9 research outputs found
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders
- Author
- Adams Mark J
- Adan Roger A H
- Adolfsson Annelie Nordin
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Akil Huda
- Albani Diego
- Alda Martin
- Alexander Madeline
- Alfredsson Lars
- Als Thomas D
- Andlauer Till F M
- Ando Tetsuya
- Andreassen Ole A
- Androutsos Christos
- Anjorin Adebayo
- Anney Richard J L
- Anttila Verneri
- Arking Dan E
- Arnold Paul D
- Arranz M. J.
- Artigas Maria Soler
- Aschauer Harald
- Asherson Philip
- Backlund Lena
- Baker Jessica H
- Baldursson Gísli
- Banaschewski Tobias
- Barr Cathy L
- Barta Csaba
- Bass Nicholas
- Bauer Michael
- Baune Bernhard T
- Begemann Martin
- Belangero Sintia
- Bellgrove Mark
- Belliveau Richard A
- Bellivier Frank
- Bencko Vladimir
- Bergen Andrew W
- Bergen Sarah E
- Berger Klaus
- Berrettini Wade H
- Bettella Francesco
- Bey Katharina
- Bienvenu O Joseph
- Biernacka Joanna M
- Binder Elisabeth B
- Birgegård Andreas
- Black Donald W
- Blackwood Douglas H R
- Boomsma Dorret I
- Bramon Elvira
- Brandt Harry
- Breen Gerome
- Brown Lawrence W
- Buccola Nancy G
- Budde Monika
- Budman Cathy
- Buitelaar Jan
- Bulik Cynthia M
- Bunney William
- Burghardt Roland
- Burmeister Margit
- Burton Christie L
- Buxbaum Joseph D
- Bybjerg-Grauholm Jonas
- Byerley William
- Byrne Enda M
- Bækvad-Hansen Marie
- Bøen Erlend
- Børglum Anders D
- Cairns Murray J
- Campion Dominique
- Carlberg Laura
- Carr Vaughan J
- Casas Miquel
- Cassina Matteo
- Castelao Enrique
- Cath Danielle
- Cerrato Felecia
- Chambert Kimberly
- Cheon Keun-Ah
- Christensen Jane H
- Churchhouse Claire
- Cichon Sven
- Ciullo Valentina
- Clarke Toni-Kim
- Clementi Maurizio
- Cloninger C Robert
- Coffey Barbara J
- Cohen David
- Coleman Jonathan R I
- Collier David A
- Collins Ryan L
- Colodro-Conde Lucía
- Cook Edwin H
- Coon Hilary
- Coppola Giovanni
- Cormand Bru
- Corvin Aiden
- Courtet Philippe
- Craddock Nicholas
- Crawford Steven
- Crosbie Jennifer
- Crow Scott
- Crowley James J
- Curtis David
- Cusi Daniele
- Czerski Piotr M
- Dale Anders M
- Dalkner Nina
- Dalsgaard Søren
- Daly Mark J
- Danner Unna N
- Dannlowski Udo
- Davis Lea K
- Davis Oliver S P
- de Geus E. J. C.
- De Rubeis Silvia
- Degenhardt Franziska
- Degortes Daniela
- DeLisi Lynn E
- Delorme Richard
- Demontis Ditte
- Denys Damiaan
- Depienne Christel
- Derks Eske M
- DeSocio Janiece E
- Di Florio Arianna
- Dick Danielle M
- Dietrich Andrea
- Dina Christian
- Direk Nese
- Docampo Elisa
- Docherty Anna R
- Domenici Enrico
- Domschke Katharina
- Donohoe Gary
- Doyle Alysa E
- Duan Jubao
- Dudbridge Frank
- Dumont Ashley
- Duncan Laramie E
- Dunn Erin C
- Eapen Valsamma
- Edenberg Howard J
- Egberts Karin
- Ehrenreich Hannelore
- Ehrlich Stefan
- Elia Josephine
- Elvsåshagen Torbjørn
- Espeseth Thomas
- Etain Bruno
- Falkai Peter
- Fanous Ayman H
- Faraone Stephen V
- Feng Yen-Chen A
- Fernandez Thomas V
- Fernández-Aranda Fernando
- Fichter Manfred M
- Fischer Sascha B
- Foo Jerome C
- Foretova Lenka
- Forstner Andreas J
- Forty Liz
- Forzan Monica
- Frank Josef
- Franke Barbara
- Freedman Robert
- Frye Mark
- Fullerton Janice M
- Gade Katrin
- Gambaro Giovanni
- Garcia-Delgar Blanca
- Gaspar Héléna A
- Ge Tian
- Gejman Pablo V
- Gelernter Joel
- Geller Daniel A
- Gershon Elliot S
- Geschwind Daniel H
- Giegling Ina
- Gilbert Donald L
- Gill Michael
- Godard Stephanie
- Goes Fernando S
- Golimbet Vera
- Gonidakis Fragiskos
- Gordon Scott D
- Gordon-Smith Katherine
- Gorwood Philip
- Grabe Hans J
- Grados Marco A
- Green Melissa J
- Greenberg Erica
- Greenwood Tiffany A
- Grice Dorothy E
- Grigoroiu-Serbanescu Maria
- Grotzinger Andrew D
- Grove Jakob
- Grünblatt Edna
- Gudmundsson Olafur O
- Guo Yiran
- Guzman-Parra José
- Haavik Jan
- Hagstrøm Julie
- Hakonarson Hakon
- Halmi Katherine A
- Hamilton Steven P
- Hanna Gregory L
- Hansen Christine S
- Hansen Thomas F
- Hartman Catharina A
- Hartmann Andreas
- Hartmann Annette M
- Hatzikotoulas Konstantinos
- Hauser Joanna
- Hautzinger Martin
- Hawi Ziarih
- Hebebrand Johannes
- Hedderly Tammy
- Heilbronner Urs
- Heiman Gary A
- Helder Sietske G
- Henskens Frans A
- Herms Stefan
- Herpertz-Dahlmann Beate
- Hervás Amaia
- Herzog Wolfgang
- Heyman Isobel
- Hinney Anke
- Hoekstra Pieter J
- Hoffmann Per
- Holland Dominic
- Holmans Peter A
- Hong Hyun Ju
- Hope Sigrun
- Horn Carsten
- Hottenga Jouke-Jan
- Hougaard David M
- Howard David
- Howrigan Daniel P
- Huang Alden
- Huang Hailiang
- Hultman Christina M
- Huyser Chaim
- Ibanez-Gomez Laura
- Ikeda Masashi
- Imgart Hartmut
- Ising Marcus
- Iwata Nakao
- Jablensky Assen V
- Jamain Stéphane
- Jiménez-Murcia Susana
- Joa Inge
- Joachim Oedegaard Ketil
- Johnson Craig
- Jones Ian
- Jones Lisa A
- Jordan Jennifer
- Julià Antonio
- Jönsson Erik G
- Kaminská Deborah
- Kandaswamy Radhika
