Influence of Contact Definitions in Assessment of the Relative Importance of Social Settings in Disease Transmission Risk

BACKGROUND: Realistic models of disease transmission incorporating complex population heterogeneities require input from quantitative population mixing studies. We use contact diaries to assess the relative importance of social settings in respiratory pathogen spread using three measures of person contact hours (PCH) as proxies for transmission risk with an aim to inform bipartite network models of respiratory pathogen transmission. METHODS AND FINDINGS: Our survey examines the contact behaviour for a convenience sample of 65 adults, with each encounter classified as occurring in a work, retail, home, social, travel or "other" setting. The diary design allows for extraction of PCH-interaction (cumulative time in face-face conversational or touch interaction with contacts)--analogous to the contact measure used in several existing surveys--as well as PCH-setting (product of time spent in setting and number of people present) and PCH-reach (product of time spent in setting and number of people in close proximity). Heterogeneities in day-dependent distribution of risk across settings are analysed using partitioning and cluster analyses and compared between days and contact measures. Although home is typically the highest-risk setting when PCH measures isolate two-way interactions, its relative importance compared to social and work settings may reduce when adopting a more inclusive contact measure that considers the number and duration of potential exposure events. CONCLUSIONS: Heterogeneities in location-dependent contact behaviour as measured by contact diary studies depend on the adopted contact definition. We find that contact measures isolating face-face conversational or touch interactions suggest that contact in the home dominates, whereas more inclusive contact measures indicate that home and work settings may be of higher importance. In the absence of definitive knowledge of the contact required to facilitate transmission of various respiratory pathogens, it is important for surveys to consider alternative contact measures

Wages of Righteousness: The Economy of Heaven in the Gospel According to Matthew

<p>In comparison to Mark and Luke, Matthew's Gospel contains a striking preponderance of economic imagery, especially in passages dealing with sin, righteousness, and divine recompense. This cluster of economic terms is found in every strand of tradition in Matthew's Gospel, and frequently appears to be the result of Matthean redaction. A good chunk of this language occurs in five uniquely Matthean parables dealing either with the pricelessness of the kingdom or judgment and reward (the hidden treasure in 13:44; the pearl in 13:45-46; the parable of the unforgiving servant in 18:23-35; the parable of the workers in the vineyard 20:1-16; the sheep and the goats in 25:31-46). Matthean additions to the triple tradition also tend to contain economic language. </p><p> In this dissertation I begin by analyzing Matthew's economic language against the backdrop of similar language in other early Jewish and Christian literature. I then go on to examine the import of this language for the narrative as a whole, arguing that some of the Gospel's central claims about Jesus emerge from this conceptual matrix. To be more specific, the narrative provides a coherent description of how Jesus saves his people from their sins and comes to be enthroned as Son of Man. Matthew draws on images of exile and debt-bondage to depict the people Jesus came to save as captives because of the debt of their sins. Jesus is introduced as the one born to save his people from their sins (1:21), and throughout the Gospel he does this by teaching them how to find debt forgiveness and store up treasure in the heavens in order to acquire eternal life. From the time Jesus begins predicting his death and resurrection he also teaches his disciples to follow him in giving their lives and being repaid with resurrection (16:24-28; 19:29), participation in the rule of the Son of Man (19:27-28), and the price of release for others who are in captivity. The passion narrative portrays the very repayment Jesus told the disciples that both he and they would receive: Jesus is raised from the dead, given all authority as Son of Man, and earns the ransom-price for the many. The end of the age remains in the future, and so suffering and doubt persist. Nevertheless, God's repayment of Jesus' self-giving is a foretaste of the coming settling of accounts.</p>Dissertatio

Monocyte/macrophage infiltration in tumors: modulators of angiogenesis

Abstract: The role of a tumor immune infiltrate in cancer progression and metastasis has been debated frequently. Although often considered to be associated with improved prognosis and leading to the enhanced survival of cancer patients, inflammatory cells have also been described to assist the tumor’s capabilities to progress, proliferate, and metastasize. Tumor-associated macrophages (TAMs), for example, have been shown to be symbiotically related to tumor cells: Tumor cells recruit TAMs and provide them with survival factors, and TAMs in turn produce a variety of angiogenic factors in response to the tumor microenvironment. This review will describe the composition of an immune infiltrate in tumors and the angiogenic and angiostatic properties of the cells present. Special emphasis will be on the angiogenesis-associated activities of TAMs. The development of immunotherapy and gene therapy using TAMs to mediate tumor cytotoxicity or to deliver gene constructs will be discussed as well. As immunotherapy has so far not been as effective as anticipated, a combination therapy in which angiostatic agents are used as well is put forward as a novel strategy to trea