56 research outputs found
A multicenter randomized-controlled trial of hypothermic oxygenated perfusion (HOPE) for human liver grafts before transplantation
- Author
- Adam Rene
- Allard Marc Antoine
- Amberg Stefanie
- Attia Magdy
- Berlakovich Gabriela
- Cerisuelo Miriam Cortes
- Clavien Pierre Alain
- de Rougemont Olivier
- Dutkowski Philipp
- Eden Janina
- Haring Martijn P.D.
- Heaton Nigel D.
- Jochmans Ina
- Kollmann Dagmar
- Kranich Anne L.
- Kron Philipp
- Lesurtel Mickaël
- Mabrut Jean Yves
- Monbaliu Diethard
- Mueller Matteo
- Muiesan Paolo
- Muller Xavier
- Müllhaupt Beat
- Panconesi Rebecca
- Parente Alessandro
- Petterson Karin
- Porte Robert J.
- Rogiers Xavier
- Schlegel Andrea
- Sousa Da Silva Richard X.
- Steigmiller Klaus
- von Felten Stefanie
- Publication venue
- Publication date
- 01/04/2023
- Field of study
Background & Aims: Machine perfusion is a novel method intended to optimize livers before transplantation. However, its effect on morbidity within a 1-year period after transplantation has remained unclear. Methods: In this multicenter controlled trial, we randomly assigned livers donated after brain death (DBD) for liver transplantation (LT). Livers were either conventionally cold stored (control group), or cold stored and subsequently treated by 1-2 h hypothermic oxygenated perfusion (HOPE) before implantation (HOPE group). The primary endpoint was the occurrence of at least one post-transplant complication per patient, graded by the Clavien score of ≥III, within 1-year after LT. The comprehensive complication index (CCI), laboratory parameters, as well as duration of hospital and intensive care unit stay, graft survival, patient survival, and biliary complications served as secondary endpoints. Results: Between April 2015 and August 2019, we randomized 177 livers, resulting in 170 liver transplantations (85 in the HOPE group and 85 in the control group). The number of patients with at least one Clavien ≥III complication was 46/85 (54.1%) in the control group and 44/85 (51.8%) in the HOPE group (odds ratio 0.91; 95% CI 0.50-1.66; p = 0.76). Secondary endpoints were also not significantly different between groups. A post hoc analysis revealed that liver-related Clavien ≥IIIb complications occurred less frequently in the HOPE group compared to the control group (risk ratio 0.26; 95% CI 0.07-0.77; p = 0.027). Likewise, graft failure due to liver-related complications did not occur in the HOPE group, but occurred in 7% (6 of 85) of the control group (log-rank test, p = 0.004, Gray test, p = 0.015). Conclusions: HOPE after cold storage of DBD livers resulted in similar proportions of patients with at least one Clavien ≥III complication compared to controls. Exploratory findings suggest that HOPE decreases the risk of severe liver graft-related events. Impact and implications: This randomized controlled phase III trial is the first to investigate the impact of hypothermic oxygenated perfusion (HOPE) on cumulative complications within a 12-month period after liver transplantation. Compared to conventional cold storage, HOPE did not have a significant effect on the number of patients with at least one Clavien ≥III complication. However, we believe that HOPE may have a beneficial effect on the quantity of complications per patient, based on its application leading to fewer severe liver graft-related complications, and to a lower risk of liver-related graft loss. The HOPE approach can be applied easily after organ transport during recipient hepatectomy. This appears fundamental for wide acceptance since concurring perfusion technologies need either perfusion at donor sites or continuous perfusion during organ transport, which are much costlier and more laborious. We conclude therefore that the post hoc findings of this trial should be further validated in future studies.</p
A multicenter randomized-controlled trial of hypothermic oxygenated perfusion (HOPE) for human liver grafts before transplantation
- Author
- Adam Rene
- Allard Marc Antoine
- Amberg Stefanie
- Attia Magdy
- Berlakovich Gabriela
- Cerisuelo Miriam Cortes
- Clavien Pierre Alain
- de Rougemont Olivier
- Dutkowski Philipp
- Eden Janina
- Haring Martijn P.D.
- Heaton Nigel D.
- Jochmans Ina
- Kollmann Dagmar
- Kranich Anne L.
- Kron Philipp
- Lesurtel Mickaël
- Mabrut Jean Yves
- Monbaliu Diethard
- Mueller Matteo
- Muiesan Paolo
- Muller Xavier
- Müllhaupt Beat
- Panconesi Rebecca
- Parente Alessandro
- Petterson Karin
- Porte Robert J.
- Rogiers Xavier
- Schlegel Andrea
- Sousa Da Silva Richard X.
- Steigmiller Klaus
- von Felten Stefanie
- Publication venue
- Publication date
- 01/04/2023
- Field of study
Background & Aims: Machine perfusion is a novel method intended to optimize livers before transplantation. However, its effect on morbidity within a 1-year period after transplantation has remained unclear. Methods: In this multicenter controlled trial, we randomly assigned livers donated after brain death (DBD) for liver transplantation (LT). Livers were either conventionally cold stored (control group), or cold stored and subsequently treated by 1-2 h hypothermic oxygenated perfusion (HOPE) before implantation (HOPE group). The primary endpoint was the occurrence of at least one post-transplant complication per patient, graded by the Clavien score of ≥III, within 1-year after LT. The comprehensive complication index (CCI), laboratory parameters, as well as duration of hospital and intensive care unit stay, graft survival, patient survival, and biliary complications served as secondary endpoints. Results: Between April 2015 and August 2019, we randomized 177 livers, resulting in 170 liver transplantations (85 in the HOPE group and 85 in the control group). The number of patients with at least one Clavien ≥III complication was 46/85 (54.1%) in the control group and 44/85 (51.8%) in the HOPE group (odds ratio 0.91; 95% CI 0.50-1.66; p = 0.76). Secondary endpoints were also not significantly different between groups. A post hoc analysis revealed that liver-related Clavien ≥IIIb complications occurred less frequently in the HOPE group compared to the control group (risk ratio 0.26; 95% CI 0.07-0.77; p = 0.027). Likewise, graft failure due to liver-related complications did not occur in the HOPE group, but occurred in 7% (6 of 85) of the control group (log-rank test, p = 0.004, Gray test, p = 0.015). Conclusions: HOPE after cold storage of DBD livers resulted in similar proportions of patients with at least one Clavien ≥III complication compared to controls. Exploratory findings suggest that HOPE decreases the risk of severe liver graft-related events. Impact and implications: This randomized controlled phase III trial is the first to investigate the impact of hypothermic oxygenated perfusion (HOPE) on cumulative complications within a 12-month period after liver transplantation. Compared to conventional cold storage, HOPE did not have a significant effect on the number of patients with at least one Clavien ≥III complication. However, we believe that HOPE may have a beneficial effect on the quantity of complications per patient, based on its application leading to fewer severe liver graft-related complications, and to a lower risk of liver-related graft loss. The HOPE approach can be applied easily after organ transport during recipient hepatectomy. This appears fundamental for wide acceptance since concurring perfusion technologies need either perfusion at donor sites or continuous perfusion during organ transport, which are much costlier and more laborious. We conclude therefore that the post hoc findings of this trial should be further validated in future studies.</p
