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Targeting medication non-adherence behavior in selected autoimmune diseases: a systematic approach to digital health program development
- Author
- A Garcia-Gonzalez
- A O'Connor
- AC Moss
- AJ Claxton
- AL Strauss
- AL Strauss
- BG Glaser
- BJ van den Bemt
- BJ van den Bemt
- CA Jackson
- CA McHorney
- CD Lorish
- CD Lorish
- CT Carter
- D Moher
- DE Morisky
- E de Klerk
- E Fisher
- EW Karlson
- F Bermejo
- G Eysenbach
- GJ Treharne
- GM Daleboudt
- Graham R. Wallace
- GS Cooper
- HP McDonald
- I Bernal
- J Hill
- J Stone
- JA Cramer
- JA Cunningham
- JA Cunningham
- JF Wolfswinkel
- JM Corbin
- JP Ediger
- JS Richards
- JV Olthuis
- K Charmaz
- K Pal
- K Thompson
- K Zivin
- KP Krueger
- LJ Julian
- M Binks
- M Binks
- M Civljak
- M Lambert
- M Viswanathan
- MA Blum
- MA De Vera
- MC Belcon
- MC Sokol
- MF Marengo
- MG Garcia Popa-Lisseanu
- Michael Ingham
- MP Trotta
- MR DiMatteo
- P Dutton
- P Farvolden
- P Li
- P Manchanda
- P Ruiz
- P Selby
- PL Lakatos
- R Horne
- R Horne
- Rachel Fournier
- RB Haynes
- S Fox
- S Gill
- S Kane
- S Koneru
- S McLean
- S Schneider
- S Yusuf
- SZ Shariff
- T van Mierlo
- TN Robinson
- Trevor van Mierlo
- TV Ting
- WA Bardwell
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 24/06/2015
- Field of study
Background
29 autoimmune diseases, including Rheumatoid Arthritis, gout, Crohnâs Disease, and Systematic Lupus Erythematosus affect 7.6-9.4% of the population. While effective therapy is available, many patients do not follow treatment or use medications as directed. Digital health and Web 2.0 interventions have demonstrated much promise in increasing medication and treatment adherence, but to date many Internet tools have proven disappointing. In fact, most digital interventions continue to suffer from high attrition in patient populations, are burdensome for healthcare professionals, and have relatively short life spans.
Objective
Digital health tools have traditionally centered on the transformation of existing interventions (such as diaries, trackers, stage-based or cognitive behavioral therapy programs, coupons, or symptom checklists) to electronic format. Advanced digital interventions have also incorporated attributes of Web 2.0 such as social networking, text messaging, and the use of video. Despite these efforts, there has not been little measurable impact in non-adherence for illnesses that require medical interventions, and research must look to other strategies or development methodologies. As a first step in investigating the feasibility of developing such a tool, the objective of the current study is to systematically rate factors of non-adherence that have been reported in past research studies.
Methods
Grounded Theory, recognized as a rigorous method that facilitates the emergence of new themes through systematic analysis, data collection and coding, was used to analyze quantitative, qualitative and mixed method studies addressing the following autoimmune diseases: Rheumatoid Arthritis, gout, Crohnâs Disease, Systematic Lupus Erythematosus, and inflammatory bowel disease. Studies were only included if they contained primary data addressing the relationship with non-adherence.
Results
Out of the 27 studies, four non-modifiable and 11 modifiable risk factors were discovered. Over one third of articles identified the following risk factors as common contributors to medication non-adherence (percent of studies reporting): patients not understanding treatment (44%), side effects (41%), age (37%), dose regimen (33%), and perceived medication ineffectiveness (33%). An unanticipated finding that emerged was the need for risk stratification tools (81%) with patient-centric approaches (67%).
Conclusions
This study systematically identifies and categorizes medication non-adherence risk factors in select autoimmune diseases. Findings indicate that patients understanding of their disease and the role of medication are paramount. An unexpected finding was that the majority of research articles called for the creation of tailored, patient-centric interventions that dispel personal misconceptions about disease, pharmacotherapy, and how the body responds to treatment. To our knowledge, these interventions do not yet exist in digital format. Rather than adopting a systems level approach, digital health programs should focus on cohorts with heterogeneous needs, and develop tailored interventions based on individual non-adherence patterns
The Physics of the B Factories
- Author
- A Abashian
- A. A. Botov
- A. A. Grillo
- A. A. Korol
- A. A. Salnikov
- A. Abashian
- A. Adametz
- A. Agarwal
- A. Anjomshoaa
- A. B. Breon
- A. Bala
- A. Bay
- A. Bondar
- A. Bozek
- A. Buzzo
- A. C. Forti
- A. C. Wren
- A. Calcaterra
- A. Cecchi
- A. Cervelli
- A. Ceseracciu
- A. Chen
- A. Chuvikov
- A. Cotta Ramusino
- A. Crescente
- A. Cunha
- A. D. Bukin
- A. Das
- A. de Lesquen
- A. De Silva
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- A. Drutskoy
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- A. E. Rubin
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- A. Go
- A. Gordon
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- Y. Yoshimura
- Y. Yuan
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- Y. Zheng
- Yu. G. Kolomensky
- Yu.I. Skovpen
- Z. C. Clifton
- Z. DoleĆŸal
- Z. DrĂĄsal
- Z. G. Zhao
- Z. Georgette
- Z. Huard
- Z. J. Guo
- Z. M. Zhu
- Z. Natkaniec
- Z. P. Mao
- Z. P. Zhang
- Z. P. Zheng
- Z. Q. Liu
- Z. W. Yin
- Z. Yasin
- Z. Yu
- Z. Z. Xu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
This work is on the Physics of the B Factories. Part A of this book contains a brief description of the SLAC and KEK B Factories as well as their detectors, BaBar and Belle, and data taking related issues. Part B discusses tools and methods used by the experiments in order to obtain results. The results themselves can be found in Part C
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
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- Zonneveldt H
- Zou X
- Zoulamoglou M
- Zsisku L
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44Â 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
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- Author
- Abbass Hakam
- Adhikari Neill
- Affleck Julia
- Agno Sathianathan Ronan
- Ahmad Norfaizan
- Ahmed Iram
- Ainscough Kate
- Al Qasim Eman
- Al Swaidan Lolowa
- Al-Bassam Wisam
- Al-Beidh Farah
- Al-Beidh Farah
- Albert Martin
- Alegria Ana
- Alexander Brian
- Alexander Peter
- Allan Angela
- Allan Elizabeth
- Allen Louise
- Allibone Suzanne
- Amaro dos Santos Catorze Teodoro
- Anderson Tom
- Andric Zdravko
- Angus Derek
- Angus Derek C
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Annane Djillali
- Anstey Matthew
- Antcliffe David
- Aparicio Christelle
- Appelt Peter
- Arabi Yaseen
- Arabi Yaseen
- Arbane Gill
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arishi Hatim
- Arnold Donald
- Asghar Adeeba
- Ashelford Angela
- Attwood Ben
- Austin Karen
- Aysel Florescu Simin
- Azaiz Amine
- Babel JakĆĄa
- Babio-Galan Maite
- Badie Julio
- Bagshaw Sean
- Baillie Kenneth
- Baker Evelyn
- Bakthavatsalam Dhanalakshmi
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbazza Leanne
- Barber Russell
- Barge Deborah
- Barnes Nicky
- BarĆĄiÄ Bruno
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bates Michelle
- Bauchmuller Kris
- Bean Sarah
- Beane Abigail
- Beane Abigail
- Beasley Richard
- Begin Phillipe
- Bellemare David
- Benettaib Fatna
- Benzekri Dalila
- Berdaguer Fernando Daniel
- Bergin Colin
- Berry Lindsay
- Berry Lindsay
- Berry Scott
- Berry Scott
- Bhimani Zahra
- Bhimani Zahra
- Bihari Shailesh
- Bihari Shilesh
- Binnie Alexandra
- Bion Julian
- Biradar Vishwanath
- Birch Janine
- Birch Jenny
- Birchall Katie
- Birkinshaw Isobel
- Black Ethel
- Bloos Frank
- Board Jasmin
- Bone Allsion
- Bonner Stephen
- Bonten Marc
- Bonten Marc
- Borgatta Barbara
- Borrill Zoe
- Bosch Ziekenhuis Jeroen
- Boschert Catherine
- Bossard Isabelle
- Boumahni Dounia
- Bourgoin Charlotte
- Bourne Michelle
- Bourne Richard
- Bouwman Wietske
- Bowler Helen
- Boyd Craig
- Bracke Stephanie
- Bradbury Charlotte
- Bradbury Charlotte
- Bradley-Potts Joanne
- Brailsford Jane
- Brain Matthew
- Brant Emily
- Breen Patrick
- Brett Stephen
- Brewer Chris
- Brickell Kathy
- Brightling Chris
- Brillinger Nicole
- Brimfield Lutece
- Brinkerhoff Gail
- Brochard Laurent
- Brohi Farooq
- Browne Troy
- Brunkhorst Frank
- Brunkhorst Frank
- Budd Joanna
- Buehner Ulrike
- Buhr Heidi
- Bullman Laetitia
- Burns Karen
- Burt Karen
