Superconducting Antenna Concept for Gravitational Waves

The most advanced contemporary efforts and concepts for registering gravitational waves are focused on measuring tiny deviations in large arm (kilometers in case of LIGO and thousands of kilometers in case of LISA) interferometers via photons. In this report we discuss a concept for the detection of gravitational waves using an antenna comprised of superconducting electrons (Cooper pairs) moving in an ionic lattice. The major challenge in this approach is that the tidal action of the gravitational waves is extremely weak compared with electromagnetic forces. Any motion caused by gravitational waves, which violates charge neutrality, will be impeded by Coulomb forces acting on the charge carriers (Coulomb blockade) in metals, as well as in superconductors. We discuss a design, which avoids the effects of Coulomb blockade. It exploits two different superconducting materials used in a form of thin wires -“spaghetti.” The spaghetti will have a diameter comparable to the London penetration depth, and length of about 1-10 meters. To achieve competitive sensitivity, the antenna would require billions of spaghettis, which calls for a challenging manufacturing technology. If successfully materialized, the response of the antenna to the known highly periodic sources of gravitational radiation, such as the Pulsar in Crab Nebula will result in an output current, detectable by superconducting electronics. The antenna will require deep (0.3K) cryogenic cooling and magnetic shielding. This design may be a viable successor to LISA and LIGO concepts, having the prospect of higher sensitivity, much smaller size and directional selectivity. This concept of compact antenna may benefit also terrestrial gradiometry

Superconducting Antenna Concept for Gravitational Waves

The most advanced contemporary efforts and concepts for registering gravitational waves are focused on measuring tiny deviations in large arm (kilometers in case of LIGO and thousands of kilometers in case of LISA) interferometers via photons. In this report we discuss a concept for the detection of gravitational waves using an antenna comprised of superconducting electrons (Cooper pairs) moving in an ionic lattice. The major challenge in this approach is that the tidal action of the gravitational waves is extremely weak compared with electromagnetic forces. Any motion caused by gravitational waves, which violates charge neutrality, will be impeded by Coulomb forces acting on the charge carriers (Coulomb blockade) in metals, as well as in superconductors. We discuss a design, which avoids the effects of Coulomb blockade. It exploits two different superconducting materials used in a form of thin wires -“spaghetti.” The spaghetti will have a diameter comparable to the London penetration depth, and length of about 1-10 meters. To achieve competitive sensitivity, the antenna would require billions of spaghettis, which calls for a challenging manufacturing technology. If successfully materialized, the response of the antenna to the known highly periodic sources of gravitational radiation, such as the Pulsar in Crab Nebula will result in an output current, detectable by superconducting electronics. The antenna will require deep (0.3K) cryogenic cooling and magnetic shielding. This design may be a viable successor to LISA and LIGO concepts, having the prospect of higher sensitivity, much smaller size and directional selectivity. This concept of compact antenna may benefit also terrestrial gradiometry

“Spaghetti” Design for Gravitational Wave Superconducting Antenna

A new concept for detectors of gravitational wave radiation is discussed. Estimates suggest that strain sensitivity essentially better than that of the existing devices can be achieved in the wide frequency range. Such sensitivity could be obtained with devices about one meter long. Suggested device consists of multi-billion bimetallic superconducting wires ( spaghettis ) and requires cryogenic operational temperatures (~0.3K in the case considered)

Skunk River Review Fall 2000, Vol 12

https://openspace.dmacc.edu/skunkriver/1020/thumbnail.jp

Large Eccentricity, Low Mutual Inclination: The Three-dimensional Architecture of a Hierarchical System of Giant Planets

We establish the three-dimensional architecture of the Kepler-419 (previously KOI-1474) system to be eccentric yet with a low mutual inclination. Kepler-419b is a warm Jupiter at semi-major axis ɑ = 0.370^(+0.007)_(-0.006) AU with a large eccentricity (e = 0.85^(+0.08)_(-0.07)) measured via the "photoeccentric effect." It exhibits transit timing variations (TTVs) induced by the non-transiting Kepler-419c, which we uniquely constrain to be a moderately eccentric (e = 0.184 ± 0.002), hierarchically separated (a = 1.68 ± 0.03 AU) giant planet (7.3 ± 0.4 M J_(up)). We combine 16 quarters of Kepler photometry, radial-velocity (RV) measurements from the HIgh Resolution Echelle Spectrometer on Keck, and improved stellar parameters that we derive from spectroscopy and asteroseismology. From the RVs, we measure the mass of the inner planet to be 2.5 ± 0.3 M J_(up) and confirm its photometrically measured eccentricity, refining the value to e = 0.83 ± 0.01. The RV acceleration is consistent with the properties of the outer planet derived from TTVs. We find that despite their sizable eccentricities, the planets are coplanar to within 9^(+8)_(-6) degrees, and therefore the inner planet's large eccentricity and close-in orbit are unlikely to be the result of Kozai migration. Moreover, even over many secular cycles, the inner planet's periapse is most likely never small enough for tidal circularization. Finally, we present and measure a transit time and impact parameter from four simultaneous ground-based light curves from 1 m class telescopes, demonstrating the feasibility of ground-based follow-up of Kepler giant planets exhibiting large TTVs