- Kaprio Jaakko
- Karhunen Leila
- Karwautz Andreas
- Kas Martien J H
- Kaye Walter H
- Kelly Brian J
- Kelsoe John R
- Kendler Kenneth S
- Kennedy James L
- Kennedy Martin A
- Keski-Rahkonen Anna
- Khramtsova Ekaterina A
- Kim Youl-Ri
- Kim Young Key
- Kim Young-Shin
- King Robert A
- Kirov George
- Kittel-Schneider Sarah
- Klareskog Lars
- Klei Lambertus
- Kloiber Stefan
- Klump Kelly L
- Knight Jo
- Knudsen Gun Peggy S
- Kogevinas Manolis
- Koh Yun-Joo
- Koller Anna C
- Konstantinidis Anastasios
- Konte Bettina
- Kook Sodahm
- Kranzler Henry R
- Kuntsi Jonna
- Kuperman Samuel
- Ladd-Acosta Christine
- Landén Mikael
- Langley Kate
- Laurent-Levinson Claudine
- Lavebratt Catharina
- Le Hellard Stephanie
- Lee Jimmy
- Lee Phil H
- Lencz Todd
- Lerer Bernard
- Lesch Klaus-Peter
- Leung Patrick W L
- Leventhal Bennett L
- Levinson Douglas F
- Levitan Robert D
- Lewis Cathryn M
- Lewis Cathryn M
- Lewis Glyn
- Li Dong
- Li Qingqin S
- Lichtenstein Paul
- Lissowska Jolanta
- Lochner Christine
- Loo Sandra K
- Loohuis Loes M O
- Loughland Carmel M
- Lucae Susanne
- Ludolph Andrea G
- Luykx Jurjen J
- Maaser Anna
- Madruga-Garrido Marcos
- Magnusson Pall
- Magnusson Patrik K E
- Maj Mario
- Malaty Irene
- Malhotra Anil K
- Mallet Jacques
- Malt Ulrik F
- Maras Athanasios
- Marsal Sara
- Martin Alicia R
- Martin Joanna
- Martin Nicholas G
- Martinsson Lina
- Mathews Carol A
- Mattheisen Manuel
- Mayora Monica Gratacos
- Mbarek Hamdi
- McCracken James T
- McDevitt Sara
- McDonald Colm
- McElroy Susan L
- McGough James J
- McIntosh Andrew M
- McMahon Francis J
- McQuillin Andrew
- Medland Sarah E
- Meijer Inge A
- Melle Ingrid
- Metspalu Andres
- Middeldorp Christel M
- Millischer Vincent
- Mir Pablo
- Mitchell James
- Mitchell Karen S
- Mitchell Philip B
- Mitjans Marina
- Monteleone Alessio Maria
- Monteleone Palmiero
- Montgomery Grant W
- Moran Jennifer L
- Morer Astrid
- Morken Gunnar
- Morris Derek W
- Mors Ole
- Mortensen Preben B
- Mostafavi Sara
- Mowry Bryan J
- Mullins Niamh
- Munn-Chernoff Melissa A
- Murphy Kieran C
- Murphy Tara L
- Murray Robin M
- Myers Richard M
- Müller-Myhsok Bertram
- Müller-Vahl Kirsten R
- Münchau Alexander
- Naarden Allan
- Nacmias Benedetta
- Nagy Peter
- Navratilova Marie
- Neale Benjamin M
- Neale Michael C
- Nestadt Gerald
- Nestadt Paul S
- Nicolini Humberto
- Nievergelt Caroline M
- Nivard Michel G
- Nordentoft Merete
- Nurmi Erika L
- Nurnberger John I
- Nyegaard Mette
- Nyholt Dale R
- Nærland Terje
- Nöthen Markus M
- O'Donovan Michael C
- O'Neill F Anthony
- O'Toole Julie K
- Oades Robert D
- Oh Sang-Yun
- Okun Michael S
- Ophoff Roel A
- Owen Michael J
- Paciga Sara A
- Padyukov Leonid
- Palmer Duncan S
- Palotie Aarno
- Pantel Jacques
- Pantelis Christos
- Papezova Hana
- Paschou Peristera
- Pato Carlos N
- Pato Michele T
- Pedersen Carsten B
- Pedersen Marianne G
- Penninx Brenda Wjh
- Perica Vesna Boraska
- Perlis Roy H
- Perry Amy
- Peters Triinu
- Peterson Roseann E
- Petryshen Tracey L
- Pinto Dalila
- Piras Fabrizio
- Piras Federica
- Pistis Giorgio
- Pittenger Christopher
- Plessen Kerstin J
- Porteous David J
- Posthuma Danielle
- Potash James B
- Poterba Timothy
- Poulsen Jesper B
- Preisig Martin
- Pulver Ann E
- Quested Digby J
- Quiroz Jorge A
- Qvist Per
- Rabionet Raquel
- Raevuori Anu
- Ramos-Quiroga Josep Antoni
- Ramoz Nicolas
- Rehnström Karola
- Reichborn-Kjennerud Ted
- Reichenberg Abraham
- Reichert Jennifer
- Reif Andreas
- Reinbold Céline S
- Ribasés Marta
- Ricca Valdo
- Richter Margaret A
- Rietschel Marcella
- Riley Brien
- Ripke Stephan
- Rivera Margarita
- Rizzo Renata
- Roberson Mary
- Roberts Marion
- Robertson Mary
- Roeder Kathryn
- Roessner Veit
- Rohde Luis A
- Rosenthal Jacob
- Rothenberger Aribert
- Rouleau Guy A
- Rovira Paula
- Ruhrmann Stephan
- Rujescu Dan
- Rybakowski Filip
- Saemundsen Evald
- Samuels Jack F
- Sanders Alan R
- Sanders Stephan J
- Sandin Sven
- Sandor Paul
- Santangelo Susan L
- Satterstrom F Kyle
- Schachar Russell
- Schaefer Catherine
- Schall Ulrich
- Schalling Martin
- Scharf Jeremiah M
- Scherag André
- Schlögelhofer Monika
- Schmidt Ulrike
- Schofield Peter R
- Schulte Eva C
- Schulze Thomas G
- Schwab Sibylle G
- Scott Laura J
- Scott Rodney J
- Seitz Jochen
- Serretti Alessandro
- Sham Pak C
- Shi Jianxin
- Shin Eun-Young
- Sigurdsson Engilbert
- Silverman Jeremy M
- Sim Kang
- Singer Harvey
- Slachtova Lenka
- Slof-Op't Landt Margarita C T
- Slopien Agnieszka
- Smeland Olav B
- Smith Daniel J
- Smoller Jordan W
- Song Dong-Ho
- Song Jungeun
- Sorbi Sandro
- Southam Lorraine
- Spalletta Gianfranco
- St Pourcain Beate
- Stahl Eli A
- Stefansson Hreinn
- Stefansson Kari
- Stein Dan J
- Stein Murray B
- Steinberg Stacy
- Steixner Agnes A
- Stewart S Evelyn
- Storch Eric A
- Stordal Eystein
- Stranger Barbara
- Streit Fabian