Лапаротомия в системе лечения перитонитов
- Author
- A Chandran
- A Iaboni
- Aarón Salinas Rodríguez
- Alfred Yawson
- B Ferguson
- Betty Manrique Espinoza
- C Launay
- CA Reyes-Ortiz
- CA Reyes-Ortiz
- CJL Murray
- CL Himes
- CL Hsu
- CM Nielson
- CMY Lee
- D Gu
- E Latimer Hill
- EMC Lau
- Fan Wu
- GD Dinsa
- GS Brassington
- Heather Hestekin
- HG Silva Da
- J Jagnoor
- J Jagnoor
- Jennifer Stewart Williams
- JR Beard
- JS Schiller
- K Peltzer
- K Uusi-Rasi
- Karl Peltzer
- L Day
- LW Chu
- M Cardona
- M Halil
- ME Tinetti
- MK Karlsson
- MM Kwan
- N-V Castell
- P Kannus
- P Kannus
- P Kowal
- PA Stalenhoef
- Paul Kowal
- Perianayagam Arokiasamy
- PL Yu
- R Norton
- Richard Biritwum
- RM Jha
- RM Sousa
- S Ancoli-Israel
- S Kalra
- S Moussavi
- S Rojanasthien
- SA Dsouza
- Somnath Chatterji
- SS Ramirez De
- SW Muir
- SZ Kalula
- T Kvelde
- Tamara Maximova
- TB Ustun
- TE Gildner
- Tristan O’Driscoll
- W He
- World Health Organization
- World Health Organization
- World Health Organization
- X Fang
- X Ling
- Y Wu
- YH Li
- Publication venue
- ВГМУ
- Publication date
- 01/01/1998
- Field of study
ПЕРИТОНИТ /ХИРБРЮШИНЫ БОЛЕЗНИ /ХИРЛАПАРОТОМИЯХИРУРГИЧЕСКИЕ ОПЕРАЦИИ /МЕТОДЫРЕЛАПАРОТОМИ
The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
- Author
- Abadia M
- Abassy J
- Abate E
- Abbott Tom EF
- Abdelaal Samir A
- Abdeldayem H
- Abdelkabir M
- Abdelsamed A
- Abdulwahed E
- Abiyere H
- Abou Chaar MK
- Abukhalaf SA
- Abukhalaf Sadi
- Adamina Michel
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Adeyeye A
- Adisa Adewale
- Afzal MF
- Agarwal Arnav
- Aggarwal M
- Agnes A
- Agostini C
- Agrawal A
- Agrawal N
- Agresta F
- Aguiar Junior S
- Ahmed A
- Ahmed K
- Ahmed Nafees R
- Ahmed Z
- Ahn JH
- Aime A
- Akhtar N
- Akkulak Murat
- Akrivou D
- Al Abdallah M
- Al Riyami S
- Al Sayed M
- Al-Masri M
- Al-Najjar H
- Al-Slaibi I
- Alaa S
- Alakaloko Felix
- Alameer Ehab
- Alamri Alex
- Alawneh F
- Albertsmeier M
- Albertsmeier Markus
- Alderson Derek
- Aldokali N
- Alemanno G
- Alfieri S
- Algallai M
- Ali AA
- Alkadiki Ghadah Z
- Almaadany Faraj S
- Almeida AC
- Almeida-Reis R
- Almezghwi H
- Almond Max
- Alrahawy M
- Alser Osaid
- Alshaar Muhammad
- Alshareea E
- Alshareef K
- Alshryda Sattar
- Alsoufi A
- Altamirano Riquoir C
- Altomare DF
- Altomi I
- Alurralde C
- Alvarez MR
- Alvi A
- Alwarfly S
- AlZAEDE S
- Alzeerelhouseini IAH
- Amaral MJ
- Amira G
- Amorim E
- Amrani L
- Anania G
- Anastasi A
- Andrade Kam da Silva A
- Andrade R
- Annessi V
- Annicchiarico A
- Antonakis P
- Antonopoulou M
- Aprile A
- Aremu M
- Arias-Amezquita F
- Aribi N
- Aribi S
- Arkadopoulos N
- Armao T
- Armatura G
- Arminio A
- Arnaud Alexis P
- Arora A
- Arslan K
- Ashoush F
- Athanasakis E
- Attia D
- Augestad Knut Magne
- Aversano A
- Avlund T
- Awada Barakat J
- Ayasra F
- Ayasra Faris
- Ayasra Y
- Ayub B
- Ayubi A
- Ayyaz M
- Azevedo C
- Azevedo J
- Azevedo Jose
- Azevedo P
- Azman Mohd ZA
- Azzam AY
- Babalola O
- Badra R
- Bagraith K
- Baili E
- Balabel M
- Balconi A
- Baldari L
- Baldi C
- Baldini E
- Bali K
- Ballabio M
- Ballouhey Q
- Baloyiannis I
- Bandovas JP
- Bankhead-Kendall Brittany K
- Banky B
- Banuelos Romero E
- Baptista VH
- Barker D
- Barlow Emma
- Barod Ravi
- Barone R
- Baronio G
- Barrat B
- Barros Vieira A
- Bartalucci B
- Bartolini I
- Bashir Y
- Bass G
- Batistotti P
- Batstone Martin
- Baxevanidou K
- Beard David
- Becker R
- Bekele K
- Belia F
- Belkhadir ZH
- Bellacci A
- Belli A
- Bellolio F
- Bellora P
- Belluco C
- Belvedere A
- Bendjemar L
- Benkabbou A
- Benson Ruth A
- Bergamini C
- Bergeat D
- Bernante P
- Berselli M
- Bertelli G
- Bertolani E
- Besser N
- Beyer K
- Beyrne C
- Bezerra Santos T
- Bhangu Aneel A
- Bhat GA
- Bhat MA
- Biala M
- Bianchini M
- Bianco F
- Biel Juan Rey
- Bigam D
- Biondi A
- Birolo SL
- Bisagni P
- Blanco-Colino Ruth
- Bodanese B
- Boeker C
- Bondurri A
- Bong C
- Boni L
- Bonilla A
- Bonnet S
- Bordoni P
- Borges Castro F
- Borges N
- Borghi F
- Bork U
- Borroni G
- Bouchagier K
- Bouche PA
- Bouliaris K
- Boutros M
- Bowman S
- Boyce R
- Brachini G
- Bradulskis S
- Braham H
- Brar Amanpreet
- Bravo Ana Minaya
- Breen Kerry A
- Bretherton Chris
- Bristow Rob
- Bromage Steve
- Brown C
- Brunelli Alessandro
- Bruscino A
- Buarque Igor Lima
- Buarque Lima
- Bucci Fares A
- Buerba GA
- Burgan D
- Burke Joshua
- Butt U
- Bywater Edward
- Caccetta M
- Calabro M
- Camacho C
- Camara P
- Camarneiro R
- Caminsky N
- Campagnaro T
- Canas-Martinez A
- Canonico G
- Capelli P
- Capezzuoli L
- Capolupo GT
- Capunge I
- Caram EL
- Carannante F
- Carbone F
- Carcoforo P
- Cardoso N
- Cardoso P
- Carissimi F
- Caruana Edward J
- Carvello MM
- Casati M
- Cassinotti E
- Catena F
- Cecire J
- Ceelen W
- Ceretti Pisani A
- Cervellera M
- Cetares C
- Chaar Mohammad
- Chakrabortee Sohini
- Chan E
- Charalabopoulos A
- Charre L
- Chaturvedi A
- Chaturvedi H
- Chatzikomnitsa P
- Chaudhry Daoud
- Chebaro A
- Chen S
- Chessa A
- Chiappini A
- Chiarugi M
- Chinda J
- Chiozza M
- Chisthi M
- Chiva Luis
- Choong E
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- Christensen P
- Christensen Peter
- Christidis P
- Christou C
- Chrysos E
- Chumbinho B
- Cianflocca D
- Cicerchia PM
- Cirillo B
- Clarizia G
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- Coffey JC
- Cohen Paul
- Colletti G
- Colombo F
- Colquhoun Alexandra
- Confalonieri M
- Connelly T
- Conti L
- Contis I
- Coonar Aman S
- Corbellini C
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- Corless K
- Corrigan M
- Cosentino Marino L
- Cosimelli M
- Costa M
- Costa Matos P
- Costa MJMA
- Costanzi A
- Costeira B
- Cotoia A
- Cotte E
- Cox Daniel
- Cozza V
- Creavin B
- Cremonini C
- Crespo A
- Cuasquen Velasquez BG
- Cukier M
- Cukier Moises
- Cullivan O
- Cunha C
- Cunha MF
- Cunha Miguel F
- Cunha R
- Cunningham RM
- D'Aloisio G
- D'Ugo D
- D'Ugo S
- D'Urso A
- da Cruz Lima L
- da Silva Abreu A
- da Silva Lima C
- Dainius E
- Dajani K
- Daly A
- Danias N
- Davidson Giana H
- Dawson AC
- Dawson Brett E
- de Almeida Ramalho F
- de Barros Figueiredo
- De Lima RK
- De Lucia F
- De Nardi P
- De Palma G
- de Sa Correia T
- de Sampaio Regina L
- De Simone V
- De Sousa X
- De Toma G
- De Troia A
- De Vincenti R
- Deirino A
- Delinasios G
- Dell A
- Della Giustina E
- Dellaportas D
- Delrio P
- Demetriades Andreas K