Aptamer-based multiplexed proteomic technology for biomarker discovery

Interrogation of the human proteome in a highly multiplexed and efficient manner remains a coveted and challenging goal in biology. We present a new aptamer-based proteomic technology for biomarker discovery capable of simultaneously measuring thousands of proteins from small sample volumes (15 [mu]L of serum or plasma). Our current assay allows us to measure ~800 proteins with very low limits of detection (1 pM average), 7 logs of overall dynamic range, and 5% average coefficient of variation. This technology is enabled by a new generation of aptamers that contain chemically modified nucleotides, which greatly expand the physicochemical diversity of the large randomized nucleic acid libraries from which the aptamers are selected. Proteins in complex matrices such as plasma are measured with a process that transforms a signature of protein concentrations into a corresponding DNA aptamer concentration signature, which is then quantified with a DNA microarray. In essence, our assay takes advantage of the dual nature of aptamers as both folded binding entities with defined shapes and unique sequences recognizable by specific hybridization probes. To demonstrate the utility of our proteomics biomarker discovery technology, we applied it to a clinical study of chronic kidney disease (CKD). We identified two well known CKD biomarkers as well as an additional 58 potential CKD biomarkers. These results demonstrate the potential utility of our technology to discover unique protein signatures characteristic of various disease states. More generally, we describe a versatile and powerful tool that allows large-scale comparison of proteome profiles among discrete populations. This unbiased and highly multiplexed search engine will enable the discovery of novel biomarkers in a manner that is unencumbered by our incomplete knowledge of biology, thereby helping to advance the next generation of evidence-based medicine

Measuring the health-related Sustainable Development Goals in 188 countries : a baseline analysis from the Global Burden of Disease Study 2015

Background In September, 2015, the UN General Assembly established the Sustainable Development Goals (SDGs). The SDGs specify 17 universal goals, 169 targets, and 230 indicators leading up to 2030. We provide an analysis of 33 health-related SDG indicators based on the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015). Methods We applied statistical methods to systematically compiled data to estimate the performance of 33 health-related SDG indicators for 188 countries from 1990 to 2015. We rescaled each indicator on a scale from 0 (worst observed value between 1990 and 2015) to 100 (best observed). Indices representing all 33 health-related SDG indicators (health-related SDG index), health-related SDG indicators included in the Millennium Development Goals (MDG index), and health-related indicators not included in the MDGs (non-MDG index) were computed as the geometric mean of the rescaled indicators by SDG target. We used spline regressions to examine the relations between the Socio-demographic Index (SDI, a summary measure based on average income per person, educational attainment, and total fertility rate) and each of the health-related SDG indicators and indices. Findings In 2015, the median health-related SDG index was 59.3 (95% uncertainty interval 56.8-61.8) and varied widely by country, ranging from 85.5 (84.2-86.5) in Iceland to 20.4 (15.4-24.9) in Central African Republic. SDI was a good predictor of the health-related SDG index (r(2) = 0.88) and the MDG index (r(2) = 0.2), whereas the non-MDG index had a weaker relation with SDI (r(2) = 0.79). Between 2000 and 2015, the health-related SDG index improved by a median of 7.9 (IQR 5.0-10.4), and gains on the MDG index (a median change of 10.0 [6.7-13.1]) exceeded that of the non-MDG index (a median change of 5.5 [2.1-8.9]). Since 2000, pronounced progress occurred for indicators such as met need with modern contraception, under-5 mortality, and neonatal mortality, as well as the indicator for universal health coverage tracer interventions. Moderate improvements were found for indicators such as HIV and tuberculosis incidence, minimal changes for hepatitis B incidence took place, and childhood overweight considerably worsened. Interpretation GBD provides an independent, comparable avenue for monitoring progress towards the health-related SDGs. Our analysis not only highlights the importance of income, education, and fertility as drivers of health improvement but also emphasises that investments in these areas alone will not be sufficient. Although considerable progress on the health-related MDG indicators has been made, these gains will need to be sustained and, in many cases, accelerated to achieve the ambitious SDG targets. The minimal improvement in or worsening of health-related indicators beyond the MDGs highlight the need for additional resources to effectively address the expanded scope of the health-related SDGs.Peer reviewe