Cyborg Art: An Explorative and Critical Inquiry into Corporeal Human-Technology Convergence

This thesis introduces and examines the undervalued concept of corporeal human-technology interface art, or 'cyborg art', which describes literal, figural and metaphorical representations of increasing body and technology integration. The transforming (post)human being is therefore the focus; who we are today, and who or what we may become as humanity increasingly interfaces with technology. Theoretical analysis of cyborg imagery centres on the science fiction domain, in particular film and television, as opposed to art. Yet a profusion of cyborg art and art practices abound within contemporary society; each differing art form (for example, performance, interactive, digital, sculpture or painting), offering possible 'symbolic function' and 'critical potential' concerning increasing cyborgisation. I therefore argue in this thesis that cyborg art has social value, and reveal throughout the way this artistic focus depicts key ontological and sociological themes of body-technology merger. Seventy-two artworks are examined in total, each demonstrating relevant concerns and aspirations regarding present and envisioned impacts of technoscience. The cyborg-inspired artworks included in this study are primarily situated within four fundamental dimensions of humanity: birth, death, gender and ethnicity; and within three main spheres of corporeal-technological developments: prosthetics, telematics and genetics. Key concepts and themes explored within these realms include ectogenesis, post-genderism, necrotic and ethno-cyborgs, augmentation and reconstruction, tele-erotics and tele-puppets, and transgenics. In addition, three new cyborgian concepts are introduced: the udopian cyborg, which is an aesthetic representing technology's paradoxical dimension - technology as evoking fear and yearning, and having the potential to benefit and harm humanity; the permeative gaze of technoscience, which is a new technologised gaze focusing on how human skin no longer serves as a boundary and barrier to the inner corporeal realm; and lastly, triadic convergence, which denotes the way artists are increasingly creating entities which are a melding of animal, technological and human components. Multimethod research serves as the methodological base for this thesis, as both qualitative and quantitative methods are incorporated into the research design. Hermeneutics is adopted as the analytical/interpretive perspective and approach. The empirical research includes semi-structured in-depth interviews, qualitative (artists') email questionnaires, and structured quantitative questionnaires. Triangulation is employed in order to obtain varied responses to, and perspectives on, technology and the technological epoch, art and cyborg art, and the cyborg. A theory of cyborg art is constructed by interweaving the collated findings with interview participants' responses to a selection of cyborg artworks, and theorists' perspectives on the aforementioned concepts, derived from visual culture, cyborg theory, and critical postmodern theory. The ultimate goal of this thesis is to present the underlying theoretical breadth and creative depth of cyborg art, and to demonstrate that cyborg art can act as a catalyst for increasing societal awareness of, and interest in, corporeal human-technology merger. I analyse the critical relevance of this under-examined artistic focus, and address why cyborg art should be recognised as a new postmodern art genre, and complementary to theoretical discussions of cyborgisation. I argue overall that cyborg art is a valid and critical sphere of inquiry into the increasing integration which exists between humanity and technology

Urban adolescents\u27 field trip experiences: a phenomenological perspective

Evidence is mounting that field trips are vanishing from school life, as districts across the nation report reductions and eliminations of these outings because of funding concerns. The matter is of special importance in urban areas, where a wealth of museums are situated nearby neighborhoods in which poor and minority children live and attend school. These children are absent from the museum, less likely to visit with family because of the powerful exclusionary effect that educational attainment and income level have on museum socialization, making school the place where a connection to the museum is formed. However, opportunities for learning in museums are diminished in multiple ways for urban students, who receive less arts and humanities instruction and more instruction emphasizing basic literacies intended to improve achievement on high-stakes standardized tests. Further, the social, emotional, and educational value of field trips are underappreciated by the formal education community because of epistemological differences in what constitutes learning, which tend to emphasize cognitive gains that are common to the school environment, while ignoring the motivating and satisfying aspects of learning in out-of-school settings. The purpose of this phenomenological inquiry is to explore what meaning or significance urban students derive from their field trip experiences in the context of educational opportunities provided at school. Using a critical lens, this study problematizes field trips as a curriculum issue to shed light on what is lost to students as learners when these experiences are not offered by school. The participants in this study are nine middle-school students and two teachers from two schools located in a large Midwestern city. Through qualitative procedures of interviews and observations, three key findings emerged that describe students\u27 field trip experiences: 1) students gain appreciation and empathy from their field trip experiences; 2) students desire more autonomy in their learning experiences and perceive learning as defined by classroom routines, and 3) students value learning as a social activity, in which interaction with peers is paramount to their experience of learning. These findings contribute to a better understanding of the meaning and significance of field trip experiences to students