- Strober Michael
- Strohmaier Jana
- Stuhrmann Manfred
- Sullivan Patrick F
- Sutcliffe James S
- Sánchez-Mora Cristina
- Talkowski Michael E
- Tarnok Zsanett
- Thomson Pippa A
- Thorgeirsson Thorgeir E
- Thornton Laura M
- Tiemeier Henning
- Tischfield Jay A
- Tooney Paul A
- Tortorella Alfonso
- Tozzi Federica
- Treasure Janet
- Treutlein Jens
- Tucker-Drob Elliot M
- Turecki Gustavo
- Turley Patrick
- Tziouvas Konstantinos
- Tübing Jennifer
- Uher Rudolf
- Vaaler Arne E
- van der Auwera Sandra
- van Elburg Annemarie A
- van Os Jim
- Vawter Marquis P
- Vieta Eduard
- Vincent John B
- Visscher Frank
- Vulink Nienke
- Wade Tracey D
- Wagner Gudrun
- Wagner Michael
- Walitza Susanne
- Walsh Dermot
- Walters G Bragi
- Walters James T R
- Walters Raymond K
- Walton Esther
- Wanderer Sina
- Wang Meg M-J
- Wang Yunpeng
- Watson Hunna J
- Weiser Mark
- Weiss Lauren A
- Weissman Myrna M
- Werge Thomas
- Wichmann H-Erich
- Wildenauer Dieter B
- Williams Nigel M
- Willsey A Jeremy
- Witt Stephanie H
- Won Hyejung
- Woods Martin
- Woodside D Blake
- Worbe Yulia
- Wormley Brandon K
- Wray Naomi R
- Yu Dongmei
- Zai Clement C
- Zai Gwyneth
- Zandi Peter
- Zayats Tetyana
- Zeggini Eleftheria
- Zerwas Stephanie
- Zhang Fuquan
- Zheutlin Amanda
- Zhu Zhaozhong
- Zinner Samuel H
- Zipfel Stephan
- Publication venue
- Publication date
- 01/01/2019
- Field of study
Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyper-activity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome. Genetic correlation analyses revealed a meaningful structure within the eight disorders, identifying three groups of inter-related disorders. Meta-analysis across these eight disorders detected 109 loci associated with at least two psychiatric disorders, including 23 loci with pleiotropic effects on four or more disorders and 11 loci with antagonistic effects on multiple disorders. The pleiotropic loci are located within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes. These findings have important implications for psychiatric nosology, drug development, and risk prediction.Peer reviewe
VLF measurements and modeling of the D-region response to the 2017 total solar eclipse
- Author
- Publication venue
- 'Institute of Electrical and Electronics Engineers (IEEE)'
- Publication date
- 01/01/2019
- Field of study
Abstract
In this paper, we report measurements in Colorado and Utah of the disturbed very-low-frequency (VLF) signals from the NML Navy transmitter in North Dakota during the 2017 solar eclipse. Using an occultation mask of solar fluxes together with detailed chemistry and VLF propagation simulations, we quantify the D-region response to the eclipse, in terms of electron density variation, as well as the expected signatures of VLF transmitter signals. The VLF measurements, including an anomalous amplitude enhancement recorded in UT, can be quantitatively explained using the Wait and Spies ionospheric profile with a sharpness parameter of β = 0.3 km⁻¹ above ~55 km and an increase in the D-region ionosphere height of Δh′ ≃ 8 km. This sharpness parameter is consistent with previously reported rocket measurements and first-principles calculations. The best-fit results suggest a reduction of D-region electron density by ~90% during the eclipse in the D-region, implying an occultation of Lyman-α by nearly 99%. This finding agrees with detailed calculations of time-dependent obscuration factors utilizing the He 30.4-nm images from Solar Dynamics Observatory as a proxy for the distribution of Lyman-α across the solar disk and limb. Moreover, the present results show that subionospheric VLF propagation is sensitive to the sharpness parameter of the electron density profile in the D-region. Previously reported first-principles simulations have shown that the sharpness parameter is mostly controlled by the background concentration of minor neutral species. Thus, the VLF technique can be likely used to remotely sense these neutral species at and below the effective reflection altitudes of VLF waves
Some Atmospheric Effects on Infrasound Signal Amplitudes
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Mid-Latitude Temperatures at 87 km: Results From Multi-Instrument Fourier Analysis
- Author
- Publication venue
- Publication date
- 01/07/2000
- Field of study
Using a novel Fourier fitting method we combine two years of mid-latitude temperature measurements at 87 km from the High Resolution Doppler Imager, the Colorado State University lidar, and the Peach Mountain Interferometer. After accounting for calibration bias, significant local-time variations on the order of 10 K were observed. Stationary planetary waves with amplitudes up to 10 K were observed during winter, with weaker wave amplitudes occurring during other seasons. Because of calibration biases among these instruments, we could estimate the annual mean temperature to no better than 193.5 plus or minus 8.5 K
