SOFT TISSUE LOADS AT THE HUMAN KNEE DURING RUNNING AND CUTTING MANOEUVRES

Tensile forces on the ACL increase when the knee is in an extended posture and required to accommodate applied moments in flexion, varus, valgus and/or internal rotation. However, the loading of knee joint support structures during sporting actions that are related to non-contact injuries are largely unknown. We studied external loading of the knee during running, side-stepping and cross-over cutting in 10 male subjects under both pre-planned and unanticipated conditions. Soft tissue structures of the knee were exposed to high FE, VV and IE applied moments during the cutting tasks, especially when performed in the unanticipated condition. Whilst muscle activation could accommodate some of this applied load, soft tissue structures were particularly vulnerable during the cross-over cut task where the residual loads were high

THE EFFECT OF LOWER LIMB TRAINING ON MUSCULAR SUPPORT OF THE KNEE AND RISK OF ANTERIOR CRUCIATE LIGAMENT INJURY.

An intervention study was performed to investigate the effect of lower-limb training programs on knee muscle activation patterns and their potential to support the knee load during running and cutting manoeuvres. It is known that balance training can reduce ACL injury but the underlying mechanisms are unknown. The effects that strength training has on support for the knee joint during sporting manoeuvres are also not known. Analysis of activation levels and patterns of leg muscles during running, sidestepping and crossover-cutting manoeuvres prior to and following 12-week training programs revealed important results in terms of potential support of load on the ACL. Balance training increased co-contraction and supportive muscle activation patterns, as did the combination of machine and balance training to a lesser extent. The strength training programs tended to reduce co-contraction and were associated with changes which would lead to less stability of the knee during sporting manoeuvres. It is recommended that balance training should be implemented to reduce an athlete’s risk of ACL injury

CFD study of filtration process in moulded filters within a vacuum pump

Air/Oil filtration through filters is commonly utilised in the vacuum industry where oil lubricated pumps are used across a number of different applications such as food and packaging, industrial, pharmaceutical, R&D, forming and drying. The air/oil filters are crucial in the reduction of exhaust emissions, which, when suspended as fine particulate matter can cause great harm to the environment, climate, equipment life and public health. However, the behaviour of flow through the filters is not fully understood and much of the design and development work is based on historical know-how and experimental studies. Computational Fluid Dynamics (CFD) is a powerful tool to understand the flow characteristics and droplet trajectory through the filters which is challenging through experimental techniques. In this study, a CFD model is developed by using the commercial ANSYS FLUENT code. Oil droplets from the pump entering the filter are treated as a discrete phase. Euler-Lagrangian frame is used to characterise the multiphase flow, K-Ɛ as a turbulence model, Rosin-Rammler distribution of oil droplets, User Defined Functions (UDF) are written for droplet injection, distribution and deposition. Various methodologies and tests were developed to obtain the required data to feed into the model and validate the data predicted by the computational model. The obtained computational data agrees well with the experimental data

Quantum nonlocality and applications in quantum-information processing of hybrid entangled states

The hybrid entangled states generated, e.g., in a trapped-ion or atom-cavity system, have exactly one ebit of entanglement, but are not maximally entangled. We demonstrate this by showing that they violate, but in general do not maximally violate, Bell's inequality due to Clauser, Horne, Shimony and Holt. These states are interesting in that they exhibit the entanglement between two distinct degrees of freedom (one is discrete and another is continuous). We then demonstrate these entangled states as a valuable resource in quantum information processing including quantum teleportation, entanglement swapping and quantum computation with "parity qubits". Our work establishes an interesting link between quantum information protocols of discrete and continuous variables.Comment: 5 pages, no figur

Entanglement concentration of continuous variable quantum states

We propose two probabilistic entanglement concentration schemes for a single copy of two-mode squeezed vacuum state. The first scheme is based on the off-resonant interaction of a Rydberg atom with the cavity field while the second setup involves the cross Kerr interaction, auxiliary mode prepared in a strong coherent state and a homodyne detection. We show that the continuous-variable entanglement concentration allows us to improve the fidelity of teleportation of coherent states.Comment: 7 pages, 7 figure

Untreated hypertension in the UK household population ? Who are missed by the general health checks?