- Buscher Hergen
- Butler Amelia
- Butler M
- Buxton Meredith
- Buxton Meredith
- Buzgau Adrian
- Byrne Deborah
- Byrne Kathleen
- BĂ©lteczki JĂĄnos
- Cabreros Leilani
- Calfee Carolyn
- Callender Owen
- Campbell Andy
- Campbell Hilary
- Campbell Lewis
- Camsooksai Julie
- Caplin Cecile
- Carbonneau Elaine
- Carmona Flores Rosario
- Carr-Knott Lisa
- Carrier François Martin
- Carrier Marc
- Cartner Brittney
- Casey Ruth
- Casey Siobhan
- Castro Ferreira Ricardo Manuel
- Cate Heidi
- Cathcart Susanne
- Cavayas Alexandros
- Cawley Kathryn
- Cazzola Federica
- Centofanti John
- Chablani Manish
- Chamara Warnapura Loku
- Chan Carmen
- Chan Charles
- Chan Peter
- Charlewood Richard
- Charron Cyril
- Chartier Delphine
- Chasse Michael
- Chassé Michaël
- Chen Yan
- Cheng Allen
- Cheng Allen C
- Cherian Shiney
- Cheung Winston
- Chhablani Manish
- Chudeau Nicolas
- Cirstea Emanuel
- Clarey Emma
- Claridge Helen
- Clark Michele
- Clark Sarah
- Claxton Andrew
- Clermont Giles
- Cloutier Ăve
- Coburn Susan
- Codreanu Daniel
- Coghlan Phoebe
- Cole Jade
- Coles Holly
- Coles Jennifer
- Colin Gwenhael
- Collier Dawn
- Collins Daniel
- Collins Emma
- Collins Joanne
- Connor Jason
- Cooke Jill
- Cooper Jamie
- Cooper Melanie
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- Cort Jon
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- Cowdrey Keri-Anne
- Cowley Nicholas
- Cowton Amanda
- Coyne Mark
- Craner Michelle
- Craven Thomas
- Creagh-Brown Ben
- Crisp Nikki
- Croft Maria
- Cusack Rebecca
- Cutler Sean
- Cviljevic Sabina
- CĂĄrcel FernĂĄndez Sheila
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- Daly Zoe
- Daneman Nick
- Dark Paul
- Darreau CĂ©dric
- Dasgin Joanne
- Davey Miriam
- Davidson Neil
- Davies Gwyneth
- Davies Louisa
- Davies Michelle
- Dawda Ashlish
- Day Christopher
- De Beaux Fiona
- De Bus Liesbet
- de Courcy-Golder Kim
- de Jager P
- de Jong Menno
- De Jong Menno
- de Jonge E
- de la Fuente Martos Carmen
- de Lima Pereira Tiago Nuno Alfaro
- de Man Angelique
- De Waele Jan
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- Duan Erick
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- Dyas Sarah
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- DâSouza Ramsy
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- Elin Hall Rebecca
- Ellis Christine
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- Everitt Robert
- Evers Mirjam
- Farahi Neda
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- Faulkner Beverley
- Faulkner Maria
- Fazekas Ăgnes
- Felton Tim
- Ferguson Niall
- Ferguson Susan
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- FernĂĄndez de Pinedo Artaraz Ziortza
- Ferrier Janet
- Fierens Jan
- Finn André
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- Fitzgerald Mark
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- Friedrich Hinrichs Carl
- Frohlich Stephen
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- Gallagher Linda Jude
- Ganguly Saibal
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- Godement Mathieu
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- Goodson Jennifer
- Goodwin Jayne
- Goossens Herman
- Goossens Herman
- Gopal Shameer
- Gopinath Amitha
- Gordon Anthony
- Gordon Anthony C
- Gordon Elizabeth
- Gosbell Iain
- Gould Richard
- Grecu Irina
- Green Cameron
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- Gregory Jane
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- Grimmer Lisa
- Grimwade Kate
- Guilder E
- Guitton Christophe
- Hacking Danielle
- Hadebe Bernard
- Hagel Stefan
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- Hall Kathryn
- Hamilton David Oliver
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- Harland Cain
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- Hickey Naomi
- Higgins Alisa M
- Higgins Lisa
- Hill Helen
- Hills Thomas
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- Hoiting Oscar
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- Huang David
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- Hugill Keith
- Hullegie Sebastiaan
- Hullegie Sebastiaan J
- Hulley Amanda
- Hulme Jonathan
- Hunt Beverley
- Hunter Stephanie
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- Hutton Paula
- Innes Richard
- Ireland Jane
- Isgro Graziella
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- Jarczak Dominik
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- Kluge Stefan
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- Kruger Peter
- Kuitunen Anne
- Kumar Anand
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- Kurenda Catherine
- KutleĆĄa Marko
- KuĆĄan Ira
- KyereDiabour Thyra
- Kyeremeh Lynsey
- Labbe Vincent
- Laffan Mike
- Laffey John
- Laha Shondipon
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- Lamb Thomas
- Lamonagne Francois
- Lamontagne Francois
- Lamontagne Francois
- Lamontagne François
- Landais Mickaël
- Lane Janis-Best
- Lankester Liana
- Laver Russell
- Lawler Patrick
- Lawler Patrick R
- Lawless Patrick
- Lazaro Juan Martin
- Leaver Susannah
- Leblond Julie
- Lee Kelvin
- Lee Stephanie
- Leparco CĂ©cile
- Lesona Eden
- Leszkoven JĂĄnos
- Lewis Roger
- Lewis Roger J
- Lewis Sarah
- LeĂłn LĂłpez Rafael
- Limb James
- Linstrum Kelsey
- Linstrum Kelsey
- Litton Ed
- Litton Edward
- Litton Edward
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- Lowe Benjamin
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- Pellicano Annamaria
- Pereira Sousa Bastos Joana Margarida
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- Writing Committee for the REMAP-CAP Investigators
- Xavier Kugan
- Xia Le Tai Charlotte
- Yarad Elizabeth
- Yates David
- Young Chelsea
- Young Ian
- Young Meredith
- Young Paul
- Yusuff Hakeem
- Zaharia Miahela Florentina
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zammit Claire
- Zapalac Marija
- Zarychanski Ryan
- Zarychanski Ryan
- Zhao Xiao Bei
- Zinzoni Vanessa
- Zitter Letizia
- Äimoti Renata
- Publication venue
- JAMA: Journal of the American Medical Association
- Publication date
- 06/10/2020
- Field of study
Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020. Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (nâ=â143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (nâ=â152), or no hydrocortisone (nâ=â108). Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%). Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (nâ=â137), shock-dependent (nâ=â146), and no (nâ=â101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively. Conclusions and Relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. Trial Registration: ClinicalTrials.gov Identifier: NCT02735707
The Physics of the B Factories
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- Publication venue
- Springer Verlag
- Publication date
- 29/01/2015
- Field of study
Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery (EPOCH): a stepped-wedge cluster-randomised trial
- Author
- Abbott Tom
- Abdul Nazar
- Abercrombie John
- Abraham Ajit
- Ackland Gareth
- Adams Ferdinand
- Adegoke Kenneth
- Agarwal Banwari
- Agostini Helen
- Akhtar Mansoor
- Al Shama Majed
- Alegria Ana
- Alexander Peter
- Ali Dhiraj
- Allen Katherine
- Anderson Iain
- Andrews Sam
- Ankers Alastair
- Aravind Biju
- Arnold Glenn
- Aryal Kamal
- Asaria Miqdad
- Baig Faisal
- Bailey Flora
- Bailey Lindsay
- Bailey Simon
- Baillie Kirsty
- Baker Susie
- Baldwin Lee
- Banerjea Ayan
- Banks Victoria
- Barker Jonathon
- Bartlett Rachel
- Baxter Linden
- Baxter Stephen
- Beavis Sarah
- Belagodu Zakaulla
- Bell Louise
- Bell Stephanie
- Bengeri Sheshagiri
- Benlloch Raoul
- Bews-hair Maria
- Bhardwaj Sian
- Bhowmick Arnab
- Bion Julian
- Bion Julian
- Black Helen
- Blazeby Jane
- Blenk Karl
- Blunt Mark
- Bodger Phoebe
- Borgeaud Nathan
- Bothma Pieter
- Bothma Pieter
- Bottomley David
- Bowery Sarah
- Boyd Christine
- Bradburn Mike
- Bradburn Mike
- Brady Will
- Brennan Andrew
- Brennan Emma
- Brescia Giovanni
- Brett Stephen
- Broad Dan
- Brodbeck Andreas
- Bromilow James
- Bronder Christine
- Browell David
- Brown James
- Brown Stephanie
- Bryce Gavin
- Buckley Sarah
- Bunker Nick
- Burns Karen
- Burrow James
- Burrow James
- Burrows Lorna
- Burtenshaw Andrew
- Cabreros Leilani
- Cain Kathryn
- Cain Martyn
- Calder Verity
- Campbell Marta
- Campbell-smith Tim
- Carey Kate
- Carmichael Jack
- Cartmell Mark
- Cartwright Charles
- Cecconi Maurizio
- Chadwick Michael
- Chambers Rob
- Chan Peter
- Chana Avninder
- Chatzimichail Stelios
- Chitre Vivek
- Christie Iain
- Cirstea Emanuel
- Claxton Andrew
- Clement Ian
- Coldwell Chris
- Coleman Mark
- Colley Julie
- Collins Paddy
- Conway Daniel
- Cook Esther