Middle Atmosphere Variability and Model Uncertainties as Investigated in the Framework of the ARISE Project
- Author
- A Butler
- A Hauchecorne
- A Hauchecorne
- A Hauchecorne
- A Hauchecorne
- A Pichon Le
- A Pichon Le
- A Pichon Le
- A Pichon Le
- A Pichon Le
- A Schöch
- AJ Charlton-Perez
- Alain Hauchecorne
- Alain Hauchecorne
- Alfred J. Bedard
- Andrew J. Charlton
- AS Medvedev
- B. Kaifler
- B. P. Williams
- Benoit Alcoverro
- C Delclos
- C. Pilger
- CS Bretherton
- D Fee
- D Pendlebury
- D Rind
- D Rind
- D Rind
- David A. Newnham
- DC Fritts
- DG Andrews
- DJ Sandford
- DL Wu
- DN Green
- Dorianne Tailpied
- Douglas P. Drob
- DP Drob
- DP Lalas
- DWJ Thompson
- E Blanc
- E Manzini
- E. Blanc
- E. Blanc
- E. Marchetti
- EP Gerber
- F Lott
- FJ Lübken
- Franz-Josef Lübken
- G Baumgarten
- G Baumgarten
- G Stober
- GJ Shutts
- GL Manney
- IP Chunchuzov
- Isamu Hirota
- J Cohen
- J Hildebrand
- J Höffner
- J Marty
- J. D. Assink
- J. D. Assink
- Jeffrey M. Forbes
- JG Charney
- JM Forbes
- JM Lalande
- JR Bowman
- JR Holton
- JR Holton
- JR Holton
- K Antier
- K Kodera
- K Labitzke
- KW Hoppel
- L Ceranna
- L Goncharenko
- LG Evers
- M Baldwin
- M Bertin
- M Diamantakis
- M Kohma
- M Landes
- M Sigmond
- M Venkat Ratnam
- M. L. Chanin
- MJ Alexander
- ML Salby
- MP Baldwin
- MP Hickey
- MR Schoeberl
- MR Schoeberl
- N. Mzé
- NA Bakas
- NJ Mitchell
- Om P. Tripathi
- P Keckhut
- P Maury
- P. Kishore
- Philippe Keckhut
- PSM Smets
- PSM Smets
- PW Jones
- R Rüfenacht
- R Wilson
- R. S. Lindzen
- RJ Wit de
- RJ Wit de
- Robin S. Matoza
- RS Lindzen
- S. J. Gibbons
- S. N. Kulichkov
- S. Pawson
- Sergey Kulichkov
- T Hirooka
- T Matsuno
- TA Shaw
- TA Shaw
- TG Shepherd
- U Zahn von
- V Limpasuvan
- V Matthias
- WJ Randel
- WK Hocking
- WL Donn
- Y Cansi
- Y. I. Portnyagin
- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 01/04/2018
- Field of study
International audienc
Volcano infrasound and the International Monitoring System
- Author
- A Gerst
- A Gerst
- A Harris
- A Pichon Le
- A Pichon Le
- A Pichon Le
- A Tempest
- A Yokoo
- A Yokoo
- A Yokoo
- A. Goto
- A. Le Pichon
- AA Atchley
- AD Pierce
- AD Pierce
- AF Richards
- AL Dabrowa
- AL Dabrowa
- Andrew Tupper
- BA Bolt
- BA Chouet
- C. Delclos
- C. L. Pekeris
- CE Needham
- CF Waythomas
- CG Newhall
- CH Liu
- CKW Tam
- CKW Tam
- Corentin Caudron
- CR Rowell
- CR Wilson
- CR Wilson
- D Delle Donne
- D Dzurisin
- D Fee
- D Fee
- D Fee
- D Fee
- D Fee
- D Fee
- D Fee
- D Harkrider
- D. Delle Donne
- D. N. Green
- D. R. Christie
- David Fee
- DC Bowman
- DG Harkrider
- DK Chester
- DN Green
- DN Green
- DN Green
- DN Green
- Dorianne Tailpied
- Douglas P. Drob
- DP Drob
- E Marchetti
- E Marchetti
- E Marchetti
- EF Medici
- F Press
- F Press
- FJ Mauk
- G Lacanna
- G Lacanna
- G Ulivieri
- G Woulff
- G. I. Taylor
- G. I. Taylor
- GS Gorshkov
- H Kanamori
- H Lamb
- H Oshima
- H Yamasato
- H Yamasato
- J Caplan-Auerbach
- J Johnson
- J LeConte
- J Taddeucci
- J-M Lalande
- J. D. Assink
- J. D. Assink
- J. Taddeucci
- Jack W. Reed
- JB Johnson
- JB Johnson
- JB Johnson
- JB Johnson
- JB Johnson
- JB Johnson
- JB Lonzaga
- JD Assink
- JE Piercy
- Jeffrey B. Johnson
- JJ Lyons
- JM Lees
- JM Lees
- JM Snodgrass
- John R. Banister
- JP Richardson
- JW Reed
- K Antier
- K Ishihara
- K Kim
- K Kim
- K Kim
- K Kim
- K Nishida
- K Viswanathan
- KR Jones
- KR Jones
- Kristoffer T. Walker
- LC Sutherland
- LG Evers
- M Båth
- M Cerminara
- M Garces
- M Garces
- M Ichihara
- M Ichihara
- M Iguchi
- M Iguchi
- M Landès
- M Ripepe
- M Ripepe
- M Ripepe
- M Tahira
- M. Garcés
- M. Ripepe
- MA Garces
- MA Garces
- Maurizio Ripepe
- Maurizio Ripepe
- Maurizio Ripepe
- Milton A. Garcés
- MJ Buckingham
- MJ Lighthill
- MJ Lighthill
- MM Morrissey
- MP Dalton
- MT Hagerty
- N Curle
- O. Marcillo
- OA Godin
- OA Godin
- OD Lamb
- P Segall
- P. P. Firstov
- PM Morse
- PP Firstov
- R Genco
- RD Lorenz
- RH Scott
- RH Strachey
- Robin S. Matoza
- Robin S. Matoza
- RR Dibble
- RS Matoza
- RS Matoza
- RS Matoza
- RS Matoza
- RS Matoza
- RS Matoza
- RS Matoza
- RS Matoza
- RS Matoza
- S Angelis De
- S Angelis De
- S Vergniolle
- S Vergniolle
- S Vergniolle
- S Watada
- SG Prejean
- SJ Lane
- SN Kulichkov
- SR Ford
- SR McNutt
- SR McNutt
- ST Sahetapy-Engel
- T Braun
- T Gabrielson
- T Lopez
- T Sakai
- TM Georges
- V. Vidal
- VE Ostashev
- Verbeek
- VH Goerke
- WL Donn
- WL Donn
- WL Donn
- Y Cansi
- Publication venue
- eScholarship, University of California
- Publication date
- 01/01/2019
- Field of study
Evaluating Different Techniques for Constraining Lower Atmospheric Variability in an Upper Atmosphere General Circulation Model: A Case Study During the 2010 Sudden Stratospheric Warming
- Author
- Adams J. C.
