The Risk of Exposure to Diagnostic Ultrasound in Postnatal Subjects

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135382/1/jum2008274565.pd

White Matter fMRI Activation Cannot Be Treated as a Nuisance Regressor: Overcoming a Historical Blind Spot

Despite past controversies, increasing evidence has led to acceptance that white matter activity is detectable using functional magnetic resonance imaging (fMRI). In spite of this, advanced analytic methods continue to be published that reinforce a historic bias against white matter activation by using it as a nuisance regressor. It is important that contemporary analyses overcome this blind spot in whole brain functional imaging, both to ensure that newly developed noise regression techniques are accurate, and to ensure that white matter, a vital and understudied part of the brain, is not ignored in functional neuroimaging studies

Absolute Paleointensity Study of Miocene Tiva Canyon Tuff, Yucca Mountain, Nevada: Role of Fine‐Particle Grain‐Size Variations

Fine‐grained, Ti‐poor titanomagnetite in the ~12.7 Ma Tiva Canyon (TC) Tuff systematically increases in grain size from superparamagnetic (SP) at the flow base to single domain (SD) at a few meters height. This allows us to examine the role of grain‐size variation on paleointensity, within the transition from SP to stable SD. We present magnetic properties from two previously unreported sections of the TC Tuff, as well as Thellier‐type paleointensity estimates from the lowermost ~7.0 m of the flow. Magnetic hysteresis, frequency‐dependent susceptibility, and thermomagnetic data show that sample grain‐size distribution is dominated by SP in the lower ~3.6 m, transitioning upwards to mostly stable SD. Paleointensity results are closely tied to stratigraphic height and to magnetic properties linked to domain state. SD samples have consistent absolute paleointensity values of 28.5 ± 1.94 μT (VADM of 51.3 ZAm2) and behaved ideally during paleointensity experiments. The samples including a significant SP fraction have consistently higher paleointensities and less ideal behavior but would likely pass many traditional quality‐control tests. We interpret the SD remanence to be a primary thermal remanent magnetization but discuss the possibility of a partial thermal‐chemical remanent magnetization if microcrystal growth continued at T \u3c Tc and/or the section is affected by post‐emplacement vapor‐phase alteration. The link between paleointensity and domain state is stronger than correlations with water content or other evidence of alteration and suggests that the presence of a significant SP population may adversely impact paleointensity results, even in the presence of a stable SD fraction

Chronicles of Oklahoma

Notes and Documents, Chronicles of Oklahoma, Volume 52, Number 1, Spring 1974. It includes documents about celebrations, memorials, historical notes, notes about Oklahoma State University activities, the creation of a new award, an activities of the Oklahoma Historical Society

MutLα heterodimers modify the molecular phenotype of Friedreich ataxia

This article has been made available through the Brunel Open Access Publishing Fund.Background: Friedreich ataxia (FRDA), the most common autosomal recessive ataxia disorder, is caused by a dynamic GAA repeat expansion mutation within intron 1 of FXN gene, resulting in down-regulation of frataxin expression. Studies of cell and mouse models have revealed a role for the mismatch repair (MMR) MutS-heterodimer complexes and the PMS2 component of the MutLα complex in the dynamics of intergenerational and somatic GAA repeat expansions: MSH2, MSH3 and MSH6 promote GAA repeat expansions, while PMS2 inhibits GAA repeat expansions. Methodology/Principal Findings: To determine the potential role of the other component of the MutLα complex, MLH1, in GAA repeat instability in FRDA, we have analyzed intergenerational and somatic GAA repeat expansions from FXN transgenic mice that have been crossed with Mlh1 deficient mice. We find that loss of Mlh1 activity reduces both intergenerational and somatic GAA repeat expansions. However, we also find that loss of either Mlh1 or Pms2 reduces FXN transcription, suggesting different mechanisms of action for Mlh1 and Pms2 on GAA repeat expansion dynamics and regulation of FXN transcription. Conclusions/Significance: Both MutLα components, PMS2 and MLH1, have now been shown to modify the molecular phenotype of FRDA. We propose that upregulation of MLH1 or PMS2 could be potential FRDA therapeutic approaches to increase FXN transcription. © 2014 Ezzatizadeh et al.This article has been made available through the Brunel Open Access Publishing Fund

PARP inhibitors and the treatment of breast cancer: beyond BRCA1/2?

Poly(ADP-ribose) polymerase (PARP) inhibitors have been explored as therapeutic agents for the treatment of hereditary breast and ovarian cancers harboring mutations in BRCA1 or BRCA2. In a new study, Inbar-Rozensal and colleagues show that phenanthridine-derived PARP inhibitors promote cell cycle arrest and cell death in breast cancer cells lacking BRCA1 and BRCA2 mutations and prevent the growth of tumors from xenografts of these cells in immunocompromised mice. These results suggest a potential broader utility of PARP-1 inhibitors in the treatment of breast cancer, although further mechanistic studies are needed

Measurement of the cross-section and charge asymmetry of WW bosons produced in proton-proton collisions at s=8\sqrt{s}=8 TeV with the ATLAS detector

This paper presents measurements of the $W^+ \rightarrow \mu^+\nu$ and $W^- \rightarrow \mu^-\nu$ cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables, submitted to EPJC. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13

Search for chargino-neutralino production with mass splittings near the electroweak scale in three-lepton final states in √s=13 TeV pp collisions with the ATLAS detector

A search for supersymmetry through the pair production of electroweakinos with mass splittings near the electroweak scale and decaying via on-shell W and Z bosons is presented for a three-lepton final state. The analyzed proton-proton collision data taken at a center-of-mass energy of √s=13  TeV were collected between 2015 and 2018 by the ATLAS experiment at the Large Hadron Collider, corresponding to an integrated luminosity of 139  fb−1. A search, emulating the recursive jigsaw reconstruction technique with easily reproducible laboratory-frame variables, is performed. The two excesses observed in the 2015–2016 data recursive jigsaw analysis in the low-mass three-lepton phase space are reproduced. Results with the full data set are in agreement with the Standard Model expectations. They are interpreted to set exclusion limits at the 95% confidence level on simplified models of chargino-neutralino pair production for masses up to 345 GeV

Mastcam multispectral database from the Curiosity rover’s traverse in the Gale crater, Mars (sols 2302-3672)

The Mars Science Laboratory (MSL) Curiosity rover has continued to explore the lower strata of Mt. Sharp in Gale Crater. Evidence for fluvial, lacustrine, and aeolian paleoenvironments has been found by multiple instruments. Curiosity’s multispectral imaging instrument, Mast Camera (Mastcam), is able to collect reflectance data covering visible to near-infrared wavelengths from 445 nm to 1013 nm. The primary control on Mastcam multispectral variability is the presence and amount of iron oxides. However, Mastcam can still make broad interpretations regarding mineralogy and diagenesis, especially when used in tandem with other instruments. This dataset includes Mastcam spectra from 266 observations, collected from sols 2302 to 3672 in Glen Torridon, Greenheugh pediment, and the clay-sulfate transition. Geologic metadata, like the type of rock surface and its position in stratigraphy, is included with each spectrum in the database, as well as image products (decorrelation and enhanced color stretches) that aided in our analyses, and context images that show where the spectra were extracted from