First record of the Hauxwell's Thrush, Turdus hauxwelli Lawrence, 1869 (Aves: Turdidae) from Mato Grosso do Sul, Brazil, and geographic range extension

We report the first record of the Hauxwell’s Thrush, Turdus hauxwelli Lawrence, 1869 (Aves: Turdidae) in the state of Mato Grosso do Sul, Brazil. During an ornithological inventory conducted in Serra de Maracajú, municipality of Corguinho, we mist-netted and collected an individual of the species. The specimen was prepared as study skin and is held in the ornithological collection of the Museu Nacional, Universidade Federal do Rio de Janeiro, Rio de Janeiro. This record is located 472 km south of the closest visual/song record and 616 km southeast of the closest museum specimen, being the southernmost occurrence of this thrush

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

Oxyura vittata (Philippi, 1860) (Aves, Anatidae): range extension and first record from the Upper Paraguay basin, Brazil

This note extends the range of Oxyura vittata (Philippi, 1860) to the Upper Paraguay basin in the Brazilian Pantanal and presents the first record of this species from Mato Grosso do Sul state

Relações interfirmas e emprego na rede de empresas: a experiência de externalização de uma empresa no setor de telecomunicações<a name=volta1></a> Intercompany relations and employment in the businesses network: the experience of internalization of one company from the telecommunications industry

A reestruturação do setor de telecomunicações vem implicando a formação de estruturas empresariais na forma de rede. Neste artigo, examinam-se os padrões de relacionamento interfirmas e de emprego na rede de empresas liderada pela Companhia Riograndense de Telecomunicações (CRT). A análise abrange onze empresas, prestadoras de diferentes tipos de serviços (digitalização de centrais de comutação, cabeamento e instalação de terminais telefônicos) e localizadas em diversos níveis da rede ("empresas terceiras", "quartas", "quintas" e "sextas"). Conclui-se que existe grande diversidade no relacionamento interempresas (relacionadas à interação entre a estratégia competitiva da empresa central e os tipos de serviços prestados) e nas práticas de emprego (associadas às relações interfirmas e à posição das empresas nos níveis da rede).<br>Restructuring in the telecommunications industry has implied the construction of network business structures. In this article, patterns of relationship between companies and employment within the network led by CRT (Companhia Riograndense de Telecomunicações, the Telecommunications Company in the southern Brazilian State of Rio Grande do Sul) are examined. The analysis encompasses eleven companies providing different kinds of services (switch units digitalization, cables and phone lines installation) and located at several levels of the network ("third", "fourth", "fifth" and "sixth" companies). We come to the conclusion that there is a great variety within the relationship between companies (regarding the interaction between competitive strategy of the leading company and the kind of services provided) and in employment practices (associated to intercompany relationships and the position of each company at the network levels)