Hypertension is an age-related, long-term condition and a leading risk factor for premature death and disability worldwide. Due to its asymptomatic nature it can often be left undiagnosed. Long-term treatment is available, but blood pressure can also be reduced through health behaviour changes in weight control, smoking cessation, higher physical activity levels, reduced salt and alcohol intake, and healthful diets if discovered early. This paper investigates the prevalence and characteristics of those with untreated (compared to treated) hypertension who did not have a history of cardiovascular disease (CVD); a group who is in effect missed by general health checks. Untreated hypertension was studied in 8933 individuals aged 40?74 years representative of the UK household population, who were interviewed and underwent a physical health examination in their home, 2010?2012. The prevalence of untreated hypertension without a history of CVD was 7% for men, 2% for women, and 5% overall. Untreated hypertension was particularly high among the 55?64 year age group. Age and sex-adjusted analyses found strong positive associations with male gender, smoking, self-reported good?excellent health, full fat dairy preference, white bread preference, higher alcohol consumption, and living alone. Strong negative associations were found for possessing 5 + prescription drugs, statins or antiplatelets, being diagnosed with diabetes or possessing antidiabetics, and long-term limiting illness status. Notably, many reported their health as good to excellent. A fact which emphasises the importance of motivating individuals to take part in the general health checks for an asymptomatic condition such as hypertension

Improving quality of care and outcome at very preterm birth: the Preterm Birth research programme, including the Cord pilot RCT

BACKGROUND:Being born very premature (i.e. before 32 weeks’ gestation) has an impact on survival and quality of life. Improving care at birth may improve outcomes and parents’ experiences. OBJECTIVES:To improve the quality of care and outcomes following very preterm birth. DESIGN:We used mixed methods, including a James Lind Alliance prioritisation, a systematic review, a framework synthesis, a comparative review, qualitative studies, development of a questionnaire tool and a medical device (a neonatal resuscitation trolley), a survey of practice, a randomised trial and a protocol for a prospective meta-analysis using individual participant data. SETTING:For the prioritisation, this included people affected by preterm birth and health-care practitioners in the UK relevant to preterm birth. The qualitative work on preterm birth and the development of the questionnaire involved parents of infants born at three maternity hospitals in southern England. The medical device was developed at Liverpool Women’s Hospital. The survey of practice involved UK neonatal units. The randomised trial was conducted at eight UK tertiary maternity hospitals. PARTICIPANTS:For prioritisation, 26 organisations and 386 individuals; for the interviews and questionnaire tool, 32 mothers and seven fathers who had a baby born before 32 weeks’ gestation for interviews evaluating the trolley, 30 people who had experienced it being used at the birth of their baby (19 mothers, 10 partners and 1 grandmother) and 20 clinicians who were present when it was being used; for the trial, 261 women expected to have a live birth before 32 weeks’ gestation, and their 276 babies. INTERVENTIONS:Providing neonatal care at very preterm birth beside the mother, and with the umbilical cord intact; timing of cord clamping at very preterm birth. MAIN OUTCOME MEASURES:Research priorities for preterm birth; feasibility and acceptability of the trolley; feasibility of a randomised trial, death and intraventricular haemorrhage. REVIEW METHODS:Systematic review of Cochrane reviews (umbrella review); framework synthesis of ethics aspects of consent, with conceptual framework to inform selection criteria for empirical and analytical studies. The comparative review included studies using a questionnaire to assess satisfaction with care during childbirth, and provided psychometric information. RESULTS:Our prioritisation identified 104 research topics for preterm birth, with the top 30 ranked. An ethnographic analysis of decision-making during this process suggested ways that it might be improved. Qualitative interviews with parents about their experiences of very preterm birth identified two differences with term births: the importance of the staff appearing calm and of staff taking control. Following a comparative review, this led to the development of a questionnaire to assess parents’ views of care during very preterm birth. A systematic overview summarised evidence for delivery room neonatal care and revealed significant evidence gaps. The framework synthesis explored ethics issues in consent for trials involving sick or preterm infants, concluding that no existing process is ideal and identifying three important gaps. This led to the development of a two-stage consent pathway (oral assent followed by written consent), subsequently evaluated in our randomised trial. Our survey of practice for care at the time of birth showed variation in approaches to cord clamping, and that no hospitals were providing neonatal care with the cord intact. We showed that neonatal care could be provided beside the mother using either the mobile neonatal resuscitation trolley we developed or existing equipment. Qualitative interviews suggested that neonatal care beside the mother is valued by parents and acceptable to clinicians. Our pilot randomised trial compared cord clamping after 2 minutes and initial neonatal care, if needed, with the cord intact, with clamping within 20 seconds and initial neonatal care after clamping. This study demonstrated feasibility of a large UK randomised trial. Of 135 infants allocated to cord clamping ≥ 2 minutes, 7 (5.2%) died and, of 135 allocated to cord clamping ≤ 20 seconds, 15 (11.1%) died (risk difference –5.9%, 95% confidence interval –12.4% to 0.6%). Of live births, 43 out of 134 (32%) allocated to cord clamping ≥ 2 minutes had intraventricular haemorrhage compared with 47 out of 132 (36%) allocated to cord clamping ≤ 20 seconds (risk difference –3.5%, 95% CI –14.9% to 7.8%). LIMITATIONS:Small sample for the qualitative interviews about preterm birth, single-centre evaluation of neonatal care beside the mother, and a pilot trial. CONCLUSIONS:Our programme of research has improved understanding of parent experiences of very preterm birth, and informed clinical guidelines and the research agenda. Our two-stage consent pathway is recommended for intrapartum clinical research trials. Our pilot trial will contribute to the individual participant data meta-analysis, results of which will guide design of future trials. FUTURE WORK:Research in preterm birth should take account of the top priorities. Further evaluation of neonatal care beside the mother is merited, and future trial of alternative policies for management of cord clamping should take account of the meta-analysis. STUDY REGISTRATION:This study is registered as PROSPERO CRD42012003038 and CRD42013004405. In addition, Current Controlled Trials ISRCTN21456601. FUNDING:This project was funded by the National Institute for Health Research (NIHR) Programme Grants for Applied Research programme and will be published in full in Programme Grants for Applied Research; Vol. 7, No. 8. See the NIHR Journals Library website for further project information