- Demyttenaere S
- Denet C
- Depalma N
- Derksen T
- Desai Anant
- Desio M
- Desoouza A
- Deus AC
- Devarakonda S
- Devezas V
- Devine M
- Dhamija P
- Dharanipragada K
- Di Bella A
- Di Franco G
- Di Lauro K
- Di Martino C
- Di Marzo F
- Di Saverio Salomone
- Diamantis A
- Diaz P
- Dijan E
- Domingues J
- Donati D
- dos Santos Martins G
- Doudakmanis C
- Dowdy Sean
- Doyle A
- Drake Thomas M
- Drane A
- Droghetti M
- Duchalais E
- Dudi-Venkata NN
- Dumitra Sinziana
- Duran Sosa EE
- Earley H
- Eastmond A
- Ebbehoj AL
- Ebben L
- Economopoulou P
- Edwards John
- Edwards John G
- Efthimiou M
- Egoroff N
- El Ahmadi B
- El Amrani M
- El Arbi N
- El Bouazizi Y
- El Kassas M
- Elazzazy E
- Eldaly A
- Elghazaly MS
- Elhadi Muhammed
- Elliott JA
- Ellojli I
- Elmorsi R
- Emile Sameh
- Emmanuel K
- Enoch E
- Esene Ignatius
- Eskinazi DG
- Esposito G
- Esquide Ruiz M
- Essam E
- Evans Jonathan P
- Evans Richard PT
- Eveno C
- Ewedah M
- Ezanno AC
- Fabbri N
- Facundo H
- Fagotti Anna
- Fahey BA
- Fahmawee T
- Farik Shebani
- Farnesi F
- Farooka MW
- Fathi NQ
- Faustino A
- Fayed Y
- Federico P
- Federico Pipitone NS
- Feo C
- Feo CF
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- Fernandes U
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- Ferrario L
- Ferraz I
- Ferreira C
- Ferreira Peralta M
- Ferro Carvalho C
- Ferro Rey M
- Finnegan L
- Fiore M
- Fiore Marco
- Fiori E
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- Fitzgerald J Edward
- Flamey N
- Fleming CA
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- Fonsi GB
- Foo CC
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- Ford Samuel
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- Fritzmann J
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- Ghosh Dhruva
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- Giaglaras A
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- Gillis AE
- Giraudo G
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- Giuffrida MC
- Giunta A
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- Glehen O
- Gold-Deutch R
- Gomes GMA
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- Gomes J
- Gomez-Mayorga JL
- Gori A
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- Grasset E
- Grasso M
- Grechenig M
- Grechi A
- Grecinos Gustavo
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- Griffiths Ewen A
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- Gronchi Alessandro
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- Grossi U
- Grotenhuis BA
- Gruber R
- Gruendl Magdalena
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- Gutelkin Murat
- Hakami I
- Halkias Constantine
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- Heritage Emily
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- Hisham Intisar
- Hmedat A
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- Hwang Shelley
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- Impellizzeri H
- Inama M
- Incollingo P
- Inzunza M
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- Jacome F
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- Jesudason MR
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- Jeyarajan E
- Ji Almeida
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- Jo Bello
- Joao Alagoa A
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- Jonescheit J
- Jonker Pascal
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- Jouffret L
- Jovine E
- Jusoh Che A
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- Kaafarani Haytham MA
- Kalayarasan R
- Kalfountzos C
- Kamal N
- Kamarajah Sivesh K
- Kamoka E
- Kamphues C
- Kanemitsu Y
- Kappenberger A
- Karaitianos IG
- Karimuddin A
- Karlovic D
- Kashif M
- Kasivisvanathan Veeru
- Katusic Z
- Kauppila JH
- Kavanagh D
- Kayyal MY
- Keatley James M
- Keller Debby
- Kembuan G
- Kennelly R
- Kerawala AA
- Khan S
- Khan Tabassum
- Khatri Chetan
- Khaw Rachel A
- Khokhar M
- Kia Madani T
- Kilani A
- Killeen S
- Kim NJ
- Kjaer DW
- Klatte Tobias
- Kleeff J
- Klimopoulos S
- Knight Andrew
- Kokkinos G
- Kokoropoulos P
- Kolias Angelos
- Kolla C
- Kollengode VV
- Konigsrainer A
- Konney Thomas
- Konstadoulakis M
- Konsten J
- Koukoulis G
- Kowalewski P
- Krarup P
- Kredan A
- Kristensen HO
- Kroon HM
- Krsul D
- Kruijff Schelto
- Kubiliute E
- Kuiper S
- Kumar A
- Kumar S
- Kumar V
- Kuttanchettiyar KG
- Kwiatkowski A
- La Torre F
- Laface L
- Laforest A
- Laharwal A
- Lakkis Z
- Lamb Benjamin
- Lapolla P
- Laporte G
- Larentzakis A
- Larkin J
- Lauretta A
- Lauscher J
- Lavy R
- Lawani Ismail
- Lawday Samuel
- Layton Georgia R
- Lazaro A
- Lc Nespoli
- Le Roy B
- Lecolle K
- Lederhuber Hans
- Lee N
- Leite Lira dos Santos A
- Leung Elaine Yl
- Leventoglu Sezai
- Li Elizabeth
- Liakakos T
- Lim RZM
- Lima MJ
- Linari C
- Lippa Laura
- Litta F
- Litvin Andrey
- Liu J
- Lizzi V
- Lo Abdur-Rahman
- Locatelli A
- Loch FN
- Loehrer Andrew
- Loffler Markus W
- Loffler MW
- Longhi M
- Longhini A
- Lopes L
- Lopes Vieira Paiva AC
- Lorena Maria Aguilera
- Lorenzon L
- Lott N
- Loutzidou L
- Lowery A
- Lucchini SM
- Luglio G
- Lun EWY
- Lunghi EG
- Lynch N
- Machado D
- Machado N
- Macina S
- Madonini M
- Maffioli A
- Magadia Uy E
- Mahajan A
- Mahmood M
- Maida P
- Maimbo Mayaba
- Majbar AM
- Major P
- Major Piotr
- Majumdar KS
- Mak TWC
- Malgras B
- Maltinti G
- Manatakis DK
- Manfredelli S
- Manrique E
- Manso I
- Marafante C
- Marano A
- Marcal A
- Marchbank Adrian
- Marcus Hani J
- Mari G
- Marialva J
- Mariani NM
- Marie-Macron L
- Marinello P
- Marino M
- Marino M
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- Publication venue
- 'Royal College of Obstetricians & Gynaecologists (RCOG)'
- Publication date
- 01/06/2022
- Field of study
AIM: The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. METHODS: This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. RESULTS: Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P < 0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0.90-1.55, P = 0.224), which was consistent in elective patients only (OR 0.94, 95% CI 0.69-1.27, P = 0.672). Longer delays were not associated with poorer outcomes. CONCLUSION: One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
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- AKI Research Group
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- Cutuli SL
- Câmara M
- D'Arsigny C
- da Silva SL
- da Silva VZ
- Daga-Ruiz D
- Dalhuisen A
- Dalorzo M
- Damas P
- Dambrosio M
- Damås JK
- Das Neves A
- David H
- Davis C
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- Day A
- de Abreu MG
- De Backer A
- De Brito-Ashurst I
- De Cassai A
- De Freitas FF
- De Gasperi A
- de Hoyos EA
- De la Calle-Pedrosa N
- de la Fuente MV
- De La Fuente-Martos C
- De La Fuente-Martos C
- De La Rica AS
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- De Maglie M
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- de Molina FJ
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- De Pascale G