Zika virus in the Americas: Early epidemiological and genetic findings

Submitted by sandra infurna ([email protected]) on 2016-06-21T16:53:42Z No. of bitstreams: 1 gonzalo2_bello_etal_IOC_2016.pdf: 1066180 bytes, checksum: d43c1cf1b828de79e634ed276cc62178 (MD5)Approved for entry into archive by sandra infurna ([email protected]) on 2016-06-21T17:27:43Z (GMT) No. of bitstreams: 1 gonzalo2_bello_etal_IOC_2016.pdf: 1066180 bytes, checksum: d43c1cf1b828de79e634ed276cc62178 (MD5)Made available in DSpace on 2016-06-21T17:27:43Z (GMT). No. of bitstreams: 1 gonzalo2_bello_etal_IOC_2016.pdf: 1066180 bytes, checksum: d43c1cf1b828de79e634ed276cc62178 (MD5) Previous issue date: 2016Submitted by Angelo Silva ([email protected]) on 2016-07-07T11:16:45Z No. of bitstreams: 3 gonzalo2_bello_etal_IOC_2016.pdf.txt: 51037 bytes, checksum: bebf604bcb5623ddff92fec2bebc02a5 (MD5) gonzalo2_bello_etal_IOC_2016.pdf: 1066180 bytes, checksum: d43c1cf1b828de79e634ed276cc62178 (MD5) license.txt: 2991 bytes, checksum: 5a560609d32a3863062d77ff32785d58 (MD5)Approved for entry into archive by sandra infurna ([email protected]) on 2016-07-07T11:43:23Z (GMT) No. of bitstreams: 3 license.txt: 2991 bytes, checksum: 5a560609d32a3863062d77ff32785d58 (MD5) gonzalo2_bello_etal_IOC_2016.pdf: 1066180 bytes, checksum: d43c1cf1b828de79e634ed276cc62178 (MD5) gonzalo2_bello_etal_IOC_2016.pdf.txt: 51037 bytes, checksum: bebf604bcb5623ddff92fec2bebc02a5 (MD5)Made available in DSpace on 2016-07-07T11:43:23Z (GMT). No. of bitstreams: 3 license.txt: 2991 bytes, checksum: 5a560609d32a3863062d77ff32785d58 (MD5) gonzalo2_bello_etal_IOC_2016.pdf: 1066180 bytes, checksum: d43c1cf1b828de79e634ed276cc62178 (MD5) gonzalo2_bello_etal_IOC_2016.pdf.txt: 51037 bytes, checksum: bebf604bcb5623ddff92fec2bebc02a5 (MD5) Previous issue date: 2016Ministério da Saúde. Instituto Evandro Chagas, Centro de Inovação tecnológica. Ananindeua, PA, Brasil / University of Oxford. Department of Zoology. Oxford, UK.Ministério da Saúde. Instituto Evandro Chagas. Departamento de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.University of Oxford. Department of Zoology. Oxford, UK.Universidade de São Paulo. Instituto Adolfo Lutz. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto Adolfo Lutz. São Paulo, SP, Brasil.University of Oxford. Department of Zoology. Oxford, UK.University of Oxford. Department of Zoology. Oxford, UK.University of Oxford. Department of Zoology. Oxford, UK.University of Oxford. Wellcome Trust Centre for Human Genetics. Oxford, UK.University of Oxford. Wellcome Trust Centre for Human Genetics. Oxford, UK.Universidade de São Paulo. Instituto Adolfo Lutz. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto Adolfo Lutz. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto Adolfo Lutz. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto Adolfo Lutz. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto Adolfo Lutz. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto Adolfo Lutz. São Paulo, SP, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Departamento de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Departamento de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Departamento de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Departamento de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Departamento de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Departamento de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Departamento de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Departamento de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Departamento de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Departamento de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Departamento de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Departamento de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Departamento de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Departamento de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.University of Oxford. Department of Zoology. Oxford, UK / Metabiota. San Francisco, CA 94104, USA.University of Oxford. Department of Zoology. Oxford, UK.University of Oxford. Department of Zoology. Oxford, UK.Fundação Oswaldo Cruz. Salvador, BA, Brasil.Universidade Estadual de Feira de Santana, Feira de Santana. Departamento de Saúde. Centro de Pós-Graduação em Saúde Coletiva. Feira de Santana, BA, Brasil.Fundação Oswaldo Cruz. Salvador, BA, Brasil.University of Washington. Institute for Health Metrics and Evaluation,. Seattle, WA, USA / University of Oxford. Wellcome Trust Centre for Human Genetics. Oxford, UK.Ministério da Saúde. Instituto Evandro Chagas, Centro de Inovação tecnológica. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas, Centro de Inovação tecnológica. Ananindeua, PA, BrasilMinistério da Saúde. Instituto Evandro Chagas, Centro de Inovação tecnológica. Ananindeua, PA, BrasilMinistério da Saúde. Instituto Evandro Chagas, Centro de Inovação tecnológica. Ananindeua, PA, BrasilMinistério da Saúde. Instituto Evandro Chagas, Centro de Inovação tecnológica. Ananindeua, PA, BrasilMinistério da Saúde. Instituto Evandro Chagas, Centro de Inovação tecnológica. Ananindeua, PA, BrasilMinistério da Saúde. Instituto Evandro Chagas, Centro de Inovação tecnológica. Ananindeua, PA, BrasilMinistério da Saúde. Instituto Evandro Chagas, Centro de Inovação tecnológica. Ananindeua, PA, BrasilMinistério da Saúde. Instituto Evandro Chagas, Centro de Inovação tecnológica. Ananindeua, PA, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Li Ka Shing Knowledge Institute. St. Michael’s Hospital. Toronto, Canada / University of Toronto. Department of Medicine. Division of Infectious Diseases. Toronto, Canada.University of Toronto.Dalla Lana School of Public Health. Toronto, Canada;Brasil. Ministério da Saúde. Brasília, DF, Brasil.Brasil. Ministério da Saúde. Brasília, DF, Brasil.University of Texas Medical Branch. Department of Pathology. Galveston, TX, USA.University of Oxford. Department of Zoology. Oxford, UK / Metabiota. San Francisco, CA 94104, USA.Ministério da Saúde. Instituto Evandro Chagas, Centro de Inovação tecnológica. Ananindeua, PA, Brasil / University of Texas Medical Branch. Department of Pathology. Galveston, TX, USA.Ministério da Saúde. Instituto Evandro Chagas. Departamento de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Brazil has experienced an unprecedented epidemic of Zika virus (ZIKV), with ~30,000 cases reported to date. ZIKV was first detected in Brazil in May 2015 and cases of microcephaly potentially associated with ZIKV infection were identified in November 2015. Using next generation sequencing we generated seven Brazilian ZIKV genomes, sampled from four self-limited cases, one blood donor, one fatal adult case, and one newborn with microcephaly and congenital malformations. Phylogenetic and molecular clock analyses show a single introduction of ZIKV into the Americas, estimated to have occurred between May-Dec 2013, more than 12 months prior to the detection of ZIKV in Brazil. The estimated date of origin coincides with an increase in air passengers to Brazil from ZIKV endemic areas, and with reported outbreaks in Pacific Islands. ZIKV genomes from Brazil are phylogenetically interspersed with those from other South American and Caribbean countries. Mapping mutations onto existing structural models revealed the context of viral amino acid changes present in the outbreak lineage; however no shared amino acid changes were found among the three currently available virus genomes from microcephaly cases. Municipality-level incidence data indicate that reports of suspected microcephaly in Brazil best correlate with ZIKV incidence around week 17 of pregnancy, although this does not demonstrate causation. Our genetic description and analysis of ZIKV isolates in Brazil provide a baseline for future studies of the evolution and molecular epidemiology in the Americas of this emerging virus