Imagining Sounds and Images : Decoding the Contribution of Unimodal and Transmodal Brain Regions to Semantic Retrieval in the Absence of Meaningful Input

In the absence of sensory information, we can generate meaningful images and sounds from representations in memory. However, it remains unclear which neural systems underpin this process and whether tasks requiring the top-down generation of different kinds of features recruit similar or different neural networks. We asked people to internally generate the visual and auditory features of objects, either in isolation (car, dog) or in specific and complex meaning-based contexts (car/dog race). Using an fMRI decoding approach, in conjunction with functional connectivity analysis, we examined the role of auditory/visual cortex and transmodal brain regions. Conceptual retrieval in the absence of external input recruited sensory and transmodal cortex. The response in transmodal regions-including anterior middle temporal gyrus-was of equal magnitude for visual and auditory features yet nevertheless captured modality information in the pattern of response across voxels. In contrast, sensory regions showed greater activation for modality-relevant features in imagination (even when external inputs did not differ). These data are consistent with the view that transmodal regions support internally generated experiences and that they play a role in integrating perceptual features encoded in memory

Back to BAC: The Use of Infectious Clone Technologies for Viral Mutagenesis

Bacterial artificial chromosome (BAC) vectors were first developed to facilitate the propagation and manipulation of large DNA fragments in molecular biology studies for uses such as genome sequencing projects and genetic disease models. To facilitate these studies, methodologies have been developed to introduce specific mutations that can be directly applied to the mutagenesis of infectious clones (icBAC) using BAC technologies. This has resulted in rapid identification of gene function and expression at unprecedented rates. Here we review the major developments in BAC mutagenesis in vitro. This review summarises the technologies used to construct and introduce mutations into herpesvirus icBAC. It also explores developing technologies likely to provide the next leap in understanding these important viruses

1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function

HapMap imputed genome-wide association studies (GWAS) have revealed >50 loci at which common variants with minor allele frequency >5% are associated with kidney function. GWAS using more complete reference sets for imputation, such as those from The 1000 Genomes project, promise to identify novel loci that have been missed by previous efforts. To investigate the value of such a more complete variant catalog, we conducted a GWAS meta-analysis of kidney function based on the estimated glomerular filtration rate (eGFR) in 110,517 European ancestry participants using 1000 Genomes imputed data. We identified 10 novel loci with p-value < 5 × 10(-8) previously missed by HapMap-based GWAS. Six of these loci (HOXD8, ARL15, PIK3R1, EYA4, ASTN2, and EPB41L3) are tagged by common SNPs unique to the 1000 Genomes reference panel. Using pathway analysis, we identified 39 significant (FDR < 0.05) genes and 127 significantly (FDR < 0.05) enriched gene sets, which were missed by our previous analyses. Among those, the 10 identified novel genes are part of pathways of kidney development, carbohydrate metabolism, cardiac septum development and glucose metabolism. These results highlight the utility of re-imputing from denser reference panels, until whole-genome sequencing becomes feasible in large samples

Increased platelet reactivity is associated with circulating platelet-monocyte complexes and macrophages in human atherosclerotic plaques