- Akmaev R. A.
- Akmaev R. A.
- Anthes R. A.
- Astrid Maute
- Burns A. G.
- Butler A. H.
- Chang L. C.
- Codrescu S. M.
- David E. Siskind
- Douglas P. Drob
- Eckermann S. D.
- England S. L.
- Fang T.‐W.
- Forbes J. M.
- Forbes J. M.
- Forbes J. M.
- Fuller‐Rowell T. J.
- Funke B.
- Goncharenko L. P.
- Goncharenko L. P.
- Hagan M. E.
- Hagan M. E.
- Hagan M. E.
- Heelis R. A.
- Hogan T. F.
- Jeuken A. B. M.
- Jin H.
- John P. McCormack
- Jones M.
- Jones M.
- Jones M.
- Kenneth F. Dymond
- Kim Y.‐J.
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- Publication venue
- 'American Geophysical Union (AGU)'
- Publication date
- Field of study
New insights into the genetic etiology of Alzheimer’s disease and related dementias
- Author
- A David Smith
- Aaltonen L.
- Aaltonen V.
- Aarno Palotie
- Aarsland D.
- Aavikko M.
- Abalos M. S.
- Abdelnour C.
- Abner E.
- Abraham R.
- Ad Adarmes-Gómez
- Adam Boxer
- Adam Ziemann
- Adams H.
- Adams P. M.
- Adarmes-Gómez A.
- Adarmes-Gómez A. D.
- Adriana Gamboa
- Adrienne L Cupples
- Adrienne Tin
- Aguilera N.
- Aguilera N.
- Aguirre A.
- Agustina Legaz
- Ahmad S.
- Aimee Pierce
- Aino Salminen
- Airi Jussila
- Aisha Khaleeq
- Aki Havulinna
- Akinyemi R. O.
- Al-Chalabi A.
- Alan B Stevens
- Alan Lerner
- Alarcón-Martín E.
- Albert M. S.
- Alberto Benussi
- Albin R. L.
- Alcolea D.
- Aldo Saenz
- Alegret M.
- Alessandra Chesi
- Alessandro Vacca
- Alexander Teumer
- Alexis Brice
- Ali M.
- Alisa Manning
- Alison E Fohner
- Allan I Levey
- Allen M.
- Allende I. R.
- Alonso M. D.
- Alonso M. D.
- Alvarez I.
- Alvarez L.
- Alvin Thomas
- Alyssa Aguirre
- Amanda Cano
- Amanda Elliott
- Amanda G Smith
- Amanda J Myers
- Amer-Ferrer G.
- Amin N.
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- Amouyel P.
- Amy Gerrish
- Amy Williams
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- Ana Pancho
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- Anders Malarstig
- Andrade V.
- Andrea Ganna
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- Andreoni S.
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- Andrew McQuillin
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- Anna Antonell
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- Anna Podgornaia
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- Vesa Aaltonen
- Vicente M. P.
- Victor W Henderson
- Victoria Fernandez-Hernandez
- Victoria Perez
- Victoriana Martínez
- Vidal J. -S.
- Vigo-Ortega R.
- Vilas R. H.
- Vinay Mehta
- Vincent Deramecourt
- Vincent Deramerourt
- Vincent Llorens
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- Vyhnalek M.
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- Wayne C McCormick
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- Weber H.
- Wei Gu
- Wei Zhou
- Weinhold L.
- Weinstein G.
- Weintraub S.
- Welsh-Bohmer K. A.
- Whelan C.
- Whitehead P. L.
- Wichmann H. -E.
- Wigmore E.
- Wijsman E. M.
- Wilcock G.
- Wilhelmsen K. C.
- Will S Bush
- William Kremen
- William Nash
- William W Seeley
- Williams A.
- Williams B.
- Williams D.
- Williams J.
- Williamson J.
- Wilms H.
- Wiltfang J.
- Windle G.
- Wingo T. S.
- Wisniewski T.
- Wittfeld K.
- Woltjer R. L.
- Wong R.
- Woods B.
- Woon M.
- Wright C. B.
- Wu C. -K.
- Wu Y.
- Xia T. -H.
- Xing Chen
- Xinli Hu
- Xiongwei Zhu
- Xu E.
- Xu F.
- Xuan Liu
- Yanbing Wang
- Yanek L.
- Yang Q.
- Yang Y.
- Yannakoulia M.
- Yaqub A.
- Yasaman Saba
- Yash Patel
- Yeunjoo E Song
- Yi Zhao
- Ying Wu
- Yoav Ben-Shlomo
- Yogen Patel
- Younkin S. G.
- Yu C. -E.
- Yu L.
- Yuanchao Zhang
- Yuk Yee Leung
- Yunfeng Huang
- Yunju Yang
- Zare H.
- Zdenka Pausova
- Zhang X.
- Zhang Y.
- Zhao Y.
- Zhao Y.
- Zhou W.