- Cook Fabian
- Cook Nicola
- Cooke Katie
- Cope Sean
- Cornforth Belinda
- Correia Carmen
- Corson John
- Crabtree Michael
- Craven Rachael
- Cromwell David
- Cruickshank Neil
- Cuming Tamzin
- Cunha Pedro
- Cupitt Jason
- Curtis Edward
- D'souza Rovan
- Davies Peter
- Davis Emma
- Davis Huw
- Dawson Chris
- Debrunner Robert
- Desikan Somi
- Dhingsa Rajpal
- Dickinson Natalie
- Divekar Nandita
- Dodd Phil
- Dorman Frankie
- Doughan Samer
- Dowling Susan
- Downey Sarah
- Doyle Donna
- Drake Sharon
- Dreyer Fanus
- Dumpala Rajesh
- Durant Emma
- Edwards Jennifer
- Edwards Mark
- El-damatty Essam
- El-masry Nabil
- Engel Arnth
- Escofet Xavier
- Evans Thomas
- Everingham Kirsty
- Evley Rachel
- Faiz Omar
- Farhat Sami
- Farrow Catherine
- Fawcet Adrian
- Felipe Rowena
- Fernandes Roy
- Finch Guy
- Fitton Laura
- Fitzgerald Peter
- Fletcher Simon
- Fletcher Steve
- Flint Neil
- Forbes Gordon
- Freshwater-turner Dan
- Full Jens
- Furneval Julie
- Ganepola Ranjit
- Gardner Matt
- Garg Sudha
- Gaughan Matthew
- Gay Mike
- Geary Tim
- Gerrard David
- Gerstina Nabua
- Gibbs Richard
- Gibson Bruce
- Gibson Simon
- Gill Kathryn
- Gillies Michael
- Girgis Amira
- Girling Alan
- Gokhale Jay
- Gordon Anthony
- Graham Laura
- Graham Linda
- Greenwood Jamie
- Griffin Ruth
- Griffith John
- Griffiths Ewen
- Griffiths Megan
- Grocott Mike
- Gursevak Singh
- Gurung Sarada
- Guruswamy Raman
- Hadi Nada
- Haigh Fran
- Hale Beth
- Hales Dawn
- Hall Elizabeth
- Hall Elizabeth
- Hanousek Jan
- Harper Nick
- Harris James
- Harris Simon
- Harrison Ewen
- Harrison Paul
- Hartopp Richard
- Harvard Tim
- Harwood Elizabeth
- Haslop Richard
- Hayden Paul
- Henderson Steven
- Henwood Mark
- Hermandes Anil
- Hester Simon
- Hill Oliver
- Hilton Valerie
- Hodges Stacy
- Hollister Nigel
- Holt Peter
- Holtham Anitha
- Hool Alison
- Hopkins Phil
- Hopper John
- Horner Chris
- Howard-griffin Richard
- Howell Simon
- Howes Helen
- Hu Ying
- Hudson Liam
- Humes David
- Hurford Dom
- Husain Tariq
- Hutchinson Steve
- Iftikhar Syed
- Ijaz Sami
- Inglis David
- Iqbal Qamar
- Ishaan Maitra
- Jah Asif
- Jain Susan
- Janokowski Stas
- Januszewska Marta
- Jardine Catherine
- Jemmet Kim
- Jennings Adrian
- Jhamatt Anita
- Jovaisa Tomas
- Jovestani Keiarash
- Kahan Brennan
- Kahan Brennan
- Karat Isabella
- Karlikowsk Michael
- Karvonen Jyrki
- Kerry Sally
- Kerry Sally
- Khalaf Wael
- Khater Magdy
- Kightly Lynsey
- Kirby-bott James
- Kirk-bayley Justin
- Knight Georgia
- Knowles Charles
- Kocman David
- Kuduvalli Preeti
- Kukreja Neil
- Kuldip Rai
- Kumar Peeyush
- Kunst Gudrun
- Kushakovsky Vlad
- Laba Damian
- Lake Stephen
- Lal Roshan
- Lamb Peter
- Lams Edward
- Langton Helen
- Lawson Maria
- Lawton Greg
- Leno Emma
- Leuwer Martin
- Leuwer Martin
- Lewis Chris
- Lewis Ricky
- Liasis Lampros
- Lilford Richard
- Limb James
- Lindner Andrew
- Linnett Vanessa
- Lobo Dileep
- Lourtie Jose
- Lyness Craig
- Lynne Kaighan
- Lythell Nicola
- Machesney Michael
- Mackinnon John
- Macklin Christopher
- Mahajan Ravi
- Mahroof Razeen
- Maiya Bala
- Makris Nikolaos
- Marangoni Gabriele
- Martin Graham
- Martin Graham
- Martin Graham
- Martin Michael
- Marwick Jeremy
- Mason Nick
- Mateo Dolores
- May Denzil
- Mcafee Sean
- Mcarthur Carol
- Mccairn Amanda
- Mccullough Jonathan
- Mcilveen Erin
- Mclachan Jenny
- Mclaren Paul
- Mcmenemie Fiona
- Mcmullan Sean
- Mcnelis Una
- Medici Thomas
- Melville David
- Menezes Flavia
- Mercer Stuart
- Miller Andrew
- Millican Dean
- Milne Gordon
- Minto Gary
- Minto Gary
- Mirza Nazzia
- Misane Inga
- Modha Jigna
- Mohanty Manab
- Mohr Otto
- Mohsen Yasser
- Mole Jonathon
- Moncaster Gareth
- Monk David
- Monkhouse Diane
- Moonesinghe Ramani
- Morgan Richard
- Morgan-jones Tom
- Morris Craig
- Morrison Alan
- Mosley Frances
- Moug Susan
- Mukherjee Dipankar
- Mull Ajaya
- Mullenheim Jost
- Munro Mark
- Murray Dave
- Murray David
- Murray Diane
- Murray Therese
- Muthuswamy Babu
- Myers Alister
- Mythen Monty
- Nadarajavan Senthil
- Naik Veena
- Narula Harjeet
- Nash Guy
- Natarajan Nat
- Niebrzegowska Edyta
- Noble Hamish
- Noble Paul
- Noblett Sophie
- Northey Martin
- Nutt Chris
- O'carroll-kuehn Britta
- O'connell Gillian
- O'dwyer Grainne
- O'loughlin Paul
- Obichere Marion
- Obideyi Ayodele
- Odejinmi Oluremi
- Omer Abdel
- Outram Matt
- Owen Tom
- Owen Tom
- Paddle Jonathan
- Panikkar Kumar
- Papagrigoriadis Savvas
- Parker Thomas
- Parrington Simon
- Parry Jones Jack
- Parsons Anthony
- Patel Hitesh
- Patel Panna
- Patel Rajan
- Patel Sanjiv
- Patil Vishal
- Patrick Abigail
- Pearse Rupert
- Pearse Rupert M
- Peden Carol
- Peden Carol J
- Pemberton Phillippa
- Perrin-brown Laura
- Phull Mandeep
- Pick Sara
- Pickford Alison
- Pitman Catherine
- Pogson David
- Porter Helen
- Pow Colin
- Prabhudesai Ash
- Pratt Heather
- Prematie Andreou
- Prestwich Stewart
- Protopapas Michael
- Pulletz Mark
- Pulsa Stefan
- Pushpa Nathan
- Radford Nicola
- Rafi Amir
- Raj Ashok
- Rajagopal Ramesh
- Raju Pasupathy
- Raulusaite Ilona
- Razouk Khaled
- Reed Helen
- Rehman Almas
- Richardson Gerry
- Richardson Gerry
- Richardson Peter
- Riddington David
- Riddington Sid
- Rimmer Catherine
- Ritzema Jenny
- Rivett Kate
- Rivett Kate
- Robert Glenn
- Robin Nicole
- Rochester Chloe
- Rooney Kevin
- Rooney Laura
- Rope Tamsin
- Rose Alastair
- Ross-anderson Davina
- Roth Sally
- Rousseau Guy
- Roy Alistair
- Rubulotta Francesca
- Sagadai Saravanna
- Sanders Grant
- Sange Mansoor
- Saran Taj
- Sarfi Shameem
- Satisha Mallikarjunappa
- Saunders David
- Saunders David
- Scase Anne
- Schwarz Magen
- Scott Alexandra
- Sebastian Dominic
- Shah Tanuja
- Shankar Kirosh
- Sharma Abhiram
- Sharma Meghna
- Shaw Debbie
- Shawcross Robert
- Shenoy Shrisha
- Shukla Amit
- Silsby Joseph
- Sim Kevin
- Sim Malcolm
- Simeson Karen
- Singh Jagdeep
- Singh Satish
- Singh Surjait
- Sivasankaranand Ajit
- Sleight Simon
- Smart Simon
- Smith Hannah
- Smith Neil
- Snazelle Mark
- Somasekar Krishnamurthy
- Sonia Makvana
- Sonksen Julian
- Spimpolo Jennifer
- Stacey Brenda
- Stafford Helena
- Stanley David
- Stapleton Clare
- Stapleton Clare
- Stark Gail
- Steel Alistair
- Stephens Tim
- Stephens Tim
- Stergios Tezas
- Stevens Amanda
- Stevenson Richard
- Stewart Lynn
- Stone Julian
- Stotz Martin
- Stranix Nicola
- Stuart Hazel
- Subar Daren
- Sugavanam Anita
- Suggett Nigel
- Sunthareswaran Rame
- Surendran Karthik
- Susarla Jay
- Sutcliffe Robert
- Szakmany Tamas
- Szakmany Tamas
- Talwar Anjay
- Tan Kerwei
- Tan Melanie
- Tanqueray Tabitha
- Tansley John
- Tarrant Carolyn
- Taylor Lynn
- Thacker Andy
- Thomas Ruth
- Thomson Ann
- Thomson Ann
- Thorn Chris
- Thorniley Andrew
- Thrush Jessica
- Tierney Gill
- Tighe Sean
- Tofte Barclay
- Toth-tarsoly Piroska
- Townsend Roger
- Tucker Olga
- Tucker Vanessa
- Tutton Matthew
- Tyson Susan
- Ukoumunne Obioha
- Vaganov Sergei
- Van De Velde Niko
- Varcada Massimo
- Varma Sandeep
- Vashisht Shubha
- Velchuru Vamsi
- Verma Karan
- Vig Stella
- Vimalchandran Dale
- Visavadia Rakhee
- Vivek Chitre
- Waddy Sam
- Wakeford Julie
- Waldmann Carl
- Walker Simon
- Waring Justin
- Waring Justin
- Warusavitarne Janindra
- Watfah Josef
- Watson Geoff
- Watson Mark
- Watson Nicholas
- Watson Nick
- Watters Malcolm
- Way Carolyn
- Wells Duncan
- Wells Duncan
- Wells John
- Welsh Fenella
- Welters Ingeborg
- Wharton Richard
- White Andrew
- White Tim
- Wijeykoon Sanjay
- Wilkinson Jonny
- Wilkinson Mark
- Williams Alexandra
- Williams Dewi
- Williams Gail
- Williams Gethin
- Wilson Chris
- Wilson Graham
- Wilson Lawrence
- Wollaston Julie
- Wolverson Adam
- Wong Kate
- Wood Marcus
- Woods Justin
- Wrathall Wayne
- Wright Jenny
- Yang Fan
- Ziprin Paul
- Ziprin Paul
- Zuzan Oliver
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/06/2019
- Field of study