Data from: Zika virus in the Americas: early epidemiological and genetic findings

Brazil has experienced an unprecedented epidemic of Zika virus (ZIKV), with ~30,000 cases reported to date. ZIKV was first detected in Brazil in May 2015 and cases of microcephaly potentially associated with ZIKV infection were identified in November 2015. Using next generation sequencing we generated seven Brazilian ZIKV genomes, sampled from four self-limited cases, one blood donor, one fatal adult case, and one newborn with microcephaly and congenital malformations. Phylogenetic and molecular clock analyses show a single introduction of ZIKV into the Americas, estimated to have occurred between May-Dec 2013, more than 12 months prior to the detection of ZIKV in Brazil. The estimated date of origin coincides with an increase in air passengers to Brazil from ZIKV endemic areas, and with reported outbreaks in Pacific Islands. ZIKV genomes from Brazil are phylogenetically interspersed with those from other South American and Caribbean countries. Mapping mutations onto existing structural models revealed the context of viral amino acid changes present in the outbreak lineage; however no shared amino acid changes were found among the three currently available virus genomes from microcephaly cases. Municipality-level incidence data indicate that reports of suspected microcephaly in Brazil best correlate with ZIKV incidence around week 17 of pregnancy, although this does not demonstrate causation. Our genetic description and analysis of ZIKV isolates in Brazil provide a baseline for future studies of the evolution and molecular epidemiology in the Americas of this emerging virus

