212 research outputs found
Efecto de la coaplicaciĂłn de herbicidas y adiciĂłn de alperujo como enmienda en el comportamiento de diurĂłn y terbutilazina en un suelo arcillo-limoso
Congreso celebrado del 21-24 de septiembre 2010, en Granada, EspaĂąa.Los herbicidas se aplican a los cultivos como formulaciones que habitualmente
incluyen mĂĄs de un principio activo. Sin embargo, los estudios sobre comportamiento
de herbicidas en suelos en el laboratorio suelen hacerse aplicando los herbicidas de
forma individual.Peer reviewe
Population genetic suggestions to offset the extinction ratchet in the endangered Canarian endemic Atractylis preauxiana (Asteraceae)
Abstract We examined the levels and apportionment of genetic variation of the 11 known subpopulations of Atractylis preauxiana at 95 RAPD loci to help streamline a conservation strategy for this Canarian endemic taxon, which is in a critical situation because of the constant exposure of plants to intensive, uncontrolled anthropic action in the last few decades. Our results revealed low genetic variation levels that match with the general picture of demographic and habitat degradation that this taxon is undergoing. Although geographic isolation between Tenerife and Gran Canaria is an effective barrier to gene flow, genetic heterogeneity within islands is also substantial, plausibly due to the negative impact of fragmentation on genetic variation. Our genetic results, together with declining population sizes, poor seedling survival, and recent population extinctions, compellingly indicate that A. preauxiana is undergoing an extinction ratchet, whereby every further local extinction will add up to the probability of total species' extinction. Our genetic results suggest that mitigating the deleterious consequences of this effect entails urgent mixed reinforcements of all sub-populations with sub-populations from the same island and urgent translocation of the two sub-populations from Tenerife that are doomed to extinction to ecologically suitable areas, together with seed collection and preservation in a convenient ex situ banking facility
Measurement of the Forward-Backward Asymmetry in the B -> K(*) mu+ mu- Decay and First Observation of the Bs -> phi mu+ mu- Decay
We reconstruct the rare decays , , and in a data sample
corresponding to collected in collisions at
by the CDF II detector at the Fermilab Tevatron
Collider. Using and decays we report the branching ratios. In addition, we report
the measurement of the differential branching ratio and the muon
forward-backward asymmetry in the and decay modes, and the
longitudinal polarization in the decay mode with respect to the squared
dimuon mass. These are consistent with the theoretical prediction from the
standard model, and most recent determinations from other experiments and of
comparable accuracy. We also report the first observation of the {\mathcal{B}}(B^0_s \to
\phi\mu^+\mu^-) = [1.44 \pm 0.33 \pm 0.46] \times 10^{-6}27 \pm 6B^0_s$ decay observed.Comment: 7 pages, 2 figures, 3 tables. Submitted to Phys. Rev. Let
Hydrotherapy as a recovery strategy after exercise: a pragmatic controlled trial
Trial registration
ClinicalTrials.gov Identifier: NCT01765387Background
Our aim was to evaluate the recovery effects of hydrotherapy after aerobic exercise in cardiovascular, performance and perceived fatigue.
Methods
A pragmatic controlled repeated measures; single-blind trial was conducted. Thirty-four recreational sportspeople visited a Sport-Centre and were assigned to a Hydrotherapy group (experimental) or rest in a bed (control) after completing a spinning session. Main outcomes measures including blood pressure, heart rate, handgrip strength, vertical jump, self-perceived fatigue, and body temperature were assessed at baseline, immediately post-exercise and post-recovery. The hypothesis of interest was the session*time interaction.
Results
The analysis revealed significant session*time interactions for diastolic blood pressure (P=0.031), heart rate (P=0.041), self perceived fatigue (P=0.046), and body temperature (P=0.001); but not for vertical jump (P=0.437), handgrip (P=0.845) or systolic blood pressure (P=0.266). Post-hoc analysis revealed that hydrotherapy resulted in recovered heart rate and diastolic blood pressure similar to baseline values after the spinning session. Further, hydrotherapy resulted in decreased self-perceived fatigue after the spinning session.