- Zhu C.
- Zhu X.
- Ziemann A.
- Zoia C. P.
- Zompo M. D.
- Zulaica M.
- Zulma Sevillano
- Álvarez V.
- Åsa Hedman
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
New insights into the genetic etiology of Alzheimer’s disease and related dementias
- Author
- Aaltonen Lauri
- Aaltonen Vesa
- Aarsland Dag
- Aavikko Mervi
- Abalos Mariana Sanchez
- Abdelnour Carla
- Abner Erin
- Abraham Richard
- Adams Hieab
- Adams Perrie M.
- Adarmes-Gómez Ad
- Adarmes-Gómez Astrid D.
- Aguilera Nuria
- Aguilera Nuria
- Aguirre Alyssa
- Ahmad Shahzad
- Akinyemi Rufus O.
- Al-Chalabi Ammar
- Alarcón-Martín Emilio
- Albert Marilyn S.
- Albin Roger L.
- Alcolea Daniel
- Alegret Montserrat
- Ali Muhammad
- Allen Mariet
- Allende Irene Rosas
- Alonso María Dolores
- Alonso María Dolores
- Alvarez Ignacio
- Alvarez Lisa
- Amer-Ferrer Guillermo
- Amin Najaf
- Amouyel Philippe
- Anastasiou Anna
- Anastasiou Costas
- Andrade Victor
- Andreassen Ole A.
- Andreoni Simona
- Antequera Martirio
- Antikainen Riitta
- Antonell Anna
- Anttonen Vuokko
- Antúnez Carmen
- Aparicio Hugo J.
- Apostolova Liana G.
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Armstrong Nicola
- Armstrong Nicola J.
- Arnold Steven E.
- Arosio Beatrice
- Arvas Mikko
- Assogna Francesca
- Asthana Sanjay
- Athanasiu Lavinia
- Atwood Craig S.
- Auge Franck
- Auranen Annika
- Auvinen Päivi
- Awaisa Ghazal
- Ayres Gayle
- Bacha Juan Ignacio
- Bahadori Maryam
- Bahrami Shahram
- Bailly Henri
- Baldwin Clinton T.
- Banaj Nerisa
- Baquero Miquel
- Barber Robert C.
- Barnes Lisa L.
- Barral Sandra
- Barral Sandra
- Bass Nicholas J.
- Bass Nick
- Bastiani Patrizia
- Bayer Anthony
- Beach Thomas G.
- Becker James T.
- Becker James T.
- Becker Tim
- Beecham Gary W.
- Beekly Duane
- Behrens Tim
- Beiser Alexa
- Belezhanska Diyana
- Bellenguez Céline
- Below Jennifer E.
- Below Jennifer E.
- Ben-Shlomo Yoav
- Benchek Penelope
- Benchek Penelope
- Benitez Bruno A.
- Bennett David
- Benussi Alberto
- Benussi Luisa
- Bergh Sverre
- Bernardo-Harrington Mateus
- Berr Claudine
- Bertelson John
- Besse Céline
- Bessi Valentina
- Betts Jo
- Bhangale Tushar
- Biessels Geert Jan
- Binetti Giuliano
- Bing Nan
- Bird Thomas D.
- Bis Joshua C.
- Biswas Shameek
- Bizarro Alessandra
- Bjerke Maria
- Blacker Deborah
- Blesa Rafael
- Blomster Timo
- Boada Mercè
- Boecker Henning
- Boerwinkle Eric
- Boeve Bradley F.
- Boland Anne
- Borroni Barbara
- Boschi Silvia
- Bosnes Ingunn
- Bossù Paola
- Bowen James D.
- Bowers Natalie
- Boxer Adam
- Brauer Matt
- Brayne Carol
- Brein Georg
- Bresner Catherine
- Bressler Jan
- Breteler Monique
- Brewer James
- Brice Alexis
- Brodaty Henry
- Broeckhoven Christine Van
- Bronson Paola
- Brookes KJ
- Brown Kristelle
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- Brusco Luis Ignacio
- Bråthen Geir
- Buendia Mar
- Buiza-Rueda Dolores
- Bullido María J.
- Burguera Juan Andrés
- Burholt Vanessa
- Burke James R.
- Burns Jeffrey M.
- Bush Will S.
- Bush William S.
- Buxbaum Joseph D.
- Bûrger Katharina
- Cairns Nigel J.
- Calero Miguel
- Caliskan Minal
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- Call Kathy
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- Campos-Martin Rafael
- Cano Amanda
- Cantwell Laura B.
- Cao Chuanhai
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- Carlsson Cynthia M.
- Carney Regina M.
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- Carracedo Ángel
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- Casajeros María José
- Castaño Eduardo M.
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- Cañabate Pilar
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- Cervera-Carles Laura
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- Chapuis Julien
- Charbonnier Camille
- Chasman Daniel
- Chasse Scott
- Chatelain Clement
- Chauhan Ganesh
- Chen Chia-Yen
- Chen Hao
- Chen Hubert
- Chen Hung-Hsin
- Chen Xing
- Chene Geneviève
- Chesi Alessandra
- Chesselet Marie-Francoise
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- Chillotti Caterina
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- Comic Hata
- Conti Elisa
- Cores Valeria
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- Costa Marcos R.
- Costantini Emanuele
- Cox Simon
- Craft Suzanne
- Craig David
- Crane Paul K.
- Cribbs David H.
- Crocco Elizabeth A.
- Crohns Marika
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- Cuccaro Michael L.
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- Cuesta Carolina
- Cullum Munro
- Cummings Beryl
- Cupples Adrienne L.
- Custodero Carlo
- Daian Delphine
- Dalmasso Maria Carolina
- Daly Mark
- Damotte Vincent
- Daniele Antonio
- Darby Eveleen
- Dardiotis Efthimios
- Dartigues Jean-François
- Davies Chloe
- Davies Gail
- Davis Barbara
- Davis Justin Wade
- de Deyn Peter Paul
- De Jager Philip L.
