Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.

Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150 134 European ancestry individuals and sought significant evidence for independent replication in a further 228 245 individuals. We report 6 new signals of association in or near HSPB7, TNXB, LRP12, LOC283335, SEPT9, and AKT2, and provide new replication evidence for a further 2 signals in EBF2 and NFKBIA Combining large whole-blood gene expression resources totaling 12 607 individuals, we investigated all novel and previously reported signals and identified 48 genes with evidence for involvement in blood pressure regulation that are significant in multiple resources. Three novel kidney-specific signals were also detected. These robustly implicated genes may provide new leads for therapeutic innovation

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.

Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. These findings suggest that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways

Marija Klepo, harfa : diplomski ispit

Diplomski ispit Marije Klepo (harfa), studentice MA. Ispit je održan na MA u dvorani "Lhotka" 24. rujna 2020. Klavirska pratnja: Domagoj Guščić; mentorica: Diana Grubišić Ćiković. Program: 1. Johann Sebastian Bach - Marcel Grandjany: Allemande iz Violinske partite br. 2; 2. Camille Saint-Saens: Morceau de Concert, Op. 154; 3. Eric Schmidt: Etude No. 1 iz Six Etudes pour Harpe; 4. Germaine Tailleferre: Sonate pour Harpe (I. Allegretto, II. Lento, III. Perpetuum Mobile); 5. Claude Debussy: Clair de Lune iz Suite Bergamasque; 6. Tomislav Uhlik: Žalobne Varijacije/ Melancholy Variations; 7. Marcel Grandjany: The Colorado Trail, Fantaisie for Harp, Op. 28

Marija Klepo, harfa : diplomski ispit

Diplomski ispit Marije Klepo (harfa), studentice MA. Ispit je održan na MA u dvorani "Lhotka" 24. rujna 2020. Klavirska pratnja: Domagoj Guščić; mentorica: Diana Grubišić Ćiković. Program: 1. Johann Sebastian Bach - Marcel Grandjany: Allemande iz Violinske partite br. 2; 2. Camille Saint-Saens: Morceau de Concert, Op. 154; 3. Eric Schmidt: Etude No. 1 iz Six Etudes pour Harpe; 4. Germaine Tailleferre: Sonate pour Harpe (I. Allegretto, II. Lento, III. Perpetuum Mobile); 5. Claude Debussy: Clair de Lune iz Suite Bergamasque; 6. Tomislav Uhlik: Žalobne Varijacije/ Melancholy Variations; 7. Marcel Grandjany: The Colorado Trail, Fantaisie for Harp, Op. 28

Lans, un campement de plein-air gravettien dans la vallée de la Saône

International audienc

Lans, un campement de plein-air gravettien dans la vallée de la Saône

International audienc

Lans, un campement de plein-air gravettien dans la vallée de la Saône

International audienc

Concertos for harp and orchestra /

Morceau de concert ensol majeur pour harpe avec accompagnemetn d'orchestre op. 154 / Camille Saint-SaënsConcertino pour harpe et orchestre / Germaine TailleferreConcierto para arpa y orquesta / Alberto Ginaster