Lensed Quasar Hosts

Gravitational lensing assists in the detection of quasar hosts by amplifying and distorting the host light away from the unresolved quasar core images. We present the results of HST observations of 30 quasar hosts at redshifts 1 < z < 4.5. The hosts are small in size (r_e <~ 6 kpc), and span a range of morphologies consistent with early-types (though smaller in mass) to disky/late-type. The ratio of the black hole mass (MBH, from the virial technique) to the bulge mass (M_bulge, from the stellar luminosity) at 1<z<1.7 is broadly consistent with the local value; while MBH/M_bulge at z>1.7 is a factor of 3--6 higher than the local value. But, depending on the stellar content the ratio may decline at z>4 (if E/S0-like), flatten off to 6--10 times the local value (if Sbc-like), or continue to rise (if Im-like). We infer that galaxy bulge masses must have grown by a factor of 3--6 over the redshift range 3>z>1, and then changed little since z~1. This suggests that the peak epoch of galaxy formation for massive galaxies is above z~1. We also estimate the duty cycle of luminous AGNs at z>1 to be ~1%, or 10^7 yrs, with sizable scatter.Comment: 8 pages, 6 figures, review article with C. Impey at the conference on "QSO Host Galaxies: Evolution and Environment", Aug. 29-Sep. 2, 2005, Lorentz Center, Leiden, The Netherland

Spectroscopic Redshifts for Seven Lens Galaxies

We report VLT observations of 11 lensed quasars, designed to measure the redshifts of their lens galaxies. We successfully determined the redshifts for seven systems, five of which were previously unknown. The securely measured redshifts for the lensing galaxies are: HE0047-1756 z=0.408; PMNJ0134-0931 z=0.766; HE0230-2130 z=0.522; HE0435-1223 z=0.455; SDSS0924+021 z=0.393; LBQS1009-025 z=0.871; and WFIJ2033-472 z=0.658. For four additional systems (BRI0952-0115, Q1017-207, Q1355-2257 and PMNJ1632-003) we estimate tentative redshifts based on some features in their spectra.Comment: 8 pages, ApJ, submitte

PKS 1830-211: A Face-On Spiral Galaxy Lens

We present new Hubble Space Telescope images of the gravitational lens PKS 1830-211, which allow us to characterize the lens galaxy and update the determination of the Hubble constant from this system. The I-band image shows that the lens galaxy is a face-on spiral galaxy with clearly delineated spiral arms. The southwestern image of the background quasar passes through one of the spiral arms, explaining the previous detections of large quantities of molecular gas and dust in front of this image. The lens galaxy photometry is consistent with the Tully-Fisher relation, suggesting the lens galaxy is a typical spiral galaxy for its redshift. The lens galaxy position, which was the main source of uncertainty in previous attempts to determine H_0, is now known precisely. Given the current time delay measurement and assuming the lens galaxy has an isothermal mass distribution, we compute H_0 = 44 +/- 9 km/s/Mpc for an Omega_m = 0.3 flat cosmological model. We describe some possible systematic errors and how to reduce them. We also discuss the possibility raised by Courbin et al. (2002), that what we have identified as a single lens galaxy is actually a foreground star and two separate galaxies.Comment: 21 pp., 4 figs., accepted by ApJ, section added to discuss related work by Courbin et al. (astro-ph/0202026

Unveiling the broad band X-ray continuum and iron line complex in Mkr 841

Mkr 841 is a bright Seyfert 1 galaxy known to harbor a strong soft excess and a variable K$\alpha$ iron line. It has been observed during 3 different periods by XMM for a total cumulated exposure time of $\sim$108 ks. We present in this paper a broad band spectral analysis of the complete EPIC-pn data sets. We were able to test two different models for the soft excess, a relativistically blurred photoionized reflection (\r model) and a relativistically smeared ionized absorption (\a model). The continuum is modeled by a simple cut-off power law and we also add a neutral reflection. These observations reveal the extreme and puzzling spectral and temporal behaviors of the soft excess and iron line. The 0.5-3 keV soft X-ray flux decreases by a factor 3 between 2001 and 2005 and the line shape appears to be a mixture of broad and narrow components. We succeed in describing this complex broad-band 0.5-10 keV spectral variability using either \r or \a to fit the soft excess. Both models give statistically equivalent results even including simultaneous BeppoSAX data up to 200 keV. Both models are consistent with the presence of remote reflection characterized by a constant narrow component in the data. However they differ in the presence of a broad line component present in \r but not needed in \a. This study also reveals the sporadic presence of relativistically redshifted narrow iron lines.Comment: Accepted in A&A. 17 pages and 21 figure