Conclusions
Our results support that hydrotherapy is an adequate strategy to facilitate cardiovascular recovers and perceived fatigue, but not strength, after spinning exercise
The Latin American experience of allografting patients with severe aplastic anaemia: real-world data on the impact of stem cell source and ATG administration in HLA-identical sibling transplants
We studied 298 patients with severe aplastic anaemia (SAA) allografted in four Latin American countries. The source of cells
was bone marrow (BM) in 94 patients and PBSCs in 204 patients. Engraftment failed in 8.1% of recipients with no difference
between BM and PBSCs (P = 0.08). Incidence of acute GvHD (aGvHD) for BM and PBSCs was 30% vs 32% (P = 0.18), and for grades
IIIâIV was 2.6% vs 11.6% (P = 0.01). Chronic GvHD (cGvHD) between BM and PBSCs was 37% vs 59% (P = 0.002) and extensive 5% vs
23.6% (P = 0.01). OS was 74% vs 76% for BM vs PBSCs (P = 0.95). Event-free survival was superior in patients conditioned with
anti-thymocyte globulin (ATG)-based regimens compared with other regimens (79% vs 61%, P = 0.001) as excessive secondary graft
failure was seen with other regimens (10% vs 26%, P = 0.005) respectively. In multivariate analysis, aGvHD IIâIV (hazard ratio (HR)
2.50, confidence interval (CI) 1.1â5.6, P = 0.02) and aGvHD IIIâIV (HR 8.3 CI 3.4â20.2, Po0.001) proved to be independent negative
predictors of survival. In conclusion, BM as a source of cells and ATG-based regimens should be standard because of higher GvHD
incidence with PBSCs, although the latter combining with ATG in the conditioning regimen could be an option in selected high-risk
patient
Documento de posiciĂłn sobre las necesidades y niveles Ăłptimos de vitamina D
IntroducciĂłnEn los Ăşltimos aĂąos se ha producido un notable interĂŠs por la vitamina D, no sĂłlo por su importancia crucial en el metabolismo mineral Ăłseo, sino tambiĂŠn por los efectos extraĂłseos, cada vez mejor conocidos.
Asi mismo, se ha constatado la existencia de valores sĂŠricos bajos de vitamina D, por debajo de lo deseable, en diferentes poblaciones, tanto sanas como enfermas, y se discute cuĂĄles serĂan los niveles Ăłptimos de vitamina D en sangre.
Por todo ello, la Sociedad EspaĂąola de InvestigaciĂłn Ăsea y Metabolismo Mineral (SEIOMM), conjuntamente con todas las Sociedades CientĂficas implicadas en el estudio del metabolismo Ăłseo, han elaborado el presente documento de posiciĂłn sobre las necesidades y niveles Ăłptimos de vitamina D
Comparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice: GLORIA-AF Registry
Background and purpose: Prospectively collected data comparing the safety and effectiveness of individual non-vitamin K antagonists (NOACs) are lacking. Our objective was to directly compare the effectiveness and safety of NOACs in patients with newly diagnosed atrial fibrillation (AF). Methods: In GLORIA-AF, a large, prospective, global registry program, consecutive patients with newly diagnosed AF were followed for 3 years. The comparative analyses for (1) dabigatran vs rivaroxaban or apixaban and (2) rivaroxaban vs apixaban were performed on propensity score (PS)-matched patient sets. Proportional hazards regression was used to estimate hazard ratios (HRs) for outcomes of interest. Results: The GLORIA-AF Phase III registry enrolled 21,300 patients between January 2014 and December 2016. Of these, 3839 were prescribed dabigatran, 4015 rivaroxaban and 4505 apixaban, with median ages of 71.0, 71.0, and 73.0 years, respectively. In the PS-matched set, the adjusted HRs and 95% confidence intervals (CIs) for dabigatran vs rivaroxaban were, for stroke: 1.27 (0.79â2.03), major bleeding 0.59 (0.40â0.88), myocardial infarction 0.68 (0.40â1.16), and all-cause death 0.86 (0.67â1.10). For the comparison of dabigatran vs apixaban, in the PS-matched set, the adjusted HRs were, for stroke 1.16 (0.76â1.78), myocardial infarction 0.84 (0.48â1.46), major bleeding 0.98 (0.63â1.52) and all-cause death 1.01 (0.79â1.29). For the comparison of rivaroxaban vs apixaban, in the PS-matched set, the adjusted HRs were, for stroke 0.78 (0.52â1.19), myocardial infarction 0.96 (0.63â1.45), major bleeding 1.54 (1.14â2.08), and all-cause death 0.97 (0.80â1.19). Conclusions: Patients treated with dabigatran had a 41% lower risk of major bleeding compared with rivaroxaban, but similar risks of stroke, MI, and death. Relative to apixaban, patients treated with dabigatran had similar risks of stroke, major bleeding, MI, and death. Rivaroxaban relative to apixaban had increased risk for major bleeding, but similar risks for stroke, MI, and death. Registration: URL: https://www.clinicaltrials.gov. Unique identifiers: NCT01468701, NCT01671007. Date of registration: September 2013