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- de Vera AP
- de Wilde W
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- Deblier I
- DeBrunnar R
- Del Arco A
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- Del Olmo R
- Del Rosario CG
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- Di Gravio V
- Di Gregorio A
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- Dimopoulou IK
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- Elgendy M
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- Endacott R
- Engelberts D
- ENVIN-HELICS Study Group
- Erb J
- Erdogan M
- Eroles AA
- Escalada SH
- Escalada SH
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- Escórcio S
- Eslami S
- Espinasse F
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- Esteban A
- Estella A
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- Fernández IF
- Fernández L
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- Fernández PA
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- Fernández-Mondéjar E
- Fernández-Ortega JF
- Ferraz AB
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- Ferri F
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- Ferrón FR
- Ferrón FR
- Fiks T
- Fiks T
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- Filho CA
- Filho CA
- Filho CA
- Filipe E
- FINNRESUSCI Study Group
- Fischer G
- Fleischmann E
- Fless K
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- Flowers E
- Follin A
- Follin A
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- Fontaiña LP
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- Frithiof R
- Fritz C
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- Fromentin M
- Frontera PR
- Fuentes M
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- GETGAG Working Group
- GETGAG/SEMICYUC
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- Giesinger RE
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- Gonçalves B
- Goodwin S
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- Gordillo-Brenes A
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- Gordon M
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- Gouveia J
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- Grangé S
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- Hernández A
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- Hernández-Tejedor A
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- Huang WC
- Huang WC
- Huang WC
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- Hung CY
- Hung WT
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- Hutchings S
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- Hwang GS
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- Ibsen M
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- Idei M
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- Ignacio ML
- Iida A
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- Ilyina V
- Imanaka H
- Inaloo S
- Ince C
- Iotti GA
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- Iotti GA
- IPREA Study Group
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- Jang BH
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- Janotka M
- Janotka M
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- Jansen N
- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
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- Jardim M
- Jareño A
- Javadpour S
- Jayasinghe S
- Jean-Baptiste S
- Jean-Baptiste S
- Jensen AE
- Jensen JU
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- Jeong IY
- Jeong WY
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- Jiao LR
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- Jiménez GJ
- Jo YH
- Joachim J
- Jochmans S
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- Jonas M
- Jonas M
- Jones C
- Joshi R
- Joshi V
- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
- Juan WC
- Juanas CA
- Judickas S
- Juez A
- Juliarena A
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- Jun IG
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- Junior JM
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- Kaminsky GE
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- Kolnikova I
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- Kulkarni AP
- Kumari BK
- Kumbamu A
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- Kurmukov IA
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- Kwon HM
- Kwon WY
- Kwon WY
- Kwon WY
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- Kyle UG
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- Lafuente E
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- Lai CH
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- Latini R
- Latini R
- Latorre J
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- Lombardo MD
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- MacKay A
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- Maghsoudi B
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- Marcos-Zambrano LJ
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- Martín-Loeches I
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- Martínez L
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- Martínez MP
- Martínez MV
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- Martínez-Carmona JF
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- Mercat A
- Mercat A
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- Messenger D
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- Midwinter MJ
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- Miguelena PR
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- Mora-Ordóñez JM
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- Morán I
- Motos A
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- Okayama Research Investigation Organizing Network (ORION)investigators
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- PS-ICU Group
- Psarologakis C
- Puerto-Morlán A
- Pugliese F
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- Pulitano' SM
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- Rapid Diagnosis of Infections in the Critically Ill Team
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- ReVA Research Network and the PROVE Network Investigators
- Revel N
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- Riozzi P
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- Rivera-Fernandez R
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- Rizoli S
- Rizos M
- Roasio A
- Robaglia D
- Robert R
- Robles CM
- Roca JM
- Rocha LL
- Rodrigues DP
- Rodrigues NJ
- Rodriguez A
- Rodriguez P
- Rodriguez-Biendicho A
- Rodriguez-Fernandez S
- Rodríguez FG
- Roesthuis L
- Rogero S
- Rolin N
- Rolla F
- Rolland-Debord C
- Romero DG
- Romero I
- Romero JC
- Romero JC
- Romero JC
- Romero JC
- Romeu JD
- Rood PJ
- Ros Martínez J
- Rosario LE
- Rosario LE
- Rosario LE
- Rosario LE
- Rosario LE
- Rosario LE
- Rossetti AO
- Rossi S
- Rossini P
- Rosstalnaya A
- Rota L
- Roth GA
- Rottoli MR
- Rotzel HB
- Rousseau AF
- Routsi C
- Rouw N
- Rouzé A