A Survey for Large Separation Lensed FIRST Quasars

Little is known about the statistics of gravitationally lensed quasars at large (7''-30'') image separations, which probe masses on the scale of galaxy clusters. We have carried out a survey for gravitationally-lensed objects, among sources in the FIRST 20cm radio survey that have unresolved optical counterparts in the digitizations of the Palomar Observatory Sky Survey. From the statistics of ongoing surveys that search for quasars among FIRST sources, we estimate that there are about 9100 quasars in this source sample, making this one of the largest lensing surveys to date. Using broad-band imaging, we have isolated all objects with double radio components separated by 5''-30'', that have unresolved optical counterparts with similar BVI colours. Our criteria for similar colours conservatively allow for observational error and for colour variations due to time delays between lensed images. Spectroscopy of these candidates shows that none of the pairs are lensed quasars. This sets an upper limit (95% confidence) on the lensing fraction in this survey of 3.3x10^-4, assuming 9100 quasars. Although the source redshift distribution is poorly known, a rough calculation of the expected lensing frequency and the detection efficiencies and biases suggests that simple theoretical expectations are of the same order of magnitude as our observational upper limit. Our procedure is novel in that our exhaustive search for lensed objects does not require prior identification of the quasars in the sample as such. Characterization of the FIRST-selected quasar population will enable using our result to constrain quantitatively the mass properties of clusters.Comment: 10 pages, accepted for publication in MNRA

Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway

This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2009 Orton et al.BACKGROUND: The Epidermal Growth Factor Receptor (EGFR) activated Extracellular-signal Regulated Kinase (ERK) pathway is a critical cell signalling pathway that relays the signal for a cell to proliferate from the plasma membrane to the nucleus. Deregulation of the EGFR/ERK pathway due to alterations affecting the expression or function of a number of pathway components has long been associated with numerous forms of cancer. Under normal conditions, Epidermal Growth Factor (EGF) stimulates a rapid but transient activation of ERK as the signal is rapidly shutdown. Whereas, under cancerous mutation conditions the ERK signal cannot be shutdown and is sustained resulting in the constitutive activation of ERK and continual cell proliferation. In this study, we have used computational modelling techniques to investigate what effects various cancerous alterations have on the signalling flow through the ERK pathway. RESULTS: We have generated a new model of the EGFR activated ERK pathway, which was verified by our own experimental data. We then altered our model to represent various cancerous situations such as Ras, B-Raf and EGFR mutations, as well as EGFR overexpression. Analysis of the models showed that different cancerous situations resulted in different signalling patterns through the ERK pathway, especially when compared to the normal EGF signal pattern. Our model predicts that cancerous EGFR mutation and overexpression signals almost exclusively via the Rap1 pathway, predicting that this pathway is the best target for drugs. Furthermore, our model also highlights the importance of receptor degradation in normal and cancerous EGFR signalling, and suggests that receptor degradation is a key difference between the signalling from the EGF and Nerve Growth Factor (NGF) receptors. CONCLUSION: Our results suggest that different routes to ERK activation are being utilised in different cancerous situations which therefore has interesting implications for drug selection strategies. We also conducted a comparison of the critical differences between signalling from different growth factor receptors (namely EGFR, mutated EGFR, NGF, and Insulin) with our results suggesting the difference between the systems are large scale and can be attributed to the presence/absence of entire pathways rather than subtle difference in individual rate constants between the systems.This work was funded by the Department of Trade and Industry (DTI), under their Bioscience Beacon project programme. AG was funded by an industrial PhD studentship from Scottish Enterprise and Cyclacel