Fire emissions from C-3 and C-4 vegetation and their influence on interannual variability of atmospheric CO2 and delta (CO2) - C- 13

Measurements of atmospheric trace gases provide evidence that fire emissions increased during the 1997/1998 El Niño event and these emissions contributed substantially to global C

Population policies and education: exploring the contradictions of neo-liberal globalisation

The world is increasingly characterised by profound income, health and social inequalities (Appadurai, 2000). In recent decades development initiatives aimed at reducing these inequalities have been situated in a context of increasing globalisation with a dominant neo-liberal economic orthodoxy. This paper argues that neo-liberal globalisation contains inherent contradictions regarding choice and uniformity. This is illustrated in this paper through an exploration of the impact of neo-liberal globalisation on population policies and programmes. The dominant neo-liberal economic ideology that has influenced development over the last few decades has often led to alternative global visions being overlooked. Many current population and development debates are characterised by polarised arguments with strongly opposing aims and views. This raises the challenge of finding alternatives situated in more middle ground that both identify and promote the socially positive elements of neo-liberalism and state intervention, but also to limit their worst excesses within the population field and more broadly. This paper concludes with a discussion outling the positive nature of middle ground and other possible alternatives

Iron and ferritin accumulate in separate cellular locations in Phaseolus seeds

<p>Abstract</p> <p>Background</p> <p>Iron is an important micronutrient for all living organisms. Almost 25% of the world population is affected by iron deficiency, a leading cause of anemia. In plants, iron deficiency leads to chlorosis and reduced yield. Both animals and plants may suffer from iron deficiency when their diet or environment lacks bioavailable iron. A sustainable way to reduce iron malnutrition in humans is to develop staple crops with increased content of bioavailable iron. Knowledge of where and how iron accumulates in seeds of crop plants will increase the understanding of plant iron metabolism and will assist in the production of staples with increased bioavailable iron.</p> <p>Results</p> <p>Here we reveal the distribution of iron in seeds of three <it>Phaseolus </it>species including thirteen genotypes of <it>P. vulgaris</it>, <it>P. coccineus</it>, and <it>P. lunatus</it>. We showed that high concentrations of iron accumulate in cells surrounding the provascular tissue of <it>P. vulgaris </it>and <it>P. coccineus </it>seeds. Using the Perls' Prussian blue method, we were able to detect iron in the cytoplasm of epidermal cells, cells near the epidermis, and cells surrounding the provascular tissue. In contrast, the protein ferritin that has been suggested as the major iron storage protein in legumes was only detected in the amyloplasts of the seed embryo. Using the non-destructive micro-PIXE (Particle Induced X-ray Emission) technique we show that the tissue in the proximity of the provascular bundles holds up to 500 μg g^-1of iron, depending on the genotype. In contrast to <it>P. vulgaris </it>and <it>P. coccineus</it>, we did not observe iron accumulation in the cells surrounding the provascular tissues of <it>P. lunatus </it>cotyledons. A novel iron-rich genotype, NUA35, with a high concentration of iron both in the seed coat and cotyledons was bred from a cross between an Andean and a Mesoamerican genotype.</p> <p>Conclusions</p> <p>The presented results emphasize the importance of complementing research in model organisms with analysis in crop plants and they suggest that iron distribution criteria should be integrated into selection strategies for bean biofortification.</p