Background: Emergency abdominal surgery is associated with poor patient outcomes. We studied the effectiveness of a national quality improvement (QI) programme to implement a care pathway to improve survival for these patients. Methods: We did a stepped-wedge cluster-randomised trial of patients aged 40 years or older undergoing emergency open major abdominal surgery. Eligible UK National Health Service (NHS) hospitals (those that had an emergency general surgical service, a substantial volume of emergency abdominal surgery cases, and contributed data to the National Emergency Laparotomy Audit) were organised into 15 geographical clusters and commenced the QI programme in a random order, based on a computer-generated random sequence, over an 85-week period with one geographical cluster commencing the intervention every 5 weeks from the second to the 16th time period. Patients were masked to the study group, but it was not possible to mask hospital staff or investigators. The primary outcome measure was mortality within 90 days of surgery. Analyses were done on an intention-to-treat basis. This study is registered with the ISRCTN registry, number ISRCTN80682973. Findings: Treatment took place between March 3, 2014, and Oct 19, 2015. 22 754 patients were assessed for elegibility. Of 15 873 eligible patients from 93 NHS hospitals, primary outcome data were analysed for 8482 patients in the usual care group and 7374 in the QI group. Eight patients in the usual care group and nine patients in the QI group were not included in the analysis because of missing primary outcome data. The primary outcome of 90-day mortality occurred in 1210 (16%) patients in the QI group compared with 1393 (16%) patients in the usual care group (HR 1·11, 0·96â1·28). Interpretation: No survival benefit was observed from this QI programme to implement a care pathway for patients undergoing emergency abdominal surgery. Future QI programmes should ensure that teams have both the time and resources needed to improve patient care. Funding: National Institute for Health Research Health Services and Delivery Research Programme
Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery (EPOCH): a stepped-wedge cluster-randomised trial
- Author
- Abbott
- Abdel Omer
- Abhiram Sharma
- Abigail Patrick
- Adam Wolverson
- Adrian Fawcet
- Adrian Jennings
- Aggarwal
- Ahmed
- Ajaya Mull
- Ajit Abraham
- Ajit Sivasankaranand
- Alan Girling
- Alan Morrison
- Alastair Ankers
- Alastair Rose
- Alexandra Scott
- Alexandra Williams
- Alison Hool
- Alison Pickford
- Alistair Roy
- Alistair Steel
- Alister Myers
- Almas Rehman
- Amanda McCairn
- Amanda Stevens
- Amir Rafi
- Amira Girgis
- Amit Shukla
- Ana Alegria
- Anderson
- Andreas Brodbeck
- Andreou Prematie
- Andrew Brennan
- Andrew Burtenshaw
- Andrew Claxton
- Andrew Lindner
- Andrew Miller
- Andrew Thorniley
- Andrew White
- Andy Thacker
- Anil Hermandes
- Anita Jhamatt
- Anita Sugavanam
- Anitha Holtham
- Anjay Talwar
- Ann Thomson
- Ann Thomson
- Anne Scase
- Anthony Gordon
- Anthony Parsons
- Arnab Bhowmick
- Arnth Engel
- Ash Prabhudesai
- Ashok Raj
- Asif Jah
- Auerbach
- Avninder Chana
- Ayan Banerjea
- Ayodele Obideyi
- Babu Muthuswamy
- Bala Maiya
- Banwari Agarwal
- Barclay Tofte
- Batalden
- Belinda Cornforth
- Benning
- Beth Hale
- Biju Aravind
- Bion
- Brenda Stacey
- Brennan C Kahan
- Brennan Kahan
- Britta O'Carroll-Kuehn
- Bruce Gibson
- Carl Waldmann
- Carmen Correia
- Carol J Peden
- Carol Mcarthur
- Carol Peden
- Carolyn Tarrant
- Carolyn Way
- Catherine Farrow
- Catherine Jardine
- Catherine Pitman
- Catherine Rimmer
- Charles Cartwright
- Charles Knowles
- Chitre Vivek
- Chloe Rochester
- Chris Coldwell
- Chris Dawson
- Chris Horner
- Chris Lewis
- Chris Nutt
- Chris Thorn
- Chris Wilson
- Christine Boyd
- Christine Bronder
- Christopher Macklin
- Clare Stapleton
- Clare Stapleton
- Colin Pow
- Craig Lyness
- Craig Morris
- Dale Vimalchandran
- Damian Laba
- Damschroder
- Dan Broad
- Dan Freshwater-Turner
- Daniel Conway
- Daren Subar
- Dave Murray
- David Bottomley
- David Browell
- David Cromwell
- David Gerrard
- David Humes
- David Inglis
- David Kocman
- David Melville
- David Monk
- David Murray
- David Pogson
- David Riddington
- David Saunders
- David Saunders
- David Stanley
- Davina Ross-Anderson
- Dawn Hales
- Dean Millican
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- Dom Hurford
- Dominic Sebastian
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- Duncan Wells
- Edward Curtis
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- Esther Cook
- Everingham
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- Georgia Knight
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- Sandeep Varma
- Sanjay Wijeykoon
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- Sarah Bowery
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- Saravanna Sagadai
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- Savvas Papagrigoriadis
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- Sean Cope
- Sean McAfee
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- Sedgwick
- Senthil Nadarajavan
- Sergei Vaganov
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- Sharon Drake
- Sheshagiri Bengeri
- Shrisha Shenoy
- Shubha Vashisht
- Sian Bhardwaj
- Sid Riddington
- Simon Bailey
- Simon Fletcher
- Simon Gibson
- Simon Harris
- Simon Hester
- Simon Howell
- Simon Parrington
- Simon Sleight
- Simon Smart
- Simon Walker
- Singh Gursevak
- Somi Desikan
- Sophie Noblett
- Stacy Hodges
- Stas Janokowski
- Stefan Pulsa
- Stelios Chatzimichail
- Stella Vig
- Stephanie Bell
- Stephanie Brown
- Stephen Baxter
- Stephen Brett
- Stephen Lake
- Stephens
- Steve Fletcher
- Steve Hutchinson
- Steven Henderson
- Stewart Prestwich
- Stuart Mercer
- Sudha Garg
- Surjait Singh
- Susan Dowling
- Susan Jain
- Susan Moug
- Susan Tyson
- Susie Baker
- Syed Iftikhar
- Tabitha Tanqueray
- Taj Saran
- Tamas Szakmany
- Tamas Szakmany
- Tamsin Rope
- Tamzin Cuming
- Tanuja Shah
- Tariq Husain
- Tengberg
- Tezas Stergios
- Therese Murray
- Thomas Evans
- Thomas Medici
- Thomas Parker
- Tim Campbell-Smith
- Tim Geary
- Tim Harvard
- Tim Stephens
- Tim Stephens
- Tim White
- Tom Abbott
- Tom Morgan-Jones
- Tom Owen
- Tom Owen
- Tomas Jovaisa
- Una McNelis
- Valerie Hilton
- Vamsi Velchuru
- Vanessa Linnett
- Vanessa Tucker
- Veena Naik
- Verity Calder
- Vester-Andersen
- Victoria Banks
- Vishal Patil
- Vivek Chitre
- Vlad Kushakovsky
- Wael Khalaf
- Wayne Wrathall
- White
- White
- Will Brady
- Williams
- Xavier Escofet
- Yasser Mohsen
- Ying Hu
- Zakaulla Belagodu
- Publication venue
- 'Elsevier BV'
- Publication date
- 05/10/2018
- Field of study
BACKGROUND: Emergency abdominal surgery is associated with poor patient outcomes. We studied the effectiveness of a national quality improvement (QI) programme to implement a care pathway to improve survival for these patients. METHODS: We did a stepped-wedge cluster-randomised trial of patients aged 40 years or older undergoing emergency open major abdominal surgery. Eligible UK National Health Service (NHS) hospitals (those that had an emergency general surgical service, a substantial volume of emergency abdominal surgery cases, and contributed data to the National Emergency Laparotomy Audit) were organised into 15 geographical clusters and commenced the QI programme in a random order, based on a computer-generated random sequence, over an 85-week period with one geographical cluster commencing the intervention every 5 weeks from the second to the 16th time period. Patients were masked to the study group, but it was not possible to mask hospital staff or investigators. The primary outcome measure was mortality within 90 days of surgery. Analyses were done on an intention-to-treat basis. This study is registered with the ISRCTN registry, number ISRCTN80682973. FINDINGS: Treatment took place between March 3, 2014, and Oct 19, 2015. 22â754 patients were assessed for elegibility. Of 15â873 eligible patients from 93 NHS hospitals, primary outcome data were analysed for 8482 patients in the usual care group and 7374 in the QI group. Eight patients in the usual care group and nine patients in the QI group were not included in the analysis because of missing primary outcome data. The primary outcome of 90-day mortality occurred in 1210 (16%) patients in the QI group compared with 1393 (16%) patients in the usual care group (HR 1·11, 0·96-1·28). INTERPRETATION: No survival benefit was observed from this QI programme to implement a care pathway for patients undergoing emergency abdominal surgery. Future QI programmes should ensure that teams have both the time and resources needed to improve patient care. FUNDING: National Institute for Health Research Health Services and Delivery Research Programme
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro CarĂ Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
- Austin Karen
- Austin Pauline
- Auvet Adrien
- Avard Bronwyn
- Awan Sidra
- Ayee Robert
- Azaiz Amine
- Azzaui Harun
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
- Bailey Lucy
- Baillie Kenneth
- Bain William
- Baker Alice
- Baker Evelyn
- Baker Stuart
- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
- Balls-Burgess Sam
- Bamford Amy
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbash Ian
- Barber Russell
- Barbier François
- Barge Deborah
- Bariola Ryan
- Barker Gareth
- Barker Stephanie
- Barnes Nicky
- Baron Rebecca M.