- Rowlerson A
- Ruberto F
- Rubiera M
- Rubio RJ
- Rudiger A
- Ruffini C
- Ruffini C
- Ruijter A
- Ruiz A
- Ruiz BL
- Ruiz FC
- Ruiz J
- Ruiz-Ramos J
- Ruiz-Rodriguez JC
- Ruiz-Rodríguez JC
- Ruiz-Ruano RDEL
- Runge I
- Runge I
- Runge I
- Rutherford WB
- Rutten AM
- Rydingsward JE
- Saadat F
- Sabetian G
- Sabeļņikovs O
- Sabirov D
- Sadamoto Y
- Sadamoto Y
- Sadamoto Y
- Saeed S
- Saha T
- Saigal S
- Saito M
- Saito N
- Saitou N
- Sakai Y
- Sakieva FI
- Sakuma M
- Sakuraya M
- Sales G
- Salgado DR
- Salluh J
- Sampath S
- Sampath S
- Sampley S
- Sampson D
- Samuels T
- Samy W
- Sanchez A
- Sanchez JA
- Sanchez-Orézzoli MG
- Sandiumenge A
- Sandiumenge A
- Sandroni C
- Sani D
- Santacruz C
- Santana JD
- Santana JD
- Santana MC
- Santana MC
- Santana PS
- Santana PS
- Santana SR
- Santana SR
- Santiago AI
- Santiago AI
- Santos F
- Sanui M
- Sanz ER
- Sanz ER
- Sanz ER
- Sanz ER
- Sanz ER
- Sanz ER
- Sanz NM
- Sanz NM
- Sanz NM
- Sato K
- Savi C
- Savin I
- Savvidou S
- Sawamura A
- Sawamura A
- Sawamura A
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- Scala S
- Scales DC
- Scanziani E
- Scanziani E
- Schaller SJ
- Schlaepfer P
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- Schmidt M
- Schneider AG
- Schoenenberger JA
- Schortgen F
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- Schröder T
- Schuepbach R
- Schultz MJ
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- Sciurti R
- Scott SH
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- Shin WJ
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- Shinotsuka CR
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- Shu CW
- Shuinotsuka C
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- Sigurta A
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- Sobhanian S
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- Spronk PE
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- St George’s University of London
- Stamm J
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- Stubbs C
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- Suchomel P
- Suh GJ
- Suh GJ
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- Tabatabaei HR
- Tabei SH
- Taccone F
- Taccone FS
- Taccone FS
- Taccone FS
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- Villamizar PR
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- Villarreal E
- Villarreal E
- Vincent B
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- Vincent JL
- Vinje LJ
- Vinsonneau C
- Vitaller S
- Vittone F
- Vogelaers D
- Voiriot G
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- Volta CA
- Volta CA
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- Vondrakova D
- Vondrakova D
- Vong LV
- Vourli S
- Vrettou C
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- Vázquez CF
- Vázquez CF
- Wada T
- Wada T
- Wada T
- Wada T
- Waldauf P
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- Wang H
- Wann SR
- Wann SR
- Wann SR
- Wann SR
- Wathanawatthu T
- Wee S
- Welte T
- Welters I
- Wetz A
- Weyer CM
- White C
- Wiesner O
- Wijayatilake DS
- Wildenberg L
- Wilks M
- Wilson ME
- WIND study group
- WIND study group
- WIND study group
- Winder-Rhodes S
- Witter T
- Wolf M
- Wolff M
- Wong Y
- Wood B
- Wood CA
- Wood D
- Wood M
- Wray J
- Xie Z
- Xini A
- Xini A
- Xiol EA
- Xu M
- Yager T
- Yaguchi A
- Yaguchi A
- Yamaguchi O
- Yamaguchi O
- Yamaguchi Y
- Yamaguchi Y
- Yamamoto H
- Yamamoto N
- Yaman G
- Yamashita K
- Yamazaki A
- Yan WW
- Yan WW
- Yang JH
- Yang JS
- Yang YL
- Yasuda H
- Yatabe T
- Yebenes JC
- Yeh YC
- Yemets H
- Yergaliyeva A
- Yılmaz G
- Yilmazer F
- Yodice P
- Yokoyama M
- Yonis H
- Yonis H
- Yonis H
- Yoon SZ
- Yoruk F
- Yoshida K
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshihiro S
- Yoshitake E
- You KM
- Youn AM
- Young A
- Yu KM
- Yumoto T
- Yuzawa J
- Yuzawa J
- Zabaletta WJ
- Zabini D
- Zahorec M
- Zaien I
- Zakynthinos S
- Zanello M
- Zani D
- Zarantonello F
- Zayas B
- Zepeda EM
- Zeroual N
- Zerva L
- Zhang J
- Zhou JC
- Zhou JC
- Zhou JX
- Zhovnir V
- Zibandah N
- Zijlstra F
- Zimmerman J
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- Zogheib E
- Zogheib E
- Zullino V
- Zwaag J
- Zýková I
- Álvarez JT
- Álvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Use of anticoagulants and antiplatelet agents in stable outpatients with coronary artery disease and atrial fibrillation. International CLARIFY registry
- Author
- A. L. R. Ng
- Abardia Oliva F. J.
- Abdel Malak S.
- Abdel Wahab H.
- Abdul Kareem B. B.
- Abdul Manap H.
- Abdul Rahim A. A.
- Abdulkader F.
- Abdulla A. H. K.
- AbdulWahab M. Z.
- Abduvalieva V.
- Abele S.
- Aboyans V.
- Abreu P. E.
- Adam-Blanpain M.
- Adamaszek K.
- Adamczyk-Kot D.
- Adamkiewicz-Piejko A.
- Adda M.
- Aftab A.
- Agrawal A.
- Aguiar C.
- Ahuad Guerrero A.
- Ahuja R.
- Ai F.
- Aimouch N.
- Aiyegbayo O.
- Ajani A.
- Akbar M.
- Aksyutina N.
- Al Dhanki M.
- Al Ghool S.
- Al Kandari F.
- Al Lawati A.
- Al Mahmeed W.
- Al Radaideh G.
- Al Rashdan I.
- Al Sousi A.
- Al Suwaidi J.
- Al Tamimi F.
- Al Wahshi Y.
- Al Yazeedi J.
- Al Zaibag M.
- Al-Baker H.
- Al-Faleh H.
- Al-Hersi A.
- Al-Khalidi B.
- Al-Shamiri M.
- Al-Zaibag M.
- Alam A.
- Alanazy M.
- Alanbaei M.
- Albero Martinez V.
- Alberto Ramirez Reyes H.
- Albuquerque A.
- Alcaravela J.
- Alcocer Gamba M.
- Alegret Colomer J. M.
- Alegria Ezquerra E.
- Alekseenko V.
- Alekseeva T.
- Alexanderson E.
- Alexopoulos I.
- Alford K.
- Alitto F.
- Alizon F.
- Allcock A.
- Almeida Fernandez C. A.
- Altevogt B. -M.
- Altmann U.
- Alvarenga Recalde N.
- Alvarez Aunon A.
- Alvarez Garcia P.
- Alvarez Gil J.
- Alvarez Ramires F. J.
- Alves Costa M.
- Alves C.
- Amiel Oster Sauvinet G.
- Amini R.
- Amlaiky A.
- Amo Fernandez C.
- Amor R.
- Amoretti R.
- Amoros Galito C.
- Anastasiou E.
- Ancin Viguiristi R.
- Ancliff H.
- Andersen L. K.
- Andreev E.
- Andreicheva E.
- Andrews M.
- Ang C. C.
- Angela R.
- Anghel M.
- Ansalone G.
- Antia V.
- Antona Makoshi J.
- Antonelli G.
- Antoniadis G. A.
- Antonicelli R.
- Antunes J.
- Aparici Feal M.
- Apinyasawat S.
- Apitamsuntorn S.
- Appeltants H.
- Arabadzhi N.
- Arden C.
- Ardiaca Capell A.
- Ardill J.
- Ardouin L.
- Arenas Leon J. L.
- Arfaras V.
- Arias Mendoza A.
- Arkhipova Y.
- Arnau Vives M. A.
- Arnedillo Pardo J.
- Arquero Garcia G.
- Arrarte Esteban V.
- Arroja I.
- Arsenescu Georgescu C.
- Arsentieva T.
- Ashford A.
- Ashmak K.
- Ashton T. H.
- Asplanato M.
- Assouline S.
- Astrakhantseva P.
- Astridge P.
- Atamanchuk N.
- Attia G.
- Atueva K.
- Aubry J.
- Audibert H.
- Augarde R.
- Auhser F.
- Aumjaud A.
- Avgerinos C.
- Avlonitis S.
- Ayche M.
- Aylward P.
- Azar Manzur F.
- Azzolini P.
- Baar M.
- Babes K.
- Baboshina N.
- Bachmann B.
- Badariene J.
- Badorff C.
- Badr-Eslam R.
- Bahal A.
- Baika A.
- Bailey A.
- Bajcsi E.
- Bakbak A. I.
- Balai R.
- Balbi M.
- Baldev S.
- Baleeva L.
- Baleon R.
- Balice-Pasquinelli M. A.
- Ballet A.
- Balogh G.
- Banach J.
- Banham S.
- Banikova A.
- Banu M.
- Baptista S.
- Baquero Alonso M.
- Bar J. -P.