- de Mendonça Alexandre
- de Munain Adolfo Lopez
- de Paiva Lopes Katia
- de Rojas Itziar
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- Debette Stéphanie
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- Deckert Jürgen
- del Ser Teodoro
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- della Briotta Parola Pietro
- della Briotta Parolo Pietro
- Deloukas Panagiotis
- Deloukas Pangiotis
- Denning Nicola
- Deramecourt Vincent
- Deramerourt Vincent
- DeStefano Anita
- DeToledo John
- Dichgans Martin
- Dick Malcolm
- Dickson Dennis W.
- Diego Susana
- Diehl-Schmid Janine
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- Dupuis Josée
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- Düzel Emrah
- Eaton Susan
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- Eklund Kari
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- Engelborghs Sebastiaan
- Epelbaum Jacques
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- Feulner Thomas
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- Gailhajenet Anna
- Galasko Douglas R.
- Galeano Pablo
- Galimberti Daniela
- Gamboa Adriana
- Ganguli Mary
- Ganna Andrea
- Garcia-Gonzalez Pablo
- Garcia-Madrona Sebastian
- Garcia-Ribas Guillermo
- Garcia-Tabuenca Javier
- García-Alberca Jose Maria
- García-González Pablo
- Garrote-Espina L.
- Garrote-Espina Lorena
- Gearing Marla
- Geerlings Mirjam
- Georgantas Bob
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- Germani Sandra
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- Geschwind Daniel H.
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- Ghidoni Roberta
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- Guerreiro Rita
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- Gwilliam Rhian
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- Haapasalo Annakaisa
- Habes Mohamad
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- Harold Denise
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- Hartmann Annette M.
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- Harwood Janet
- Hausner Lucrezia
- Haut Jacob
- Hautala Nina
- Havulinna Aki
- Head Elizabeth
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- Heckbert Susan R.
- Hedman Åsa
- Heikkinen Sami
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- Henderson Victor W.
- Hendolin Minna
- Heneka Michael T.
- Hernandez Michelle
- Hernández Isabel
- Herold Christine
- Heron Samuel
- Herrmann Martin J.
- Heun Reinhard
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- Hiekkalinna Tero
- Hiltunen Mikko
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- Hodges Angela
- Hofer Edith
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- Johansson Charlotte
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- Partanen Jukka
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- Peterson Andrew
- Petrovski Slavé
- Phillips-Cremins Jennifer E.
- Pickering-Brown Stuart
- Pierce Aimee
- Pihlajamäki Jussi
- Pijnenburg Yolande A. L.
- Pikkarainen Sampsa
- Pinchler Sabrina
- Pineda Juan A.
- Pineda-Sánchez R.
- Pineda-Sánchez Rocío
- Piras Fabrizio
- Piras Federica
- Pirilä Laura
- Pisanu Claudia
- Pitkäranta Anne
- Piñol-Ripoll Gerard
- Plenge Robert
- Podgornaia Anna
- Polak Thomas
- Politis Daniel G.
- Polk Marsha
- Poon Wayne W.
- Popovic Relja
- Popp Julius
- Posthuma Danielle
- Potter Huntington
- Powell John
- Powell John F.
- Preckler Silvia
- Prestia Federico Ariel
- Priller Josef
- Proitsi Petra
- Prokic Ivana
- Psaty Bruce M.
- Puerta Raquel
- Pulford David
- Pulkki Kari
- Pussinen Pirkko
- Pylkäs Katri
- Pärn Kalle
- Pérez-Cordón Alba
- Pérez-Tur Jordi
- Qu Liming
- Quarless Danjuma
- Quenez Olivier
- Quiceno Mary
- Quinn Joseph F.
- Quintela Inés
- Rahimov Fedik
- Raikkonen-Talvitie Katri
- Rainero Innocenzo
- Raj Ashok
- Raj Towfique
- Rajabli Farid
- Rajpal Deepak
- Rajula Reddy
- Ramakers Inez
- Ramirez Alfredo
- Raskind Murray
- Rathinakannan Venkat Subramaniam
- Real de Asúa Diego
- Real Luis M.
- Reeve Mary Pat
- Reiman Eric M.
- Reinders Marcel J. T.
- Reisberg Barry
- Reisch Joan S.
- Reitz Christiane
- Remes Anne
- Reyes-Dumeyer Dolly
- Riaz Moeen
- Rice David
- Rich Stephen
- Ridge Perry
- Riedel-Heller Steffi
- Riederer Peter
- Riemenschneider Matthias
- Riley-Gillis Bridget
- Ringman John M.
- Rinne Juha
- Rios Mario
- Ripatti Samuli
- Ritari Jarmo
- Rivas Manuel
- Roberson Erik D.
- Roberto Natalia
- Rodrigo Silvia
- Rodrigo-Herrero Silvia
- Rodriguear Monica
- Rodriguez-Rodriguez Eloy
- Rodríguez Carmen Martínez
- Roeck Ellen De
- Rogaeva Ekaterina
- Rojo Matias
- Romero Jose
- Rongve Arvid
- Rosen Howard J.
- Rosenberg Roger N.
- Rosende-Roca Maitée
- Roshchupkin Gena
- Rossi Giacomina
- Rossi Paolo Dionigi
- Rossor Martin
- Rossor Martin
- Rotter Jerome
- Roveta Fausto
- Royall Donald R.
- Royo Jose Luis
- Rubino Elisa
- Rubinsztein David C.
- Ruiz Agustín
- Rujescu Dan
- Runz Heiko
- Ryan Natalie S.
- Ryan Nathalie
- Rábano Alberto
- Rüeger Sina
- Saba Yasaman
- Sachdev Perminder
- Saenz Aldo
- Sager Mark A.
- Sakka Paraskevi
- Sala Gessica
- Salmi Teea
- Salminen Aino
- Salo Tuula
- Salomaa Veikko
- Saltvedt Ingvild
- Salvadori Nicola
- Sanabria Ángela
- Sanchez-Garcia Florentino
- Sando Sigrid B.
- Sano Mary
- Sargurupremraj Murali
- Sarnowski Chloé
- Sastre Isabel
- Satizabal Claudia L.
- Saykin Andrew J.
- Scamosci Michela
- Scarmeas Nikolaos
- Scarpini Elio
- Schellenberg Gerard D.
- Scheltens Philip
- Scherbaum Norbert
- Scherer Martin
- Schleutker Johanna
- Schmid Matthias
- Schmidt Helena
- Schmidt Reinhold
- Schneider Anja
- Schneider Julie A.