- Barreau Amelie
- Barreau Amélie
- Bart Robert
- Bartholomew Jazz
- Bartley Shauna
- Barton David
- Barton Frances
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bassford Christopher
- Bastos Joana Margarida Pereira Sousa
- Bates Michelle
- Bates Samantha
- Batista Teresa Margarida Oliveira
- Bauchmuller Kris
- Bayne Madeleine
- Bean Sarah
- Beane Abi
- Beane Abigail
- Beard Gregory
- Beasley Richard
- Beaudoin Rosalie
- Beavis Sarah
- Beddows Seonaid
- Bedford Caroline
- Beer Deborah
- Beer Sally
- Begin Phillipe
- Begum Salma
- Bell Gillian
- Bellemare David
- Belletti Allesandro
- Bendjemar Lynda
- Benettaib Fatna
- Bensen Nicole
- Bentley Andrew
- Benyon Sarah
- Benzekri Dalila
- Beqai Besa
- Berdaguer Fernando
- Beresford Stephanie
- Bergin Colin
- Berry Lindsay R.
- Berry Scott
- Berryman Emily
- Bertel Melanie
- Best-Lane Janis
- Besten Henny
- Bevan Emily
- Bewley Jeremy
- Beyerl Ashley
- Bhagani Sanjay
- Bhandal Khushpreet
- Bharaj Kiranjit
- Bhattarai Bina
- Bhattarai Binita
- Bhonagiri Deepak
- Biddie Simon
- Bigas Judit
- Bihari Shailesh
- Bin Hasan Mohd Shahnaz
- Bindels Manon
- Binnie Alexandra
- Biradar Vishwanath
- Birch Catherine
- Birch Janine
- Birch Sophie
- Birchall Kathrine
- Birkinshaw Isobel
- Black Ethel
- Blackledge Bethany
- Blakemore Hayley
- Blanck Wendy
- Bland Yvonne
- Blank Elisabeth
- Bleasdale John
- Bloomfield Jack
- Bloos Frank
- Board Jasmin
- Boardman Melanie
- Boari Gianluca
- Bocher Simon
- Bociek Aneta
- Boivin Anne-Helene
- Boivin Anne-HĂ©lĂšne
- Bojunga Jörg
- Bomken Charlotte
- Bonaccorso Allesandra
- Bongaerts Katherine
- Bonner Stephen
- Bonten Marc J. M.
- Borgatta Barbara
- Borislavova Borislava
- Borrill Zoe
- Boschert Catherine
- Bossard Isabelle
- Bothma Pieter
- Boudineau Michel
- Boulanger Marie-Claude
- Boumahni Dounia
- Bouman Angela
- Bounab Rania
- Bourgoin Charlotte
- Bourne Michelle
- Bourne Richard
- Boutin Mireille
- Bouvier Elodie
- Bouw-Ruiter Marianne
- Boué Yvonnick
- Bowen James
- Bowler Helen
- Boyd Craig
- Boyles Rebecca
- Bracke Stephanie
- Bradbury Charlotte A.
- Bradley Paul
- Brady Kara
- Brailsford Jane
- Brain Matthew
- Brakké Karen
- Brant Emily
- Brasselet Aurélie
- Breen Patrick
- Bremmer Pamela
- Brend Morwenna
- Brennan Aoife
- Bretagnol Anne
- Brett Stephen
- Brewer Chris
- Brickell Kathy
- Bridges Sarah
- Brieger Klaus-Gerd
- Brightling Chris
- Brimfield Lutece
- Brittain Michael
- Britton Kate
- Brochard Laurent
- Brodbeck Andreas
- Brohi Farooq
- Brooks Nicole
- Brown Cynthia
- Brown Julia
- Brown Louise
- Brown Nerissa
- Brown Zarah
- Brugman Curt
- Brunetta Enrico
- Brunkhorst Frank M.
- Brunskill Nigel
- Bryan-Morris Kayla
- Bryden Emma
- Budd Joanna
- Buehner Ulrike
- Buhay Megan
- Buhr Heidi
- Burbee Dylan
- Burda Dorota
- Burgess Richard
- Burke David
- Burke Tara
- Burkey Jason
- Burnish Rachel
- Burns Dean
- Burns Karen
- Burrell Aidan
- Burt Karen
- Buscher Hergen
- Butler Amelia
- Butler Magdalena
- Butler Susan
- Buxton Meredith
- Buzgau Adrian
- Byrne Kathleen
- Byrne Rahim
- Cabrelli Louise
- Cabreros Leilani
- Cairns Tom
- Calfee Carolyn
- Callahan Jean-Christophe
- Cambalova Lenka
- Campbell Andrew
- Campbell Bridget
- Campbell Debbie
- Campbell Hilary
- Campbell Lewis
- Campbell Marion
- Campbell Ryan
- Campion Alexandra
- Campisi Josie
- Camsooksai Julie
- Caplin Cecile
- Carbonneau Elaine
- Carmichael Samantha
- Carmona Rosario
- Carn Vanessa
- Carpio Lillian
- Carr Zoe
- Carr-Wilkinson Joanne
- Carrier François
- Carrier Marc
- Carter Angus
- Carter Brittney
- Carter David
- Carter Jay
- Carter Michael
- Casali Sherry
- Casey Ruth
- Casey Siobhan
- Castelain Vincent
- Castle James
- Cathcart Susanne
- Catorze Nuno José Teodoro Amaro dos Santos
- Cattelan Jessy
- Cavayas Alexandros
- Cawley Kathryn
- Cecconi Maurizio
- Centofanti John
- Chambers Emma
- Champanerkar Shreekant
- Chan Carmen
- Chan Charles
- Chan Peter
- Chapman Rachel
- Chapman Susan
- Charles Bethan
- Charles Walton
- Charlewood Richard
- Charlton Sam
- Charron Cyril
- Chartier Delphine
- Chasse Michael
- Chassé Michaël
- Chen Jonathan
- Chen Lixian
- Chen Yan
- Cheng Allen C.
- Cherian Shiney
- Chhablani Manish
- Chin Teri
- Chudeau Nicolas
- Chukkambotla Sri
- Ciccarelli Michele
- Cirstea Emanuel
- Clair Bernard
- Clark Amy
- Clark Michele
- Clark Richard
- Clark Sarah
- Clarke Frances
- Clarke Jennifer
- Claxton Andrew
- Cleary Joanne
- Clement Ian
- Clere-Jehl Raphael
- Clermont Giles
- Clermont Gilles
- Clinton Alison
- Cloutier Ăve
- Cockrell Maeve
- Codreanu Daniel
- Coetzee Samantha
- Coghlan Phoebe
- Cole Jade
- Coles Jennifer
- Colin Gwenhael
- Collier Dawn
- Collins Amy
- Collins Daniel
- Collins Emma
- Collins Joanne
- Collins Ărin
- Collis Matthew
- Combaux Daniele
- Commons Robert
- Comp Susan
- Concha Pablo
- Connolly Karen
- Constantini Elena
- Constantino-Occhipinti Claudia
- Contou Damien
- Convery Karen
- Conway Robert
- Conzelmann Nadine
- Cook Deborah
- Cook Tim
- Cooke Jill
- Cooke Justin
- Cooper Jamie
- Cooper Josh
- Cooper Lauren
- Cooper Melanie
- Cooper Nichola
- Corbett Sarah
- Corcoran Ele
- Corcoran Kathleen
- Cornell Sarah
- Cornell Thomas
- Cort Jon
- Costerousse Olivier
- Couillard-ChĂ©nard Ămilie
- Courtin Laura
- Coutts Amanda
- Couture Lourie
- Cove Matthew
- Cowdrey Keri-Anne
- Cowley Nicholas
- Cowton Amanda
- Coyne Mark
- Craddock Richard
- Craner Michelle
- Craven Thomas
- Crawshaw Sarah
- Creagh-Brown Ben
- Creange Vanessa
- Cremer Olaf
- Crisp Nikki
- Croft Maria
- Csabi Peter
- Cudlipp Joanna
- Cuesta Jeronimo
- Cuffaro Raffaele
- Curley Gerard
- Currie Andrew
- Cusack Rebecca
- Cuthbertson Brian
- Cutler Sean
- CĂĄrcel Sheila
- CĂŽtĂ© Ămilie
- D?Amato Fabiola
- D?Aragon Frédérick
- Daebis Admad
- Daher Rana
- Dale Katie
- Daley Jessica
- Dalton James
- Daly James
- Daly Zoe
- Daneman Nick
- Dark Paul
- Darnell Robert
- Darreau Cedric
- Daugherty Jason
- Davey Miriam
- Davidson Neil
- Davies Ellie
- Davies Gwyneth
- Davies Jennifer
- Davies Louisa
- Davies Michelle
- Davies Rhys
- Dawson Laura Ann
- Dawvda Ashlish
- Day Christopher
- Da Rocha Joana
- De Bus Liesbet
- de Courcy-Golder Kim
- de Groot Klaas
- de Jong Menno
- de Jonge Evert
- De Keulenaer Bart
- de la Torre Cisneros Julian
- de Man Angelique
- De Neef Mark
- De Smeytere Anouska
- Deacon Bethan
- Dean Steven
- Dean Tessa
- Dearden Joy
- Dechert William
- Declercq Pierre-Louis
- Degracia Anna
- del Sorbo Lorenzo
- Dela Rosa Arnold
- Delaney Kirsha
- Dell Abbie
- del Prado Michael
- Demetriou Carrie
- Dempster Debra
- Denham Lynn
- Denmade Craig
- Dent Martin
- Depante Maria
- Depuydt Pieter
- Dequin Pierre-François
- Derde Lennie P. G.