- Barahona Perez P.
- Baranes C.
- Baranova O.
- Barauskiene G.
- Bardachenko L.
- Bardaji Mayor J. L.
- Bariaud M.
- Baril J. F.
- Barjhoux C.
- Baroudi R.
- Barrera Bustillos M.
- Barriales Alvarez V.
- Barron G.
- Basara M.
- Bashkirtcev O.
- Baslaib F.
- Bastian B.
- Basto L.
- Batalla Celorio A.
- Bateman A.
- Bates F.
- Bath P. S.
- Batushkin V.
- Baurenski L.
- Bautista G.
- Baverstock M.
- Bayakhchan L.
- Baylac Domengetroy F.
- Bazargani N.
- Bdeir M.
- Beacock D.
- Beaurain C.
- Beckers J.
- Beinhauer A.
- Belanger A.
- Belcastro F.
- Belisle P.
- Bell J.
- Beltrame J. F.
- Benacka J.
- Benett I.
- Bennouna M. A.
- Berdnik K.
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- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2015
- Field of study
Measurement of the W-boson mass in pp collisions at √s=7 TeV with the ATLAS detector
- Author
- A Salam
- A Sirlin
- A Valassi
- A. A. Affolder
- A. A. Alshehri
- A. A. E. Bannoura
- A. A. Elliot
- A. A. Grillo
- A. A. J. Lesage
- A. A. Komar
- A. A. Korol
- A. A. Maier
- A. A. Minaenko
- A. A. Nepomuceno
- A. A. O’Rourke
- A. A. Snesarev
- A. A. Solodkov
- A. A. Talyshev
- A. Aloisio
- A. Alonso
- A. Amorim
- A. Andreazza
- A. Angerami
- A. Annovi
- A. Antonov
- A. Arbuzov
- A. Artamonov
- A. Ashkenazi
- A. B. Fenyuk
- A. B. Kowalewska
- A. Baroncelli
- A. Basalaev
- A. Bassalat
- A. Beddall
- A. Bellerive
- A. Bethani
- A. Bingul
- A. Blue
- A. Bocci
- A. Borisov
- A. Boveia
- A. Brandt
- A. Bruni
- A. Buzatu
- A. C. Daniells
- A. C. König
- A. C. Martyniuk
- A. C. Schaffer
- A. C. Taylor
- A. Calandri
- A. Camplani
- A. Campoverde
- A. Castelli
- A. Catinaccio
- A. Cattai
- A. Cerri
- A. Cervelli
- A. Chafaq
- A. Chatterjee
- A. Chegwidden
- A. Cheplakov
- A. Chitan
- A. Chr. Dudder
- A. Ciocio
- A. Clark
- A. Coccaro
- A. Cortes-Gonzalez
- A. Cueto
- A. D. Pilkington
- A. Dattagupta
- A. De Benedetti
- A. De Maria
- A. De Salvo
- A. De Santo
- A. Dell’Acqua
- A. Demilly
- A. Dewhurst
- A. Di Ciaccio
- A. Di Girolamo
- A. Di Simone
- A. Dimitrievska
- A. Doria
- A. Dudarev
- A. Durglishvili
- A. E. Baas
- A. E. Barton
- A. E. Dumitriu
- A. E. Kiryunin
- A. E. Lionti
- A. Ereditato
- A. Ezhilov
- A. F. Saavedra
- A. F. Webb
- A. Farbin
- A. Farilla
- A. Favareto
- A. Ferrari
- A. Ferrer
- A. Filipčič
- A. Fischer
- A. Formica
- A. Forti
- A. G. Bogdanchikov
- A. G. Buckley
- A. G. Foster
- A. G. Goussiou
- A. G. Kharlamov
- A. G. Leister
- A. G. Myagkov
- A. Gabrielli
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- A. Gascon Bravo
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- A. Haas
- A. Hadef
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- C. Diaconu
- C. Doglioni
- C. E. Pandini
- C. Eckardt
- C. Escobar
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- T. Trefzger
- T. Varol
- T. Vazquez Schroeder
- T. Vickey
- T. Wang
- T. Wenaus
- T. Wengler
- T. Y. Ng
- T. Yamanaka
- T. Z. Kowalski
- T. Ženiš
- Th. D. Papadopoulou
- Torbjörn Sjöstrand
- Torbjörn Sjöstrand
- U Baur
- U. Blumenschein
- U. Bratzler
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- U. Gul
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- U. Schnoor
- U. Schäfer
- U. Soldevila
- V. A. Bednyakov
- V. A. Kantserov
- V. A. Kramarenko
- V. A. Mitsou
- V. A. Schegelsky
- V. Andrei
- V. Araujo Ferraz
- V. B. Vinogradov
- V. Boisvert
- V. Bortolotto
- V. Büscher
- V. Canale
- V. Castillo Gimenez
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- V. D. Peshekhonov
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- V. P. Maleev
- V. Pleskot
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- V. R. Pascuzzi
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- V. Radescu
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- W-M. Yao
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- W. A. Leight
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- W. Blum
- W. Buttinger
- W. C. Fisher
- W. D. Breaden Madden
- W. Dabrowski
- W. Davey
- W. F. Mader
- W. Fedorko
- W. Guan
- W. Guo
- W. H. Hopkins
- W. J. Dearnaley
- W. J. Fawcett
- W. J. Johnson
- W. J. Murray
- W. K. Balunas
- W. K. Brooks
- W. K. Di Clemente
- W. Kozanecki
- W. Lampl
- W. Lavrijsen
- W. Liebig
- W. Lukas
- W. Płaczek
- W. S. Chan
- W. Taylor
- W. Trischuk
- W. Van Den Wollenberg
- W. Vandelli
- W. Verkerke
- W. Wagner
- W. Walkowiak
- W. Wang
- W. Wang
- W. Wiedenmann
- X. Chen
- X. Hoad
- X. Ju
- X. Lei
- X. Li
- X. Lou
- X. Ruan
- X. Sun
- X. T. Meng
- X. Wu
- X. Zhang
- X. Zhao
- X. Zhuang
- Y. A. Kurochkin
- Y. Abulaiti
- Y. Amaral Coutinho
- Y. Arai
- Y. Benhammou
- Y. C. Yap
- Y. Chen
- Y. Cheng
- Y. Coadou
- Y. Du
- Y. Enari
- Y. F. Ryabov
- Y. Fang
- Y. Gao
- Y. Guo
- Y. H. Chiu
- Y. Hasegawa
- Y. Heng
- Y. Hernández Jiménez
- Y. Horii
- Y. Huang
- Y. Ikegami
- Y. Ilchenko
- Y. J. Lu
- Y. Jiang
- Y. K. Kim
- Y. Kataoka
- Y. Komori
- Y. Kulchitsky
- Y. L. Chan
- Y. L. Liu
- Y. Li
- Y. Liu
- Y. Ma
- Y. Makida
- Y. Minami
- Y. Minegishi
- Y. Ming
- Y. Nagasaka
- Y. Nakahama
- Y. Ninomiya
- Y. Noguchi
- Y. Okumura
- Y. Oren
- Y. P. Kulinich
- Y. Qin
- Y. Rodina
- Y. Rozen
- Y. S. Gao
- Y. Sakurai
- Y. Shen
- Y. Smirnov
- Y. Sugaya
- Y. Takubo
- Y. Tayalati
- Y. Tu
- Y. Unno
- Y. Wu
- Y. Yamaguchi
- Y. Yamazaki
- Y. Yang
- Y. Yasu
- Y. Zhang
- Y. Zhao
- Y. Zhu
- Yu. A. Tikhonov
- Z. Barnovska-Blenessy
- Z. D. Greenwood
- Z. Dolezal
- Z. H. Citron
- Z. Hubacek
- Z. J. Grout
- Z. Jiang
- Z. Liang
- Z. M. Karpova
- Z. Marshall
- Z. Rurikova
- Z. Xi
- Z. Yan
- Z. Yang
- Z. Zhang
- Z. Zhao
- Z. Zinonos
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 18/12/2017
- Field of study
A measurement of the mass of the W boson is presented based on proton–proton collision data recorded in 2011 at a centre-of-mass energy of 7 TeV with the ATLAS detector at the LHC, and corresponding to 4.6 fb−1 of integrated luminosity. The selected data sample consists of 7.8×106 candidates in the W→μν channel and 5.9×106 candidates in the W→eν channel. The W-boson mass is obtained from template fits to the reconstructed distributions of the charged lepton transverse momentum and of the W boson transverse mass in the electron and muon decay channels, yielding
mW=80370±7 (stat.)±11(exp. syst.)
