APPLICATION TYPE AND AIB minicuttings IN SEEDLING PRODUCTION OF Handroanthus heptaphyllus Mattos

O objetivo deste trabalho foi avaliar o efeito do tipo de miniestacas e a necessidade de aplica\ue7\ue3o de \ue1cido indolbut\uedrico sobre o enraizamento e qualidade das mudas formadas de Handroanthus heptaphyllus . As miniestacas apicais e intermedi\ue1rias foram obtidas em minijardim multiclonal formado a partir de sementes. As miniestacas foram preparadas com 5 cm de comprimento, um par de folhas reduzidas a 50% da \ue1rea foliar e estaqueadas sem e com AIB na concentra\ue7\ue3o de 8000 mg L-1. As avalia\ue7\uf5es foram realizadas aos 30 dias, na expedi\ue7\ue3o do setor de enraizamento e aos 120 dias, quando a muda se encontrava formada. O experimento foi conduzido em delineamento inteiramente casualizado, em esquema fatorial 3 x 2 x 2 (tr\ueas \ue9pocas de coleta, duas concentra\ue7\uf5es de AIB e duas posi\ue7\uf5es do prop\ue1gulo), com quatro repeti\ue7\uf5es, sendo 12 miniestacas por repeti\ue7\ue3o. De acordo com os resultados, o AIB n\ue3o foi necess\ue1rio para o enraizamento das miniestacas, entretanto, sua utiliza\ue7\ue3o promove incremento do n\ufamero e comprimento de ra\uedzes. As miniestacas intermedi\ue1rias proporcionaram maior massa seca de ra\uedzes aos 30 dias ap\uf3s o estaqueamento, e aos 120 dias, maior n\ufamero de folhas e de ra\uedzes. A \ue9poca de coleta influenciou a qualidade final das mudas. Aquelas produzidas na \ufaltima coleta (oitavo) apresentaram valores m\ue9dios inferiores nas caracter\uedsticas biom\ue9tricas, exceto para o comprimento e n\ufamero de ra\uedzes de primeira ordem.The objective of this study was to evaluate the effect of type of cuttings and the need for application of IBA on rooting and quality of the seedlings formed Handroanthus heptaphyllus . The apical and intermediate cuttings were obtained in multiclonal minigarden formed from seeds. The cuttings were prepared with 5 cm length, a pair of leaves reduced to 50% of leaf area without staked and IBA at a concentration of 8000 mg L-1. Evaluations were performed at 30 days, the expedition rooting sector and at 120 days, when the change was in formed. The experiment was conducted in a completely randomized design in a factorial 3 x 2 x 2 (three sampling times, two concentrations of IBA and two positions of propagules), with four replications, with 12 cuttings per replicate. According to the results, the IBA was not necessary for the rooting of the shoots, however, their use promotes an increase in the number and length of roots. The intermediate cuttings showed higher dry mass of roots at 30 days after striking, and at 120 days, more leaves and roots. The collection time influenced the final quality of the seedlings. Those produced in the last collection (eighth) had lower mean scores in biometric characteristics, except for the length and number of roots of the first order

Soluble guanylate cyclase stimulators in patients with heart failure with reduced ejection fraction across the risk spectrum

Patients with heart failure with reduced ejection fraction (HFrEF) have a high residual risk of adverse outcomes, even when treated with optimal guideline-directed medical therapy and in a clinically stable state. Soluble guanylate cyclase (sGC) stimulators have the potential to lower this risk by modifying the nitric oxide–sGC–cyclic guanosine monophosphate cascade – a pathophysiological pathway that has been targeted with limited success in HFrEF previously. Vericiguat, an sGC stimulator, was shown to improve outcomes in patients with HFrEF in the VICTORIA (Vericiguat Global Study in Subjects with Heart Failure with Reduced Ejection Fraction) trial. However, this trial included patients with recently worsening disease. In this brief review, we discuss the rationale of evaluating sGC stimulators in lower-risk HFrEF patients. First, all key HFrEF medications have been evaluated in both higher- and lower-risk populations, and the treatment effect is not always consistent across the risk spectrum. Second, pre-clinical studies and post-hoc studies of the VICTORIA trial have suggested that sGC stimulators may have cardioprotective effects – these effects may be more apparent when the medication is initiated earlier in the disease process. Third, the effect of vericiguat on cardiovascular mortality remains uncertain and a trial with a longer follow-up in a lower-risk population may allow better assessment of its effect on cardiovascular mortality. Therefore, there is a pertinent need to investigate the effects of vericiguat in optimally treated, low-risk HFrEF patients (i.e. those without recently worsening heart failure).</p

First-Line Ipatasertib, Atezolizumab, and Taxane Triplet for Metastatic Triple-Negative Breast Cancer: Clinical and Biomarker Results.