- Deshpande Kush
- Detry Michelle A.
- Deye Nicolas
- de la Fuente Carmen
- De Waele Jan
- Dheke Krishan
- Di Lucca Giuseppe
- Dias Priya
- Dice Julie
- Digby Stephen
- Diridis Kristina
- Distler Michael
- Dobell-Brown Kelsey
- Doble Patricia
- Dobson Jade
- Doherty Kaleigh
- Doherty Ronan
- Doi Yohei
- Dolman Rozzie
- Domingo-Marco Joana
- Donadee Chenell
- Donaldson Kate
- Dondrop Arjen
- Donegan Clare
- Donlon Sinead
- Donnelly Adrian
- Donnelly Kieran
- Donnison Phil
- Doonan Reece
- Doran Peter
- Dore Rachael
- Dormand Natalie
- Dos Santos Filipa
- Douillard Thomas
- Drake Chelsea
- Drapola Debra
- Drayss Maria
- Drummond Andrew
- Drury Kay
- Duan Erick
- Duberley Stephen
- Duffy Eamon
- Duffy Oscar
- Duke Graeme
- Duke Zoe
- Duncan Tracy
- Dunsavage Janice
- Duplaix Mathilde
- Duric Natalie
- Duroux Maree
- Dushianthan Ahilanandan
- Dyas Sarah
- Eapen Beena
- Eastgate Christine
- Ebenezer R
- Edmunds Natasha
- Edwards Alexandra
- Efford Georgia
- Egreteau Pierre
- Ehrmann Stephan
- Eichenauer Dennis
- Eisenbeis Simone
- Ekhérian Jean-Michel
- El-Khawas Khaled
- Elender Corinna
- Elgendy Ahmad
- Elhassan Munzir
- Ellervee Anneli
- Ellis Chiara
- Ellis Christine
- Ellis Yvette
- Elmahi Einas
- Elsefi Tarek
- Eltayeb Ayaa
- Elvira Evangeline
- England Jenna
- Englert Sarah
- English Shane
- Epelmanž Slava
- Eroglu Ege
- Estcourt Lise J.
- Estensen Kristen
- Evans Amy
- Evans Andrew
- Evans Debra
- Evans Gabrielle
- Everitt Robert
- Evers Mirjam
- Evetts George
- Ewalds Esther
- Ezekowitz Justin
- Fagan Laura
- Fagbodun Elizabeth
- Farahi Neda
- Fareed Komal
- Farnell-Ward Sarah
- Fartoukh Muriel
- Faulkner Beverley
- Faulkner Maria
- Fazla Fathima
- Featherstone Peter
- Felton Tim
- Fennessy Gerard
- Ferguson Niall
- Ferguson Susan
- Fergusson Dean
- Fernandes Edna
- Fernandez Maria
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- Fernåndez de Pinedo Artaraz Ziortza
- Ferreira Ricardo Manuel Castro
- Ferrier Janet
- Ferringer Cindy
- Fesz Jessica
- Fierens Jan
- Finch Cheryl
- Finn André
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- Fowler Robert
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- Fragner Gertrud
- Frakking Thuy
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- Fujitani Shigeki
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- Goddard Wendy
- Godement Mathieu
- Godoy Lucas C.
- Goebeler M.E.
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- Gopinath Amitha
- Goralski Patricia
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- Gosbell Iain
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- Halden Sandra
- Haldeos Anne
- Hall Alistair S
- Hall Amelia
- Hall Andrew
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- Hammond Naomi
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- Harris Jade
- Harris John
- Harrison David A.
- Harrison Susan
- Harrow Kath
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- Harvala-Simmonds Heli
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- Healey Gail
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- Hegazy Mohamed
- Heinonen Jonna
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- Henry Joanne
- Henry Lavinia
- Hensley Joseph
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- Hernandez Erik
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- Hey Samuel
- Hickey John
- Hierons Sarah
- Higgins Alisa M.
- Hill Claire
- Hill Dianne
- Hill Helen
- Hilldrith Anette
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- Hin Lui Lok
- Hindle Grace
- Hinrichs Carl
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- Hodge Christopher
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- Homes Jennifer
- Honda Hitoshi
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- Hormis Anil
- Horner Dan
- Hornsby James
- Horton Michelle
- Horvat Christopher M.
- Howcroft Clare
- Howell Alice
- Hower Martin
- Howie Lucy
- Howle Ryan
- Hoxha Elvira
- Huang David T.
- Hughes Debbie
- Hugill Keith
- Huijbens Danique
- Hullegie Sebastiaan
- Hulley Amanda
- Hulme Jonathan
- Hulse Sarah
- Humphrey Charlotte
- Hunt Beverley
- Hunter Stephanie
- Hurford Sally-Anne
- Hussain Mahwish
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- Hutchinson Christina
- Hutton Paula
- HĂŒning Vanessa
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- Ijaz Nazia
- Ikhena Ikhuemose
- Inskip Deborah
- Irving Ben
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- Ivatt Helen
- Jackson Carolyn
- Jackson Shane
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- Jacob Reni
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- Jafarzadeh Mina
- Jagannathan Vijay
- Jain Susan
- James Augustian
- James Christie
- Jan Hassing Robert
- Janin Pierre
- Jarczak Dominik
- Jarman Claire
- Jayakumar Deva
- Jayakumar Devachandran
- Jean-Pierre Eraldi
- Jeblaoui Asma
- Jenkins Samuel
- Jenkins Sarah
- Jenkins Steve
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- Jepson Eleanor
- Jerenec Katja
- Jesty Robert
- Jha Avinash
- Jha Rajeev
- Jhanji Shaman
- Jin Xia
- Jindai Kazuaki
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- Jongebloed Katherine
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- Juffermans Nicole
- Juhaz Vera
- Kadam Umesh
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- Kalchthaler Kyle
- Kaliappan Agilan
- Kalla Ismail
- Kalogirou Michael
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- Kamel Toufik
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- Kamra Maneesha
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- Karachi Tim
- Karim Hina
- Karki Rakshya
- Karlikowski Michal
- Karlsson Sari
- Kasipandian Vidya
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- Katary Amro
- Kato Hideaki
- Kavanagh Lisa
- Kayani Abdul
- Kayastha Srijana
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- KC Shirsh
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- Keeler Sheryl
- Keen Alexandra
- Keen Sherbrina
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- Kelsall Olivia
- Kendrick Sara
- Kernan Maeve
- Kerslake Ian
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- Khare Divya
- Khoso Nasir
- Khoud Ahmed
- Khwaja Kosar
- Kidwai Aneela
- Kiiski Heikki
- Kilner Mari
- Kim Edy Y.
- Kimpton Sarah
- King Andrew
- Kinney Fiona
- Kirk Jill
- Kirk Rosemary
- Kirkby Amy
- Kirkham Simon
- Kit Barbara
- Kitsios Georgios
- Kittridge Lauren
- Klein Daniela
- Klop-Riehl Margreet
- Kluge Stefan
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- Kochanek Matthias
- Kochert Erik
- Koelink Maaike
- Koirala Kanchan
- Koirala Sabin
- Kolanos Steffi
- Kolovou Angeliki
- Konecny Pam
- Kong Jing
- Koopmans Matty
- Kosa Alma
- Kremling Julius
- KreĂ Gabriele
- Krishnamoorthy S
- Krishnamurthy Vinodh
- Kruger Peter
- Kruisdijk-Gerritsen Arriette
- Kruisselbrink Rebecca
- Kuitunen Anne
- Kumar Anand
- Kumar Nikhil
- Kumar Rohit
- Kummerlen Christine
- Kunishima Hiroyuki
- Kunwar Puja
- Kunz Kevin
- Kurenda Catherine
- Kutsogiannis Demetrios
- Kuybida Yuriy
- Kwan Yvonne
- Kyeremeh Lynsey
- Kyle Laura
- L?Hotellier Sylvie
- Labbe Vincent
- Laffan Mike
- Laffey John
- Laha Shondipon
- Lai Vivian
- Lambert Bridget
- Lamontagne Francois
- Lampro Lamprini
- Landais Michaël
- Landoni Giovanni
- Landsiedel-Mechenbier Elke
- Lang Eva
- Langridge Emma
- Latham Victoria
- Latino Reece
- Laudi Svenja
- Laugs Fabian
- Lavana Jayshree
- Laver Russell D.