Probing the Coevolution of Supermassive Black Holes and Galaxies Using Gravitationally Lensed Quasar Hosts

In the present-day universe, supermassive black hole masses (MBH) appear to be strongly correlated with their galaxy's bulge luminosity, among other properties. In this study, we explore the analogous relationship between MBH, derived using the virial method, and the stellar R-band bulge luminosity (Lr) or stellar bulge mass (M*) at epochs of 1 < z < 4.5 using a sample of 31 gravitationally lensed AGNs and 20 non-lensed AGNs. At redshifts z > 1.7 (10--12 Gyrs ago), we find that the observed MBH--Lr relation is nearly the same (to within ~0.3 mag) as it is today. When the observed Lr are corrected for luminosity evolution, this means that the black holes grew in mass faster than their hosts, with the MBH/M* mass ratio being a factor of > 4(+2)(-1) times larger at z > 1.7 than it is today. By the redshift range 1<z<1.7 (8-10 Gyrs ago), the MBH/M* ratio is at most two times higher than today, but it may be consistent with no evolution. Combining the results, we conclude that the ratio MBH/M* rises with look-back time, although it may saturate at ~6 times the local value. Scenarios in which moderately luminous quasar hosts at z>1.7 were fully formed bulges that passively faded to the present epoch are ruled out.Comment: ApJ accepted, includes Referee comments and statistics to better quantify the statistical significance of results. 23 pages, 11 figures, 4 table

The redshift distribution of gravitational lenses revisited: Constraints on galaxy mass evolution

The redshifts of lens galaxies in known gravitational lens systems probe the volume distribution of lensing mass. Following earlier work by Kochanek, we re-derive the lens redshift probability distribution, allowing for mass and number density evolution of the lensing galaxies, and apply this test to a much enlarged sample of lens systems. From a literature survey of all known lenses, we have selected an unbiased sample of 15 lenses with complete redshift information. For a flat Universe and no lens evolution, we can only put an upper limit on the cosmological constant of Omega_lambda<0.89 at the 95% CL. Omega_lambda~0.7 and no evolution is consistent with the data. Allowing for evolution in an Omega_m=0.3, Omega_lambda=0.7 cosmology, we find that the best-fit evolution in sigma* (i.e., the characteristic velocity dispersion in a Schechter-like function) of early-type galaxies, in the redshift range z~0 to 1, is d[log sigma*(z)]/dz=-0.10+/-0.06. This is consistent with no evolution and implies that, at 95% CL, sigma* of early-type galaxies at z~1 was at least 63% of its current value. Alternatively, if there is no mass evolution, a present-day value of sigma*>175 km/s for elliptical galaxies is required (95% CL).Comment: 15 pages, MNRAS, in pres

Template-dependent polymerization across discontinuous templates by the heterodimeric primase from the hyperthermophilic archaeon Sulfolobus solfataricus

The eukaryotic-like primase from the hyperthermophilic archaeon Sulfolobus solfataricus (SsoPriSL) exhibits a range of activities including template-dependent de novo primer synthesis, primer extension and template-independent terminal nucleotidyl transfer using either rNTPs or dNTPs. Remarkably, the enzyme is able to synthesize products far longer than templates in vitro. Here we show that the long products resulted from template-dependent polymerization across discontinuous templates (PADT) by SsoPriSL. PADT was initiated through either primer synthesis or terminal transfer, and occurred efficiently on templates containing contiguous dCs. Template switching took place when the 3′-end of a growing strand synthesized on one template annealed to another template directly or following the terminal addition of nucleotides, and was subsequently extended on the new template. The key to PADT was the ability of SsoPriSL to promote strand annealing. SsoPriSL catalyzed PADT with either dNTPs or rNTPs as the substrates but preferred the latter. The enzyme remained active in PADT but became inefficient in primer synthesis in vitro when temperature was raised from 55°C to 70°C. Our results suggest that SsoPriSL is capable of bridging noncomplementary DNA ends and, therefore, may serve a role in double-strand DNA break repair in Archaea

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London