±14(mod. syst.) MeV
=80370±19MeV,
where the first uncertainty is statistical, the second corresponds to the experimental systematic uncertainty, and the third to the physics-modelling systematic uncertainty. A measurement of the mass difference between the W+ and W−bosons yields mW+−mW−=−29±28 MeV
Genetic mechanisms of critical illness in COVID-19.
- Author
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- M Male
- M Marani
- M Margarson
- M Marotti
- M Matharu
- M McLaughlin
- M McPhail
- M Meredith
- M Mpelembue
- M Msiska
- M Mulcahy
- M Mupudzi
- M Nauman Akhtar
- M Newton
- M Oblak
- M Odam
- M Ostermann
- M Patel
- M Peiu
- M Penacerrada
- M Peters
- M Popescu
- M Poulaka
- M Purewal
- M Raj
- M Robinson
- M Sangombe
- M Shankar-Hari
- M Sim
- M Slaughter
- M Smith
- M Smith
- M Spivey
- M T Hijazi
- M Taylor
- M Taylor
- M Taylor
- M Taylor
- M Taylor
- M Templeton
- M Thankachen
- M Thirumaran
- M Thomas
- M Tolson
- M Usher
- M Varghese
- M Verlander
- M Vertue
- M Watters
- M White
- M Wiles
- M Williams
- M Wills
- M Woodruff
- M Young
- Maaike Swets
- Mahdad Noursadeghi
- Manu Shankar-Hari
- Marco Castori
- Marco Feri
- Marco Gori
- Marco Mandalà
- Marco Sita
- Margherita Baldassarri
- Mari E K Niemi
- Mari Ward
- Maria Antonietta Mazzei
- Maria Antonietta Mencarelli
- Maria Bandini
- Maria Eugenia Quiros-Roldan
- Maria Palmieri
- Maria Zambon
- Marie Connor
- Mario Capasso
- Mario U Mondelli
- Marta Corridi
- Maslove David
- Massimiliano Fabbiani
- Massimo Carella
- Massimo Girardis
- Massimo Palmarini
- Massimo Vaghi
- Matteo Bassetti
- Matteo Della Monica
- Matteo Siano
- Mattia Cordioli
- Maurizio Sanarico
- Maurizio Sanguinetti
- Maurizio Spagnesi
- McAuley Danny
- Meera Chand
- Meynert Alison
- Michelle Girvan
- Millar Jonathan
- Mirella Bruttini
- Miriana D'Alessandro
- Montgomery Hugh
- Moore Shona C
- Moutsianas Loukas
- Murphy Lee
- Murray Wham
- N Ahmad
- N Bandla
- N Baxter
- N Boyle
- N Capps
- N Clarke
- N Crisp
- N Davidson
- N Dormand
- N Grau
- N Harris
- N Jacques
- N Keenan
- N Lancaster
- N Love
- N MacCallum
- N Michalak-Glinska
- N Motherwell
- N Muchenje
- N Nikitas
- N Pathan
- N Pattison
- N Proudfoot
- N Rea
- N Richardson
- N Rodden
- N Roe
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- N Runciman
- N Schumacher
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- N Staines
- N Thomson
- N Truman
- N White
- Nichol Alistair
- Nicholas Parkinson
- Nicholas Price
- Nicky Day
- Nicola Picchiotti
- O Adanini
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- O Ezeobu
- O Jones
- O Kelsall
- O Mercer
- O Mitchelmore
- O Olufuwa
- O Prysyazhna
- O Zongo
- Oosthuyzen Wilna
- Openshaw Peter J M
- P Alexander
- P Anderson
- P Bamford
- P Barry
- P Boyle
- P Clark
- P Coghlan
- P Doble
- P Donnison
- P Ebano
- P Gondo
- P Grant
- P Harding
- P Henderson
- P Hutton
- P Jackson
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- P May
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- P O'Brien
- P O'Neil
- P Parkinson
- P Parsons
- P Paul
- P Polgarova
- P Ranga
- P Rice
- P Rogers
- P Saunderson
- P Shanmugasundaram
- P Springle
- P Szedlak
- P Turner
- P Williams
- Pairo-Castineira Erola
- Pamela Raggi
- Paola Magro
- Paolo Cameli
- Paolo Piacentini
- Parkinson Nick
- Pasko Dorota
- Patrick Sulem
- Patrizia Zucchi
- Paul Finernan
- Paul Klenerman
- Pereira Alexandre C
- Peter W Horby
- Pier Giorgio Scotton
- Pierpaolo Parravicini
- Pietro Pinoli
- Ponting Chris P
- Porteous David J
- R Astin-Chamberlain
- R Barber
- R Baruah
- R Bi
- R Bolton
- R Bowles
- R Boyle
- R Bradley
- R Campbell
- R Campbell
- R Chan
- R Charlesworth
- R Clark
- R Crawley
- R Crowe
- R Cusack
- R Davies
- R Doonan
- R Flanagan
- R Gascoyne
- R Girach
- R Gomez
- R Griffiths
- R Hall
- R Hamill
- R Haq
- R Harford
- R Harper
- R Herdman-Grant
- R Howle
- R Jacob
- R Jha
- R Johnson
- R Jones
- R Joy
- R Kanu
- R Kapoor
- R Kausar
- R Khade
- R Kitson
- R Kumar
- R Lean
- R Lim
- R Loosley
- R Lorusso
- R M Genetu
- R Marshall
- R O'Leary
- R Paramsothy
- R Parker
- R Partridge
- R Penn
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- R Pollard
- R Price
- R Prout
- R Pugh
- R Raobaikady
- R Reece-Anthony
- R Rikunenko
- R Rojo
- R Saha
- R Sandhu
- R Shaw
- R Shokkar
- R Simms
- R Stead
- R Stewart
- R Sundaram
- R Tully
- R Tutton
- R Vincent
- R Walker
- R Wilcox
- R Wolf-Roberts
- R Worner
- R Wulandari
- Rachel Law
- Raffaele Scala
- Rawlik Konrad
- Renieri
- Renzo Scaggiante
- Richard Clark
- Richard S Tedder
- Richmond Anne
- Riinu Pius
- Rita Perna
- Roberta Russo
- Ross Hendry
- Rossella Tita
- Rowan Kathy
- Russell Clark D
- Ruth Armstrong
- Ruth Lyons
- Ryan S Thwaites
- S Agrawal
- S Allen
- S Allibone
- S Anderson
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- S Bean
- S Beavis
- S Bell
- S Bennett
- S Benyon
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- S Campos
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- S Chapman
- S Charlton
- S Cherian
- S Chukkambotla
- S Clamp
- S Clark
- S Clements
- S Coetzee
- S Cole
- S Cornell
- S Cutler
- S Dale
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- S Farnell-Ward
- S Fowler
- S Garrioch
- S Gibson
- S Gopal
- S Greer
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- S Henderson
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- S Jhanji
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- S Jose
- S Joseph
- S Kaul
- S Keenan
- S Keith
- S Kennedy-Hay
- S Kimber
- S Kumar
- S Laha
- S Latham
- S Leaver
- S Lee
- S Leggett
- S MacFadyen
- S Manna
- S Marriott
- S Masuko
- S McIvor
- S McKechnie
- S Melling
- S Mellor
- S Mepham
- S Metherell
- S Mitchard
- S Mohamed Ally
- S Monnery
- S Moore
- S Morrison
- S Moultrie
- S Mtuwa
- S Mulla
- S Munt
- S Murdoch
- S O'Sullivan
- S Packham
- S Patch
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- S Preston
- S Purvis
- S Quaid
- S Ray
- S Roche
- S Rose
- S Rundell
- S Salmi
- S Sathe
- S Selvanayagam
- S Shelton
- S Shepardson
- S Siddiqui
- S Smuts
- S Sousa Arias
- S Spencer
- S Srikaran
- S Stone
- S Swann
- S Tilbey
- S Turki
- S Turney
- S Twiss
- S Wadd
