Behavioral Deficits and Axonal Injury Persistence after Rotational Head Injury Are Direction Dependent

Pigs continue to grow in importance as a tool in neuroscience. However, behavioral tests that have been validated in the rodent model do not translate well to pigs because of their very different responses to behavioral stimuli. We refined metrics for assessing porcine open field behavior to detect a wide spectrum of clinically relevant behaviors in the piglet post-traumatic brain injury (TBI). Female neonatal piglets underwent a rapid non-impact head rotation in the sagittal plane (n=8 evaluable) or were instrumented shams (n=7 evaluable). Open field testing was conducted 1 day prior to injury (day −1) in order to establish an individual baseline for analysis, and at days +1 and +4 after injury. Animals were then killed on day +6 after injury for neuropathological assessment of axonal injury. Injured piglets were less interested in interacting with environmental stimuli and had a lower activity level than did shams. These data were compared with previously published data for axial rotational injuries in neonatal piglets. Acute behavioral outcomes post-TBI showed a dependence on the rotational plane of the brain injury, with animals with sagittal injuries demonstrating a greater level of inactivity and less random usage of the open field space than those with axial injuries. The persistence of axonal injury is also dependent on the rotational plane, with sagittal rotations causing more prolonged injuries than axial rotations. These results are consistent with animal studies, finite element models, and studies of concussions in football, which have all demonstrated differences in injury severity depending upon the direction of head impact rotation

Higher Order Force Gradient Symplectic Algorithms

We show that a recently discovered fourth order symplectic algorithm, which requires one evaluation of force gradient in addition to three evaluations of the force, when iterated to higher order, yielded algorithms that are far superior to similarly iterated higher order algorithms based on the standard Forest-Ruth algorithm. We gauge the accuracy of each algorithm by comparing the step-size independent error functions associated with energy conservation and the rotation of the Laplace-Runge-Lenz vector when solving a highly eccentric Kepler problem. For orders 6, 8, 10 and 12, the new algorithms are approximately a factor of $10^3$, $10^4$, $10^4$ and $10^5$ better.Comment: 23 pages, 10 figure

Perfect mirrors and the self-accelerating box paradox

We consider the question raised by Unruh and Wald of whether mirrored boxes can self-accelerate in flat spacetime (the ``self-accelerating box paradox''). From the point of view of the box, which perceives the acceleration as an impressed gravitational field, this is equivalent to asking whether the box can be supported by the buoyant force arising from its immersion in a perceived bath of thermal (Unruh) radiation. The perfect mirrors we study are of the type that rely on light internal degrees of freedom which adjust to and reflect impinging radiation. We suggest that a minimum of one internal mirror degree of freedom is required for each bulk field degree of freedom reflected. A short calculation then shows that such mirrors necessarily absorb enough heat from the thermal bath that their increased mass prevents them from floating on the thermal radiation. For this type of mirror the paradox is therefore resolved. We also observe that this failure of boxes to ``float'' invalidates one of the assumptions going into the Unruh-Wald analysis of entropy balances involving boxes lowered adiabatically toward black holes. Nevertheless, their broad argument can be maintained until the box reaches a new regime in which box-antibox pairs dominate over massless fields as contributions to thermal radiation.Comment: 11 pages, Revtex4, changes made in response to referee and to enhance clarity, discussion of massive fields correcte

On the Status of Highly Entropic Objects

It has been proposed that the entropy of any object must satisfy fundamental (holographic or Bekenstein) bounds set by the object's size and perhaps its energy. However, most discussions of these bounds have ignored the possibility that objects violating the putative bounds could themselves become important components of Hawking radiation. We show that this possibility cannot a priori be neglected in existing derivations of the bounds. Thus this effect could potentially invalidate these derivations; but it might also lead to observational evidence for the bounds themselves.Comment: 6 pages, RevTex, a few editorial change

Paradox as invitation to act in problematic change situations

It has been argued that organizational life typically contains paradoxical situations such as efforts to manage change which nonetheless seem to reinforce inertia. Four logical options for coping with paradox have been explicated, three of which seek resolution and one of which ‘keeps the paradox open’. The purpose of this article is to explore the potential for managerial action where the paradox is held open through the use of theory on ‘serious playfulness’. Our argument is that paradoxes, as intrinsic features in organizational life, cannot always be resolved through cognitive processes. What may be possible, however, is that such paradoxes are transformed, or ‘moved on’ through action and as a result the overall change effort need not be stalled by the existence of embedded paradoxes

Tall tales from de Sitter space II: Field theory dualities

We consider the evolution of massive scalar fields in (asymptotically) de Sitter spacetimes of arbitrary dimension. Through the proposed dS/CFT correspondence, our analysis points to the existence of new nonlocal dualities for the Euclidean conformal field theory. A massless conformally coupled scalar field provides an example where the analysis is easily explicitly extended to 'tall' background spacetimes.Comment: 31 pages, 2 figure

Large violation of Bell inequalities with low entanglement

In this paper we obtain violations of general bipartite Bell inequalities of order $\frac{\sqrt{n}}{\log n}$ with $n$ inputs, $n$ outputs and $n$-dimensional Hilbert spaces. Moreover, we construct explicitly, up to a random choice of signs, all the elements involved in such violations: the coefficients of the Bell inequalities, POVMs measurements and quantum states. Analyzing this construction we find that, even though entanglement is necessary to obtain violation of Bell inequalities, the Entropy of entanglement of the underlying state is essentially irrelevant in obtaining large violation. We also indicate why the maximally entangled state is a rather poor candidate in producing large violations with arbitrary coefficients. However, we also show that for Bell inequalities with positive coefficients (in particular, games) the maximally entangled state achieves the largest violation up to a logarithmic factor.Comment: Reference [16] added. Some typos correcte

Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector

A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results

Measurement of the polarisation of W bosons produced with large transverse momentum in pp collisions at sqrt(s) = 7 TeV with the ATLAS experiment

This paper describes an analysis of the angular distribution of W->enu and W->munu decays, using data from pp collisions at sqrt(s) = 7 TeV recorded with the ATLAS detector at the LHC in 2010, corresponding to an integrated luminosity of about 35 pb^-1. Using the decay lepton transverse momentum and the missing transverse energy, the W decay angular distribution projected onto the transverse plane is obtained and analysed in terms of helicity fractions f0, fL and fR over two ranges of W transverse momentum (ptw): 35 < ptw < 50 GeV and ptw > 50 GeV. Good agreement is found with theoretical predictions. For ptw > 50 GeV, the values of f0 and fL-fR, averaged over charge and lepton flavour, are measured to be : f0 = 0.127 +/- 0.030 +/- 0.108 and fL-fR = 0.252 +/- 0.017 +/- 0.030, where the first uncertainties are statistical, and the second include all systematic effects.Comment: 19 pages plus author list (34 pages total), 9 figures, 11 tables, revised author list, matches European Journal of Physics C versio