Anticoagulant selection in relation to the SAMe-TT2R2 score in patients with atrial fibrillation. the GLORIA-AF registry
Aim: The SAMe-TT2R2 score helps identify patients with atrial fibrillation (AF) likely to have poor anticoagulation control during anticoagulation with vitamin K antagonists (VKA) and those with scores >2 might be better managed with a target-specific oral anticoagulant (NOAC). We hypothesized that in clinical practice, VKAs may be prescribed less frequently to patients with AF and SAMe-TT2R2 scores >2 than to patients with lower scores. Methods and results: We analyzed the Phase III dataset of the Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation (GLORIA-AF), a large, global, prospective global registry of patients with newly diagnosed AF and âĽ1 stroke risk factor. We compared baseline clinical characteristics and antithrombotic prescriptions to determine the probability of the VKA prescription among anticoagulated patients with the baseline SAMe-TT2R2 score >2 and ⤠2. Among 17,465 anticoagulated patients with AF, 4,828 (27.6%) patients were prescribed VKA and 12,637 (72.4%) patients an NOAC: 11,884 (68.0%) patients had SAMe-TT2R2 scores 0-2 and 5,581 (32.0%) patients had scores >2. The proportion of patients prescribed VKA was 28.0% among patients with SAMe-TT2R2 scores >2 and 27.5% in those with scores â¤2. Conclusions: The lack of a clear association between the SAMe-TT2R2 score and anticoagulant selection may be attributed to the relative efficacy and safety profiles between NOACs and VKAs as well as to the absence of trial evidence that an SAMe-TT2R2-guided strategy for the selection of the type of anticoagulation in NVAF patients has an impact on clinical outcomes of efficacy and safety. The latter hypothesis is currently being tested in a randomized controlled trial. Clinical trial registration: URL: https://www.clinicaltrials.gov//Unique identifier: NCT01937377, NCT01468701, and NCT01671007
Observation of long-range, near-side angular correlations in proton-proton collisions at the LHC
This is the pre-print version of the Published Article, which can be accessed from the link below - Copyright @ 2010 Springer VerlagResults on two-particle angular correlations for charged particles emitted in proton-proton collisions at center-of-mass energies of 0.9, 2.36, and 7 TeV are presented, using data collected with the CMS detector over a broad range of pseudorapidity (eta) and azimuthal angle (phi). Short-range correlations in Delta(eta), which are studied in minimum bias events, are characterized using a simple "independent cluster" parametrization in order to quantify their strength (cluster size) and their extent in eta (cluster decay width). Long-range azimuthal correlations are studied differentially as a function of charged particle multiplicity and particle transverse momentum using a 980 inverse nb data set at 7 TeV. In high multiplicity events, a pronounced structure emerges in the two-dimensional correlation function for particle pairs with intermediate transverse momentum of 1-3 GeV/c, 2.0< |Delta(eta)| <4.8 and Delta(phi) near 0. This is the first observation of such a long-range, near-side feature in two-particle correlation functions in pp or p p-bar collisions
Observation of long-range, near-side angular correlations in proton-proton collisions at the LHC
Results on two-particle angular correlations for charged particles emitted in proton-proton collisions at center-of-mass energies of 0.9, 2.36, and 7TeV are presented, using data collected with the CMS detector over a broad range of pseudorapidity (eta) and azimuthal angle (phi). Short-range correlations in Delta(eta), which are studied in minimum bias events, are characterized using a simple "independent cluster" parametrization in order to quantify their strength (cluster size) and their extent in eta (cluster decay width). Long-range azimuthal correlations are studied differentially as a function of charged particle multiplicity and particle transverse momentum using a 980 nb(-1) data set at 7TeV. In high multiplicity events, a pronounced structure emerges in the two-dimensional correlation function for particle pairs with intermediate p(T) of 1-3 GeV/c, 2.
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