Objective: Platelet reactivity, platelet binding to monocytes and monocyte infiltration play a detrimental role in atherosclerotic plaque progression. We investigated whether platelet reactivity was associated with levels of circulating platelet-monocyte complexes (PMCs) and macrophages in human atherosclerotic carotid plaques. Methods: Platelet reactivity was determined by measuring platelet P-selectin expression after platelet stimulation with increasing concentrations of adenosine diphosphate (ADP), in two independent cohorts: the Circulating Cells cohort (n = 244) and the Athero-Express cohort (n = 91). Levels of PMCs were assessed by flow cytometry in blood samples of patients who were scheduled for percutaneous coronary intervention (Circulating Cells cohort). Monocyte infiltration was semi-quantitatively determined by histological examination of atherosclerotic carotid plaques collected during carotid endarterectomy (Athero-Express cohort). Results: We found increased platelet reactivity in patients with high PMCs as compared to patients with low PMCs (median (interquartile range): 4153 (1585-11267) area under the curve (AUC) vs. 9633 (3580-21565) AUC, P<0.001). Also, we observed increased pl

Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.

Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150 134 European ancestry individuals and sought significant evidence for independent replication in a further 228 245 individuals. We report 6 new signals of association in or near HSPB7, TNXB, LRP12, LOC283335, SEPT9, and AKT2, and provide new replication evidence for a further 2 signals in EBF2 and NFKBIA Combining large whole-blood gene expression resources totaling 12 607 individuals, we investigated all novel and previously reported signals and identified 48 genes with evidence for involvement in blood pressure regulation that are significant in multiple resources. Three novel kidney-specific signals were also detected. These robustly implicated genes may provide new leads for therapeutic innovation

Children’s and adolescents’ rising animal-source food intakes in 1990–2018 were impacted by age, region, parental education and urbanicity

Animal-source foods (ASF) provide nutrition for children and adolescents’ physical and cognitive development. Here, we use data from the Global Dietary Database and Bayesian hierarchical models to quantify global, regional and national ASF intakes between 1990 and 2018 by age group across 185 countries, representing 93% of the world’s child population. Mean ASF intake was 1.9 servings per day, representing 16% of children consuming at least three daily servings. Intake was similar between boys and girls, but higher among urban children with educated parents. Consumption varied by age from 0.6 at <1 year to 2.5 servings per day at 15–19 years. Between 1990 and 2018, mean ASF intake increased by 0.5 servings per week, with increases in all regions except sub-Saharan Africa. In 2018, total ASF consumption was highest in Russia, Brazil, Mexico and Turkey, and lowest in Uganda, India, Kenya and Bangladesh. These findings can inform policy to address malnutrition through targeted ASF consumption programmes.publishedVersio

Incident type 2 diabetes attributable to suboptimal diet in 184 countries

The global burden of diet-attributable type 2 diabetes (T2D) is not well established. This risk assessment model estimated T2D incidence among adults attributable to direct and body weight-mediated effects of 11 dietary factors in 184 countries in 1990 and 2018. In 2018, suboptimal intake of these dietary factors was estimated to be attributable to 14.1 million (95% uncertainty interval (UI), 13.8–14.4 million) incident T2D cases, representing 70.3% (68.8–71.8%) of new cases globally. Largest T2D burdens were attributable to insufficient whole-grain intake (26.1% (25.0–27.1%)), excess refined rice and wheat intake (24.6% (22.3–27.2%)) and excess processed meat intake (20.3% (18.3–23.5%)). Across regions, highest proportional burdens were in central and eastern Europe and central Asia (85.6% (83.4–87.7%)) and Latin America and the Caribbean (81.8% (80.1–83.4%)); and lowest proportional burdens were in South Asia (55.4% (52.1–60.7%)). Proportions of diet-attributable T2D were generally larger in men than in women and were inversely correlated with age. Diet-attributable T2D was generally larger among urban versus rural residents and higher versus lower educated individuals, except in high-income countries, central and eastern Europe and central Asia, where burdens were larger in rural residents and in lower educated individuals. Compared with 1990, global diet-attributable T2D increased by 2.6 absolute percentage points (8.6 million more cases) in 2018, with variation in these trends by world region and dietary factor. These findings inform nutritional priorities and clinical and public health planning to improve dietary quality and reduce T2D globally.publishedVersio