Venice in Varanasi: Fluid landscapes, aesthetic encounters and the unexpected geographies of tourist representation

This article has developed from a broader research project on tourist representations and practices in Varanasi, India's renowned sacred city and popular tourist destination situated by the 'holy' Ganges. Here, a recurring 'sense of Venice' emerged from Western travel narratives and landscape representations, evoked by both visual and morethan-visual encounters. Drawing on cultural geographies of landscape engaging postcolonial, representational and non-representational theories, the article unravels Venice's capacity to exist beyond Venice and to mobilise affectual aesthetic connections across different social, material, spatial and temporal contexts. Through an empirical analysis of aesthetic experiences of 'Venice-in-Varanasi', it illuminates the ontological liminality of Venice as waterland and image and its epistemological capacity to navigate the entangled material, affective and representational modes through which we encounter the world. Advancing relational theories of landscape via an empirical focus on the waterscapes of Venice and Varanasi, the article contributes to water studies and critical tourism by proposing a fluid and mobile ontology of landscape which seeks to destabilise the representational/non-representational binary, thus feeding into growing research in this direction

Children and young people as geological agents? Time, scale and multispecies vulnerabilities in the new epoch

In this paper we frame children as geological agents, very much part of epoch and biospherical processes, enfolded in Earth system changes. We draw on the experiences of Indian childhoods in a context where the land, water, animals, children's bodies and forests are being shaped by a politics of corporate city building. We analyse how children and young people contribute to Earth system changes and consider the everyday, multispecies consequences of living with anthropogenic urbanism. The paper shows how children's bodies are entangled with human and non-human forces; they are geological agents which challenge, negotiate and have cyclical and rhythmic relationships with land and resources. We argue that time, scale and multispecies vulnerabilities are important reference points in our thinking through anthropogenic processes and thus contribute to a more nuanced understanding of the place of children and young people in the new epoch

Sacred Journeys and Profane Travellers: Representation and Spatial Practice in Varanasi (India)

This thesis is concerned with tourist representations and practices in India. Orientalist aesthetics have often associated this country with notions of spirituality and mysticism; tourist narratives sustain and reinforce such representations by describing India as a land of ancient rituals and timeless traditions. The visual construction of India's 'spiritual landscapes' has been largely deployed as a powerful tool for subduing the unfamiliar Other within reassuring epistemological categories. However, tourism research has recently become interested in exploring the role of tourist practices in landscape production. Not only do tourists 'gaze upon' landscapes, they also script landscapes through practices and performances. By focusing on the case of Varanasi, the Indian pilgrimage city on the banks of the Ganges, this thesis shows how tourist practices (re)produce and make sense of the city's 'sacredscape'. Special attention is paid to the riverfront, which epitomizes the cultural and spiritual significance ascribed to the city. Both Hindu and tourist narratives depict the riverfront as embodying a special power, a unique meaning, whether this uniqueness is held to be a 'spiritual' or a 'picturesque' one. The thesis analyses the city's riverfront asthe place where tourist, ritual, and day-to-day activities are played out and negotiated, and where the aesthetics of landscape is confronted with the materialities and the practices inherent to this place. The research has adopted an ethnographic approach, combining participant observation, interviews and questionnaires, visual methods, and textual analysis of popular tourist literature.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Analysis of shared heritability in common disorders of the brain