Establishment and cryptic transmission of Zika virus in Brazil and the Americas

University of Oxford. Department of Zoology, Oxford, UK / Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.University of Birmingham. Institute of Microbiology and Infection. Birmingham, UK.University of Oxford. Department of Zoology. Oxford UK.University of Oxford. Department of Zoology. Oxford, UK / Harvard Medical School. Boston, MA, USA / Boston Children's Hospital. Boston, MA, USA.University of Oxford. Department of Zoology. Oxford, UK.Fred Hutchinson Cancer Research Center. Vaccine and Infectious Disease Division. Seattle, WA, USA / University of Washington. Department of Epidemiology. Seattle, WA, USA.University of São Paulo. School of Medicine &Institute of Tropical Medicine. Department of Infectious Disease. São Paulo, SP, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.University of Oxford. Department of Statistics. Oxford, UK.University of Oxford. Department of Zoology. Oxford, UK.Institut Pasteur. Biostatistics and Integrative Biology. Mathematical Modelling of Infectious Diseases and Center of Bioinformatics. Paris, FR / Centre National de la Recherche Scientifique. Paris, FR.University of Oxford. Department of Zoology. Oxford, UK.Ministry of Health. Coordenação dos Laboratórios de Saúde. Brasília, DF, Brazil.Ministry of Health. Coordenação Geral de Vigilância e Resposta às Emergências em Saúde Pública. Brasília, DF, Brazil / Fundação Oswaldo Cruz. Center of Data and Knowledge Integration for Health. Salvador, BA, Brazil.Ministry of Health. Departamento de Vigilância das Doenças Transmissíveis. Brasilia, DF, Brazil.Ministry of Health. Coordenação Geral dos Programas de Controle e Prevenção da Malária e das Doenças Transmitidas pelo Aedes. Brasília, DF, Brazil / Pan American Health Organization (PAHO). Buenos Aires, AR.Ministry of Health. Coordenação Geral dos Programas de Controle e Prevenção da Malária e das Doenças Transmitidas pelo Aedes. Brasília, DF, Brazil / Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brazil.Ministry of Health. Coordenação Geral dos Programas de Controle e Prevenção da Malária e das Doenças Transmitidas pelo Aedes. Brasília, DF, BrazilMinistry of Health. Departamento de Vigilância das Doenças Transmissíveis. Brasilia, DF, Brazil.Ontario Institute for Cancer Research. Toronto, ON, Canada.University of Nottingham. Nottingham, UKThe Scripps Research Institute. Department of Immunology and Microbial Science. La Jolla, CA, USA.The Scripps Research Institute. Department of Immunology and Microbial Science. La Jolla, CA, USA.University of California. Departments of Laboratory Medicine and Medicine & Infectious Diseases. San Francisco, CA, USA.University of California. Departments of Laboratory Medicine and Medicine & Infectious Diseases. San Francisco, CA, USA.Instituto Mexicano del Seguro Social. División de Laboratorios de Vigilancia e Investigación Epidemiológica. Ciudad de México, MC.Instituto Mexicano del Seguro Social. División de Laboratorios de Vigilancia e Investigación Epidemiológica. Ciudad de México, MC.Universidad Nacional Autónoma de México. Instituto de Biotecnología. Cuernavaca, MC.Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brazil.Paul-Ehrlich-Institut. Langen, Germany.Laboratório Central de Saúde Pública Noel Nutels. Rio de Janeiro, RJ, Brazil.Laboratório Central de Saúde Pública Noel Nutels. Rio de Janeiro, RJ, Brazil.Laboratório Central de Saúde Pública Noel Nutels. Rio de Janeiro, RJ, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Fundação Oswaldo Cruz. Salvador, BA, Brazil.Laboratório Central de Saúde Pública. Natal, RN, Brazil.Laboratório Central de Saúde Pública. Natal, RN, Brazil / Universidade Potiguar. Natal, RN, Brazil.Laboratório Central de Saúde Pública. Natal, RN, Brazil / Faculdade Natalense de Ensino e Cultura. Natal, RN, Brazil.Laboratório Central de Saúde Pública. João Pessoa, PB, Brazil.Laboratório Central de Saúde Pública. João Pessoa, PB, Brazil.Laboratório Central de Saúde Pública. João Pessoa, PB, Brazil.Laboratório Central de Saúde Pública. João Pessoa, PB, Brazil.Fundação Oswaldo Cruz. Recife, PE, Brazil.Fundação Oswaldo Cruz. Recife, PE, Brazil.Fundação Oswaldo Cruz. Recife, PE, Brazil / Colorado State University. Department of Microbiology, Immunology &Pathology. Fort Collins, CO, USA.Fundação Oswaldo Cruz. Recife, PE, Brazil.Heidelberg University Hospital. Department for Infectious Diseases. Section Clinical Tropical Medicine. Heidelberg, Germany.Fundação Oswaldo