PURPOSE: To evaluate a triplet regimen combining immune checkpoint blockade, AKT pathway inhibition, and (nab-) paclitaxel as first-line therapy for locally advanced/metastatic triple-negative breast cancer (mTNBC). PATIENTS AND METHODS: The single-arm CO40151 phase Ib study (NCT03800836), the single-arm signal-seeking cohort of IPATunity130 (NCT03337724), and the randomized phase III IPATunity170 trial (NCT04177108) enrolled patients with previously untreated mTNBC. Triplet therapy comprised intravenous atezolizumab 840 mg (days 1 and 15), oral ipatasertib 400 mg/day (days 1-21), and intravenous paclitaxel 80 mg/m2 (or nab-paclitaxel 100 mg/m2; days 1, 8, and 15) every 28 days. Exploratory translational research aimed to elucidate mechanisms and molecular markers of sensitivity and resistance. RESULTS: Among 317 patients treated with the triplet, efficacy ranged across studies as follows: median progression-free survival (PFS) 5.4 to 7.4 months, objective response rate 44% to 63%, median duration of response 5.6 to 11.1 months, and median overall survival 15.7 to 28.3 months. The safety profile was consistent with the known toxicities of each agent. Grade ≥3 adverse events were more frequent with the triplet than with doublets or single-agent paclitaxel. Patients with PFS >10 months were characterized by NF1, CCND3, and PIK3CA alterations and increased immune pathway activity. PFS <5 months was associated with CDKN2A/CDKN2B/MTAP alterations and lower predicted phosphorylated AKT-S473 levels. CONCLUSIONS: In patients with mTNBC receiving an ipatasertib/atezolizumab/taxane triplet regimen, molecular characteristics may identify those with particularly favorable or unfavorable outcomes, potentially guiding future research efforts

Search for Gravitational Wave Bursts from Soft Gamma Repeaters

We present the results of a LIGO search for short-duration gravitational waves (GWs) associated with Soft Gamma Repeater (SGR) bursts. This is the first search sensitive to neutron star f-modes, usually considered the most efficient GW emitting modes. We find no evidence of GWs associated with any SGR burst in a sample consisting of the 27 Dec. 2004 giant flare from SGR 1806-20 and 190 lesser events from SGR 1806-20 and SGR 1900+14 which occurred during the first year of LIGO's fifth science run. GW strain upper limits and model-dependent GW emission energy upper limits are estimated for individual bursts using a variety of simulated waveforms. The unprecedented sensitivity of the detectors allows us to set the most stringent limits on transient GW amplitudes published to date. We find upper limit estimates on the model-dependent isotropic GW emission energies (at a nominal distance of 10 kpc) between 3x10^45 and 9x10^52 erg depending on waveform type, detector antenna factors and noise characteristics at the time of the burst. These upper limits are within the theoretically predicted range of some SGR models.Comment: 6 pages, 1 Postscript figur

Stacked Search for Gravitational Waves from the 2006 SGR 1900+14 Storm

We present the results of a LIGO search for short-duration gravitational waves (GWs) associated with the 2006 March 29 SGR 1900+14 storm. A new search method is used, "stacking'' the GW data around the times of individual soft-gamma bursts in the storm to enhance sensitivity for models in which multiple bursts are accompanied by GW emission. We assume that variation in the time difference between burst electromagnetic emission and potential burst GW emission is small relative to the GW signal duration, and we time-align GW excess power time-frequency tilings containing individual burst triggers to their corresponding electromagnetic emissions. We use two GW emission models in our search: a fluence-weighted model and a flat (unweighted) model for the most electromagnetically energetic bursts. We find no evidence of GWs associated with either model. Model-dependent GW strain, isotropic GW emission energy E_GW, and \gamma = E_GW / E_EM upper limits are estimated using a variety of assumed waveforms. The stacking method allows us to set the most stringent model-dependent limits on transient GW strain published to date. We find E_GW upper limit estimates (at a nominal distance of 10 kpc) of between 2x10^45 erg and 6x10^50 erg depending on waveform type. These limits are an order of magnitude lower than upper limits published previously for this storm and overlap with the range of electromagnetic energies emitted in SGR giant flares.Comment: 7 pages, 3 figure

A First Search for coincident Gravitational Waves and High Energy Neutrinos using LIGO, Virgo and ANTARES data from 2007

We present the results of the first search for gravitational wave bursts associated with high energy neutrinos. Together, these messengers could reveal new, hidden sources that are not observed by conventional photon astronomy, particularly at high energy. Our search uses neutrinos detected by the underwater neutrino telescope ANTARES in its 5 line configuration during the period January - September 2007, which coincided with the fifth and first science runs of LIGO and Virgo, respectively. The LIGO-Virgo data were analysed for candidate gravitational-wave signals coincident in time and direction with the neutrino events. No significant coincident events were observed. We place limits on the density of joint high energy neutrino - gravitational wave emission events in the local universe, and compare them with densities of merger and core-collapse events.Comment: 19 pages, 8 figures, science summary page at http://www.ligo.org/science/Publication-S5LV_ANTARES/index.php. Public access area to figures, tables at https://dcc.ligo.org/cgi-bin/DocDB/ShowDocument?docid=p120000

BRS symmetry restoration of chiral Abelian Higgs-Kibble theory in dimensional renormalization with a non-anticommuting γ5\gamma_5

The one-loop renormalization of the abelian Higgs-Kibble model in a general 't Hooft gauge and with chiral fermions is fully worked out within dimensional renormalization scheme with a non-anticommuting $\gamma_5$. The anomalous terms introduced in the Slavnov-Taylor identities by the minimal subtraction algorithm are calculated and the asymmetric counterterms needed to restore the BRS symmetry, if the anomaly cancellation conditions are met, are computed. The computations draw heavily from regularized action principles and Algebraic Renormalization theory.Comment: 32 pages, 11 figures, one table, plane tex in several files, uses epsf.tex. Mathematica programs which generate the tex files with results are included. V.2: references added and minor typos correcte