- Law Daniel
- Lawler Patrick R.
- Le Basnier Elliot
- Le Guen LenaĂŻg
- Le Loup Guillaume
- Leaf David E.
- Lean Richard
- Leaver Susannah
- Leavis Helen
- Leblond Julie
- Leditschke Anne
- Lee Kelvin
- Lee Stephanie
- Lee Stephen
- Lefevre Montaine
- Leffelaar Evelien
- Lehalleur Adrien
- Lellouche Francois
- Lemaire-Brunel Delphine
- Lembo Rosalba
- Leparco CĂ©cile
- Leroyer Marie-Helene
- Lesona Eden
- Levett Chris
- Lewis Joanne
- Lewis Roger J.
- Lewis Sarah
- LewisProsser Lorraine
- Liao Angela
- Lim Rosario
- Limb James
- Lindergard Gabriella
- Linnett Vanessa
- Linstrum Kelsey M.
- Litton Ed
- Litton Edward
- Liu Theresa
- Lizotte Patricia
- Lock Stephen
- Lockett Teresa
- Logan Meg
- Lomme Kaatje
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- Lopus Alyssa
- Lorenzi Elizabeth
- Lother Sylvain
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- Luo Ji
- Lye Alison
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- LĂłpez Maria
- LĂłpez Rafael
- Löbel Madlen
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- Madarbukus Daanyaal
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- Maiden Matthew
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- Makky Ahmed
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- Mali Sharmila
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- Manley Rachel
- Manoharan Venika
- Maquigneau Natacha
- Marchesi Mattia
- Mariappa Vasanth
- Marin-Corral Judith
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- Markota Andrej
- Marmol Joy
- Marnai Remy
- Marriot Cheryl
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- Marroquin Oscar
- Marsden Tracy
- Marsh Emma
- Marshall John C.
- Marshall Lucy
- Marten Nicole
- Martin Elise
- Martin Emma
- Martin Jane
- Martin Laila
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- Martin-Lazarro Juan
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- Martucci Antonio
- Martynoga Robert
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- Mason Brittany
- Masood Sobia
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- Masse Marie-Helene
- Massey Natalie
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- Mataliotakis Michail
- Mathew Meghena
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- Mathonnet Armelle
- Matimba-Mupaya Wadzanai
- Matsa Ramprasad
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- Maxime Virginie
- Mayak Katelyn
- Mayangao Irving
- Maynard Victoria
- Mayr Florian
- Mc-Kenzie Josette
- McAdams David
- McArthur Colin J.
- McAuley Daniel F.
- McAuley Julie
- McCallion Edmund
- McCarthy Aine
- McClintock Declan
- McConnochie Rachael
- McCracken Phoebe
- McCreary Erin
- McCreath Gordan
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- McCullagh Liz
- McCulloch Corrienne
- McCullough James
- McDonald Bree
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- McEldrew Ben
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- McEvoy Natalie
- McGain Forbes
- McGarry Karen
- McGhee Christopher
- McGlothlin Anna
- McGloughlin Steve
- McGlynn Deborah
- McGoldrick Clare
- McGuigan Peter
- McGuinness Shay P.
- McIntyre Joanne
- McIntyre Lauralyn
- McKee Madeleine
- McKenna Shirley
- McKenna Sonia
- Mckeon Laurie
- Mclaughlan Danielle
- McMaster Moyra
- McMillan Alexandra
- McMillan Catherine
- McMillan Helen
- McMorrow Liam
- McNamara Amanda
- McNamara Robert
- McNicholas Bairbre
- McQuilten Zoe
- McVerry Bryan J.
- McWilliam Stephen
- Medhurst Laura
- Medva Rebecca
- Meermeier Werner
- Megarbane Bruno
- Mehrtens Jan
- Mehta Reena
- Meijer Karina
- Menon David
- Mercier Emmanuelle
- Mercier Romain
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- Metherell Stella
- Meunier Juliette
- Mevavala Bhaumik
- Mew Louise
- Meyer Jason
- Mezher Chaouki
- Meziani Ferhat
- Mfuko Celina
- Mguni Nhlanhla
- Michael Angiy
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- Middledorp Saskia
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- Millen Tina
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- Moakes Emma
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- Morel Guillaume
- Morgan Karen
- Morgan Matt
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- Mouncey Paul R.
- Mowery Brent
- Mrad Aymen
- Mtuwa Shelia
- Mukherjee Dipak
- Mulder John
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- Murphy Aisling
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- Mwaura Esther
- Mwembani Tina
- Naeem Anas
- Naidu Brintha
- Naim Giulia
- Nair Priya
- Nakamuro Hiromi
- Nakazono Kenichi
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- Nand Kiran
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- Nay Mai-Anh
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- Naz Mobeena
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- Nee Jens
- Neill Andy
- Nelli Apoorva
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- Nemeth-Roszpopa Karolina
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- Netherton Kimberley
- Neto Ary
- Newbould David
- Newlands Jessica
- Newman Julie
- Newman Tabitha
- Ng Anthony
- NG Christopher
- Nguyen Philippe
- Nguyen-Valat Thi-My-Hue
- Nichol Alistair D.
- Nicholier Tiphaine
- Nicholson Andrew
- Nicholson Anne
- Nicholson Sarah
- Nickoleit-Bitzenberger Daniela
- Nierhaus Axel
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- Nygren Maria
- O Rourke Kate
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- O?Brien Julie
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- O?Halloran Sinead
- O?Kane Cecilia
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- O?Reilly Kevin
- Oakley Susan
- Oborska Aneta
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- Ochin Evelina
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- Oliver Martyn
- Omer Nimca
- Oncea Lynne
- Orford Neil
- Oritz-Ruiz de Gordoa Laura
- Orlikowska Izabela
- Orlikowski David
- Orr Katrina
- Osagie Rawlings
- Osborne Alexander
- Osborne Jason
- Osinga Margreet
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- Ottens Thomas
- Owen David R. J.
- Oza Deepali
- Padmakumar Anand
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- Paneru Hem
- Panjwani Ashok
- Panwar Rakshit
- Pappa Evita
- Paramasivam Elankumaran
- Parekh Dhruv
- Parikh Harshel G.
- Parke Rachael L.
- Parker Jane C.
- Parker Lorraine
- Parker Natasha
- Parmar Dinesh
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- Pasieka Bastian
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- Phalod Gunjan
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- Plummer Bethany
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- Pogson David
- Polfliet Margot
- Polgarova Petra
- Polley Grace
- Pollock Katrina M.
- Pomeroy Fiona
- Poojara Latesh
- Pooni Jagtar- Singh
- Porteous Rebecca
- Porter David
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- Raithatha Ajay
- Raj Ashok
- Ralston Maximillian
- Ramakrishnan N
- Ramali Mohamed
- Ramamurthi Balaji
- Ramanan Mahesh
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- Ramos Lidia
- Randell Georgina
- Rangan Ritika
- Ranganathan Lakshmi
- Rao Deepak
- Rashan Aasiyah
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- Ratcliffe Megan
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- Reay Michael
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- Rounds Charles
- Rovere-Querini Patrizia
- Rowan Kathryn M.
- Rowe-Leete Louise
- Rowland Matthew
- Roy Alistair
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- RueĂ-Paterno Giusi
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- Salvati Stefano
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- Sandhu Gyan
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- Santamaria John
- Santos Filipa
- Santos Marlene S.
- Sapsford David
- Sara Treena
- Saran Anita
- Sathe Sonia
- Sathianathan Kushaharan
- Sathianathan Prasannakumari
- Saull Michelle
- Saunders Christina T.
- Saunderson Paula
- Sauras-ColĂłn Esther
- Saxena Manoj
- Sayada Sarah
- Sayehli Cyrus
- Scanlan Jeremy
- Scano Riccardo
- Schaaf Bernhard
- Schlegel Christian
- Schmidhofer Mark
- Schneider Francis
- Schoenling Andrew
- Scholl Denise
- Schotsman Joost
- Schouten Jeroen
- Schueler Robert
- Schuster-Bruce Martin
- Schutgens Roger
- Schweikert Sacha
- Scott Kathryn
- Scott Zoe
- Scully Michael
- Seaman Rebecca
- Seidel Antje
- Seidu Fatima
- Seigne Patick
- Sekiwala Rose
- Sellers Katharine
- Selmi Carlo
- Sement Arnaud
- Senya Ho
- Seppelt Ian
- Sernicola Elisa
- Serri Karim
- Sevilla Chanthou
- Seymour Christopher W.
- Shah Faraaz
- Shahid Tasnin
- Shaikh Arif
- Shaikh Mohiuddin
- Shakya Roshni
- Shankar-Hari Manu
- Sharma Deepak
- Shaw David
- Shaw Deborah
- Shaw Joanne
- Shearer Audrey
- Sheath Ben
- Sheffield Jonathan
- Shehabi Yahya
- Shekar Kiran
- Shelton Sarah
- Sherwood Nick
- Shetty Varun
- Shields Fiona
- Shimabukuro-Vornhagen Alexander
- Shintani Ayumi
- Shirley Kim
- Shovelton Charmaine
- Shree Madhu
- Shrestha Namrata
- Shrestha Sabita
- Shrestha Tapaswi
- Shu Ki Lok Jennifer
- Shyamsundar Murali
- Siami Shidasp
- Sibin Sindhu
- Sicat Christine
- Siddiqui Atif
- Siddiqui Ayesha
- Sidéris Georgios
- Siewerski Chris
- Siika Wangari
- Sikondari Nyma
- Silversides Jon
- Sim Malcolm
- Simmonds Catherine
- Simons Koen
- Simpson Benjamin
- Simpson Joanna
- Simpson Scott
- Simpson Tom
- Sinclair Julie-Ann
- Singh Jayaprakash
- Singh Rajeev
- Singh Vanessa
- Singler Karen
- Singleton Jo
- Sinha Pratik
- Skinner Denise
- Skinner Tabitha
- Skorko Agnieszka
- Skrtich Aimee
- Slaughter Melanie
- Slieker Kitty
- Sligl Wendy
- Sloan Andrew
- Sloots-Cuppen Sonja
- Small Charlotte
- Smallshaw Karen
- Smallwood Andrew
- Smee Joanna
- Smit Albertine
- Smith Alex
- Smith Catherine
- Smith Eleanor
- Smith Emma
- Smith John
- Smith Judith
- Smith Julie
- Smith Kerry
- Smith Lucie
- Smith Matthew
- Smith Natalie
- Smith Oliver
- Smith Paul
- Smith Simon
- Smith Tim
- Smuts Sara
- Smyth Kirsty
- Smyth Michelle
- Smyth Naoise
- Soar Natalie
- Solesbury Amanda
- Somerville Alastair
- Song Rima
- Soukup Jens
- Southern David
- Southin Sara
- Spain Sandra
- Speight Holly
- Spencer Kayleigh
- Spencer Stephen
- Spencer Thomas
- Speyer Rebecca
- Spiers Catriona
- Spittle Nick
- Spivey Michael
- Spong Adam
- Sprinckmoller Stefan
- Squires Rebecca
- Stambaugh Martha
- Stammers Katie
- Stanciu Delia
- Stanley Timothy
- Stanworth Simon
- Stapleton Liana
- Starke Lisa
- Stavor Dara
- Stedman Roger
- Steffen Melanie
- Stephanie Gelinotte
- Stephens Deanna
- Stevenson Lesley
- Stewart Richard
- Stienstra Riejanne
- Stone Sarah
- Stowe Bethan
- Stratton Emma
- Stronach Lucy
- Suber Tomeka
- Sukuraman Anila
- Summerfield Anna
- Summers Charlotte
- Sundaram Radha
- Sundaran Dhinesh
- Sunkara Krishna
- Surti Zuhra
- Sutherland Helen
- Sutherland Sara-Beth
- Sutterlin Laetitia
- Sutton Joanne
- Sutu Mihaela
- Sven?ek Franc
- Svit?kar Nikolai
- Swabe Jacqueline
- Sweet Katie
- Sy Eric
- Szakmany Tamas
- Szawarski Piotr
- Tai Charlotte
- Tait Jennifer
- Talia Nadine
- Tallott Mandy
- Tamm Tina
- Tamme Kadri
- Taqdees Huda
- Tarr Esther
- Tate Margaret
- Tatham Kate
- Tavares Silvia
- Taylor Holly
- Taylor Melanie
- Taylor Sian
- Tee Ameila
- Templeton Maie
- Teo Hoon
- Terrill Lenae
- The Stephanie
- Thedinga Karen
- Thomas Amy
- Thomas Ashly
- Thomas Emma
- Thomas Helen
- Thomas Matt
- Thomas Vicky
- Thompson Patricia
- Thompson Taylor
- Thomson Nicola
- Thrush Jessica
- Thurairatnam Saranya
- Tierney Carey
- Tinmouth Alan
- Tirot Patrice
- Tlayjeh Haytham
- Toffalo Sue
- Tolppa Timo
- Tomasi Enrico
- Tomlinson Helen
- Tong Steve
- Tong Steven
- Tony Kiran
- Totzke Juliane
- Touma Omar
- Towns Miriam
- Trapani Tony
- Trask Kara
- Traverse Eleanor
- Trickey Jemma
- Trim Fiona
- Trimmer Ken
- Triulzi Darrell
- Troeman Darren
- Trues Estefania
- Truman Nicholas
- Tsakiridou Kyriaki
- Tsang Jennifer
- Tsinaslanidis Georgios
- Tuckwell Caroline
- Tully Redmond
- Tully Riona
- Tung Raymond
- Tupper-Carey Daryl
- Turgeon Alexis F.
- Turki Salah
- Turner Anne M.
- Turner Elizabeth
- Turner Keri
- Turner-Bone Ian
- Turns Margaret
- TV Bharath
- Udayanga Ishara
- Uddin Ruzena
- Udy Andrew
- Ullmann Hannah
- Umrani Zulfiqar
- Unsworth Adam
- Uriel Alison
- Ustianowski Andrew
- Uyeki Tim
- Vaara Suvi
- Vaduganathan Muthiah
- Vahtera Annukka
- Vale Cassandra
- Valentine Eliza
- Vamplew Luke
- van Amerongen Roosmarijn
- van Bentum-Puijk Wilma
- van Bree Sjoerd
- van de Veerdonk Frank L.
- van den Berg Lettie
- van den Oever Huub
- van der Eng Hetty
- Van Der Heyden Kymbalee
- van der Kraan-Donker Annemarie
- van Gulik Laura
- van Haren Frank
- Van Hecke Jolien
- van Kimmenade Roland
- van Nieuwkoop Kees
- van Zanten Arthur
- van Zuylen Tamara
- Van?t Hoff William
- Vandewoestyne Sophie
- Vanjak Christian
- Vanmali Piyush
- van Opdorp Marjolein
- van Vonderen Marit
- Vargas Jr. Jesus
- Varghese Siby
- Vautier Sarah
- Vazquez-Grande Gloria
- Veenith Tonny
- Veillard Marion
- Venkatesh Bala
- Verlander Mark
- Vermassen Joris
- Vermeiren Daisy
- Vermont - van der Staaij Janine
- Verrier Nathalie
- Vertue Mark
- Verula Jerik
- Victor Saji
- Viehman Alex
- Vieillard-Baron Antoine
- Vignesh C
- Villot Solenne
- VilĂĄ Clara
- Vincent Rachel
- Virdee Satwinder
- Visentin Elisa
- Visser Yorik
- Vita Tina
- Vivier Dominique
- Vodovar Dominique
- Voicu Sebastian
- Voigt Ingo
- Voiriot Guillaume
- Volkov Lev
- Voza Gennaro
- Vuylsteke Alain
- Wada Asako
- Waddington Natalia
- Wahl Nadine
- Waite Alicia
- Walden Andrew
- Walker Gena
- Walker Rachel
- Walker Susan
- Walsh Joanne
- Walsh Tim
- Walsham James
- Walton Catherine
- Wang Shu
- Ward Geraldine
- Ward Kathryn
- Ward Luke
- Warnapura Loku
- Warnock Majella
- Watchorn Olivia
- Waters Abby
- Waterson Sharon
- Watkins Claire
- Watpool Irene
- Watters Malcolm
- Watts Angela
- Waugh Victoria
- Webb Steve A.
- Weber Lisa
- Webster Denise
- Weerasinghe Thanuja
- Weismann Dirk
- Weiss Daniel
- Weissman Alexandra
- Wells Alan
- Wells Colin
- Wells Karen
- Welters Ingeborg
- West Lauren
- Westlake Samantha
- Wetherill Bill
- Wetzold Richard
- Whileman Amanda
- Whitbread Jennifer
- White Alison
- White Hayden
- White Ian
- White Katie
- Whitehead Christina
- Whitehouse Tony
- Wibrow Bradley
- Wigbers Jeanette
- Wijewardena Gayathri
- Wilby Elizabeth
- Wilcox Elizabeth
- Wilcox Louise
- Wild Helen
- Wild Laura
- Wilding Laura
- Wiles Matt
- Wiley Daisy
- Wilhelmsen Elva
- Wilkinson Dean
- Willams Felicity
- Williams Alexandra
- Williams Angharad
- Williams Anna
- Williams Erin
- Williams Gemma
- Williams Hannah
- Williams Karen
- Williams Marie
- Williams Patricia
- Williams Penny
- Williams Tony
- Williams Virginie
- Williamson Dawn
- Williamson James D
- Willis Joanna
- Willson Jayne
- Wilson Anna
- Wilson Craig
- Wilson Jean
- Wilson Maggie
- Winters James
- Winters Lauren
- Wise Matt
- Wisniewski Mary
- Wittekamp Bastiaan
- Wittenberg Wendy
- Wnuk Chris
- Woelke Amy
- Wong Jenny
- Wong Onyee
- Wood Erica
- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Woodward Robert
- Woolett Melissa
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Wright Chris
- Wright Kim
- Wunderley Renee
- Wyatt Rachel
- Wylie Katharine
- Xavier Kugan
- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 nonâcritically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (nâ=â257), ARB (nâ=â248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; nâ=â10), or no RAS inhibitor (control; nâ=â264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ supportâfree days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ supportâfree days among critically ill patients was 10 (â1 to 16) in the ACE inhibitor group (nâ=â231), 8 (â1 to 17) in the ARB group (nâ=â217), and 12 (0 to 17) in the control group (nâ=â231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ supportâfree days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
Cortical Somatosensory Evoked Potentials in Cows
- Publication venue
- Online Research Commons @ ATU
- Publication date
- 01/01/1992
- Field of study
Cholinesterase Inhibitors: Applying Pharmacokinetics to Clinical Decision Making
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study