ience, this issue p. eaap8757 Structured Abstract INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed study of phenotypes with different ages of onset, severity, and presentation poses a considerable challenge. Recently developed heritability methods allow us to accurately measure correlation of genome-wide common variant risk between two phenotypes from pools of different individuals and assess how connected they, or at least their genetic risks, are on the genomic level. We used genome-wide association data for 265,218 patients and 784,643 control participants, as well as 17 phenotypes from a total of 1,191,588 individuals, to quantify the degree of overlap for genetic risk factors of 25 common brain disorders. RATIONALE Over the past century, the classification of brain disorders has evolved to reflect the medical and scientific communities' assessments of the presumed root causes of clinical phenomena such as behavioral change, loss of motor function, or alterations of consciousness. Directly observable phenomena (such as the presence of emboli, protein tangles, or unusual electrical activity patterns) generally define and separate neurological disorders from psychiatric disorders. Understanding the genetic underpinnings and categorical distinctions for brain disorders and related phenotypes may inform the search for their biological mechanisms. RESULTS Common variant risk for psychiatric disorders was shown to correlate significantly, especially among attention deficit hyperactivity disorder (ADHD), bipolar disorder, major depressive disorder (MDD), and schizophrenia. By contrast, neurological disorders appear more distinct from one another and from the psychiatric disorders, except for migraine, which was significantly correlated to ADHD, MDD, and Tourette syndrome. We demonstrate that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine. We also identify significant genetic sharing between disorders and early life cognitive measures (e.g., years of education and college attainment) in the general population, demonstrating positive correlation with several psychiatric disorders (e.g., anorexia nervosa and bipolar disorder) and negative correlation with several neurological phenotypes (e.g., Alzheimer's disease and ischemic stroke), even though the latter are considered to result from specific processes that occur later in life. Extensive simulations were also performed to inform how statistical power, diagnostic misclassification, and phenotypic heterogeneity influence genetic correlations. CONCLUSION The high degree of genetic correlation among many of the psychiatric disorders adds further evidence that their current clinical boundaries do not reflect distinct underlying pathogenic processes, at least on the genetic level. This suggests a deeply interconnected nature for psychiatric disorders, in contrast to neurological disorders, and underscores the need to refine psychiatric diagnostics. Genetically informed analyses may provide important "scaffolding" to support such restructuring of psychiatric nosology, which likely requires incorporating many levels of information. By contrast, we find limited evidence for widespread common genetic risk sharing among neurological disorders or across neurological and psychiatric disorders. We show that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures. Further study is needed to evaluate whether overlapping genetic contributions to psychiatric pathology may influence treatment choices. Ultimately, such developments may pave the way toward reduced heterogeneity and improved diagnosis and treatment of psychiatric disorders

Infected pancreatic necrosis: outcomes and clinical predictors of mortality. A post hoc analysis of the MANCTRA-1 international study

: The identification of high-risk patients in the early stages of infected pancreatic necrosis (IPN) is critical, because it could help the clinicians to adopt more effective management strategies. We conducted a post hoc analysis of the MANCTRA-1 international study to assess the association between clinical risk factors and mortality among adult patients with IPN. Univariable and multivariable logistic regression models were used to identify prognostic factors of mortality. We identified 247 consecutive patients with IPN hospitalised between January 2019 and December 2020. History of uncontrolled arterial hypertension (p = 0.032; 95% CI 1.135-15.882; aOR 4.245), qSOFA (p = 0.005; 95% CI 1.359-5.879; aOR 2.828), renal failure (p = 0.022; 95% CI 1.138-5.442; aOR 2.489), and haemodynamic failure (p = 0.018; 95% CI 1.184-5.978; aOR 2.661), were identified as independent predictors of mortality in IPN patients. Cholangitis (p = 0.003; 95% CI 1.598-9.930; aOR 3.983), abdominal compartment syndrome (p = 0.032; 95% CI 1.090-6.967; aOR 2.735), and gastrointestinal/intra-abdominal bleeding (p = 0.009; 95% CI 1.286-5.712; aOR 2.710) were independently associated with the risk of mortality. Upfront open surgical necrosectomy was strongly associated with the risk of mortality (p < 0.001; 95% CI 1.912-7.442; aOR 3.772), whereas endoscopic drainage of pancreatic necrosis (p = 0.018; 95% CI 0.138-0.834; aOR 0.339) and enteral nutrition (p = 0.003; 95% CI 0.143-0.716; aOR 0.320) were found as protective factors. Organ failure, acute cholangitis, and upfront open surgical necrosectomy were the most significant predictors of mortality. Our study confirmed that, even in a subgroup of particularly ill patients such as those with IPN, upfront open surgery should be avoided as much as possible. Study protocol registered in ClinicalTrials.Gov (I.D. Number NCT04747990)