- S Whiteley
- S Williams
- S Wood
- S Yussuf
- Sabino Scolletta
- Samreen Ijaz
- Sandro Mancarella
- Sandro Panese
- Sara Amitrano
- Sara McDonald
- Sarah Law
- Sarah McCafferty
- Saverio Giuseppe Parisi
- Saye Khoo
- Scott Richard
- Semple Malcolm G
- Serafina Valente
- Serena Ludovisi
- Sergio Daga
- Seán Keating
- Shankar-Hari Manu
- Shen Xia
- Shih Barbara
- Shiranee Sriskandan
- Shona C Moore
- Silvia Cappelli
- Simona Marcantonio
- Simone Furini
- Sophie Halpin
- Sophie Venturelli
- Stefania Mantovani
- Stefano Baratti
- Stefano Ceri
- Stefano Rusconi
- Stella Aslibekyan
- Stephanie Roberts
- Stephen R Knight
- Summers Charlotte
- Susanna Croci
- Susanna Guerrini
- T Anderson
- T Arden
- T Baird
- T Behan
- T Bemand
- T Cosier
- T Coventry
- T Duncan
- T Felton
- T Geary
- T Hazleton
- T Joefield
- T Kannan
- T Lawton
- T Marsden
- T Martin
- T McHugh
- T Newman
- T Nortcliffe
- T O Jones
- T Pogreban
- T Rees
- T Samakomva
- T Smith
- T Smith
- T Szakmany
- T Varghes
- T Williams
- T Wood
- Tammy Gilchrist
- Tenesa Albert
- Teresa Filshtein-Sonmez
- Thomas M Drake
- Thushan de Silva
- Tim Walsh
- Tom Fletcher
- Tom Solomon
- Tony Wackett
- Trevor Paterson
- Tullio Trotta
- Turtle Lance
- U Poultney
- V Amin
- V Anumakonda
- V Bastion
- V Cannons
- V Crickmore
- V Gopal
- V Irvine
- V Kasipandian
- V Krishnamurthy
- V Lake
- V Linnett
- V Martinson
- V Nagarajan
- V Page
- V Parris
- V Parris
- V Pristopan
- V Ratnam
- V Rivers
- V Sarathy
- V Thomas
- V Thwaites
- V Tuckey
- V Turner
- V Wagstaff
- V Waugh
- Valentina Anemoli
- Vanessa Sancho-Shimizu
- Victoria Shaw
- Vitart Veronique
- W Harrison
- W Khaliq
- W Khaliq
- W McCormick
- W Woodyatt
- Walker Susan
- Walsh Timothy
- Wang Bo
- Wei Shen Lim
- Wendy S Barclay
- William A Paxton
- William Greenhalf
- Wilson James F
- Wrobel Nicola
- Wu Yang
- X Qiu
- Y Baird
- Y Choudhury
- Y Hussain
- Y Jackson
- Y Thirlwall
- Yang Jian
- Yang Zhijian
- Z Alldis
- Z Belagodu
- Z Bradshaw
- Z Coton
- Z Daly
- Z Farzad
- Z Fernandez
- Z Garland
- Z Maqsood
- Z Omar
- Z Prime
- Z Scott
- Zechner Marie
- Zhai Ranran
- Zheng Chenqing
- Publication venue
- Nature
- Publication date
- 01/01/2020
- Field of study
Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 × 10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice
Machine perfusion in liver transplantation
- Publication venue
- 'Wiley'
- Publication date
- 01/11/2022
- Field of study
Although liver transplantation is a true success story, many patients still die awaiting an organ. The increasing need for liver grafts therefore remains an unsolved challenge to the transplant community. To address this, transplant donor criteria have been expanded and, for example, more liver grafts with significant steatosis or from donors with circulatory death are being used. These marginal grafts, however, carry an increased risk of graft-associated complications, such as primary nonfunction, delayed graft function, or late biliary injuries. Therefore, reliable assessment of graft viability before use is essential for further success. To achieve this, machine liver perfusion, a procedure developed more than 50 years ago but almost forgotten at the end of the last century, is again of great interest. We describe in this review the clinical most applied machine perfusion techniques, their mechanistic background, and a novel concept of combining immediate organ assessment during hypothermic oxygenated perfusion, followed by an extended phase of normothermic machine perfusion, with simultaneous ex situ treatment of the perfused liver. Such a new approach may allow the pool of usable livers to dramatically increase and improve outcomes for recipients
Outcomes of Kidney Perfusion Techniques in Transplantation from Deceased Donors: A Systematic Review and Meta-Analysis
- Publication venue
- 'MDPI AG'
- Publication date
- 01/06/2023
- Field of study
The high demand for organs in kidney transplantation and the expansion of the donor pool have led to the widespread implementation of machine perfusion technologies. In this study, we aim to provide an up-to-date systematic review of the developments in this expanding field over the past 10 years, with the aim of answering the question: “which perfusion technique is the most promising technique in kidney transplantation?” A systematic review of the literature related to machine perfusion in kidney transplantation was performed. The primary outcome measure was delayed graft function (DGF), and secondary outcomes included rates of rejection, graft survival, and patient survival rates after 1 year. Based on the available data, a meta-analysis was performed. The results were compared with data from static cold storage, which is still the standard of care in many centers worldwide. A total of 56 studies conducted in humans were included, and 43 studies reported outcomes of hypothermic machine perfusion (HMP), with a DGF rate of 26.4%. A meta-analysis of 16 studies showed significantly lower DGF rates in the HMP group compared to those of static cold storage (SCS). Five studies reported outcomes of hypothermic machine perfusion + O2, with an overall DGF rate of 29.7%. Two studies explored normothermic machine perfusion (NMP). These were pilot studies, designed to assess the feasibility of this perfusion approach in the clinical setting. Six studies reported outcomes of normothermic regional perfusion (NRP). The overall incidence of DGF was 71.5%, as it was primarily used in uncontrolled DCD (Maastricht category I-II). Three studies comparing NRP to in situ cold perfusion showed a significantly lower rate of DGF with NRP. The systematic review and meta-analysis provide evidence that dynamic preservation strategies can improve outcomes following kidney transplantation. More recent approaches such as normothermic machine perfusion and hypothermic machine perfusion + O2 do show promising results but need further results from the clinical setting. This study shows that the implementation of perfusion strategies could play an important role in safely expanding the donor pool
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