contact behavior under constant full body weight loading was significantly different in the medial and lateral tibiofemoral compartments, with greater peak cartilage contact deformation on the lateral side and greater contact area on the medial side. These data can provide insight into normal in-vivo cartilage function and provide guidelines for the improvement of ex-vivo cartilage experiments and the validation of computational models that simulate human knee joint contact
Two Mathematically Equivalent Versions of Maxwell's Equations
This paper is a review of the canonical proper-time approach to relativistic
mechanics and classical electrodynamics. The purpose is to provide a physically
complete classical background for a new approach to relativistic quantum
theory. Here, we first show that there are two versions of Maxwell's equations.
The new version fixes the clock of the field source for all inertial observers.
However now, the (natural definition of the effective) speed of light is no
longer an invariant for all observers, but depends on the motion of the source.
This approach allows us to account for radiation reaction without the
Lorentz-Dirac equation, self-energy (divergence), advanced potentials or any
assumptions about the structure of the source. The theory provides a new
invariance group which, in general, is a nonlinear and nonlocal representation
of the Lorentz group. This approach also provides a natural (and unique)
definition of simultaneity for all observers. The corresponding particle theory
is independent of particle number, noninvariant under time reversal (arrow of
time), compatible with quantum mechanics and has a corresponding positive
definite canonical Hamiltonian associated with the clock of the source.
We also provide a brief review of our work on the foundational aspects of the
corresponding relativistic quantum theory. Here, we show that the standard
square-root and the Dirac equations are actually two distinct
spin- particle equations.Comment: Appeared: Foundations of Physic
Body image is an important augmentation to quality of life in evaluating the results of laparoscopic versus classic surgery
Laser operation of an Nd:Gd<sub>3</sub>Ga<sub>5</sub>O<sub>12</sub> thin-film optical waveguide fabricated by pulsed laser deposition
We report the laser operation of a thin-film waveguide structure grown by the pulsed laser deposition technique. A 2.7-Âľm-thick crystalline film of neodymium doped Gd3Ga5O12 (Nd:GGG) lases at a wavelength centered at 1.06Âľm when pumped by a Ti:sapphire laser at 808 nm
Semiparametric theory and empirical processes in causal inference
In this paper we review important aspects of semiparametric theory and
empirical processes that arise in causal inference problems. We begin with a
brief introduction to the general problem of causal inference, and go on to
discuss estimation and inference for causal effects under semiparametric
models, which allow parts of the data-generating process to be unrestricted if
they are not of particular interest (i.e., nuisance functions). These models
are very useful in causal problems because the outcome process is often complex
and difficult to model, and there may only be information available about the
treatment process (at best). Semiparametric theory gives a framework for
benchmarking efficiency and constructing estimators in such settings. In the
second part of the paper we discuss empirical process theory, which provides
powerful tools for understanding the asymptotic behavior of semiparametric
estimators that depend on flexible nonparametric estimators of nuisance
functions. These tools are crucial for incorporating machine learning and other
modern methods into causal inference analyses. We conclude by examining related
extensions and future directions for work in semiparametric causal inference
Extrapolating SMBH correlations down the mass scale: the case for IMBHs in globular clusters
Empirical evidence for both stellar mass black holes M_bh<10^2 M_sun) and
supermassive black holes (SMBHs, M_bh>10^5 M_sun) is well established.
Moreover, every galaxy with a bulge appears to host a SMBH, whose mass is
correlated with the bulge mass, and even more strongly with the central stellar
velocity dispersion sigma_c, the `M-sigma' relation. On the other hand,
evidence for "intermediate-mass" black holes (IMBHs, with masses in the range
1^2 - 10^5 M_sun) is relatively sparse, with only a few mass measurements
reported in globular clusters (GCs), dwarf galaxies and low-mass AGNs. We
explore the question of whether globular clusters extend the M-sigma
relationship for galaxies to lower black hole masses and find that available
data for globular clusters are consistent with the extrapolation of this
relationship. We use this extrapolated M-sigma relationship to predict the
putative black hole masses of those globular clusters where existence of
central IMBH was proposed. We discuss how globular clusters can be used as a
constraint on theories making specific predictions for the low-mass end of the
M-sigma relation.Comment: 14 pages, 3 figures, accepted for publication in Astrophysics and
Space Science; fixed typos and a quote in Sec.
Field Measurements of Terrestrial and Martian Dust Devils
Surface-based measurements of terrestrial and martian dust devils/convective vortices provided from mobile and stationary platforms are discussed. Imaging of terrestrial dust devils has quantified their rotational and vertical wind speeds, translation speeds, dimensions, dust load, and frequency of occurrence. Imaging of martian dust devils has provided translation speeds and constraints on dimensions, but only limited constraints on vertical motion within a vortex. The longer mission durations on Mars afforded by long operating robotic landers and rovers have provided statistical quantification of vortex occurrence (time-of-sol, and recently seasonal) that has until recently not been a primary outcome of more temporally limited terrestrial dust devil measurement campaigns. Terrestrial measurement campaigns have included a more extensive range of measured vortex parameters (pressure, wind, morphology, etc.) than have martian opportunities, with electric field and direct measure of dust abundance not yet obtained on Mars. No martian robotic mission has yet provided contemporaneous high frequency wind and pressure measurements. Comparison of measured terrestrial and martian dust devil characteristics suggests that martian dust devils are larger and possess faster maximum rotational wind speeds, that the absolute magnitude of the pressure deficit within a terrestrial dust devil is an order of magnitude greater than a martian dust devil, and that the time-of-day variation in vortex frequency is similar. Recent terrestrial investigations have demonstrated the presence of diagnostic dust devil signals within seismic and infrasound measurements; an upcoming Mars robotic mission will obtain similar measurement types
Measurement of the B0-anti-B0-Oscillation Frequency with Inclusive Dilepton Events
The - oscillation frequency has been measured with a sample of
23 million \B\bar B pairs collected with the BABAR detector at the PEP-II
asymmetric B Factory at SLAC. In this sample, we select events in which both B
mesons decay semileptonically and use the charge of the leptons to identify the
flavor of each B meson. A simultaneous fit to the decay time difference
distributions for opposite- and same-sign dilepton events gives ps.Comment: 7 pages, 1 figure, submitted to Physical Review Letter
Search for a W' boson decaying to a bottom quark and a top quark in pp collisions at sqrt(s) = 7 TeV
Results are presented from a search for a W' boson using a dataset
corresponding to 5.0 inverse femtobarns of integrated luminosity collected
during 2011 by the CMS experiment at the LHC in pp collisions at sqrt(s)=7 TeV.
The W' boson is modeled as a heavy W boson, but different scenarios for the
couplings to fermions are considered, involving both left-handed and
right-handed chiral projections of the fermions, as well as an arbitrary
mixture of the two. The search is performed in the decay channel W' to t b,
leading to a final state signature with a single lepton (e, mu), missing
transverse energy, and jets, at least one of which is tagged as a b-jet. A W'
boson that couples to fermions with the same coupling constant as the W, but to
the right-handed rather than left-handed chiral projections, is excluded for
masses below 1.85 TeV at the 95% confidence level. For the first time using LHC
data, constraints on the W' gauge coupling for a set of left- and right-handed
coupling combinations have been placed. These results represent a significant
improvement over previously published limits.Comment: Submitted to Physics Letters B. Replaced with version publishe
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