- Schneider Lon S.
- Schott Jonathan M.
- Schutzman Jennifer
- Schürmann Britta
- Seeley William W.
- Seitsonen Sanna
- Sekhar Hema
- Selbæk Geir
- Selnes Per
- Seripa Davide
- Serpente Maria
- Serpi Raisa
- Serrano Manuel
- Seshadri Sudha
- Sevillano Zulma
- Sha Jin
- Shadrin Alexey A.
- Shaikho Elmutaz
- Shaw Christopher E.
- Shcherban Anastasia
- Shin Jean
- Shofany Jacob
- Shulman Joshua M.
- Siirtola Harri
- Simino Jeannette
- Sims Rebecca
- Sinisalo Juha
- Sipeky Csilla
- Sipilä Kirsi
- Sipilä Timo P.
- Siponen Maria
- Sistonen Tuuli
- Skrobot Olivia
- Sleegers Kristel
- Slifer Susan
- Slifer Susan H.
- Sliz Eeva
- Small Scott
- Smaoui Nizar
- Smith A. David
- Smith Amanda G.
- Smith Janet P.
- Smith Jennifer
- Snijders Gijsje J. L.
- Soininen Hilkka
- Solfrizzi Vincenzo
- Solis Patricia
- Solomon Alina
- Song Yeunjoo
- Song Yeunjoo E.
- Sonnen Joshua A.
- Sorbi Sandro
- Sotolongo-Grau Oscar
- Spallazzi Marco
- Spalletta Gianfranco
- Spina Salvatore
- Spottke Annika
- Squassina Alessio
- Stern Robert A.
- Stevens Alan B.
- Stordal Eystein
- Strandberg Timo
- Strauss Erich
- Strittmatter Stephen M.
- Ståhlbom Anne Kinhult
- Sultzer David
- Suominen Liisa
- Sussams Rebecca
- Swerdlow Russell H.
- Sáez María Eugenia
- Sánchez-Arjona María Bernal
- Sánchez-Valle Raquel
- Takalo Mari
- Tanzi Rudolph E.
- Tartan Juan Pablo
- Tasanen Kaisa
- Taskinen Marja-Riitta
- Teipel Stefan
- Teng Edmond
- Tesí Niccolo
- Teumer Alexander
- Thalamuthu Anbupalam
- Thomas Alvin
- Thomas Charlene
- Thomas Tegos
- Thomassen Jesper Qvist
- Thonberg Håkan
- Tienari Pentti
- Tilson Jeffrey L.
- Tin Adrienne
- Todd Stephen
- Toso Carlos Reyes
- Tosto Giuseppe
- Traykov Latchezar
- Tremolizzo Lucio
- Trojanowski John Q.
- Troncoso Juan C.
- Tsai Ellen
- Tsolaki Anthoula
- Tsolaki Magda
- Tsuang Debby W.
- Tsuo Kristin
- Tucker-Drob Elliot
- Tukiainen Taru
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Tuovila Outi
- Turpeinen Miia
- Turton James
- Turunen Joni A.
- Tybjærg-Hansen Anne
- Tzourio Christophe
- Tárraga Lluís
- Uitterlinden Andre
- Ullgren Abbe
- Ulstein Ingun
- Uphill James
- Usiskin Keith
- Uusitalo Hannu
- Uusitalo-Järvinen Hannele
- Vacca Alessandro
- Vainio Seppo
- Valero Sergi
- Valladares Otto
- Valladares Otto
- van Adelsberg Janet
- Van Deerlin Vivianna M.
- van den Bussche Hendrik
- van der Flier Wiesje M.
- van der Lee Sven J.
- van der Lugt Aad
- van Duijn Cornelia M.
- van Eldik Linda J.
- van Lent Debora Melo
- van Rooij Jeroen
- van Swieten John
- Vance Jeffery
- Vandenberghe Rik
- Vardarajan Badri N.
- Vardy Emma
- Vargas Liliana
- Vassar Robert
- Verhey Frans
- Vicente Maria Pilar
- Vidal Jean-Sébastien
- Vigo-Ortega R.
- Vigo-Ortega Rosario
- Vilas Raquel Huerto
- Vinters Harry V.
- Virolainen Petri
- Vivancos Liliana
- Vogelgsang Jonathan
- Vojinovic Dina
- Vonsattel Jean-Paul
- Voutilainen Markku
- Vyhnalek Martin
- Wadhawan Samir
- Wagner Michael
- Wallon David
- Wang Clarence
- Wang Li-San
- Wang Ruiqi
- Wang Yanbing
- Warden Donald
- Waring Jeff
- Waring Jeffrey
- Warner Nick
- Warren Jason D.
- Waterworth Dawn
- Weber Heike
- Weinhold Leonie
- Weinstein Galit
- Weintraub Sandra
- Welsh-Bohmer Kathleen A.
- Whelan Christopher
- Whitehead Patrice L.
- Wichmann H-Erich
- Wigmore Eleonor
- Wijsman Ellen M.
- Wilcock Gordon
- Wilhelmsen Kirk C.
- Williams Amy
- Williams Benjamin
- Williams Dylan
- Williams Julie
- Williamson Jennifer
- Wilms Henrik
- Wiltfang Jens
- Windle Gill
- Wingo Thomas S.
- Wisniewski Thomas
- Wittfeld Katharina
- Woltjer Randall L.
- Wong Regis
- Woods Bob
- Woon Martin
- Wright Clinton B.
- Wu Chuang-Kuo
- Wu Ying
- Xia Tai-he
- Xu Ethan
- Xu Fanli
- Yanek Lisa
- Yang Qiong
- Yang Yunju
- Yannakoulia Mary
- Yaqub Amber
- Younkin Steven G.
- Yu Chang-En
- Yu Lei
- Zare Habil
- Zhang Xiaoling
- Zhang Yuanchao
- Zhao Yi
- Zhao Yi
- Zhou Wei
- Zhu Congcong
- Zhu Xiongwei
- Ziemann Adam
- Zoia Chiara Paola
- Zompo Maria Del
- Zulaica Miren
- Álvarez Victoria
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/04/2022
- Field of study
Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele