Andrographis paniculata

Andrographolide is the most abundant terpenoid of A. paniculata which is used in the treatment of diabetes. In this study, we investigated the effects of A. paniculata extract (APE) and andrographolide on the expression of drug-metabolizing enzymes in rat liver and determined whether modulation of these enzymes changed the pharmacokinetics of tolbutamide. Rats were intragastrically dosed with 2 g/kg/day APE or 50 mg/kg/day andrographolide for 5 days before a dose of 20 mg/kg tolbutamide was given. APE and andrographolide reduced the AUC0–12 h of tolbutamide by 37% and 18%, respectively, compared with that in controls. The protein and mRNA levels and enzyme activities of CYP2C6/11, CYP1A1/2, and CYP3A1/2 were increased by APE and andrographolide. To evaluate whether APE or andrographolide affected the hypoglycemic action of tolbutamide, high-fat diet-induced obese mice were used and treated in the same manner as the rats. APE and andrographolide increased CYP2C6/11 expression and decreased plasma tolbutamide levels. In a glucose tolerance test, however, the hypoglycemic effect of tolbutamide was not changed by APE or andrographolide. These results suggest that APE and andrographolide accelerate the metabolism rate of tolbutamide through increased expression and activity of drug-metabolizing enzymes. APE and andrographolide, however, do not impair the hypoglycemic effect of tolbutamide

Dual Targeted Extracellular Vesicles Regulate Oncogenic Genes in Advanced Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDAC) tumours carry multiple gene mutations and respond poorly to treatments. There is currently an unmet need for drug carriers that can deliver multiple gene cargoes to target high solid tumour burden like PDAC. Here, we report a dual targeted extracellular vesicle (dtEV) carrying high loads of therapeutic RNA that effectively suppresses large PDAC tumours in mice. The EV surface contains a CD64 protein that has a tissue targeting peptide and a humanized monoclonal antibody. Cells sequentially transfected with plasmid DNAs encoding for the RNA and protein of interest by Transwell®-based asymmetric cell electroporation release abundant targeted EVs with high RNA loading. Together with a low dose chemotherapy drug, Gemcitabine, dtEVs suppress large orthotopic PANC-1 and patient derived xenograft tumours and metastasis in mice and extended animal survival. Our work presents a clinically accessible and scalable way to produce abundant EVs for delivering multiple gene cargoes to large solid tumours

Depth Profiling Photoelectron-Spectroscopic Study of an Organic Spin Valve with a Plasma-Modified Pentacene Spacer

[[abstract]]We report an enhanced magnetoresistance (MR) in an organic spin valve with an oxygen plasma-treated pentacene (PC) spacer. The spin valve containing PC without the treatment shows no MR effect, whereas those with moderately plasma-treated PC exhibit MR ratios up to 1.64% at room temperature. X-ray photoelectron spectroscopy with depth profiling is utilized to characterize the interfacial electronic properties of the plasma-treated PC spacer which shows the formation of a derivative oxide layer. The results suggest an alternative approach to improve the interface quality and in turn to enhance the MR performance in organic spin valves.[[incitationindex]]SCI[[booktype]]電子

Study of the decay mechanism for B+ to p pbar K+ and B+ to p pbar pi+

We study the characteristics of the low mass ppbar enhancements near threshold in the three-body decays B+ to p pbar K+ and B+ to p pbar pi+. We observe that the proton polar angle distributions in the ppbar helicity frame in the two decays have the opposite polarity, and measure the forward-backward asymmetries as a function of the ppbar mass for the p pbar K+ mode. We also search for the intermediate two-body decays, B+ to pbar Delta++ and B+ to p Delta0bar, and set upper limits on their branching fractions. These results are obtained from a 414 fb^{-1} data sample that contains 449 times 10^6 BBbar events collected near the Upsilon(4S) resonance with the Belle detector at the KEKB asymmetric-energy e+ e- collider.Comment: 15 pages, 5 figures (14 figure files), revisions to Phys. Lett.

The Belle II Physics Book

We present the physics program of the Belle II experiment, located on the intensity frontier SuperKEKB $e^+e^-$ collider. Belle II collected its first collisions in 2018, and is expected to operate for the next decade. It is anticipated to collect 50/ab of collision data over its lifetime. This book is the outcome of a joint effort of Belle II collaborators and theorists through the Belle II theory interface platform (B2TiP), an effort that commenced in 2014. The aim of B2TiP was to elucidate the potential impacts of the Belle II program, which includes a wide scope of physics topics: B physics, charm, tau, quarkonium, electroweak precision measurements and dark sector searches. It is composed of nine working groups (WGs), which are coordinated by teams of theorist and experimentalists conveners: Semileptonic and leptonic B decays, Radiative and Electroweak penguins, phi_1 and phi_2 (time-dependent CP violation) measurements, phi_3 measurements, Charmless hadronic B decay, Charm, Quarkonium(like), tau and low-multiplicity processes, new physics and global fit analyses. This book highlights "golden- and silver-channels", i.e. those that would have the highest potential impact in the field. Theorists scrutinised the role of those measurements and estimated the respective theoretical uncertainties, achievable now as well as prospects for the future. Experimentalists investigated the expected improvements with the large dataset expected from Belle II, taking into account improved performance from the upgraded detector.Comment: 689 page

The Physics of the B Factories

This work is on the Physics of the B Factories. Part A of this book contains a brief description of the SLAC and KEK B Factories as well as their detectors, BaBar and Belle, and data taking related issues. Part B discusses tools and methods used by the experiments in order to obtain results. The results themselves can be found in Part C

The escalation of hostilities in Manchuria, 1945-47: a study of strategic realities and normative guidelines in military conflict in the context of the Chinese civil war

© 2002 Dr. Shiu Chiang ChengThis dissertation is a revisionist study of the early stages of the Chinese Civil War with a focus on the conflict in the Manchurian theatre. The military operations in Manchuria during the late 1940s were pivotal to the outcome of the Chinese Civil War, which in turn determined the political landscape of contemporary China. Clarifying the strategies employed by both sides, this study advances beyond a history of the Civil War as milestone or watershed in Chinese political history, explaining the war from the perspective of theories of conflict. Reviewing the debate between realists and cultural theorists in the international security studies, the dissertation shows that existing interpretations of the war are haunted by tacit realist assumptions on the part of authors, combined with a relative neglect of the actual strategic practices of Chinese military leaders. Based on newly released Civil War documents from both PRC and Taiwan, supplemented by major English sources, this empirical study provides an analysis of the link between the strategic preferences and behavioral norms of political actors. Tracing the ebb and flow or war and peace during the early stages of the Civil War and the inadvertent escalation of hostilities in Manchurian theatre, the thesis demonstrates the interaction between realist position and value-driven considerations in the decision-making processes of leaders in the conflict, notably Mao Zedong and Chiang Kai-shek. The key finding is that the military decision-making of modern Chinese leaders was not founded on a simple Realpolitik approach, as Alastair Johnston might argue. Rather, their strategic culture was hybrid and heterogeneous, presenting mixed features of realist and value-driven considerations. Their perceptions of war, including preferences for guerrilla or mobile warfare, and a belief in swift and decisive victory, were influential in their techniques of crisis management. Of almost equal importance were ethical, historical and emotional factors such as nationalist sentiment, and feelings of moral responsibility or hatred for the enemy, which powerfully informed the behaviour of these leaders during military conflict