Cruz. Recife, PE, Brazil.Laboratório Central de Saúde Pública. Maceió, AL, Brazil.Laboratório Central de Saúde Pública. Maceió, AL, Brazil.Laboratório Central de Saúde Pública. Maceió, AL, Brazil.Universidade Estadual de Feira de Santana. Feira de Santana, BA, Brazil.Secretaria de Saúde de Feira de Santana. Feira de Santana, BA, Brazil.Universidade Federal do Amazonas. Manaus, AM, Brazil.University of São Paulo. School of Medicine &Institute of Tropical Medicine. Department of Infectious Disease. São Paulo, SP, Brazil.University of São Paulo. School of Medicine &Institute of Tropical Medicine. Department of Infectious Disease. São Paulo, SP, Brazil.Hospital São Francisco. Ribeirão Preto, SP, Brazil.University of São Paulo. School of Medicine &Institute of Tropical Medicine. Department of Infectious Disease. São Paulo, SP, Brazil.Universidade Federal do Tocantins. Palmas, TO, Brazil.University of São Paulo. School of Medicine &Institute of Tropical Medicine. Department of Infectious Disease. São Paulo, SP, Brazil.University of Sydney. Sydney, Australia.University of Edinburgh. Institute of Evolutionary Biology. Edinburgh, UK / National Institutes of Health. Fogarty International Center. Bethesda, MD, USA.Fred Hutchinson Cancer Research Center. Vaccine and Infectious Disease Division. Seattle, WA, USA.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil / University of Texas Medical Branch. Department of Pathology. Galveston, TX, USA.University of São Paulo. School of Medicine &Institute of Tropical Medicine. Department of Infectious Disease. São Paulo, SP, Brazil.Fundação Oswaldo Cruz. Salvador, BA, Brazil.University of Birmingham. Institute of Microbiology and Infection. Birmingham, UK.University of Oxford. Department of Zoology, Oxford, UK / Metabiota. San Francisco, CA, USA.University of São Paulo. School of Medicine &Institute of Tropical Medicine. Department of Infectious Disease. São Paulo, SP, Brazil.Fundação Oswaldo Cruz. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Salvador, BA, Brazil / University of Rome Tor Vergata. Rome, Italy.Transmission of Zika virus (ZIKV) in the Americas was first confirmed in May 2015 in northeast Brazil. Brazil has had the highest number of reported ZIKV cases worldwide (more than 200,000 by 24 December 2016) and the most cases associated with microcephaly and other birth defects (2,366 confirmed by 31 December 2016). Since the initial detection of ZIKV in Brazil, more than 45 countries in the Americas have reported local ZIKV transmission, with 24 of these reporting severe ZIKV-associated disease. However, the origin and epidemic history of ZIKV in Brazil and the Americas remain poorly understood, despite the value of this information for interpreting observed trends in reported microcephaly. Here we address this issue by generating 54 complete or partial ZIKV genomes, mostly from Brazil, and reporting data generated by a mobile genomics laboratory that travelled across northeast Brazil in 2016. One sequence represents the earliest confirmed ZIKV infection in Brazil. Analyses of viral genomes with ecological and epidemiological data yield an estimate that ZIKV was present in northeast Brazil by February 2014 and is likely to have disseminated from there, nationally and internationally, before the first detection of ZIKV in the Americas. Estimated dates for the international spread of ZIKV from Brazil indicate the duration of pre-detection cryptic transmission in recipient regions. The role of northeast Brazil in the establishment of ZIKV in the Americas is further supported by geographic analysis of ZIKV transmission potential and by estimates of the basic reproduction number of the virus

Epidemiological Data: Numbers of suspected ZIKV cases and suspected microcephaly cases per state and per epidemiological week.

Contains 1) CSV file with number suspected ZIKV cases from January 2015 to the end of December 2015; 2) CSV file with number of suspected microcephaly cases from January 2015 to the first week of January 2016. Numbers correspond to suspected microcephaly cases at week 20 of pregnancy; 3) CSV file with codes of state of residence and municipality of residence in Brazil; and 4) R scripts for correlation analysis described in SI Section 1.5

Sequence data details and alignments for dataset A and B.

Contains (1) table with accession numbers, isolate names, cell passage history, publication details, country/location of sampling, sampling dates and (2) Fasta format sequence alignments of datasets A and B