95 research outputs found

    Contralateral Cruciate Survival in Dogs with Unilateral Non-Contact Cranial Cruciate Ligament Rupture

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    BACKGROUND: Non-contact cranial cruciate ligament rupture (CrCLR) is an important cause of lameness in client-owned dogs and typically occurs without obvious injury. There is a high incidence of bilateral rupture at presentation or subsequent contralateral rupture in affected dogs. Although stifle synovitis increases risk of contralateral CrCLR, relatively little is known about risk factors for subsequent contralateral rupture, or whether therapeutic intervention may modify this risk. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a longitudinal study examining survival of the contralateral CrCL in client-owned dogs with unilateral CrCLR in a large baseline control population (n = 380), and a group of dogs that received disease-modifying therapy with arthroscopic lavage, intra-articular hyaluronic acid and oral doxycycline (n = 16), and were followed for one year. Follow-up in treated dogs included analysis of mobility, radiographic evaluation of stifle effusion and arthritis, and quantification of biomarkers of synovial inflammation. We found that median survival of the contralateral CrCL was 947 days. Increasing tibial plateau angle decreased contralateral ligament survival, whereas increasing age at diagnosis increased survival. Contralateral ligament survival was reduced in neutered dogs. Our disease-modifying therapy did not significantly influence contralateral ligament survival. Correlative analysis of clinical and biomarker variables with development of subsequent contralateral rupture revealed few significant results. However, increased expression of T lymphocyte-associated genes in the index unstable stifle at diagnosis was significantly related to development of subsequent non-contact contralateral CrCLR. CONCLUSION: Subsequent contralateral CrCLR is common in client-owned dogs, with a median ligament survival time of 947 days. In this naturally occurring model of non-contact cruciate ligament rupture, cranial tibial translation is preceded by development of synovial inflammation. However, treatment with arthroscopic lavage, intra-articular hyaluronic acid and oral doxycycline does not significantly influence contralateral CrCL survival

    Combined search for anomalous pseudoscalar HW couplings in VH(H -> b(b)over-bar) production and H -> VV decay

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    Search for lepton flavour violating decays of the Higgs boson to eτ and eμ in proton–proton collisions at √s=8 TeV

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    A direct search for lepton flavour violating decays of the Higgs boson (H) in the H→eτH→eτ and H→eμH→eμ channels is described. The data sample used in the search was collected in proton–proton collisions at View the MathML sources=8 TeV with the CMS detector at the LHC and corresponds to an integrated luminosity of 19.7 fb−1. No evidence is found for lepton flavour violating decays in either final state. Upper limits on the branching fractions, B(H→eτ)<0.69%B(H→eτ)<0.69% and B(H→eμ)<0.035%B(H→eμ)<0.035%, are set at the 95% confidence level. The constraint set on B(H→eτ)B(H→eτ) is an order of magnitude more stringent than the existing indirect limits. The limits are used to constrain the corresponding flavour violating Yukawa couplings, absent in the standard model

    Measurement of the tt¯ production cross section in the all-jets final state in pp collisions at √s = 8 TeV

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    The cross section for tt¯ production in the all-jets final state is measured in pp collisions at a centre-of-mass energy of 8 TeV at the LHC with the CMS detector, in data corresponding to an integrated luminosity of 18.4 fb-1 . The inclusive cross section is found to be 275.6±6.1(stat)±37.8(syst)±7.2(lumi) \,pb . The normalized differential cross sections are measured as a function of the top quark transverse momenta, pT , and compared to predictions from quantum chromodynamics. The results are reported at detector, parton, and particle levels. In all cases, the measured top quark pT spectra are significantly softer than theoretical predictions

    Search for supersymmetry in electroweak production with photons and large missing transverse energy in pp collisions at √s=8TeV

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    Results are reported from a search for supersymmetry with gauge-mediated supersymmetry breaking in electroweak production. Final states with photons and large missing transverse energy ( ETmiss ) were examined. The data sample was collected in pp collisions at s=8TeV with the CMS detector at the LHC and corresponds to 7.4 fb−1 . The analysis focuses on scenarios in which the lightest neutralino has bino- or wino-like components, resulting in decays to photons and gravitinos, where the gravitinos escape undetected. The data were obtained using a specially designed trigger with dedicated low thresholds, providing good sensitivity to signatures with photons, ETmiss , and low hadronic energy. No excess of events over the standard model expectation is observed. The results are interpreted using the model of general gauge mediation. With the wino mass fixed at 10 GeV above that of the bino, wino masses below 710 GeV are excluded at 95% confidence level. Constraints are also set in the context of two simplified models, for which the analysis sets the lowest cross section limits on the electroweak production of supersymmetric particles

    Measurement of the Z gamma -> nu(nu)over-bar gamma production cross section in pp collisions at root s=8 TeV and limits on anomalous ZZ gamma and Z gamma gamma trilinear gauge boson couplings

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    Measurement of dijet azimuthal decorrelation in pp collisions at root s=8 TeV

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    Pseudorapidity dependence of long-range two-particle correlations in pPb collisions at root sNN=5.02 TeV

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    Measurement of t(t)over-bar production with additional jet activity, including b quark jets, in the dilepton decay channel using pp collisions at root s=8TeV

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    Measurement of the t(t)over-bar production cross section in the all-jets final state in pp collisions at root s=8TeV

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